Hypocretinergic system: Role in REM-sleep regulation

Rapid Eye Movement Sleep: Regulation and Function

Volumn , Issue , 2011, Pages 234-246

  Alam, Md Noor ^a   Szymusiak, Ronald ^a   McGinty, Dennis ^a  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84886301872     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511921179.026     Document Type: Chapter

References (47)

1. Adamantidis, A. R., Zhang, F., Aravanis, A. M., Deisseroth, K. & de Lecea, L. (2007) Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 450: 420-4.
2. Alam, M. N., Gong, H., Alam, T., Jaganath, R., McGinty, D. & Szymusiak, R. (2002) Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area. J Physiol 538: 619-31.
3. Alam, M. N., Kumar, S., Bashir, T. et al. (2005) GABA-mediated control of hypocretin-but not melanin-concentrating hormone immunoreactive neurones during sleep in rats. J Physiol 563: 569-82.
4. Chemelli, R. M., Willie, J. T., Sinton, C. M. et al. (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98: 437-51.
5. de Lecea, L., Kilduff, T. S., Peyron, C. et al. (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95: 322-7.
6. Eggermann, E., Bayer, L., Serafin, M. et al. (2003) The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization. J Neurosci 23: 1557-62.
7. Eriksson, K. S., Sergeeva, O. A., Haas, H. L. & Selbach, O. (2010) Orexins/hypocretins and aminergic systems. Acta Physiol (Oxf) 198: 263-75.
8. Fort, P., Bassetti, C. L. & Luppi, P. H. (2009) Alternating vigilance states: new insights regarding neuronal networks and mechanisms. Eur J Neurosci 29: 1741-53.
9. Gallopin, T., Fort, P., Eggermann, E., et al. (2000) Identification of sleep-promoting neurons in vitro. Nature 404: 992-5.
10. Gong, H., McGinty, D., Guzman-Marin, R., et al. (2004) Activation of c-fos in GABAergic neurones in the preoptic area during sleep and in response to sleep deprivation. J Physiol 556: 935-46.
11. Hassani, O. K., Lee, M. G. & Jones, B. E. (2009) Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle. Proc Natl Acad Sci USA 106: 2418-22.
12. Henny, P. & Jones, B. E. (2006) Innervation of orexin/hypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins. J Comp Neurol 499: 645-61.
13. Huang, Z. L., Qu, W. M., Li, W. D. et al. (2001) Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci USA 98: 9965-70.
14. Jones, B. E. (2008) Modulation of cortical activation and behavioral arousal by cholinergic and orexinergic systems. Ann N YAcad Sci 1129: 26-34.
15. Kukkonen, J. P., Holmqvist, T., Ammoun, S. & Akerman, K. E. (2002) Functions of the orexinergic/hypocretinergic system. Am J Physiol Cell Physiol 283: C1567-91.
16. Kumar, S., Szymusiak, R., Bashir, T. et al. (2008) Inactivation of median preoptic nucleus causes c-Fos expression in hypocretin-and serotonin-containing neurons in anesthetized rat. Brain Res 1234: 66-77.
17. Kumar, S., Szymusiak, R., Methippara, M. M. et al. (2005) GABAergic and glutamatergic neurons in the perifornical lateral hypothalamic area exhibit differential Fos expression after sleep deprivation vs. recovery sleep. Sleep 29: A146.
18. Lee, M. G., Hassani, O. K. & Jones, B. E. (2005) Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J Neurosci 25: 6716-20.
19. Li, Y., Gao, X. B., Sakurai, T. & van den Pol, A. N. (2002) Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron: a potential mechanism for orchestrating the hypothalamic arousal system. Neuron 36:1169-81.
20. Lin, L., Faraco, J., Li, R. et al. (1999) The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98: 365-76.
21. Liu, Z. W. & Gao, X. B. (2007) Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. Neurophysiol 97: 837-48.
22. Lu, J., Sherman, D., Devor, M. & Saper, C. B. (2006) A putative flip-flop switch for control of REM sleep. Nature 441: 589-94.
