Design of Supermacroporous Biomaterials via Gelation at Subzero Temperatures-Cryogelation

Advanced Biomaterials: Fundamentals, Processing, and Applications

Volumn , Issue , 2010, Pages 499-531

  Plieva, Fatima M ^a,b   Kumar, Ashok ^c   Galaev, Igor Yu ^a   Mattiasson, Bo ^a  

^a LUND UNIVERSITY   (Sweden)

^b Protista Biotechnology AB   (Sweden)

^c INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

Author keywords

Preparation of macroporous gels (MGs) from different gel precursors; Preparation of supermacroporous biomaterials cryogelation technique; Supermacroporous biomaterials design via cryogelation, gelation at subzero temperatures

Indexed keywords

EID: 84886119203     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470891315.ch14     Document Type: Chapter

References (96)

1. Akyurt M, Zaki G, Habeebullah B. 2002. Freezing phenomena in ice-water systems. Energ. Conv. Manag. 43: 1773-1789.
2. Bajpai A, Saini R. 2005a. Preparation and characterization of biocompatible spongy cryogels of poly(vinyl alcohol)-gelatin and study of water sorption behaviour. Polym. Int. 54: 1233-1242.
3. Bajpai A, Saini R. 2005b. Preparation and characterization of spongy cryogels of poly(vinyl alcohol)-casein system: water sorption and blood compatibility. Polymer Int. 54: 796-806.
4. Bennett DJ, Burford RP, Davis TP, Tilley HJ. 1995. Synthesis of porous hydrogel structure by polymerizing the continuous phase of a microemulsion. Polymer Int. 36: 219-226.
5. Bloch K, Lozinsky VI, Galaev IYu, Yavriyanz K, Vorobeychik M, Azarov D, Damashkaln LG, Mattiasson B, Vardi P. 2005. Functional activity of insulinoma cells (INS-1E) and pancreatic islets cultured in agarose cryogel sponges. J. Biomed. Mater. Res. 75A: 802-809.
6. Bolgen N, Plieva F, Galaev IYu, Mattiasson B, Piskin E. 2007a. A novel technique "cryogelation" for preparation of biodegradable tissue engineering scaffolds. J. Biomater. Sci. Polym. Ed. 18: 1165-1179.
7. Bolgen N, Vargel I, Korkusuz P, Guzel E, Plieva F, Galaev IYu, Mattiasson B, Piskin E. 2007b. Tissue responses to novel tissue engineering biodegradable cryogel-scaffolds: an animal model. J. Biomed. Mater. Res. Part A, 2008, in press.
8. Bulcke AIVD, Bogdanov B, Rooze ND, Schacht EH, Cornelissen M, Berghmans H. 2000. Structural and rheological properties of methacrylamide modifi ed gelatin hydrogels. Biomacromolecules 1: 31-38.
9. Burg KJL, Porter S, Kellam JF. 2000. Biomaterial developments for bone tissue engineering. Biomaterials 21: 2347-2359.
10. Cai Q, Yang J, Bei J, Wang S. 2002. A novel porous cells scaffold made of polylactide-dextran blend by combining phase-separation and particle-leaching techniques. Biomaterials 23: 4483-4492.
11. Chen J, Jo S, Park K. 1995. Polysaccharide hydrogels for protein drug delivery. Carbohyd. Polym. 28: 69-76.
12. Chen S-L, Lee T-S. 1998. A study of supercooling phenomenon and freezing probability of water inside horizontal cylinders. Intern. J. Heat Mas. Trans. 41: 769-783.
13. Chen S-L, Wang P-P, Lee T-S. 1999. An experimental investigation of nucleation probability of supercooled water inside cylindrical capsules. Exp. Therm. Fluid Sci. 18: 299-306.
14. Covert RJ, Ott RD, Ku DN. 2003. Friction characteristics of a potential articular cartilage biomaterial. Wear 255: 1064-1068.
15. Dainiak MB, Kumar A, Plieva F, Galaev IYu, Mattiasson B. 2004. Integrated isolation of antibody fragments from microbial cell culture fl uids using supermacroporous cryogels. J. Chromatogr. A 1045: 93-98.
16. Dainiak MB, Kumar A, Galaev IYu, Mattiasson B. 2006. Detachment of affi nity-captured bioparticles by elastic deformation of a macroporous hydrogel. Proc. Nat. Acad. Sci. USA 103: 849-854.
