Adenosine and the homeostatic control of sleep: Effects of A1 receptor blockade in the perifornical lateral hypothalamus on sleep-wakefulness

Neuroscience

Volumn 153, Issue 4, 2008, Pages 875-880

  Thakkar, M M ^a   Engemann, S C ^a   Walsh, K M ^a   Sahota, P K ^a  

^a University of Missouri   (United States)

Author keywords

A1 receptor; adenosine; orexin; perifornical lateral hypothalamus; sleep

Indexed keywords

1,3 DIPROPYL 8 PHENYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HOMEOSTASIS; LATERAL HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SLEEP DEPRIVATION; SLEEP PATTERN; WAKEFULNESS;

ADENOSINE; ANALYSIS OF VARIANCE; ANIMALS; CIRCADIAN RHYTHM; DELTA RHYTHM; DOSE-RESPONSE RELATIONSHIP, DRUG; HOMEOSTASIS; HYPOTHALAMIC AREA, LATERAL; MALE; MICROINJECTIONS; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTOR, ADENOSINE A1; SLEEP; SLEEP DEPRIVATION; TIME FACTORS; WAKEFULNESS; XANTHINES;

EID: 43949099252     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2008.01.017     Document Type: Article

References (34)

1. Alam M.N., Gong H., Alam T., Jaganath R., McGinty D., and Szymusiak R. Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area. J Physiol 538 (2002) 619-631
2. Alam M.N., Szymusiak R., Gong H., King J., and McGinty D. Adenosinergic modulation of rat basal forebrain neurons during sleep and waking: neuronal recording with microdialysis. J Physiol 521 Pt 3 (1999) 679-690
3. Alam M.N., Szymusiak R., and McGinty D. Adenosinergic regulation of sleep: multiple sites of action in the brain. Sleep 29 (2006) 1384-1385
4. Basheer R., Strecker R.E., Thakkar M.M., and McCarley R.W. Adenosine and sleep-wake regulation. Prog Neurobiol 73 (2004) 379-396
5. Blanco-Centurion C., Xu M., Murillo-Rodriguez E., Gerashchenko D., Shiromani A.M., Salin-Pascual R.J., Hof P.R., and Shiromani P.J. Adenosine and sleep homeostasis in the basal forebrain. J Neurosci 26 (2006) 8092-8100
6. Borbely A.A. A two process model of sleep regulation. Hum Neurobiol 1 (1982) 195-204
7. Bourgin P., Huitron-Resendiz S., Spier A.D., Fabre V., Morte B., Criado J.R., Sutcliffe J.G., Henriksen S.J., and de Lecea L. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J Neurosci 20 (2000) 7760-7765
8. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Williams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., and Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 (1999) 437-451
9. Chen L., Thakkar M.M., Winston S., Bolortuya Y., Basheer R., and McCarley R.W. REM sleep changes in rats induced by siRNA-mediated orexin knockdown. Eur J Neurosci 24 (2006) 2039-2048
10. Daly J.W., Padgett W., Shamim M.T., Butts-Lamb P., and Waters J. 1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors. J Med Chem 28 (1985) 487-492
11. Datta S., and Maclean R.R. Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: Reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence. Neurosci Biobehav Rev 31 (2007) 775-824
12. Gerashchenko D., Kohls M.D., Greco M., Waleh N.S., Salin-Pascual R., Kilduff T.S., Lappi D.A., and Shiromani P.J. Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat. J Neurosci 21 (2001) 7273-7283
13. 1 receptor agonist into the perifornical lateral hypothalamic area on sleep. Program No. 458.12.2006 Neuroscience Meeting Planner, Atlanta, GA: Society for Neuroscience [online].
14. Lee M.G., Hassani O.K., and Jones B.E. Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J Neurosci 25 (2005) 6716-6720
15. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qiu X., de Jong P.J., Nishino S., and Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98 (1999) 365-376
16. Liu Z.W., and Gao X.B. Adenosine inhibits activity of hypocretin/orexin neurons via A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. J Neurophysiol (2006)
17. McCarley R.W. Neurobiology of REM and NREM sleep. Sleep Med 8 (2007) 302-330
18. Methippara M.M., Alam M.N., Szymusiak R., and McGinty D. Effects of lateral preoptic area application of orexin-A on sleep- wakefulness. Neuroreport 11 (2000) 3423-3426
19. Mignot E. Sleep, sleep disorders and hypocretin (orexin). Sleep Med 5 Suppl 1 (2004) S2-S8
20. Mileykovskiy B.Y., Kiyashchenko L.I., and Siegel J.M. Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46 (2005) 787-798
21. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates (1998), Academic Press, Boston
22. Pollock M.S., and Mistlberger R.E. Rapid eye movement sleep induction by microinjection of the GABA-A antagonist bicuculline into the dorsal subcoeruleus area of the rat. Brain Res 962 (2003) 68-77
23. Portas C.M., Thakkar M., Rainnie D.G., Greene R.W., and McCarley R.W. Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat. Neuroscience 79 (1997) 225-235
24. Radulovacki M., Virus R.M., Djuricic-Nedelson M., and Green R.D. Adenosine analogs and sleep in rats. J Pharmacol Exp Ther 228 (1984) 268-274
25. Selbach O., and Haas H.L. Hypocretins: the timing of sleep and waking. Chronobiol Int 23 (2006) 63-70
26. Strecker R.E., Morairty S., Thakkar M.M., Porkka-Heiskanen T., Basheer R., Dauphin L.J., Rainnie D.G., Portas C.M., Greene R.W., and McCarley R.W. Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state. Behav Brain Res 115 (2000) 183-204
27. Thakkar M., and Mallick B.N. Effect of rapid eye movement sleep deprivation on 5′-nucleotidase activity in the rat brain. Neurosci Lett 206 (1996) 177-180
28. Thakkar M.M., Delgiacco R.A., Strecker R.E., and McCarley R.W. Adenosinergic inhibition of basal forebrain wakefulness-active neurons: a simultaneous unit recording and microdialysis study in freely behaving cats. Neuroscience 122 (2003) 1107-1113
29. Thakkar M.M., Winston S., and McCarley R.W. A1 receptor and adenosinergic homeostatic regulation of sleep-wakefulness: effects of antisense to the A1 receptor in the cholinergic basal forebrain. J Neurosci 23 (2003) 4278-4287
30. Thakkar M.M., Ramesh V., Cape E.G., Winston S., Strecker R.E., and McCarley R.W. REM sleep enhancement and behavioral cataplexy following orexin (hypocretin)-II receptor antisense perfusion in the pontine reticular formation. Sleep Res Online 2 (1999) 112-120
31. Thakkar M.M., Ramesh V., Strecker R.E., and McCarley R.W. Microdialysis perfusion of orexin-A in the basal forebrain increases wakefulness in freely behaving rats. Arch Ital Biol 139 (2001) 313-328
32. Thakkar M.M., Winston S., and McCarley R.W. Orexin neurons of the hypothalamus express adenosine A1 receptors. Brain Res 944 (2002) 190-194
33. Thannickal T.C., Moore R.Y., Nienhuis R., Ramanathan L., Gulyani S., Aldrich M., Cornford M., and Siegel J.M. Reduced number of hypocretin neurons in human narcolepsy. Neuron 27 (2000) 469-474
34. Wurts S.W., and Edgar D.M. Caffeine during sleep deprivation: sleep tendency and dynamics of recovery sleep in rats. Pharmacol Biochem Behav 65 (2000) 155-162