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Volumn , Issue , 2013, Pages 293-307

Lipid Modifiers and NASH: Statins, Ezetimibe, Fibrates, and Other Agents

Author keywords

Cholesterol lowering drugs; Ezetimibe; Hyperlipidemia; Lipid lowering drugs; Non alcoholic fatty liver disease (NAFLD); Polyunsaturated fatty acid (PUFA); Statins

Indexed keywords


EID: 84886142392     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118556153.ch26     Document Type: Chapter
Times cited : (5)

References (50)
  • 1
    • 84861543083 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
    • Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55: 2005-23.
    • (2012) Hepatology , vol.55 , pp. 2005-2023
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3
  • 2
    • 80555136061 scopus 로고    scopus 로고
    • Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
    • Musso G, Gambino R, Cassader M, et al. Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity. Ann Med. 2011;43: 617-49.
    • (2011) Ann Med , vol.43 , pp. 617-649
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 3
    • 44949095286 scopus 로고    scopus 로고
    • Association of liver disease with postprandial large intestinal triglyceride-rich lipoprotein accumulation and pro/antioxidant imbalance in normolipidemic non-alcoholic steatohepatitis
    • Musso G, Gambino R, De Michieli F, et al. Association of liver disease with postprandial large intestinal triglyceride-rich lipoprotein accumulation and pro/antioxidant imbalance in normolipidemic non-alcoholic steatohepatitis. Ann Med. 2008;40:383-94.
    • (2008) Ann Med , vol.40 , pp. 383-394
    • Musso, G.1    Gambino, R.2    De Michieli, F.3
  • 4
    • 84865553250 scopus 로고    scopus 로고
    • Adipose tissue dysfunction predicts liver histology, glucose and lipid metabolism in NAFLD: role of maladaptive adipocyte response to fat ingestion
    • Jun 8. doi:10.1002/hep.25739
    • Musso G, Cassader M, Michieli F, et al. Adipose tissue dysfunction predicts liver histology, glucose and lipid metabolism in NAFLD: role of maladaptive adipocyte response to fat ingestion. Hepatology. 2012 Jun 8. doi:10.1002/hep.25739.
    • (2012) Hepatology
    • Musso, G.1    Cassader, M.2    Michieli, F.3
  • 5
    • 33747626511 scopus 로고    scopus 로고
    • Mitochondrial free cholesterol loading sensitizes to TNF-and Fas-mediated steatohepatitis
    • Marí M, Caballero F, Colell A, et al. Mitochondrial free cholesterol loading sensitizes to TNF-and Fas-mediated steatohepatitis. Cell Metab. 2006;4:185-98.
    • (2006) Cell Metab , vol.4 , pp. 185-198
    • Marí, M.1    Caballero, F.2    Colell, A.3
  • 6
    • 77049094855 scopus 로고    scopus 로고
    • Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice
    • Wouters K, van Bilsen M, van Gorp PJ, et al. Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice. FEBS Letters. 2010;584: 1001-5.
    • (2010) FEBS Letters , vol.584 , pp. 1001-1005
    • Wouters, K.1    van Bilsen, M.2    van Gorp, P.J.3
  • 7
    • 80053612479 scopus 로고    scopus 로고
    • Hepatic free cholesterol accumulates in obese, diabetic mice and causes non-alcoholic steatohepatitis
    • doi:10.1053/j.gastro.2011.06.040
    • Van Rooyen DM, Larter CZ, Haigh WG, et al. Hepatic free cholesterol accumulates in obese, diabetic mice and causes non-alcoholic steatohepatitis. Gastroenterology. 2011. doi:10.1053/j.gastro.2011.06.040.
    • (2011) Gastroenterology
    • Van Rooyen, D.M.1    Larter, C.Z.2    Haigh, W.G.3
  • 8
    • 84860469242 scopus 로고    scopus 로고
    • Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease
    • Min HK, Kapoor A, Fuchs M, et al. Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab. 2012;15:665-74.
