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Volumn 11, Issue 4, 2009, Pages 277-282

Recent advances in the genetics of obsessive-compulsive disorder

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; BRAIN DERIVED NEUROTROPHIC FACTOR; GLUTAMATE TRANSPORTER; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; SCAFFOLD PROTEIN; SEROTONIN TRANSPORTER;

EID: 67849124550     PISSN: 15233812     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11920-009-0040-y     Document Type: Review
Times cited : (20)

References (46)
  • 2
    • 34548073024 scopus 로고    scopus 로고
    • Genetics of obsessive-compulsive disorder: A research update
    • Grados M, Wilcox HC: Genetics of obseAsive-compulsive disorder: a research update. Expert Rev Neurother 2007, 7:967-980.
    • (2007) Expert Rev Neurother , vol.7 , pp. 967-980
    • Grados, M.1    Wilcox, H.C.2
  • 3
    • 33746527050 scopus 로고    scopus 로고
    • Familiality of obsessive-compulsive disorder in nonclinical and clinical subjects
    • Grabe HJ, Ruhrmann S, Ettelt S, et al.: Familiality of obsessive-compulsive disorder in nonclinical and clinical subjects. Am J Psychiatry 2006, 163:1986-1992.
    • (2006) Am J Psychiatry , vol.163 , pp. 1986-1992
    • Grabe, H.J.1    Ruhrmann, S.2    Ettelt, S.3
  • 5
    • 24744442746 scopus 로고    scopus 로고
    • Complex segregation analysis of obsessive-compulsive disorder in families with pediatric probands
    • Hanna GL, Fingerlin TE, Himle JA, Boehnke M: Complex segregation analysis of obsessive-compulsive disorder in families with pediatric probands. Hum Hered 2005, 60:1-9.
    • (2005) Hum Hered , vol.60 , pp. 1-9
    • Hanna, G.L.1    Fingerlin, T.E.2    Himle, J.A.3    Boehnke, M.4
  • 7
    • 33746545576 scopus 로고    scopus 로고
    • Genomewide linkage scan for obsessive-compulsive disorder: Evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q
    • Shugart YY, Samuels J, Willour VL, et al.: Genomewide linkage scan for obsessive-compulsive disorder: Evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Mol Psychiatry 2006, 11:763-770.
    • (2006) Mol Psychiatry , vol.11 , pp. 763-770
    • Shugart, Y.Y.1    Samuels, J.2    Willour, V.L.3
  • 9
    • 58849130174 scopus 로고    scopus 로고
    • Gender differences in genetic linkage and association on 11p15 in obsessive-compulsive disorder families
    • Wang Y, Samuels JF, Chang YC, et al.: Gender differences in genetic linkage and association on 11p15 in obsessive-compulsive disorder families. Am J Med Genet B Neuropsychiatr Genet 2009, 150B:33-40.
    • (2009) Am J Med Genet B Neuropsychiatr Genet , vol.150 B , pp. 33-40
    • Wang, Y.1    Samuels, J.F.2    Chang, Y.C.3
  • 10
    • 34748853081 scopus 로고    scopus 로고
    • Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder
    • Hanna GL, Weenstra-Vanderweele J, Cox NJ, et al.: Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder. Biol Psychiatry 2007, 62:856-862.
    • (2007) Biol Psychiatry , vol.62 , pp. 856-862
    • Hanna, G.L.1    Weenstra-Vanderweele, J.2    Cox, N.J.3
  • 11
    • 33646142054 scopus 로고    scopus 로고
    • The current status of association studies in obsessive-compulsive disorder
    • Hemmings SMJ, Stein DJ: The current status of association studies in obsessive-compulsive disorder. Psychiatr Clin North Am 2006, 29:411-444.
    • (2006) Psychiatr Clin North Am , vol.29 , pp. 411-444
    • Hemmings, S.M.J.1    Stein, D.J.2
  • 12
    • 51449096819 scopus 로고    scopus 로고
    • Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: Systematic review
    • Bloch MH, Landeros-Weisenberger A, Sen S, et al.: Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review. Am J Med Genet B Neuropsychiatr Genet 2008, 147B:850-858.
    • (2008) Am J Med Genet B Neuropsychiatr Genet , vol.147 B , pp. 850-858
    • Bloch, M.H.1    Landeros-Weisenberger, A.2    Sen, S.3
  • 13
    • 33745973652 scopus 로고    scopus 로고
    • Differentiation of obsessive-compulsive-, panic-, obsessive-compulsive personality-, and non-disordered individuals by variation in the promoter region of the serotonin transporter gene
    • Perez M, Brown JS, Vrshek-Schallhorn S, et al.: Differentiation of obsessive-compulsive-, panic-, obsessive-compulsive personality-, and non-disordered individuals by variation in the promoter region of the serotonin transporter gene. J Anxiety Disord 2006, 20:794-806.