23. Marcus, J. N., Aschkenasi, C. J., Lee, C. E. et al. (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435: 6-25.
24. Matsuki, T., Nomiyama, M., Takahira, H. et al. (2009) Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci USA 106: 4459-64.
25. McCarley, R.W. (2007) Neurobiology of REM and NREM sleep. Sleep Med 8: 302-30.
26. Mileykovskiy, B. Y., Kiyashchenko, L. I. & Siegel, J. M. (2005) Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46: 787-98.
27. Modirrousta, M., Mainville, L. & Jones, B. E. (2005) Orexin and MCH neurons express c-Fos differently after sleep deprivation vs. recovery and bear different adrenergic receptors. Eur J Neurosci 21: 2807-16.
28. Mori, T., Ito, S., Kuwaki, T., Yanagisawa, M. & Sawaguchi, T. (2009) Monoaminergic neuronal changes in orexin deficient mice. Neuropharmacology.
29. Nishino, S., Okuro, M., Kotorii, N. et al. (2010) Hypocretin/orexin and narcolepsy: new basic and clinical insights, Acta Physiol (Oxf) 198: 209-22.
30. Ohno, K. & Sakurai, T. (2008) Orexin neuronal circuitry: role in the regulation of sleep and wakefulness. Front Neuroendocrinol 29: 70-87.
31. Peyron, C., Faraco, J., Rogers, et al. (2000) A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 6: 991-7.
32. Peyron, C., Tighe, D. K., van den Pol, A. N., et al. (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18: 9996-10,015.
33. Sakurai, T., Amemiya, A., Ishii, M. et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-85.
34. Sakurai, T., Nagata, R., Yamanaka, A. et al. (2005) Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron 46: 297-308.
35. Saper, C. B., Cano, G. & Scammell, T. E. (2005) Homeostatic, circadian, and emotional regulation of sleep. J Comp Neurol 493: 92-8.
36. Siegel, J. M. (2004a) Hypocretin (orexin): role in normal behavior and neuropathology. Ann Rev Psychol 55: 125-48.
37. Siegel, J.M. (2004b) The neurotransmitters of sleep, J Clin Psychiatry, 65 Suppl 16: 4-7.
38. Suntsova, N., Guzman-Marin, R., Kumar, S. et al. (2007) The median preoptic nucleus reciprocally modulates activity of arousal-related and sleep-related neurons in the perifornical lateral hypothalamus. J Neurosci 27: 1616-30.
39. Suntsova, N., Szymusiak, R., Alam, M. N., Guzman-Marin, R. &McGinty, D. (2002) Sleep-waking discharge patterns of median preoptic nucleus neurons in rats. J Physiol 543: 665-77.
40. Szymusiak, R. & McGinty, D. (2008) Hypothalamic regulation of sleep and arousal. Ann N Y Acad Sci 1129: 275-86.
41. Thakkar, M. M., Engemann, S. C., Walsh, K. M. & Sahota, P. K., (2008) Adenosine and the homeostatic control of sleep: effects of A1 receptor blockade in the perifornical lateral hypothalamus on sleep-wakefulness. Neuroscience 153: 875-80.
42. Thakkar, M. M., Ramesh, V., Cape, E. G. et al. (1999) REM sleep enhancement and behavioral cataplexy following orexin (hypocretin)-II receptor antisense perfusion in the pontine reticular formation. Sleep Res Online 2: 112-20.
43. Thannickal, T. C., Moore, R. Y., Nienhuis, R. et al. (2000) Reduced number of hypocretin neurons in human narcolepsy. Neuron 27: 469-74.
44. Torrealba, F., Yanagisawa, M. & Saper, C. B. (2003) Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats. Neuroscience 119: 1033-44.
45. Uschakov, A., Gong, H., McGinty, D. & Szymusiak, R. (2006) Sleep-active neurons in the preoptic area project to the hypothalamic paraventricular nucleus and perifornical lateral hypothalamus. Eur J Neurosci 23: 3284-96.
46. Verret, L., Goutagny, R., Fort, P. et al. (2003) A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci 4:19.
47. Yoshida, K., McCormack, S., Espana, R. A., Crocker, A. & Scammell, T. E. (2006) Afferents to the orexin neurons of the rat brain. J Comp Neurol 494: 845-61.