    • (2012) Cell Metab , vol.15 , pp. 665-674
    • Min, H.K.1    Kapoor, A.2    Fuchs, M.3
  • 9
    • 67049114700 scopus 로고    scopus 로고
    • Nutritional investigation of non-obese patients with nonalcoholic fatty liver disease: the significance of dietary cholesterol
    • Yasutake K, Nakamuta M, Shima Y, et al. Nutritional investigation of non-obese patients with nonalcoholic fatty liver disease: the significance of dietary cholesterol. Scand J Gastroenterol. 2009;44:471-7.
    • (2009) Scand J Gastroenterol , vol.44 , pp. 471-477
    • Yasutake, K.1    Nakamuta, M.2    Shima, Y.3
  • 10
    • 77449157160 scopus 로고    scopus 로고
    • Is the control of dietary cholesterol intake sufficiently effective to ameliorate nonalcoholic fatty liver disease?
    • Enjoji M, Nakamuta M. Is the control of dietary cholesterol intake sufficiently effective to ameliorate nonalcoholic fatty liver disease? World J Gastroenterol. 2010;16:800-3.
    • (2010) World J Gastroenterol , vol.16 , pp. 800-803
    • Enjoji, M.1    Nakamuta, M.2
  • 11
    • 36349024819 scopus 로고    scopus 로고
    • A lipidomic analysis of nonalcoholic fatty liver disease
    • Puri P, Wiest MM, Cheung O, et al. A lipidomic analysis of nonalcoholic fatty liver disease. Hepatology. 2007;46:1081-90.
    • (2007) Hepatology , vol.46 , pp. 1081-1090
    • Puri, P.1    Wiest, M.M.2    Cheung, O.3
  • 12
    • 61849095626 scopus 로고    scopus 로고
    • Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH
    • Caballero F, Fernández A, De Lacy AM, et al. Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. J Hepatology 2009;50:789-96.
    • (2009) J Hepatology , vol.50 , pp. 789-796
    • Caballero, F.1    Fernández, A.2    De Lacy, A.M.3
  • 13
    • 74949102941 scopus 로고    scopus 로고
    • A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: a randomized placebo-controlled trial
    • Nelson A, Torres DM, Morgan AE, et al. A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: a randomized placebo-controlled trial. J Clin Gastroenterol. 2009;43:990-4.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 990-994
    • Nelson, A.1    Torres, D.M.2    Morgan, A.E.3
  • 14
    • 78649890465 scopus 로고    scopus 로고
    • Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis
    • Athyros VG, Tziomalos K, Gossios TD, et al. Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis. Lancet. 2010;376: 1916-22.
    • (2010) Lancet , vol.376 , pp. 1916-1922
    • Athyros, V.G.1    Tziomalos, K.2    Gossios, T.D.3
  • 15
    • 78650971903 scopus 로고    scopus 로고
    • Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial
    • Foster T, Budoff MJ, Saab S, et al. Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial. Am J Gastroenterol. 2011;106:71-7.
    • (2011) Am J Gastroenterol , vol.106 , pp. 71-77
    • Foster, T.1    Budoff, M.J.2    Saab, S.3
  • 16
    • 79951714665 scopus 로고    scopus 로고
    • Effects of high-dose statin on the human hepatic expression of genes involved in carbohydrate and triglyceride metabolism
    • Pramfalk C, Parini P, Gustafsson U, et al. Effects of high-dose statin on the human hepatic expression of genes involved in carbohydrate and triglyceride metabolism. J Intern Med. 2011;269:333-9.