    • (2006) J Anxiety Disord , vol.20 , pp. 794-806
    • Perez, M.1    Brown, J.S.2    Vrshek-Schallhorn, S.3
  • 14
    • 33947530691 scopus 로고    scopus 로고
    • Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder
    • Lin PY: Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2007, 31:683-689.
    • (2007) Prog Neuropsychopharmacol Biol Psychiatry , vol.31 , pp. 683-689
    • Lin, P.Y.1
  • 15
    • 33745023431 scopus 로고    scopus 로고
    • Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism
    • Hasler G, Kazuba D, Murphy DL: Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism. Am J Med Genet B Neuropsychiatr Genet 2006, 141B:403-408.
    • (2006) Am J Med Genet B Neuropsychiatr Genet , vol.141 B , pp. 403-408
    • Hasler, G.1    Kazuba, D.2    Murphy, D.L.3
  • 16
    • 27944443150 scopus 로고    scopus 로고
    • Obsessive-compulsive disorder, factor-analyzed symptom dimensions and serotonin transporter polymorphism
    • Kim SJ, Lee HS, Kim CH: Obsessive-compulsive disorder, factor-analyzed symptom dimensions and serotonin transporter polymorphism. Neuropsychobiology 2005, 52: 176-182.
    • (2005) Neuropsychobiology , vol.52 , pp. 176-182
    • Kim, S.J.1    Lee, H.S.2    Kim, C.H.3
  • 17
    • 33846820262 scopus 로고    scopus 로고
    • Association between obsessive-compulsive disorder and a variable number of tandem repeats polymorphism in intron 2 of the serotonin transporter gene
    • Baca-Garcia E, Vaquero-Lorenzo C, Diaz-Hernandez M, et al.: Association between obsessive-compulsive disorder and a variable number of tandem repeats polymorphism in intron 2 of the serotonin transporter gene. Prog Neuropsychopharmacol Biol Psychiatry 2007, 30:416-420.
    • (2007) Prog Neuropsychopharmacol Biol Psychiatry , vol.30 , pp. 416-420
    • Baca-Garcia, E.1    Vaquero-Lorenzo, C.2    Diaz-Hernandez, M.3
  • 18
    • 39749154209 scopus 로고    scopus 로고
    • A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder
    • Wendland JR, Moya PR, Kruse MR, et al.: A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet 2008, 17:717-723.
    • (2008) Hum Mol Genet , vol.17 , pp. 717-723
    • Wendland, J.R.1    Moya, P.R.2    Kruse, M.R.3
  • 19
    • 34548085906 scopus 로고    scopus 로고
    • A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder
    • Wendland JR, Kruse MR, Cromer KR, Murphy DL: A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder. Neuropsychopharmacology 2007, 32:2543-2551.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2543-2551
    • Wendland, J.R.1    Kruse, M.R.2    Cromer, K.R.3    Murphy, D.L.4
  • 20
    • 33846889750 scopus 로고    scopus 로고
    • A genetic family-based association study of OLIG2 in obsessive-compulsive disorder
    • Stewart SE, Platko J, Fagerness J, et al.: A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. Arch Gen Psychiatry 2007, 64:209-214.
    • (2007) Arch Gen Psychiatry , vol.64 , pp. 209-214
    • Stewart, S.E.1    Platko, J.2    Fagerness, J.3
  • 21
    • 33745726688 scopus 로고    scopus 로고
    • A primary candidate gene for obsessive-compulsive disorder
    • Leckman JF, Kim Y-S: A primary candidate gene for obsessive-compulsive disorder. Arch Gen Psychiatry 2006, 63:717-720.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 717-720
    • Leckman, J.F.1    Kim, Y.-S.2
  • 22
    • 33745684416 scopus 로고    scopus 로고
    • Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder
    • Dickel DE, Veenstra-VanderWeele J, Cox NJ, et al.: Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Arch Gen Psychiatry 2006, 63:778-785.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 778-785
    • Dickel, D.E.1    Veenstra-VanderWeele, J.2    Cox, N.J.3
  • 23
    • 33745712724 scopus 로고    scopus 로고
    • Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder
    • Arnold PD, Sicard T, Burroughs E, et al.: Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder. Arch Gen Psychiatry 2006, 63:769-776.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 769-776
    • Arnold, P.D.1    Sicard, T.2    Burroughs, E.3
  • 24
    • 36749066638 scopus 로고    scopus 로고
    • Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder
    • Stewart SE, Fagerness JA, Platko J, et al.: Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2007, 144:1027-1033.
