Standardized aqueous Tribulus terristris (Nerunjil) extract attenuates hyperalgesia in experimentally induced diabetic neuropathic pain model: Role of oxidative stress and inflammatory mediators

Phytotherapy Research

Volumn 27, Issue 11, 2013, Pages 1646-1657

  Ranjithkumar, Ravichandran ^a   Prathab Balaji, S ^a   Balaji, Bhaskar ^a   Ramesh, R V ^b   Ramanathan, Muthiah ^a  

^a PSG COLLEGE OF PHARMACY   (India)

^b N Rama Varier Ayurveda Foundation   (India)

Author keywords

allodynia; cytokines; nerunjil; oxidative stress; streptozotocin; thermal analgesia

Indexed keywords

CATALASE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; INSULIN; INTERLEUKIN 1BETA; LIPID PEROXIDE; PREGABALIN; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRIBULUS TERRESTRIS EXTRACT; TUMOR NECROSIS FACTOR ALPHA;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DIABETIC NEUROPATHY; DOSE RESPONSE; DRUG DOSE COMPARISON; GLUCOSE BLOOD LEVEL; HYPERALGESIA; MALE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; OXIDATIVE STRESS; PAIN THRESHOLD; PHYTOCHEMISTRY; RAT; STANDARDIZATION; TREATMENT DURATION;

RATTUS; TRIBULUS;

ALLODYNIA; CYTOKINES; NERUNJIL; OXIDATIVE STRESS; STREPTOZOTOCIN; THERMAL ANALGESIA;

ANIMALS; CATALASE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; FRUIT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYPERALGESIA; INFLAMMATION; INSULIN; INTERLEUKIN-1BETA; LIPID PEROXIDATION; MALE; MEDICINE, AYURVEDIC; NEURALGIA; OXIDATIVE STRESS; PAIN THRESHOLD; PLANT EXTRACTS; RATS; RATS, WISTAR; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRIBULUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84886284424     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4915     Document Type: Article

References (42)