17. DeMerlis CC, Schoneker DR. 2003. Review of the oral toxicity of polyvinyl alcohol (PVA). Food Chem. Tech. 41: 319-326.
18. Dinu MV, Ozmen MM, Dragan ES, Okay O. 2007. Freezing as a path to build macroporous structures: superfast responsive polyacrylamide hydrogels. Polymer 48: 195-204.
19. Dubruel P, Unger R, Vlierberghe SV, Cnudde V, Jacobs PJS, Schacht E, Kirkpatrick CJ. 2007. Porous gelatin hydrogels: 2. In vitro cell interaction study. Biomacromolecules 8: 338-344.
20. Engström JA, Lindgren LJ, Helgee B. 2006. Synthesis of novel monomers and copolymers from 1-vinylpyrrolidin-2-one: attractive materials for drug delivery systems. Macromol. Chem. Phys. 207: 536-544.
21. Fray ME, Pilaszkiewicz A, Swieszkowski W, Kurzydlowski KJ. 2007. Morphology assessment of chemically modifi ed and cryostructurated poly(vinyl alcohol) hydrogel. Eur. Polym. J. 43: 2035-2040.
22. Galaev IYu, Dainiak MB, Plieva F, Mattiasson B. 2007. Effect of matrix elasticity on affi nity binding and release of bioparticles. Elution of bound cells by temperature-induced shrinkage of the smart macroporous hydrogel. Langmuir 23: 35-40.
23. Gunatillake PA, Adhikari R. 2003. Biodegradable synthetic polymers for tissue engineering. Eur. Cells Mater. 5: 1-16.
24. Hanthamrongwit M, Wilkinson R, Osborne C, Reid WH, Grant MH. 1996. Confocal laser-scanning microscopy for determining the structure of and keratinocyte infi ltration through collagen sponges. J. Biomed. Mater. Res. 30: 331-339.
25. Hasirci V, Lewandowski K, Gresser JD, Wise DL, Trantolo DJ. 2001. Versatility of biodegradable biopolymers: degradability and in vivo applications. J. Biotechnol. 86: 135-150.
26. Hassan CM, Peppas NA. 2000. Structure and applications of poly(vinyl alcohol) hydrogels produced by convectional cross-linking or by freezing/thawing methods. Adv. Polym. Sci. 153: 37-65.
27. Hassan CM, Stewart JE, Peppas NA. 2000. Diffusional characteristics of freeze/thawed poly(vinyl alcohol) hydrogels: Applications to protein controlled release from multilaminate devices. Eur. J. Pharm. Biopharm. 49: 161-165.
28. He X, Yao K, Shen S, Yun J. 2007. Freezing characteristics of acrylamide-based aqueous solution used for the preparation of supermacroporous cryogels via cryo-copolymerization. Chem. Eng. Sci. 62: 1334-1342.
29. Hennik WE, Nostrum CF. 2002. Novel crosslinking methods to design hydrogels. Adv. Drug Deliv. Rev. 54: 13-36.
30. Hentze H-P, Antonietti M. 2002. Porous polymers and resins for biotechnological and biomedical applications. Rev. Mol. Biotechnol. 90: 27-53.
31. Hollister SJ. 2005. Porous scaffold design for tissue engineering. Nature Mater. 4: 518-524.
32. Ito T, Yeo Y, Highley CB, Bellas E, Kohane DS. 2007. Dextran-based in situ cross-linked injectable hydrogels to prevent peritoneal adhesions. Biomaterials 28: 3418-3426.
33. Jiang H, Campbell G, Boughner D, Wan W-K, Quantz M. 2004. Design and manufacture of a polyvinyl alcohol (PVA) cryogel tri-leafl et heart valve prosthesis. Med. Engin. Phys. 26: 269-277.
34. Kabiri K, Omidian H, Zohuriaan-Mehr MJ. 2003. Novel approach to highly porous superabsorbent hydrogels: synergistic effect of porogens on porosity and swelling rate. Polymer Int. 52: 1158-1164.
35. Kaufman JD, Song J, Klapperich CM. 2006. Nanomechanical analysis of bone tissue engineering scaffolds. J Biomed Mater Res 81 A: 611-623.
36. Kim SJ, Lee CK, Kim SI. 2004. Characterization of the water state of hyaluronic acid and poly(vinyl alcohol) interpenetrating polymer networks. J. Appl. Polym. Sci. 92: 1467-1472.
