Effects of Methyl Donor Diets on Incisional Pain in Mice

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Sun, Yuan ^a,b   Liang, Deyong ^a,b   Sahbaie, Peyman ^a,b   Clark, J David ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; CHOLINE; CYANOCOBALAMIN; FOLIC ACID; GENISTEIN; METHIONINE; ZINC;

ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HEAT SENSITIVITY; MALE; MOUSE; NOCICEPTION; NONHUMAN; PAIN; PAIN ASSESSMENT; PAIN THRESHOLD; PERINATAL PERIOD; SENSITIZATION; SEX DIFFERENCE; WEANING; WEIGHT GAIN;

ANIMALS; CHOLINE; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; HINDLIMB; HYPERALGESIA; MALE; METHIONINE; MICE; MICE, INBRED C57BL; PAIN; VITAMIN B 12; WEANING;

EID: 84886305584     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077881     Document Type: Article

References (25)

1. Denk F, McMahon SB, (2012) Chronic pain: emerging evidence for the involvement of epigenetics. Neuron 73: 435-444.
2. Mathers JC, Strathdee G, Relton CL, (2010) Induction of epigenetic alterations by dietary and other environmental factors. Adv Genet 71: 3-39.
3. Dominguez-Salas P, Cox SE, Prentice AM, Hennig BJ, Moore SE, (2012) Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects. Proc Nutr Soc 71: 154-165.
4. Waterland RA, Jirtle RL, (2003) Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 23: 5293-5300.
5. Hollingsworth JW, Maruoka S, Boon K, Garantziotis S, Li Z, et al. (2008) In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Invest 118: 3462-3469.
6. Schaible TD, Harris RA, Dowd SE, Smith CW, Kellermayer R, (2011) Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes. Hum Mol Genet 20: 1687-1696.
7. Jacob RA, Gretz DM, Taylor PC, James SJ, Pogribny IP, et al. (1998) Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr 128: 1204-1212.
8. Burdge GC, Lillycrop KA, Phillips ES, Slater-Jefferies JL, Jackson AA, et al. (2009) Folic acid supplementation during the juvenile-pubertal period in rats modifies the phenotype and epigenotype induced by prenatal nutrition. J Nutr 139: 1054-1060.
9. Wang Y, Liu C, Guo QL, Yan JQ, Zhu XY, et al. (2011) Intrathecal 5-azacytidine inhibits global DNA methylation and methyl- CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury. Brain Res 1418: 64-69.
10. Gruber HE, Sage EH, Norton HJ, Funk S, Ingram J, et al. (2005) Targeted deletion of the SPARC gene accelerates disc degeneration in the aging mouse. J Histochem Cytochem 53: 1131-1138.
11. Tajerian M, Alvarado S, Millecamps M, Dashwood T, Anderson KM, et al. (2011) DNA methylation of SPARC and chronic low back pain. Mol Pain 7: 65.
12. Doehring A, Oertel BG, Sittl R, Lotsch J, (2013) Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain. Pain 154: 15-23.
13. Viet CT, Ye Y, Dang D, Lam DK, Achdjian S, et al. (2011) Re-expression of the methylated EDNRB gene in oral squamous cell carcinoma attenuates cancer-induced pain. Pain 152: 2323-2332.
14. Liang DY, Sun Y, Clark JD, (2013) Dietary methyl content regulates opioid responses in mice. J Pain Res 6: 281-287.
15. Waterland RA (2003) Do maternal methyl supplements in mice affect DNA methylation of offspring? J Nutr 133: 238; author reply 239.
16. Sun Y, Li XQ, Sahbaie P, Shi XY, Li WW, et al. (2012) miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression. Anesthesiology 117: 626-638.
17. Poree LR, Guo TZ, Kingery WS, Maze M, (1998) The analgesic potency of dexmedetomidine is enhanced after nerve injury: a possible role for peripheral alpha2-adrenoceptors. Anesth Analg 87: 941-948.
18. Hargreaves K, Dubner R, Brown F, Flores C, Joris J, (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32: 77-88.
19. Suter MA, Aagaard-Tillery KM, (2009) Environmental influences on epigenetic profiles. Semin Reprod Med 27: 380-390.
20. Warner MJ, Ozanne SE, (2010) Mechanisms involved in the developmental programming of adulthood disease. Biochem J 427: 333-347.
21. Doehring A, Geisslinger G, Lotsch J, (2011) Epigenetics in pain and analgesia: an imminent research field. Eur J Pain 15: 11-16.
22. Turcot V, Bouchard L, Faucher G, Tchernof A, Deshaies Y, et al. (2011) DPP4 gene DNA methylation in the omentum is associated with its gene expression and plasma lipid profile in severe obesity. Obesity (Silver Spring) 19: 388-395.
23. Mogil JS, (2012) Pain genetics: past, present and future. Trends Genet 28: 258-266.
24. Maloney CA, Hay SM, Young LE, Sinclair KD, Rees WD, (2011) A methyl-deficient diet fed to rat dams during the peri-conception period programs glucose homeostasis in adult male but not female offspring. J Nutr 141: 95-100.
25. Sinclair KD, Allegrucci C, Singh R, Gardner DS, Sebastian S, et al. (2007) DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A 104: 19351-19356.