    • (2011) J Intern Med , vol.269 , pp. 333-339
    • Pramfalk, C.1    Parini, P.2    Gustafsson, U.3
  • 17
    • 84855883859 scopus 로고    scopus 로고
    • Effects of losartan and amlodipine alone or combined with simvastatin in hypertensive patients with nonalcoholic hepatic steatosis
    • Fogari R, Maffioli P, Mugellini A, Zoppi A, Lazzari P, Derosa G. Effects of losartan and amlodipine alone or combined with simvastatin in hypertensive patients with nonalcoholic hepatic steatosis. Eur J Gastroenterol Hepatol. 2012;24:164-71.
    • (2012) Eur J Gastroenterol Hepatol , vol.24 , pp. 164-171
    • Fogari, R.1    Maffioli, P.2    Mugellini, A.3    Zoppi, A.4    Lazzari, P.5    Derosa, G.6
  • 18
    • 77954366025 scopus 로고    scopus 로고
    • Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: an open-label, pilot study
    • Yoneda M, Fujita K, Nozaki Y, et al. Efficacy of ezetimibe for the treatment of non-alcoholic steatohepatitis: an open-label, pilot study. Hepatol Res. 2010;40:613-21.
    • (2010) Hepatol Res , vol.40 , pp. 613-621
    • Yoneda, M.1    Fujita, K.2    Nozaki, Y.3
  • 19
    • 78651473467 scopus 로고    scopus 로고
    • Efficacy of longterm ezetimibe therapy in patients with nonalcoholic fatty liver disease
    • Park H, Shima T, Yamaguchi K, et al. Efficacy of longterm ezetimibe therapy in patients with nonalcoholic fatty liver disease. J Gastroenterol. 2011;46:101-7.
    • (2011) J Gastroenterol , vol.46 , pp. 101-107
    • Park, H.1    Shima, T.2    Yamaguchi, K.3
  • 20
    • 77952674608 scopus 로고    scopus 로고
    • Effect of ezetimibe on hepatic fat, inflammatory markers and apolipoprotein B-100 kinetics in insulinresistant obese subjects on a weight loss diet
    • Chan DC, Watts GF, Gan SK, Ooi EM, Barrett PH. Effect of ezetimibe on hepatic fat, inflammatory markers and apolipoprotein B-100 kinetics in insulinresistant obese subjects on a weight loss diet. Diabetes Care. 2010;33:1134-9.
    • (2010) Diabetes Care , vol.33 , pp. 1134-1139
    • Chan, D.C.1    Watts, G.F.2    Gan, S.K.3    Ooi, E.M.4    Barrett, P.H.5
  • 21
    • 81855180302 scopus 로고    scopus 로고
    • Efficacy of ezetimibe for the treatment of non-alcoholic fatty liver disease: a randomized controlled trial
    • Takeshita Y, Takamura T, Kita Y, et al. Efficacy of ezetimibe for the treatment of non-alcoholic fatty liver disease: a randomized controlled trial. J Hep. 2011;54:S346.
    • (2011) J Hep. , vol.54
    • Takeshita, Y.1    Takamura, T.2    Kita, Y.3
  • 22
    • 33645888317 scopus 로고    scopus 로고
    • An assessment of statin safety by hepatologists
    • Cohen DE, Anania FA, Chalasani N. An assessment of statin safety by hepatologists. Am J Cardiol. 2006;97(8A):77C-81C.
    • (2006) Am J Cardiol. , vol.97 , Issue.8 A
    • Cohen, D.E.1    Anania, F.A.2    Chalasani, N.3
  • 23
    • 77549087054 scopus 로고    scopus 로고
    • Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
    • Sattar N, Preiss D, Murray HM, et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet. 2010;375:735-42.
