BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder

Journal of Psychiatric Research

Volumn 47, Issue 12, 2013, Pages 1857-1863

  Hemmings, Sian Megan Joanna ^a   Lochner, Christine ^a   van der Merwe, Lize ^b   Cath, Danielle C ^c,d,e   Seedat, Soraya ^a   Stein, Dan J ^a,f  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

^b UNIVERSITY OF THE WESTERN CAPE   (South Africa)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

^e Academic Anxiety Center   (Netherlands)

^f UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Brain derived neurotrophic factor; Childhood trauma; CTQ; Gene environment interaction; Obsessive compulsive disorder (OCD)

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ADOLESCENT; ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; CHILD; CHILD NEGLECT; CHILD SEXUAL ABUSE; CHILDHOOD INJURY; CHILDHOOD TRAUMA QUESTIONNAIRE; CONTROLLED STUDY; EARLY LIFE STRESS; EMOTIONAL ABUSE; ENVIRONMENTAL FACTOR; FEMALE; GENE; GENETIC RISK; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; OBSESSIVE COMPULSIVE DISORDER; PHYSICAL ABUSE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SCORING SYSTEM;

BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILDHOOD TRAUMA; CTQ; GENE-ENVIRONMENT INTERACTION; OBSESSIVE-COMPULSIVE DISORDER (OCD);

ADOLESCENT; ADULT; AGED; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; CHILD ABUSE; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINEAR MODELS; MALE; METHIONINE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; QUESTIONNAIRES; VALINE; YOUNG ADULT;

EID: 84886089006     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2013.08.012     Document Type: Article

References (47)

