메뉴 건너뛰기




Volumn 144-145, Issue , 2013, Pages 83-95

Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 1. Reproductive and early developmental effects

Author keywords

Antiprogestin; Mifepristone; Progesterone; Reproductive effects; RU486

Indexed keywords

11 OXOTESTOSTERONE; ESTRADIOL; MIFEPRISTONE; PROGESTERONE;

EID: 84886263441     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2013.09.033     Document Type: Article
Times cited : (60)

References (40)
  • 1
    • 0034741625 scopus 로고    scopus 로고
    • Cellular and molecular responses to endocrine-modulators and the impact on fish reproduction
    • Arukwe A. Cellular and molecular responses to endocrine-modulators and the impact on fish reproduction. Mar. Pollut. Bull. 2001, 42(8):643-655.
    • (2001) Mar. Pollut. Bull. , vol.42 , Issue.8 , pp. 643-655
    • Arukwe, A.1
  • 2
    • 84861940668 scopus 로고    scopus 로고
    • A critical role of follicle-stimulating hormone (Fsh) in mediating the effect of clotrimazole on testicular steroidogenesis in adult zebrafish
    • Baudiffier D., Hinfray N., Vosges M., Creusot N., Chadili E., Porcher J.M., Schulz R.W., Brion F. A critical role of follicle-stimulating hormone (Fsh) in mediating the effect of clotrimazole on testicular steroidogenesis in adult zebrafish. Toxicology 2012, 298:30-39.
    • (2012) Toxicology , vol.298 , pp. 30-39
    • Baudiffier, D.1    Hinfray, N.2    Vosges, M.3    Creusot, N.4    Chadili, E.5    Porcher, J.M.6    Schulz, R.W.7    Brion, F.8
  • 3
    • 84886233028 scopus 로고    scopus 로고
    • Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity
    • In Press
    • Blüthgen N., Sumpter J.P., Odermatt A., Fent K. Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity. Aquat. Toxicol. 2013, In Press. 10.1016/j.aquatox.2013.09.033.
    • (2013) Aquat. Toxicol.
    • Blüthgen, N.1    Sumpter, J.P.2    Odermatt, A.3    Fent, K.4
  • 4
    • 84886234420 scopus 로고    scopus 로고
    • Toxicological profile of the UV-filter octocrylene in adult and embryonic zebrafish revealed by transcriptomics
    • Submitted
    • Blüthgen N., Meili N., Chew G., Odermatt A., Fent K. Toxicological profile of the UV-filter octocrylene in adult and embryonic zebrafish revealed by transcriptomics. Toxicol. Appl. Pharmacol. 2013, Submitted.
    • (2013) Toxicol. Appl. Pharmacol.
    • Blüthgen, N.1    Meili, N.2    Chew, G.3    Odermatt, A.4    Fent, K.5
  • 5
    • 84865067808 scopus 로고    scopus 로고
    • Effects of the UV filter benzophenone-3 (oxybenzone) at low concentrations in zebrafish (Danio rerio)
    • Blüthgen N., Zucchi S., Fent K. Effects of the UV filter benzophenone-3 (oxybenzone) at low concentrations in zebrafish (Danio rerio). Toxicol. Appl. Pharmacol. 2012, 263:184-194.
    • (2012) Toxicol. Appl. Pharmacol. , vol.263 , pp. 184-194
    • Blüthgen, N.1    Zucchi, S.2    Fent, K.3
  • 6
    • 0025120229 scopus 로고
    • Plasma levels of ovarian steroids, including 17 alpha-20 alpha-dihydroxy-4-pregnen-3-one and 3 beta,17 alpha,20 alpha-trihydroxy-5 beta-pregnane, in female dabs (Limanda limanda)-marine flatfish-induced to mature and ovulate with human chorionic gonadotrophin
    • Canario A.V., Scott A.P. Plasma levels of ovarian steroids, including 17 alpha-20 alpha-dihydroxy-4-pregnen-3-one and 3 beta,17 alpha,20 alpha-trihydroxy-5 beta-pregnane, in female dabs (Limanda limanda)-marine flatfish-induced to mature and ovulate with human chorionic gonadotrophin. Gen. Comp. Endocrinol. 1990, 77(2):177-191.
    • (1990) Gen. Comp. Endocrinol. , vol.77 , Issue.2 , pp. 177-191
    • Canario, A.V.1    Scott, A.P.2
  • 7
    • 75449087350 scopus 로고    scopus 로고
    • Highly active human pharmaceuticals in aquatic systems: a concept for their identification based on their mode of action
    • Christen V., Hickmann S., Rechenberg B., Fent K. Highly active human pharmaceuticals in aquatic systems: a concept for their identification based on their mode of action. Aquat. Toxicol. 2010, 96:167-181.
