The neurotransmitters of sleep

Journal of Clinical Psychiatry

Volumn 65, Issue SUPPL. 16, 2004, Pages 4-7

  Siegel, Jerome M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; GLUTAMIC ACID; HISTAMINE; NEUROPEPTIDE; NORADRENALIN; OREXINS; SEROTONIN; SIGNAL PEPTIDE;

AROUSAL; FOREBRAIN; HUMAN; HYPOTHALAMUS; MOTOR ACTIVITY; MUSCLE TONE; NERVE CELL INHIBITION; PHYSIOLOGY; REVIEW; SLEEP;

AROUSAL; GLUTAMIC ACID; HISTAMINE; HUMANS; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOTOR ACTIVITY; MUSCLE TONUS; NEURAL INHIBITION; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; NOREPINEPHRINE; PROSENCEPHALON; SEROTONIN; SLEEP;

EID: 16544372236     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.v65n0101     Document Type: Review

References (34)

1. Siegel JM. Brainstem mechanisms generating REM sleep. In: Kryger MH, Roth T, Dement WC, et al, eds. 3rd ed. Principles and Practices of Sleep Medicine. Philadelphia, Pa: WB Saunders Co; 2000:112-133
2. Jacobs BL, Azmitia EC. Structure and function of the brain serotonin system. Physiol Rev 1992;72:165-229
3. Aston-Jones G, Bloom FE. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci 1981;1:876-886
4. Sakai K, El Mansari M, Lin JS, et al. The posterior hypothalamus in the regulation of wakefulness and paradoxical sleep. In: Mancia M, Marini G, eds. The Diencephalon and Sleep. New York, NY: Lippincott Williams & Wilkins; 1990:171-198
5. Strecker RE, Nalwalk J, Dauphin LJ, et al. Extracellular histamine levels in the feline preoptic/anterior hypothalamic area during natural sleep-wakefulness and prolonged wakefulness: an in vivo microdialysis study. Neuroscience 2002;113:663-670
6. John J, Wu MF, Boehmer LN, et al. Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior. Neuron 2004;42:619-634
7. Saper CB, Chou TC, Scammell TE. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci 2001;24:726-731
8. Szymusiak R. Magnocellular nuclei of the basal forebrain: substrates of sleep and arousal regulation. Sleep 1995;18:478-500
9. Nitz D, Siegel JM. GABA release in posterior hypothalamus across sleep-wake cycle. Am J Physiol 1996;271(6, pt 2):R1707-R1712
10. Lin JS, Sakai K, Jouvet M. Evidence for histaminergic arousal mechanisms in the hypothalamus of cat. Neuropharmacology 1988;27:111-122
11. Lin JS, Sakai K, Jouvet M. Hypothalamo-preoptic histaminergic projections in sleep-wake control in the cat. Eur J Neurosci 1994;6:818-825
12. Wu MF, Gulyani S, Yau E, et al. Locus coeruleus neurons: cessation of activity during cataplexy. Neuroscience 1999;91:1389-1399
13. Lai YY, Kodama T, Siegel JM. Changes in monoamine release in the ventral horn and hypoglossal nucleus linked to pontine inhibition of muscle tone: an in vivo microdialysis study. J Neurosci 2001;21:7384-7391
14. Siegel JM, Nienhuis R, Fahringer H, et al. Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla. Science 1991;252:1315-1318
15. Siegel JM, Nienhuis R, Fahringer HM, et al. Activity of medial mesopontine units during cataplexy and sleep-waking states in the narcoleptic dog. J Neurosci 1992;12:1840-1846
16. Wu MF, John J, Boehmer LN, et al. Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs. J Physiol 2004;554(pt 1):202-215
17. Nitz D, Siegel JM. GABA release in the dorsal raphe nucleus: role in the control of REM sleep. Am J Physiol 1997;273:R451-R455
18. Nitz D, Siegel JM. GABA release in the locus coeruleus as a function of the sleep/wake state. Neurosci 1997;78:795-801
19. Overeem S, Scammell TE, Lammers GJ. Hypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsy. Curr Opin Neurol 2002;15:739-745
20. Gerashchenko D, Shiromani PJ. Different neuronal phenotypes in the lateral hypothalamus and their role in sleep and wakefulness. Mol Neurobiol 2004;29:41-59
21. Thannickal TC, Moore RY, Nienhuis R, et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000;27:469-474
22. Thannickal TC, Moore RY, Aldrich M, et al. Human narcolepsy is linked to reduced number, size and synaptic bouton density in hypocretin-2 labeled neurons. Abstr Soc Neurosci 2000;26:2061
23. Thannickal TC, Siegel JM, Moore RY. Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy. Brain Pathol 2003;13:340-351
24. Nishino S, Ripley B, Overeem S, et al. Hypocretin (orexin) deficiency in human narcolepsy [letter]. Lancet 2000;355:39-40
25. Siegel JM. Hypocretin (orexin): role in normal behavior and neuropathology. Annu Rev Psychol 2004;55:125-148
26. van den Pol AN, Gao XB, Obrietan K, et al. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J Neurosci 1998;18:7962-7971
27. Follwell MJ, Ferguson AV. Cellular mechanisms of orexin actions on paraventricular nucleus neurones in rat hypothalamus. J Physiol 2002;545:855-867
28. John J, Wu MF, Kodama T, et al. Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats. J Physiol 2003;548:557-562
29. Peever JH, Lai YY, Siegel JM. Excitatory effects of hypocretin-1 (orexin-A) in the trigeminal motor nucleus are reversed by NMDA antagonism. J Neurophysiol 2003;89:2591-2600
30. Schenck CH, Mahowald MW. Motor dyscontrol in narcolepsy: rapid eye movement (REM) sleep without atonia and REM sleep behavior disorder. Ann Neurol 1992;32:3-10
31. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association; 1994
32. Chase MH, Morales FR. Control of motoneurons during sleep. In: Kryger MH, Roth T, Dement WC, et al, eds. 3rd ed. Principles and Practice of Sleep Medicine. Philadelphia, Pa: WB Saunders Co; 2000:155-168
33. Kodama T, Lai YY, Siegel JM. Changes in inhibitory amino acid release linked to pontine-induced atonia: an in vivo microdialysis study. J Neurosci 2003;23:1548-1554
34. John J, Wu MF, Siegel JM. Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs. Sleep Res Online 2000;3:23-28