1. Aguilera M., Arias B., Wichers M., Barrantes-Vidal N., Moya J., Villa H., et al. Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population. Psychological Medicine 2009, 39:1425-1432.
2. Alonso P., Gratacos M., Menchon J.M., Saiz-Ruiz J., Segalas C., Baca-Garcia E., et al. Extensive genotyping of the BDNF and NTRK2 genes define protective haplotypes against obsessive-compulsive disorder. Biological Psychiatry 2008, 63:619-628.
3. Angst J., Gamma A., Endrass J., Goodwin R., Ajdacic V., Eich D., et al. Obsessive-compulsive severity spectrum in the community: prevalence, comorbidity, and course. European Archives of Psychiatry and Clinical Neuroscience 2004, 254(3):156-164.
4. Astle W., Balding D. Population structure and cryptic relatedness in genetic association studies. Statistical Science 2009, 24(4):451-471.
5. Barbazanges A., Vallee M., Mayo W., Day J., Simon H., Le Moal M., et al. Early and later adoptions have different long-term effects on male rat offspring. Journal of Neuroscience 1996, 16:7783-7790.
6. Bernstein D.P., Fink L. Manual for the childhood trauma questionnaire: a retrospective self-report 1998, The Psychological Corporation, Harcourt Brace, New York.
7. Black D.W., Noyes R., Goldstein R.B., Blum N. Afamily study of obsessive-compulsive disorder. Archives of General Psychiatry 1992, 49:362-368.
8. Briggs E.S., Price I.R. The relationship between adverse childhood experience and obsessive-compulsive symptoms and beliefs: the role of anxiety, depression, and experiential avoidance. Journal of Anxiety Disorders 2009, 23:1037-1046.
9. Carver C.S., Johnson S.L., Joormann J., Lemoult J., Cuccaro M.L. Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis. Journal of Affective Disorders 2011, 132:89-93.
10. Casey B.J., Glatt C.E., Tottenham N., Soliman F., Bath K., Amso D., et al. Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience 2009, 164:108-120.
11. Dickel D.E., Veenstra-Vanderweele J., Bivens N.C., Wu X., Fischer D.J., Van Etten-Lee M., et al. Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder. Biological Psychiatry 2007, 61:322-329.
12. Do Rosario-Campos M.C., Leckman J.F., Curi M., Quatrano S., Katsovitch L., Miguel E.C., et al. Afamily study of early-onset obsessive-compulsive disorder. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics 2005, 136B:92-97.
13. Duman R.S., Monteggia L.M. Aneurotrophic model for stress-related mood disorders. Biological Psychiatry 2006, 59:1116-1127.
14. Du Toit P.L., van Kradenburg J., Niehaus D., Stein D.J. Comparison of obsessive-compulsive disorder patients with and without comorbid putative obsessive-compulsive spectrum disorders using a structured clinical interview. Comprehensive Psychiatry 2001, 42:291-300.
15. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112:257-269.
16. Elzinga B.M., Molendijk M.L., Oude Voshaar R.C., Bus B.A., Prickaerts J., Spinhoven P., et al. The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val66Met. Psychopharmacology (Berl) 2011, 214:319-328.
17. First M.B., Spitzer R.L., Gobbon M., Williams J.B.W. Structured clinical interview for DSM-IV axis I disorders - patient edition (SCID-I/P, version 2.0, 8/98 revision) 1998, New York State Psychiatric Institute, Biometrics Department, New York.
18. Gatt J.M., Nemeroff C.B., Dobson-Stone C., Paul R.H., Bryant R.A., Schofield P.R., et al. Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety. Molecular Psychiatry 2009, 14:681-695.
19. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischmann R.L., Hill C.L., et al. The Yale-Brown obsessive compulsive scale. I. Development, use, and reliability. Archives of General Psychiatry 1989, 46:1006-1011.
20. Gothelf D., Aharonovsky O., Horesh N., Carty T., Apter A. Life events and personality factors in children and adolescents with obsessive-compulsive disorder and other anxiety disorders. Comprehensive Psychiatry 2004, 45(3):192-198.
21. Hall D., Dhilla A., Charalambous A., Gogos J.A., Karayiorgou M. Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. American Journal of Human Genetics 2003, 73(2):370-376.
22. Hanna G.L., Fingerlin T.E., Himle J.A., Boehnke M. Complex segregation analysis of obsessive-compulsive disorder in families with pediatric probands. Human Heredity 2005, 60:1-9.
23. Hemmings S.M., Kinnear C.J., van der Merwe L., Lochner C., Corfield V.A., Moolman-Smook J.C., et al. Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD). World Journal of Biological Psychiatry 2008, 9:126-134.
24. Hoglinger G.U., Sautter J., Meyer M., Spenger C., Seiler R.W., Oertel W.H., et al. Rat fetal ventral mesencephalon grown as solid tissue cultures: influence of culture time and BDNF treatment on dopamine neuron survival and function. Brain Research 1998, 813:313-322.
25. Huang E.J., Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annual Review of Neuroscience 2001, 24:677-736.
26. Huot R.L., Gonzalez M.E., Ladd C.O., Thrivikraman K.V., Plotsky P.M. Foster litters prevent hypothalamic-pituitary-adrenal axis sensitization mediated by neonatal maternal separation. Psychoneuroendocrinology 2004, 29:279-289.
27. Jaffee S.R., Price T.S. Gene-environment correlations: a review of the evidence and implications for prevention of mental illness. Molecular Psychiatry 2007, 12(5):432-442.
28. Katerberg H., Lochner C., Cath D.C., de J.P., Bochdanovits Z., Moolman-Smook J.C., et al. The role of the brain-derived neurotrophic factor (BDNF) val66met variant in the phenotypic expression of obsessive-compulsive disorder (OCD). American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 2009, 150B(8):1050-1062.
29. Kaufman J., Plotsky P.M., Nemeroff C.B., Charney D.S. Effects of early adverse experiences on brain structure and function: clinical implications. Biological Psychiatry 2000, 48:778-790.
30. Lochner C., Du Toit P.L., Zungu-Dirwayi N., Marais A., Van Kradenburg J., Seedat S., et al. Childhood trauma in obsessive-compulsive disorder, trichotillomania and controls. Depression and Anxiety 2002, 68:66-68.
31. Lu B. BDNF and activity-dependent synaptic modulation. Learning & Memory 2003, 10:86-98.
32. Mathews C.A., Kaur N., Stein M.B. Childhood trauma and obsessive-compulsive symptoms. Depression and Anxiety 2008, 25(9):742-751.
33. McKeon J., Roa B., Mann A. Life events and personality traits in obsessive-compulsive neurosis. British Journal of Psychiatry 1984, 144:185-189.
34. Middeldorp C.M., De Geus E.J., Willemsen G., Hottenga J.J., Slagboom P.E., Boomsma D.I. The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms. Twin Research and Human Genetics 2010, 13:544-549.
35. Moffitt T.E., Caspi A., Rutter M. Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry 2005, 62:473-481.
36. Mossner R., Walitza S., Lesch K.P., Geller F., Barth N., Remschmidt H., et al. Brain-derived neurotrophic factor V66M polymorphism in childhood-onset obsessive-compulsive disorder. International Journal of Neuropsychopharmacology 2005, 8:133-136.
37. Nicolini H., Arnold P., Nestadt G., Lanzagorta N., Kennedy J.L. Overview of genetics and obsessive-compulsive disorder. Psychiatry Research 2009, 170(1):7-14.
38. Pauls D.L. The genetics of obsessive-compulsive disorder: a review. Dialogues in Clinical Neuroscience 2010, 12:149-163.
39. Perroud N., Courtet P., Vincze I., Jaussent I., Jollant F., Bellivier F., et al. Interaction between BDNF Val66Met and childhood trauma on adult's violent suicide attempt. Genes, Brain, and Behavior 2008, 7(3):314-322.
40. Pregelj P., Nedic G., Paska A.V., Zupanc T., Nikolac M., Balažic J., et al. The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide. Journal of Affective Disorders 2011, 128(3):287-290.
41. Ruscio A.M., Stein D.J., Chiu W.T., Kessler R.C. The epidemiology of obsessive-compulsive disorder in the national comorbidity survey replication. Molecular Psychiatry 2010, 15:53-63.
42. Samuels J.F. Recent advances in the genetics of obsessive-compulsive disorder. Current Psychiatry Reports 2009, 11:277-282.
43. Stein D.J., Daniels W.M., Savitz J., Harvey B.H. Brain-derived neurotrophic factor: the neurotrophin hypothesis of psychopathology. CNS Spectrums 2008, 13:945-949.
44. Tukel R., Gurvit H., Ozata B., Ozturk N., Ertekin B.A., Ertekin E., et al. Brain-derived neurotrophic factor gene Val66Met polymorphism and cognitive function in obsessive-compulsive disorder. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics 2012, 159B:850-858.
45. van Grootheest D.S., Cath D.C., Beekman A.T., Boomsma D.I. Twin studies on obsessive-compulsive disorder: a review. Twin Research and Human Genetics 2005, 8:450-458.
46. Warnes G., Gorjanc G., Leisch F., Man M. Genetics: population genetics 2011, R package version 1.3.6. Available from:. http://cran.r-project.org/package=genetics.
47. Wendland J.R., Kruse M.R., Cromer K.R., Murphy D.L. Alarge case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder. Neuropsychopharmacology 2007 Dec, 32:2543-2551.