    • (2010) Aquat. Toxicol. , vol.96 , pp. 167-181
    • Christen, V.1    Hickmann, S.2    Rechenberg, B.3    Fent, K.4
  • 10
    • 30644479441 scopus 로고    scopus 로고
    • Ecotoxicology of human pharmaceuticals
    • Fent K., Weston A.A., Caminada D. Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 2006, 76:122-159.
    • (2006) Aquat. Toxicol. , vol.76 , pp. 122-159
    • Fent, K.1    Weston, A.A.2    Caminada, D.3
  • 11
    • 84875829844 scopus 로고    scopus 로고
    • Chronic effects of exposure to a pharmaceutical mixture and municipal wastewater in zebrafish
    • Galus M., Jeyaranjaan J., Smith E., Li H., Metcalfe C., Wilson J.Y. Chronic effects of exposure to a pharmaceutical mixture and municipal wastewater in zebrafish. Aquat. Toxicol. 2013, 132-133:212-222.
    • (2013) Aquat. Toxicol. , pp. 212-222
    • Galus, M.1    Jeyaranjaan, J.2    Smith, E.3    Li, H.4    Metcalfe, C.5    Wilson, J.Y.6
  • 13
    • 48749088292 scopus 로고    scopus 로고
    • Evolutionary conservation of human drug targets in organisms used for environmental risk assessments
    • Gunnarsson L., Jauhiainen A., Kristiansson E., Nerman O., Larsson D.G.J. Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ. Sci. Technol. 2008, 42:5807-5813.
    • (2008) Environ. Sci. Technol. , vol.42 , pp. 5807-5813
    • Gunnarsson, L.1    Jauhiainen, A.2    Kristiansson, E.3    Nerman, O.4    Larsson, D.G.J.5
  • 14
    • 28744447296 scopus 로고    scopus 로고
    • Acute and chronic effects of carrier solvents in aquatic organisms: a critical review
    • Hutchinson T.H., Shillabeer N., Winter M.J., Pickford D.B. Acute and chronic effects of carrier solvents in aquatic organisms: a critical review. Aquat. Toxicol. 2006, 76:69-92.
    • (2006) Aquat. Toxicol. , vol.76 , pp. 69-92
    • Hutchinson, T.H.1    Shillabeer, N.2    Winter, M.J.3    Pickford, D.B.4
  • 15
    • 7444220540 scopus 로고    scopus 로고
    • Characterization of responses to the antiandrogen flutamide in a short-term reproduction assay with the fathead minnow
    • Jensen K.M., Kahl M.D., Makynen E.A., Korte J.J., Leino R.L., Butterworth B.C., Ankley G.T. Characterization of responses to the antiandrogen flutamide in a short-term reproduction assay with the fathead minnow. Aquat. Toxicol. 2004, 70:99-110.
    • (2004) Aquat. Toxicol. , vol.70 , pp. 99-110
    • Jensen, K.M.1    Kahl, M.D.2    Makynen, E.A.3    Korte, J.J.4    Leino, R.L.5    Butterworth, B.C.6    Ankley, G.T.7
  • 16
    • 47949133326 scopus 로고    scopus 로고
    • Analysis and occurrence of pharmaceuticals, estrogens, progestogens and polar pesticides in sewage treatment plant effluents, river water and drinking water in the Llobregat river basin (Barcelona, Spain)
    • Kuster M., López de Alda M.J., Hernando M.D., Petrovic M., Martín-Alonso J., Barceló D. Analysis and occurrence of pharmaceuticals, estrogens, progestogens and polar pesticides in sewage treatment plant effluents, river water and drinking water in the Llobregat river basin (Barcelona, Spain). J. Hydrol. 2008, 358:112-123.
    • (2008) J. Hydrol. , vol.358 , pp. 112-123
    • Kuster, M.1    López de Alda, M.J.2    Hernando, M.D.3    Petrovic, M.4    Martín-Alonso, J.5    Barceló, D.6
  • 18
    • 79951513972 scopus 로고    scopus 로고
    • Trace analysis of 28 steroids in surface water, wastewater and sludge samples by rapid resolution liquid chromatography-electrospray ionization tandem mass spectrometry
    • Liu S., Ying G.G., Zhao J.L., Chen F., Yang B., Zhou L.J., Lai H.J. Trace analysis of 28 steroids in surface water, wastewater and sludge samples by rapid resolution liquid chromatography-electrospray ionization tandem mass spectrometry. J. Chromatogr. A 2011, 1218:1367-1378.
    • (2011) J. Chromatogr. A , vol.1218 , pp. 1367-1378
    • Liu, S.1    Ying, G.G.2    Zhao, J.L.3    Chen, F.4    Yang, B.5    Zhou, L.J.6    Lai, H.J.7
  • 19
    • 77951239415 scopus 로고    scopus 로고
    • Analysis of hormone antagonists in clinical and municipal wastewater by isotopic dilution liquid chromatography tandem mass spectrometry