    • (2010) Lancet , vol.375 , pp. 735-742
    • Sattar, N.1    Preiss, D.2    Murray, H.M.3
  • 24
    • 78650323871 scopus 로고    scopus 로고
    • Relationship between kidney function and liver histology in subjects with nonalcoholic steatohepatitis
    • Targher G, Bertolini L, Rodella S, et al. Relationship between kidney function and liver histology in subjects with nonalcoholic steatohepatitis. Clin J Am Soc Nephrol. 2010;5:2166-71.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 2166-2171
    • Targher, G.1    Bertolini, L.2    Rodella, S.3
  • 25
    • 79957619541 scopus 로고    scopus 로고
    • The development of chronic kidney disease in Japanese patients with non-alcoholic fatty liver disease
    • Arase Y, Suzuki F, Kobayashi M, et al. The development of chronic kidney disease in Japanese patients with non-alcoholic fatty liver disease. Intern Med. 2011;50:1081-7.
    • (2011) Intern Med , vol.50 , pp. 1081-1087
    • Arase, Y.1    Suzuki, F.2    Kobayashi, M.3
  • 26
    • 77949882555 scopus 로고    scopus 로고
    • Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK
    • Ix JH, Sharma K. Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK. J Am Soc Nephrol. 2010;21:406-12.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 406-412
    • Ix, J.H.1    Sharma, K.2
  • 27
    • 79960134351 scopus 로고    scopus 로고
    • Transcriptional regulation of organic anion transporting polypeptide SLCO4C1 as a new therapeutic modality to prevent chronic kidney disease
    • Suzuki T, Toyohara T, Akiyama Y, et al. Transcriptional regulation of organic anion transporting polypeptide SLCO4C1 as a new therapeutic modality to prevent chronic kidney disease. J Pharm Sci. 2011;100: 3696-707.
    • (2011) J Pharm Sci , vol.100 , pp. 3696-3707
    • Suzuki, T.1    Toyohara, T.2    Akiyama, Y.3
  • 28
    • 79959695664 scopus 로고    scopus 로고
    • Statins, inflammation and kidney disease
    • Krane V, Wanner C. Statins, inflammation and kidney disease. Nat Rev Nephrol. 2011;7:385-97.
    • (2011) Nat Rev Nephrol , vol.7 , pp. 385-397
    • Krane, V.1    Wanner, C.2
  • 29
    • 81855228289 scopus 로고    scopus 로고
    • Pharmacological effects of lipid-lowering drugs on circulating adipokines
    • Wanders D, Plaisance EP, Judd RL. Pharmacological effects of lipid-lowering drugs on circulating adipokines. World J Diabetes. 2010;1:116-28.
    • (2010) World J Diabetes , vol.1 , pp. 116-128
    • Wanders, D.1    Plaisance, E.P.2    Judd, R.L.3
  • 30
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362:1675-85.
    • (2010) N Engl J Med , vol.362 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 31
    • 79955446251 scopus 로고    scopus 로고
    • Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    • Lavine JE, Schwimmer JB, Van Natta ML, et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA. 2011; 305:1659-68.
    • (2011) JAMA , vol.305 , pp. 1659-1668
    • Lavine, J.E.1    Schwimmer, J.B.2    Van Natta, M.L.3
  • 32
    • 78751615734 scopus 로고    scopus 로고
    • Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment
    • Vilà L, Rebollo A, Ad{stroke}alsteisson GS, et al. Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment. Toxicol Appl Pharmacol. 2011;251:32-40.
    • (2011) Toxicol Appl Pharmacol , vol.251 , pp. 32-40
    • Vilà, L.1    Rebollo, A.2    Adalsteisson, G.S.3
  • 33
    • 79957606434 scopus 로고    scopus 로고
    • Regulation mechanism of ABCA1 expression by statins in hepatocytes
    • Kobayashi M, Gouda K, Chisaki I, et al. Regulation mechanism of ABCA1 expression by statins in hepatocytes. Eur J Pharmacol. 2011;662(1-3):9-14.
    • (2011) Eur J Pharmacol , vol.662 , Issue.1-3 , pp. 9-14
    • Kobayashi, M.1    Gouda, K.2    Chisaki, I.3
  • 34
    • 41149120450 scopus 로고    scopus 로고
    • Ezetimibe improves high fat and cholesterol diet-induced nonalcoholic fatty liver disease in mice
    • Zheng S, Hoos L, Cook J, et al. Ezetimibe improves high fat and cholesterol diet-induced nonalcoholic fatty liver disease in mice. Eur J Pharmacol. 2008;584: 118-24.
