Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

International Journal of Cardiology

Volumn 168, Issue 4, 2013, Pages 3412-3418

  Palus, Sandra ^a   Von Haehling, Stephan ^a   Flach, Valerie C ^a   Tschirner, Anika ^a   Doehner, Wolfram ^a,b   Anker, Stefan D ^c   Springer, Jochen ^a,b,d  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^c IRCCS SAN RAFFAELE PISANA   (Italy)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Body composition; Cancer cachexia; Cardiac function; Hepatoma; Simvastatin; Survival

Indexed keywords

PLACEBO; SIMVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CACHEXIA; CONTROLLED STUDY; DRUG DOSE COMPARISON; ECHOCARDIOGRAPHY; FAT MASS; FEEDING; FOOD INTAKE; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART OUTPUT; HEART PROTECTION; LOCOMOTION; MORTALITY; MUSCLE ATROPHY; MUSCLE MASS; NONHUMAN; PRIORITY JOURNAL; QUALITY OF LIFE; RAT; RISK REDUCTION; SURVIVAL RATE; TUMOR GROWTH; WASTING SYNDROME;

BODY COMPOSITION; CANCER CACHEXIA; CARDIAC FUNCTION; HEPATOMA; SIMVASTATIN; SURVIVAL;

ANIMALS; CACHEXIA; CARDIAC OUTPUT; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; NEOPLASMS; RANDOM ALLOCATION; RATS; RATS, WISTAR; SIMVASTATIN; STROKE VOLUME; TREATMENT OUTCOME;

EID: 84886306895     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.04.150     Document Type: Article

References (37)