1. Beers RF, Sizer IW,. 1952. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 195: 133-140.
2. Beyreuther B, Callizot N, Stöhr T,. 2006. Antinociceptive efficacy of lacosamide in a rat model for painful diabetic neuropathy. Eur J Pharmacol 539: 64-70.
3. Bonnefont-Rousselot D,. 2002. Glucose and reactive oxygen species. Curr Opin Clin Nutr Metab Care 5: 561-568.
4. Calcutt NA, Jorge MC, Yaksh TL, Chaplan TL,. 1996. Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. Pain 68: 293-299.
5. Can OD, Ozturk Y, Ozturk N, et al,. 2011. Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin- diabetic rats. Fitoterapia 82: 576-584.
6. Casey GP, Paul D, Gould HJ,. 2010. Insulin is essential for the recovery from allodynia induced by complete Freund's adjuvant. Pain Med 11: 1401-1410.
7. Courteix C, Bardin M, Chantelauze J, Lavarenne J, Eschalier A,. 1994. Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics. Pain 57: 153-160.
8. Dinchev D, Janda B, Evstatieva L, Oleszek W, Aslani MR, Kostova I,. 2008. Distribution of steroidal saponins in Tribulus terrestris from different geographical regions. Phytochemistry 69: 176-186.
9. Ehrman TM, Barlow DJ, Hylands PJ,. 2010. In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. Bioorg Med Chem 18: 2204-2218.
10. Finnerup NB, Jensen TS,. 2006. Mechanisms of disease: mechanism-based classification of neuropathic pain-a critical analysis. Nat Clin Pract Neurol 2: 107-115.
11. Harini R, Ezhumalai M, Pugalendi KV,. 2012. Antihyperglycemic effect of biochanin A, a soy isoflavone, on streptozotocin-diabetic rats. Eur J Pharmacol 676: 89-94.
12. Heidari MR, Mehrabani M, Pardakhty A, et al,. 2007. The analgesic effect of Tribulus terrestris extract and comparison of gastric ulcerogenicity of the extract with indomethacine in animal experiments. Ann N Y Acad Sci 1095: 418-427.
13. Honore PH, Basnet A, Eljaja L, et al,. 2011. Neuropathic pain models in the development of analgesic drugs. Scand J Pain 2: 172-177.
14. Ignatowski TA, Covey WC, Knight PR, Severin CM, Nickola TJ, Spengler RN,. 1999. Brain-derived TNF alpha mediates neuropathic pain. Brain Res 841: 70-77.
15. Jollow DJ, Mitchell JR, Zampaglione N, Gillette JR,. 1974. Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11: 151-169.
16. Kaeidi A, Esmaeili MS, Sheibani V, et al,. 2011. Olive (Olea europaea L.) leaf extract attenuates early diabetic neuropathic pain through prevention of high glucose-induced apoptosis: in vitro and in vivo studies. J Ethnopharmacol 14: 188-196.
17. Kakkar P, Das B, Viswanathan PN,. 1984. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 21: 130-132.
18. Kamboj P, Aggarwal M, Puri S, Singla SK,. 2011. Effect of aqueous extract of Tribulus terrestris on oxalate-induced oxidative stress in rats. Indian J Nephrol 21: 154-159.
19. Khalilzadeh O, Anvari M, Khalilzadeh A, Sahebgharani M, Zarrindast MR,. 2008. Involvement of amlodipine, diazoxide, and glibenclamide in development of morphine tolerance in mice. Int J Neurosci 118: 503-518.
20. Kostova I, Dinchev D, Rentsch GH, Dimitrov V, Ivanova A,. 2002. Two new sulfated furostanol saponins from Tribulus terrestris. Z Naturforsch C 57: 33-38.
21. Kuhad A, Sharma S, Chopra K,. 2008. Lycopene attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur J Pain 12: 624-632.
22. Le Bars D, Gozariu M, Cadden SW,. 2001. Animal models of nociception. Pharmacol Rev 53: 597-652.
23. Li M, Qu W, Wang Y, Wan H, Tian C,. 2002. [ Hypoglycemic effect of saponin from Tribulus terrestris ]. Zhong Yao Cai 25: 420-422.
24. Lopes LS, Pereira SS, Silva LL, et al,. 2009. Antinociceptive effect of topiramate in models of acute pain and diabetic neuropathy in rodents. Life Sci 84: 105-110.
25. Luiz AP, Moura JD, Meotti FC, et al,. 2007. Antinociceptive action of ethanolic extract obtained from roots of Humirianthera ampla Miers. J Ethnopharmacol 114: 355-363.
26. Martin CL, Albers J, Herman WH, et al,. 2006. Neuropathy among the diabetes control and complications trial cohort 8 years after trial completion. Diabetes Care 29: 340-344.
27. Moore DJ, Gregory JM, Kumah-Crystal YA, Simmons JH,. 2009. Mitigating micro-and macro-vascular complications of diabetes beginning in adolescence. Vasc Health Risk Manag 5: 1015-1031.
28. Nurmikko TJ, Serpell MG, Hoggart B, Toomey PJ, Morlion BJ, Haines D,. 2007. Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial. Pain 133: 210-220.
29. Ohkawa H, Ohishi N, Yagi K,. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358.
30. Paglia DE, Valentine WN,. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70: 158-169.
31. Phillips OA, Mathew KT, Oriowo MA,. 2006. Antihypertensive and vasodilator effects of methanolic and aqueous extracts of Tribulus terrestris in rats. J Ethnopharmacol 104: 351-355.
32. Pop-Busui R, Marinescu V, Van HC, et al,. 2002. Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. Diabetes 51: 2619-2628.
33. Satoh J, Yagihashi S, Toyota T,. 2003. The possible role of tumor necrosis factor-alpha in diabetic polyneuropathy. Exp Diabesity Res 4: 65-71.
34. Sharifi AM, Darabi R, Akbarloo N,. 2003. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 73: 2963-2971.
35. Sharma S, Kulkarni SK, Agrewala JN, Chopra K,. 2006a. Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur J Pharmacol 536: 256-261.
36. Sharma S, Kulkarni SK, Chopra K,. 2006b. Resveratrol, a polyphenolic phytoalexin attenuates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rats. Indian J Exp Biol 44: 566-569.
37. Skundric DS, Lisak RP,. 2003. Role of neuropoietic cytokines in development and progression of diabetic polyneuropathy: from glucose metabolism to neurodegeneration. Exp Diabesity Res 4: 303-312.
38. Sreevidya N, Mehrotra S,. 2003. Spectrophotometric method for estimation of alkaloids precipitable with Dragendorff's reagent in plant materials. J AOAC Int 86: 1124-1127.
39. Tiwari V, Kuhad A, Chopra K,. 2011. Emblica officinalis Corrects Functional, Biochemical and Molecular Deficits in Experimental Diabetic Neuropathy by Targeting the Oxido-nitrosative Stress Mediated Inflammatory Cascade. Phytother Res 25: 1527-1536.
40. Tolle TR,. 2010. Challenges with current treatment of neuropathic pain. Eur J Pain Suppl 4: 161-165.
41. Vincent AM, Russell JW, Low P, Feldman EL,. 2004. Oxidative stress in the pathogenesis of diabetic neuropathy. Endocr Rev 25: 612-628.
42. Yashpal K, Radhakrishnan V, Coderre TJ, Henry JL,. 1993. CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat. Neuroscience 52: 1039-1047.