    • Liu X., Zhang J., Yin J., Duan H., Wu Y., Shao B. Analysis of hormone antagonists in clinical and municipal wastewater by isotopic dilution liquid chromatography tandem mass spectrometry. Anal. Bioanal. Chem. 2010, 396:2977-2985.
    • (2010) Anal. Bioanal. Chem. , vol.396 , pp. 2977-2985
    • Liu, X.1    Zhang, J.2    Yin, J.3    Duan, H.4    Wu, Y.5    Shao, B.6
  • 20
    • 84871833923 scopus 로고    scopus 로고
    • Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study
    • Margiotta-Casaluci L., Hannah R.E., Sumpter J.P. Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study. Aquat. Toxicol. 2013, 128-129:113-123.
    • (2013) Aquat. Toxicol. , pp. 113-123
    • Margiotta-Casaluci, L.1    Hannah, R.E.2    Sumpter, J.P.3
  • 21
    • 84886235844 scopus 로고    scopus 로고
    • Test no. 123: Guidance Document on the Diagnosis of Endocrine-related Histopathology in Fish Gonads
    • OECD
    • OECD Test no. 123: Guidance Document on the Diagnosis of Endocrine-related Histopathology in Fish Gonads. ENV/JM/MONO(2010)14 2010.
    • (2010) ENV/JM/MONO(2010)14
  • 22
    • 84894159762 scopus 로고    scopus 로고
    • Test no. 229: Fish Short term Reproduction Assay
    • OECD, OECD Publishing, Section 2
    • OECD Test no. 229: Fish Short term Reproduction Assay. OECD Guidelines for the Testing of Chemicals 2009, OECD Publishing, Section 2. 10.1787/9789264076211-en.
    • (2009) OECD Guidelines for the Testing of Chemicals
  • 23
    • 0003479924 scopus 로고    scopus 로고
    • Test no. 230: 21-day Fish Assay: A Short-term Screening for Oestrogenic and Androgenic Activity, and Aromatase Inhibition
    • OECD, OECD Publishing, Section 2
    • OECD Test no. 230: 21-day Fish Assay: A Short-term Screening for Oestrogenic and Androgenic Activity, and Aromatase Inhibition. OECD Guidelines for the testing of chemicals 2009, OECD Publishing, Section 2. 10.1787/9789264076228-en.
    • (2009) OECD Guidelines for the testing of chemicals
  • 24
    • 77958113394 scopus 로고    scopus 로고
    • Impacts of emerging organic contaminants on freshwater resources: review of recent occurrences, sources, fate and effects
    • Pal A., Gin K.Y.H., Lin A.J.C., Reinhard M. Impacts of emerging organic contaminants on freshwater resources: review of recent occurrences, sources, fate and effects. Sci. Total Environ. 2010, 408:6062-6069.
    • (2010) Sci. Total Environ. , vol.408 , pp. 6062-6069
    • Pal, A.1    Gin, K.Y.H.2    Lin, A.J.C.3    Reinhard, M.4
  • 25
    • 0025172241 scopus 로고
    • Effects of gonadotropin on ovarian intrafollicular processes during the development of oocyte maturational competence in a teleost, the Atlantic Croaker: evidence for two distinct stages of gonadotropic control of final oocyte maturation
    • Patiño R., Thomas P. Effects of gonadotropin on ovarian intrafollicular processes during the development of oocyte maturational competence in a teleost, the Atlantic Croaker: evidence for two distinct stages of gonadotropic control of final oocyte maturation. Biol. Reprod. 1990, 43(5):818-827.
    • (1990) Biol. Reprod. , vol.43 , Issue.5 , pp. 818-827
    • Patiño, R.1    Thomas, P.2
  • 26
    • 77955556274 scopus 로고    scopus 로고
    • Reproductive responses in fathead minnow and Japanese medaka following exposure to a synthetic progestin, Norethindrone
    • Paulos P., Runnalls T.J., Nallani G., La Point T., Scott A.P., Sumpter J.P., Huggett D.B. Reproductive responses in fathead minnow and Japanese medaka following exposure to a synthetic progestin, Norethindrone. Aquat. Toxicol. 2010, 99:256-262.
    • (2010) Aquat. Toxicol. , vol.99 , pp. 256-262
    • Paulos, P.1    Runnalls, T.J.2    Nallani, G.3    La Point, T.4    Scott, A.P.5    Sumpter, J.P.6    Huggett, D.B.7
  • 27
    • 84874029024 scopus 로고    scopus 로고
    • Several synthetic progestins with different potencies adversely affect reproduction in fish