1. S. von Haehling, and S.D. Anker Cachexia as a major underestimated and unmet medical need: facts and numbers J Cachex Sarcopenia Muscle 1 2010 1 5
2. R.D. Loberg, D.A. Bradley, S.A. Tomlins, A.M. Chinnaiyan, and K.J. Pienta The lethal phenotype of cancer: the molecular basis of death due to malignancy CA Cancer J Clin 57 2007 225 241
3. A. Ries, P. Trottenberg, and F. Elsner A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: an EPCRC cachexia guidelines project Palliat Med 26 2012 294 304
4. A. Shih, and K.C. Jackson II Role of corticosteroids in palliative care J Pain Palliat Care Pharmacother 21 2007 69 76
5. R.D. Kilgour, A. Vigano, and B. Trutschnigg Cancer-related fatigue: the impact of skeletal muscle mass and strength in patients with advanced cancer J Cachex Sarcopenia Muscle 1 2010 177 185
6. M. Tian, Y. Nishijima, M.L. Asp, M.B. Stout, P.J. Reiser, and M.A. Belury Cardiac alterations in cancer-induced cachexia in mice Int J Oncol 37 2010 347 353
7. P.F. Cosper, and L.A. Leinwand Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner Cancer Res 71 2011 1710 1720
8. K.C. Fearon, D.J. Glass, and D.C. Guttridge Cancer cachexia: mediators, signaling, and metabolic pathways Cell Metab 16 2012 153 166
9. G.D. Kolovou, A. Katerina, V. Ioannis, and D.V. Cokkinos Simvastatin: two decades in a circle Cardiovasc Ther 26 2008 166 178
10. S. von Haehling, S.D. Anker, and E. Bassenge Statins and the role of nitric oxide in chronic heart failure Heart Fail Rev 8 2003 99 106
11. B. Wong, W.C. Lumma, A.M. Smith, J.T. Sisko, S.D. Wright, and T.Q. Cai Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation J Leukoc Biol 69 2001 959 962
12. M.R. Graaf, D.J. Richel, C.J. van Noorden, and H.J. Guchelaar Effects of statins and farnesyltransferase inhibitors on the development and progression of cancer Cancer Treat Rev 30 2004 609 641
13. S. Rao, D.C. Porter, X. Chen, T. Herliczek, M. Lowe, and K. Keyomarsi Lovastatin-mediated G1 arrest is through inhibition of the proteasome, independent of hydroxymethyl glutaryl-CoA reductase Proc Natl Acad Sci USA 96 1999 7797 7802
14. D.J. Glass Signaling pathways perturbing muscle mass Curr Opin Clin Nutr Metab Care 13 2010 225 229
15. P. Kopterides, and M.E. Falagas Statins for sepsis: a critical and updated review Clin Microbiol Infect 15 2009 325 334
16. S. Endo, and T. Shinoki Influence of reticuloendothelial function on the growth of transplantable rat ascites hepatoma (AH-130) Tohoku J Exp Med 94 1968 81 101
17. J. Springer, A. Tschirner, and K. Hartman Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia Int J Cancer 131 2012 2187 2196
18. K. Schmidt, S. von Haehling, W. Doehner, S. Palus, S.D. Anker, and J. Springer IGF-1 treatment reduces weight loss and improves outcome in a rat model of cancer cachexia J Cachex Sarcopenia Muscle 2 2011 105 109
19. A. Tschirner, S. von Haehling, S. Palus, W. Doehner, S.D. Anker, and J. Springer Ursodeoxycholic acid treatment in a rat model of cancer cachexia J Cachex Sarcopenia Muscle 3 2012 31 36
20. Y.J. Akashi, S. Palus, and R. Datta No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure Int J Cardiol 137 2009 267 275
21. D.G. Menter, V.P. Ramsauer, and S. Harirforoosh Differential effects of pravastatin and simvastatin on the growth of tumor cells from different organ sites PLoS One 6 2011 e28813
22. J.J. Greer, A.K. Kakkar, J.W. Elrod, L.J. Watson, S.P. Jones, and D.J. Lefer Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure Am J Physiol Heart Circ Physiol 291 2006 H2743 H2751
23. A. Nakagomi, Y. Seino, and K. Kohashi Effects of statin therapy on the production of monocyte pro-inflammatory cytokines, cardiac function, and long-term prognosis in chronic heart failure patients with dyslipidemia Circ J 76 2012 2130 2138
24. S.S. Wing, S.H. Lecker, and R.T. Jagoe Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks Crit Rev Clin Lab Sci 48 2011 49 70
25. J.M. Argiles, S. Busquets, and F.J. Lopez-Soriano Anti-inflammatory therapies in cancer cachexia Eur J Pharmacol 668 Suppl. 1 2011 S81 S86
26. M.G. Catalano, N. Fortunati, and K. Arena Selective up-regulation of tumor necrosis factor receptor I in tumor-bearing rats with cancer-related cachexia Int J Oncol 23 2003 429 436
27. C. Wojcik, M. Bury, and T. Stoklosa Lovastatin and simvastatin are modulators of the proteasome Int J Biochem Cell Biol 32 2000 957 965
28. M. Muscaritoli, P. Costelli, and M. Bossola Effects of simvastatin administration in an experimental model of cancer cachexia Nutrition 19 2003 936 939
29. D. Gazzieri, M. Trevisani, and J. Springer Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury Free Radic Biol Med 43 2007 581 589
30. J. Heineke, M. Auger-Messier, and J. Xu Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure Circulation 121 2010 419 425
31. X. Zhou, J.L. Wang, and J. Lu Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival Cell 142 2010 531 543
32. S. Busquets, N. Carbo, V. Almendro, M. Figueras, F.J. Lopez-Soriano, and J.M. Argiles Hyperlipemia: a role in regulating UCP3 gene expression in skeletal muscle during cancer cachexia? FEBS Lett 505 2001 255 258
33. K. Tanaka, N. Urata, and M. Mikami Effect of iguratimod and other anti-rheumatic drugs on adenocarcinoma colon 26-induced cachexia in mice Inflamm Res 56 2007 17 23
34. K.R. Rice, M.O. Koch, L. Cheng, and T.A. Masterson Dyslipidemia, statins and prostate cancer Expert Rev Anticancer Ther 12 2012 981 990
35. R.A. Wild Dyslipidemia in PCOS Steroids 77 2012 295 299
36. M. Correale, S. Abruzzese, C.A. Greco, M. Concilio, M. Di Biase, and N.D. Brunetti Statins in heart failure Curr Vasc Pharmacol 2012 [Electronic publication ahead of print 20 Sep 2012]
37. D.G. Bezerra, and C.A. Mandarim-de-Lacerda Beneficial effect of simvastatin and pravastatin treatment on adverse cardiac remodelling and glomeruli loss in spontaneously hypertensive rats Clin Sci (Lond) 108 2005 349 355