37. Kokabi M, Sirousazar M, Hassan ZM. 2007. PVA-clay nanocomposite hydrogels for wound dressing. Eur. Polym. J. 43: 773-781.
38. Kroupova J, Horak D, Pachernik J, Dvorak P, Slour M. 2006. Functional polymer hydrogels for embryonic stem cell support. J. Biomed. Mater. Res. Part B: Appl. Biomater. 76 B: 315-325.
39. Kumar A, Plieva F, Galaev IYu, Mattiasson B. 2003. Affi nity fractionation of lymphocytes using a monolithic cryogel. J. Immunol. Methods 283: 185-194.
40. Kumar A, Bansal V, Andersson J, Roychoudhury PK. Mattiasson B. 2006a. Supermacroporous cryogel matrix for integrated protein isolation: IMAC purifi cation of urokinase from cell culture broth of a human kidney cell line. J. Chromatogr. A 1103: 35-42.
41. Kumar A, Bansal V, Nandakumar KS, Galaev IYu, Roychoudhury PK, Holmdahl R, Mattiasson B. 2006b. Integrated bioprocess for the production and isolation of urokinase from animal cell culture using supermacroporous cryogel matrices. Biotechnol. Bioeng. 93: 636-646.
42. Lai HL, Abu'khalil A, Craig DQM. 2003. The preparation and characterisation of drug-loaded alginate and chitosan sponges. Int. J. Pharm. 251: 175-181.
43. Levesque SG, Ryan RM, Shoichet MS. 2005. Macroporous interconnected dextran scaffolds of controlled porosity for tissue-engineering applications. Biomaterials 26: 7436-7446.
44. Levesque SG, Shoichet MS. 2006. Synthesis of cell-adhesive dextran hydrogels and macroporous scaffolds. Biomaterials 27: 5277-5285.
45. Liu J, Zhou Y-X. 2003. Freezing curve-based monitoring to quickly evaluate the viability of biological materials subject to freezing or thermal injury. Anal. Bioanal. Chem. 377: 173-181.
46. Liu Q, Hedberg EL, Liu Z, Bahulekar R, Meszlenyi RK, Mikos AG. 2000. Preparation of macroporous poly(2-hydroxyethyl methacrylate) hydrogels by enhanced phase separation. Biomaterials 21: 2163-2169.
47. Lozinsky VI. 1998. Cryotropic gelation of poly(vinyl alcohol) solutions. Russ. Chem. Rev. 67: 573-586.
48. Lozinsky VI. 2002. Cryogels on the basis of natural and synthetic polymers: preparation, properties and applications. Russ. Chem. Rev. 71: 489-511.
49. Lozinsky VI, Plieva FM. 1998. Poly(vinyl alcohol) cryogels employed as matrices for cell immobilization. 3. Overview of recent research and developments. Enzyme Microb. Technol. 23: 227-242.
50. Lozinsky VI, Plieva FM, Galaev IYu, Mattiasson B. 2002. The potential of polymeric cryogels in bioseparation. Bioseparation 10: 163-188.
51. Luyet BJ. 1966. An attempt at a systematic analysis of the notion of freezing rates and at an evaluation of the main contributory factors. Cryobiology 2: 198-205.
52. Mi F-L, Shyu S-S, Wu Y-B, Lee S-T, Shyong J-Y, Huang R-N. 2001. Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing. Biomaterials 22: 165-173.
53. Miralles G, Baudoin R, Dumas D, Baptiste D, Hubert P, Stoltz JF, Dellacherie E, Mainard D, Netter P, Payan E. 2001. Sodium alginate sponges with or without sodium hyaluronate: In vitro engineering of cartilage. J. Biomed. Mat. Res. 57: 268-278.
54. Nam YS, Park TG. 1999. Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation. J. Biomed. Mater. Res. 47: 8-17.
55. Nho YC, Park KR. 2001. Preparation and properties of PVA/PVP hydrogels containing chitosan by radiation. J. Appl. Polym. Sci. 85: 1787-1794.
56. Nilsang S, Nandakumar KS, Galaev IYu, Rakshit SK, Holmdahl R, Mattiasson B, Kumar A. 2007a. Monoclonal Antibody Production Using a New Supermacroporous Cryogel Perfusion Reactor. Biotechnol. Prog. DOI: 10.1021/bp0700399.
57. Nilsang S, Nehru V, Plieva F, Nandakumar KS, Rakshit SK, Holdmahl R, Mattiasson B, Kumar A. 2007b. Three-dimensional culture for monoclonal antibody production by hybridoma cells Immobilized in macroporous gel particles/submitted/.
