Synthesis of 2-([18F]Fluoro)-3-[(2S)-2-Azetidinylmethoxy]Pyridine ([18F]2FA)

Radiochemical Syntheses: Radiopharmaceuticals for Positron Emission Tomography

Volumn 1, Issue , 2012, Pages 139-154

  Ravert, Hayden T ^a   Holt, Daniel P ^a   Dannals, Robert F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Advion NanoTek microfluidic synthesis; Synthesis of 2 ( 18F fluoro) 3 (2S) 2 azetidinylmethoxy pyridine ( 18F 2FA); TRACERlab synthesis

Indexed keywords

EID: 84886209217     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118140345.ch15     Document Type: Chapter

References (39)

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11. ABX GmbH, Germany. The cartridge was washed with 2 mL high purity water and pushed dry with air.
12. SepPak Plus C-18. Waters Corporation, USA.
13. Trace metal basis, 99.995%, Sigma-Aldrich.
14. Sigma-Aldrich Trace Select.
15. Sigma-Aldrich, 98%.
16. Thermo-Fisher, silylation grade.
17. Boc-2IA was synthesized in house as described in Reference 9.
18. HPLC grade.
19. Spectrophotometric grade.
20. Matheson, UHP grade.
21. Hamilton Company, USA.
22. Acetonitrile, methanol, and water in all HPLC methods are HPLC grade.
23. Hospira, Inc., USA.
24. Acrodisc 25 mm, 0.2 μm HT Tuffryn. PALL Life Sciences, USA.
25. ABX GmbH, Germany.
26. ACS grade.
27. Waters Corporation, USA.
28. USP grade.
29. Millex FG 25 mm, 0.2 μm. Millipore Corporation, USA.
30. US Pharmacopeia Chapter <823> Radiopharmaceuticals for positron emission tomography-compounding. USP 32-NF29. 2009.
31. Varian Prostar 210 pump with a Varian Prostar 325 variable wavelength Uv detector and a Bioscan Flowcount PMT detector using Galaxie Chromatogr0061phy Data System Version 1.9 Service Pack 2B. Varian, Inc., USA.
32. Varian 3800 Gas Chromatograph using Galaxie Chromatography Data System Version 1.9, Service Pack 2B. Varian, Inc., USA.
33. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH Harmonised Tripartite Guideline Impurities: Guideline for Residual Solvents, 1997.
34. ColorPhast pH-indicator strip-pH range 2.0-9.0. EMD Chemicals, Inc., Germany.
35. SilicaGel-60 F254 5 × 7.5 mm Aluminum Back TLC Strips. EMD Chemicals, Inc., Germany.
36. Bubble Point Test Apparatus. Millipore Corporation, USA.
37. Capintec Inc., USA.
38. Endosafe PTS Reader, Integrated Software Version 7.10, Service Pack 2.0, and Printer. Charles River Laboratories, USA.
39. Becton, Dickinson and Company, USA.