Diffusional characteristics of freeze/thawed poly(vinyl alcohol) hydrogels: Applications to protein controlled release from multilaminate devices

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 49, Issue 2, 2000, Pages 161-165

  Hassan, Christie M ^a   Stewart, Jennifer E ^a   Peppas, Nikolaos A ^a  

^a Purdue University   (United States)

Author keywords

Bovine serum albumin; Freezing thawing process; Laminate; Poly(vinyl alcohol)

Indexed keywords

POLYVINYL ALCOHOL; SERUM ALBUMIN;

ARTICLE; CONTROLLED RELEASE FORMULATION; CRYSTAL; DIFFUSION; DISSOLUTION; GEL PERMEATION CHROMATOGRAPHY; HYDROGEL; THAWING;

DIFFUSION; DRUG DELIVERY SYSTEMS; FREEZING; HYDROGEL; POLYVINYL ALCOHOL; SERUM ALBUMIN, BOVINE;

EID: 0033993908     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(99)00056-9     Document Type: Article

References (14)

1. Stauffer S.R., Peppas N.A. Poly(vinyl alcohol) hydrogels prepared by freezing-thawing cyclic processing. Polymer. 33:1992;3932-3936.
2. Peppas N.A. Turbidimetric studies of aqueous poly(vinyl alcohol) solutions. Makromol. Chem. 176:1975;3433-3440.
3. Hickey A.S., Peppas N.A. Mesh size and diffusive characteristics of semicrystalline poly(vinyl alcohol) membranes prepared by freezing/thawing techniques. J. Membr. Sci. 107:1995;229-237.
4. Ficek B.J., Peppas N.A. Novel preparation of poly(vinyl alcohol) microparticles without crosslinking agent for controlled drug delivery of proteins. J. Control. Rel. 27:1993;259-264.
5. Peppas N.A., Mongia N.K. Ultrapure poly(vinyl alcohol) hydrogels with mucoadhesive drug delivery characteristics. Eur. J. Pharm. Biopharm. 43:1997;51-58.
6. Peppas N.A., Mongia N., Luttrell A.S. Bioadhesive poly(vinyl alcohol) as a carrier for controlled release of growth factors and proteins. Proc. World Meeting APGI/APV. 1:1995;817-818.
7. Peppas N.A., Anseth K.S., Mongia N.K. Mucoadhesive PVA hydrogels for release of wound healing drugs. Trans. World Biomater. Congr. 5:1996;643.
8. Mongia N.K., Anseth K.S., Peppas N.A. Mucoadhesive poly(vinyl alcohol) hydrogels produced by freezing/thawing processes: Applications in the development of wound healing systems. J. Biomater. Sci. Polym. Ed. 7:1996;1055-1064.
9. Luttrell A.S., Mongia N.K., Peppas N.A. Adhesive and diffusive characteristics of novel PVA films for medical applications. Abstr. AIChE Meeting. 1994;202c.
10. Peppas N.A., Borcherding A.S.L. Oral delivery devices from freeze/thawed poly(vinyl alcohol) hydrogels. Proc. Int. Symp. Control. Release Bioact. Mater. 23:1996;145-146.
11. Peppas N.A., Mongia N.K., Bugert C.A. Mucoadhesive poly(vinyl alcohol) films produced by freezing/thawing processes for the release of small molecular weight solutes and for wound healing systems. Proc. Int. Symp. Control. Release Bioact. Mater. 23:1996;157-158.
12. Lee P.I. Novel approach to zero-order drug delivery via immobilized nonuniform drug distribution in glassy hydrogels. J. Pharm. Sci. 73:1984;1344-1347.
13. Lu S., Ramirez F., Anseth K. Modeling and optimization of drug release from laminated polymer matrix devices. AIChE J. 44:1998;1689-1696.
14. Colton C.K. Permeability and Transport Studies in Batch and Flow Dialyzers with Applications to Hemodialysis. Ph.D. Thesis. 1969;Department of Chemical Engineering, MIT. Appendix B.