58. Noir ML, Plieva F, Hey T, Guiesse B, Mattiasson B. 2007. Macroporous molecularly imprinted polymer/cryogel composite systems for the removal of endocrine disrupting trace contaminants. J. Chromatogr. A 1154: 158-164.
59. O'Brien FJ, Harley BA, Yannas IV, Gibson L. 2004. Infl uence of freezing rate on pore structure in freeze-dried collagen-GAG scaffolds. Biomaterials 25: 1077-1086.
60. O'Brien FJ, Harley BA, Yannas IV, Gibson LJ. 2005. The effect of pore size on cell adhesion in collagen-GAG scaffolds. Biomaterials 26: 433-441.
61. Park KR, Nho YC. 2003. Preparation and characterization by radiation of hydrogels of PVA and PVP containing Aloe Vera. J. Appl. Polym. Sci. 91: 1612-1618.
62. Patel VR, Amiji MM. 1996. Preparation and characterization of freeze-dried chitosan-poly (ethylene oxide) hydrogels for site-specifi c antibiotic delivery in the stomach. Pharm. Res. 13: 588-593.
63. Peppas NA, Huang Y, Torres-Lugo M, Ward JH, Zhang J. 2000. Physicochemical foundations and structural design of hydrogels in medicine and biology. Annu. Rev. Biomed. Eng. 02: 9-29.
64. Peppas NA, Mongia NK. 1997. Ultrapure poly(vinyl alcohol)hydrogels with mucoadhesive drug delivery characteristics. Eur. J. Pharm. Biopharm. 43: 51-58.
65. Peppas NA, Stauffer SR. 1991. Reinforced uncross-linked poly(vinyl alcohol) gels produced by cyclic freezing-thawing processes: a short review. J. Contr. Release 16: 305-310.
66. Peters MC, Mooney DJ. 1997. Synthetic extracellular matrices for cell transplantation. Mater. Sci. Forum 250: 43-52.
67. Petrov P, Petrova E, Stamenova R, Tsvetanov CB, Riess G. 2006. Cryogels of cellulose derivatives prepared via UV irradiation of moderately frozen systems. Polymer 47: 6481-6484.
68. Plieva FM, Andersson J, Galaev IYu, Mattiasson B. 2004a. Characterization of polyacrylamide based monolithic columns. J. Sep. Sci. 27: 828-836.
69. Plieva F, Galaev IYu, Mattiasson B. 2007a. Macroporous gels prepared at subzero temperatures as novel materials for chromatography of particulate containing fl uids and cell culture applications. J. Sep. Sci. 30: 1657-1671.
70. Plieva F, Huiting X, Galaev IYu, Bergenstähl B, Mattiasson B. 2006a. Macroporous elastic polyacrylamide gels prepared at subzero temperatures: control of porous structure. J. Mater. Chem. 16: 4065-4073.
71. Plieva F, Karlsson M, Aguilar M-R, Gomez D, Mikhalovsky S, Galaev IYu, Mattiasson B. 2007b. Porous structure of macroporous agarose gels prepared at subzero temperatures./manuscript/.
72. Plieva FM, Karlsson M, Aguilar M-R, Gomez D, Mikhalovsky S, Galaev IYu, Mattiasson B. 2006b. Pore structure of macroporous monolithic cryogels prepared from poly (vinyl alcohol). J. Appl. Polym. Sci. 100: 1057-1066.
73. Plieva FM, Karlsson M, Aguilar M-R, Gomez D, Mikhalovsky S, Galaev IYu. 2005. Pore structure in supermacroporous polyacrylamide based cryogels. Soft Matter 1: 303-309.
74. Plieva F, Oknianska A, Degerman E, Galaev IYu, Mattiasson B. 2006c. Novel supermacroporous dextran gels. J. Biomater. Sci. Polym. Edn 17: 1075-1092.
75. Plieva FM, Oknianska A, Mattiasson B. 2007c. Macroporous gel particles as robust matrices for cell immobilization. Biotechnol. J./in press/.
76. Plieva FM, Savina IN, Deraz S, Andersson J, Galaev IYu, Mattiasson B. 2004b. Characterization of supermacroporous monolithic polyacrylamide based matrices designed for chromatography of bioparticles. J. Chromatogr. B 807: 129-137.
77. Podorozhko EA, Kurskaya EA, Kulakova VK, Lozinsky VI. 2000. Cryotropic structuring of aqueous dispersions of fi brous collagen: infl uence of the initial pH values. Food Hydrocol. 14: 111-120.