    • (2008) Eur J Pharmacol , vol.584 , pp. 118-124
    • Zheng, S.1    Hoos, L.2    Cook, J.3
  • 35
    • 68049123104 scopus 로고    scopus 로고
    • Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease
    • Nozaki Y, Fujita K, Yoneda M, et al. Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease. J Hepatol. 2009;51:548-56.
    • (2009) J Hepatol , vol.51 , pp. 548-556
    • Nozaki, Y.1    Fujita, K.2    Yoneda, M.3
  • 36
    • 77956485145 scopus 로고    scopus 로고
    • The fatty acid composition of plasma cholesteryl esters and estimated desaturase activities in patients with nonalcoholic fatty liver disease and the effect of long-term ezetimibe therapy on these levels
    • Park H, Hasegawa G, Shima T, et al. The fatty acid composition of plasma cholesteryl esters and estimated desaturase activities in patients with nonalcoholic fatty liver disease and the effect of long-term ezetimibe therapy on these levels. Clin Chim Acta. 2010;411:21-2.
    • (2010) Clin Chim Acta , vol.411 , pp. 21-22
    • Park, H.1    Hasegawa, G.2    Shima, T.3
  • 37
    • 66149132171 scopus 로고    scopus 로고
    • Efficacy and safety of ezetimibe/simvastatin combination therapy in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • Abel T, Fehér J, Dinya E, et al. Efficacy and safety of ezetimibe/simvastatin combination therapy in patients with type 2 diabetes and nonalcoholic fatty liver disease. Orv Hetil. 2009;150:989-93.
    • (2009) Orv Hetil , vol.150 , pp. 989-993
    • Abel, T.1    Fehér, J.2    Dinya, E.3
  • 38
    • 68049123104 scopus 로고    scopus 로고
    • Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease
    • Nozaki Y, Fujita K, Yoneda M, http://www.ncbi.nlm.nih.gov/pubmed?term=%22Wada%20K%22%5B Author%5D et al. Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease. J Hepatol. 2009;51:548-56.
    • (2009) J Hepatol , vol.51 , pp. 548-556
    • Nozaki, Y.1    Fujita, K.2    Yoneda, M.3
  • 39
    • 75649106483 scopus 로고    scopus 로고
    • Combination treatment with alogliptin and voglibose increases active GLP-1 circulation, prevents the development of diabetes and preserves pancreatic beta-cells in prediabetic db/db mice
    • Moritoh Y, Takeuchi K, Hazama M. Combination treatment with alogliptin and voglibose increases active GLP-1 circulation, prevents the development of diabetes and preserves pancreatic beta-cells in prediabetic db/db mice. Diabetes Obes Metab. 2010;12: 224-33.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 224-233
    • Moritoh, Y.1    Takeuchi, K.2    Hazama, M.3
  • 40
    • 80052718951 scopus 로고    scopus 로고
    • Effective therapy using voglibose for nonalcoholic steatohepatitis in a patient with insufficient dietary and exercise therapy: exploring other treatment possibilities
    • Nagai K, Matsumaru K, Takahashi Y, Nakamura N. Effective therapy using voglibose for nonalcoholic steatohepatitis in a patient with insufficient dietary and exercise therapy: exploring other treatment possibilities. Case Rep Gastroenterol. 2011;5:336-43.
    • (2011) Case Rep Gastroenterol , vol.5 , pp. 336-343
    • Nagai, K.1    Matsumaru, K.2    Takahashi, Y.3    Nakamura, N.4
  • 41
    • 0345448923 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
    • Sekiya M, Yahagi N, Matsuzaka T, et al. Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology. 2003;38: 1529-39.