    • Runnalls T.J., Beresford N., Losty E., Scott A.P., Sumpter J.P. Several synthetic progestins with different potencies adversely affect reproduction in fish. Environ. Sci. Technol. 2013, 47:2077-2084.
    • (2013) Environ. Sci. Technol. , vol.47 , pp. 2077-2084
    • Runnalls, T.J.1    Beresford, N.2    Losty, E.3    Scott, A.P.4    Sumpter, J.P.5
  • 28
    • 78650285954 scopus 로고    scopus 로고
    • Pharmaceuticals in the aquatic environment: steroids and anti-steroids as high priorities for research
    • Runnalls T.J., Margiotta-Casaluci L., Kugathas S., Sumpter J.P. Pharmaceuticals in the aquatic environment: steroids and anti-steroids as high priorities for research. Hum. Ecol. Risk Assess. 2010, 16(6):1318-1338.
    • (2010) Hum. Ecol. Risk Assess. , vol.16 , Issue.6 , pp. 1318-1338
    • Runnalls, T.J.1    Margiotta-Casaluci, L.2    Kugathas, S.3    Sumpter, J.P.4
  • 29
    • 76449085306 scopus 로고    scopus 로고
    • The role of the maturation-inducing steroid, 17,20β-dihydroxypregn-4-en-3-one, in male fishes: a review
    • Scott A.P., Sumpter J.P., Stacey N. The role of the maturation-inducing steroid, 17,20β-dihydroxypregn-4-en-3-one, in male fishes: a review. J. Fish Biol. 2010, 76:183-224.
    • (2010) J. Fish Biol. , vol.76 , pp. 183-224
    • Scott, A.P.1    Sumpter, J.P.2    Stacey, N.3
  • 30
    • 84985166056 scopus 로고
    • Seasonal variations in plasma concentrations of 11-ketotestosterone and testosterone in male rainbow trout (Salmo gairdneri Richardson)
    • Scott A.P., Bye V.J., Baynes S.M., Springate J.R.C. Seasonal variations in plasma concentrations of 11-ketotestosterone and testosterone in male rainbow trout (Salmo gairdneri Richardson). J. Fish Biol. 1980, 17:495-505.
    • (1980) J. Fish Biol. , vol.17 , pp. 495-505
    • Scott, A.P.1    Bye, V.J.2    Baynes, S.M.3    Springate, J.R.C.4
  • 32
    • 0142205817 scopus 로고    scopus 로고
    • Progesterone antagonists and progesterone receptor modulators: an overview
    • Spitz I.M. Progesterone antagonists and progesterone receptor modulators: an overview. Steroids 2003, 68:981-993.
    • (2003) Steroids , vol.68 , pp. 981-993
    • Spitz, I.M.1
  • 34
    • 20744448987 scopus 로고    scopus 로고
    • Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment
    • Sumpter J.P., Johnson A.C. Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment. Environ. Sci. Technol. 2005, 39(12):4321-4332.
    • (2005) Environ. Sci. Technol. , vol.39 , Issue.12 , pp. 4321-4332
    • Sumpter, J.P.1    Johnson, A.C.2
  • 35
    • 84856116980 scopus 로고    scopus 로고
    • Rapid steroid hormone actions initiated at the cell surface and the receptors that mediate them with an emphasis on recent progress in fish models
    • Thomas P. Rapid steroid hormone actions initiated at the cell surface and the receptors that mediate them with an emphasis on recent progress in fish models. Gen. Comp. Endocrinol. 2012, 175:367-383.
    • (2012) Gen. Comp. Endocrinol. , vol.175 , pp. 367-383
    • Thomas, P.1
  • 39
    • 84886235847 scopus 로고    scopus 로고
    • Progesterone alters global transcription profiles at environmental concentrations in brain and ovary of female zebrafish (Danio rerio)
    • In Press
    • Zucchi S., Castiglioni S., Fent K. Progesterone alters global transcription profiles at environmental concentrations in brain and ovary of female zebrafish (Danio rerio). Environ. Sci. Technol 2013, In Press.
    • (2013) Environ. Sci. Technol
    • Zucchi, S.1    Castiglioni, S.2    Fent, K.3
  • 40
    • 84860462209 scopus 로고    scopus 로고
    • Progestins and antiprogestins affect gene expression in early development in zebrafish (Danio rerio) at environmental concentrations
    • Zucchi S., Castiglioni S., Fent K. Progestins and antiprogestins affect gene expression in early development in zebrafish (Danio rerio) at environmental concentrations. Environ. Sci. Technol. 2012, 46(9):5183-5192.
    • (2012) Environ. Sci. Technol. , vol.46 , Issue.9 , pp. 5183-5192
    • Zucchi, S.1    Castiglioni, S.2    Fent, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.