78. Rizzieri R, Baker FS, Donald AM. 2003. A study of the large strain deformation and failure behaviour of mixed biopolymer gels via in situ ESEM. Polymer 44: 5927-5935.
79. Sannino A, Netti PA, Madaghiele M, Coccoli V, Luciani A, Maffezzoli A, Nicolais L. 2006. Synthesis and characterization of macroporous poly(ethylene glycol)-based hydrogels for tissue engineering application. J. Biomed. Mater. Res. 79A: 229-236.
80. Sawhney AS, Pathak CP, Hubbell JA. 1993. Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(alpha-hydroxy acid) diacrylate macromers. Macromolecules 26: 581-587.
81. Schild HG. 1992. Poly(N-isopropylacrylamide): experiment, theory and application. Prog. Polym. Sci. 17: 163-249.
82. Shapiro L, Cohen S. 1997. Novel alginate sponges for cell culture and transplantation. Biomaterials 18: 583-590.
83. Shibukawa M, Aoyagi K, Sakamoto R, Oguma K. 1999. Liquid chromatography and differential scanning calorimetry studies on the states of water in hydrophilic polymer gel packing in relation to retention selectivity. J. Chromatogr. A 832: 17-27.
84. Srivastava A, Jain E, Kumar A. 2007. The physical characterization of supermacroporous poly(N-isopropylacrylamide) cryogel: mechanical strength and swelling/de-swelling kinetics. Mat. Sci. Eng. A 464: 93-100.
85. Stauffer SR, Peppas NA. 1992. Poly(vinyl alcohol) hydrogels prepared by freezing-thawing cyclic processing. Polymer 33: 3932-3936.
86. Swieszowski W, Ku DN, Bersee HEN, Kurzydlowski KJ. 2006. An elastic material for cartilage replacement in an arthritic shoulder joint. Biomaterials 27: 1534-1541.
87. Vijayasekaran S, Chirila T, Robertson TA, Lou X, Helenfitton J, Hicks CR, Constable IJ. 2000. Calcifi cation of poly(2-hydroxyethyl methacrylate) hydrogel sponges implanted in the rabbit cornea: a 3-month study. J. Biomater. Sci. Polym. Ed. 11: 599-615.
88. Vlierberghe SV, Cnudde V, Dubruel P, Masschaele B, Cosijns A, Paepe ID, Jacobs PJS, Hoorebeke LV, Remon JP, Schacht E. 2007. Porous gelatin hydrogels: 1. Cryogenic formation and structure analysis. Biomacromolecules 8: 331-337.
89. Wan Y, Fang Y, Wu H, Cao X. 2007. Porous polylactide/chitosan scaffolds for tissue engineering. J. Biomed. Mater. Res. 80A: 776-789.
90. Watase M, Nishinari K. 1988. Thermal and reological properties of poly(vinyl alcohol) hydrogels prepared by repeated cycles of freezing and thawing. Macromol. Chem. 189: 871-880.
91. Wood CD, Cooper AI. 2001. Synthesis of macroporous polymer beads by suspension polymerization using supercritical carbon dioxide as a pressure-adjustable porogen. Macromolecules 34: 5-8.
92. Yao K, Shen S, Wang J, He X, Yu X. 2006a. Preparation of polyacrylamide-based supermacroporous monolithic cryogel beds under freezing-temperature variation conditions. Chem. Eng. Sci. 61: 6701-6708.
93. Yao K, Yun J, Shen S, Wang L, He X, Yu X. 2006b. Characterization of a novel continuous supermacroporous monolithic cryogel embedded with nanoparticles for protein chromatography. J. Chromatogr. A 1109: 103-110.
94. Yeong W-Y, Chua C-K, Leong K-F, Chandrasekaran M, Lee M-W. 2007. Comparison of drying methods in the fabrication of collagen scaffold via indirect rapid prototyping. J. Biomed. Mater. Res. Part B: Appl. Biomater. 82B: 260-266.
95. You Y, Park WH. 2004. Effect of PVA sponge containing chitooligosaccharide in the early stage of wound healing. J. Mater. Sci.: Materials in Medicine 15: 297-301.
96. Zhang X-Z, Chu C-C. 2003. Synthesis of temperature sensitive PNIPAAm cryogels in organic solvent with improved properties. J. Mater. Chem. 13: 2457-2464.