    • (2003) Hepatology , vol.38 , pp. 1529-1539
    • Sekiya, M.1    Yahagi, N.2    Matsuzaka, T.3
  • 42
    • 33748794808 scopus 로고    scopus 로고
    • A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferatoractivated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury
    • Svegliati-Baroni G, Candelaresi C, Saccomanno S, et al. A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferatoractivated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. Am J Pathol. 2006;169:846-60.
    • (2006) Am J Pathol , vol.169 , pp. 846-860
    • Svegliati-baroni, G.1    Candelaresi, C.2    Saccomanno, S.3
  • 43
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and metaanalysis of randomised trials
    • Musso G, Cassader M, Rosina F, et al. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and metaanalysis of randomised trials. Diabetologia. 2012;55: 885-904.
    • (2012) Diabetologia , vol.55 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3
  • 44
    • 79953177813 scopus 로고    scopus 로고
    • Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial
    • Nobili V, Bedogni G, Alisi A, et al. Docosahexaenoic acid supplementation decreases liver fat content in children with non-alcoholic fatty liver disease: double-blind randomised controlled clinical trial. Arch Dis Child. 2011;96:350-3.
    • (2011) Arch Dis Child , vol.96 , pp. 350-353
    • Nobili, V.1    Bedogni, G.2    Alisi, A.3
  • 45
    • 84862527560 scopus 로고    scopus 로고
    • Dissociated histological and metabolic effects of omega-3 (3000 mg/d) vs. placebo with both exercise and diet in a double-blind randomized controlled trial of NASH
    • Caldwell SH, Argo CK, Henry TD, et al. Dissociated histological and metabolic effects of omega-3 (3000 mg/d) vs. placebo with both exercise and diet in a double-blind randomized controlled trial of NASH. J Hep. 2011;54:S8.
    • (2011) J Hep. , vol.54
    • Caldwell, S.H.1    Argo, C.K.2    Henry, T.D.3
  • 46
    • 0037383865 scopus 로고    scopus 로고
    • Probucol in the treatment of non-alcoholic steatohepatitis: a double-blind randomized controlled study
    • Merat S, Malekzadeh R, Sohrabi MR, et al. Probucol in the treatment of non-alcoholic steatohepatitis: a double-blind randomized controlled study. J Hepatology. 2003;38:414-8.
    • (2003) J Hepatology , vol.38 , pp. 414-418
    • Merat, S.1    Malekzadeh, R.2    Sohrabi, M.R.3
  • 47
    • 37249059359 scopus 로고    scopus 로고
    • PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes
    • Seo YS, Kim JH, Jo NY, et al. PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes. J Gastroenterol Hepatol. 2008;23:102-9.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 102-109
    • Seo, Y.S.1    Kim, J.H.2    Jo, N.Y.3
  • 48
    • 0032776856 scopus 로고    scopus 로고
    • A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis
    • Basaranoglu M, Acbay O, Sonsuz A. A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. J Hepatol. 1999;31:384.
    • (1999) J Hepatol , vol.31 , pp. 384
    • Basaranoglu, M.1    Acbay, O.2    Sonsuz, A.3
  • 49
    • 77954519409 scopus 로고    scopus 로고
    • Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease
    • Fabbrini E, Mohammed BS, Korenblat KM, et al. Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease. J Clin Endocrinol Metab. 2010;95:2727-35.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2727-2735
    • Fabbrini, E.1    Mohammed, B.S.2    Korenblat, K.M.3
  • 50
    • 79955102629 scopus 로고    scopus 로고
    • Need for a threefocused approach to nonalcoholic fatty liver disease
    • Musso G, Gambino R, Cassader M. Need for a threefocused approach to nonalcoholic fatty liver disease. Hepatology. 2011;53:1773.
    • (2011) Hepatology , vol.53 , pp. 1773
    • Musso, G.1    Gambino, R.2    Cassader, M.3


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