    • (2007) Am J Med Genet B Neuropsychiatr Genet , vol.144 , pp. 1027-1033
    • Stewart, S.E.1    Fagerness, J.A.2    Platko, J.3
  • 25
    • 69049093878 scopus 로고    scopus 로고
    • A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families
    • Jan 16 (Epub ahead of print)
    • Shugart YY, Wang Y, Samuels JF, et al.: A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families. Am J Med Genet B Neuropsychiatr Genet 2009 Jan 16 (Epub ahead of print).
    • (2009) Am J Med Genet B Neuropsychiatr Genet
    • Shugart, Y.Y.1    Wang, Y.2    Samuels, J.F.3
  • 26
    • 34548147472 scopus 로고    scopus 로고
    • Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice
    • Welch JM, Lu J, Rodriguiz RM, et al.: Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature 2007, 448:894-901.
    • (2007) Nature , vol.448 , pp. 894-901
    • Welch, J.M.1    Lu, J.2    Rodriguiz, R.M.3
  • 27
    • 63549113512 scopus 로고    scopus 로고
    • Sapap3 and pathological grooming in humans: Results from the OCD Collaborative Genetics Study
    • Dec 2 (Epub ahead of print)
    • Bienvenu OJ, Wang Y, Shugart YY, et al.: Sapap3 and pathological grooming in humans: Results from the OCD Collaborative Genetics Study. Am J Med Genet B Neuropsychiatr Genet 2008 Dec 2 (Epub ahead of print).
    • (2008) Am J Med Genet B Neuropsychiatr Genet
    • Bienvenu, O.J.1    Wang, Y.2    Shugart, Y.Y.3
  • 29
    • 33846187299 scopus 로고    scopus 로고
    • Prenatal, perinatal, and postnatal risk factors in obsessive-compulsive disorder
    • Vasconcelos MS, Sampaio AS, Hounie AG, et al.: Prenatal, perinatal, and postnatal risk factors in obsessive-compulsive disorder. Biol Psychiatry 2007, 61:301-307.
    • (2007) Biol Psychiatry , vol.61 , pp. 301-307
    • Vasconcelos, M.S.1    Sampaio, A.S.2    Hounie, A.G.3
  • 30
    • 50849140506 scopus 로고    scopus 로고
    • Perinatal factors affecting expression of obsessive compulsive disorder in children and adolescents
    • Geller DA, Wieland N, Carey K, et al.: Perinatal factors affecting expression of obsessive compulsive disorder in children and adolescents. J Child Adolesc Psychopharmacol 2008, 18:373-379.
    • (2008) J Child Adolesc Psychopharmacol , vol.18 , pp. 373-379
    • Geller, D.A.1    Wieland, N.2    Carey, K.3
  • 31
    • 51949092913 scopus 로고    scopus 로고
    • Childhood trauma and obsessive-compulsive symptoms
    • Mathews CA, Kaur N, Stein MB: Childhood trauma and obsessive-compulsive symptoms. Depress Anxiety 2008, 25:742-751.
    • (2008) Depress Anxiety , vol.25 , pp. 742-751
    • Mathews, C.A.1    Kaur, N.2    Stein, M.B.3
  • 32
    • 34247587203 scopus 로고    scopus 로고
    • An investigation of traumatic life events and obsessive-compulsive disorder
    • Cromer KR, Schmidt NB, Murphy DL: An investigation of traumatic life events and obsessive-compulsive disorder. Behav Res Ther 2007, 45:1683-1691.
    • (2007) Behav Res Ther , vol.45 , pp. 1683-1691
    • Cromer, K.R.1    Schmidt, N.B.2    Murphy, D.L.3
  • 33
    • 40049104893 scopus 로고    scopus 로고
    • Environmental factors in obsessive-compulsive behavior: Evidence from discordant and concordant monozygotic twins
    • Cath DC, van Grootheest DS, Willemsen G, et al.: Environmental factors in obsessive-compulsive behavior: Evidence from discordant and concordant monozygotic twins. Behav Genet 2008, 38:108-120.
    • (2008) Behav Genet , vol.38 , pp. 108-120
    • Cath, D.C.1    van Grootheest, D.S.2    Willemsen, G.3
  • 34
    • 48749107334 scopus 로고    scopus 로고
    • Recent advances in compulsive hoarding
    • Saxena S: Recent advances in compulsive hoarding. Curr Psychiatry Rep 2008, 10:297-303.
    • (2008) Curr Psychiatry Rep , vol.10 , pp. 297-303
    • Saxena, S.1
  • 35
    • 34047157648 scopus 로고    scopus 로고
    • Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: Results from the OCD Collaborative Genetics Study
    • Samuels J, Shugart YY, Grados MA, et al.: Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: Results from the OCD Collaborative Genetics Study. Am J Psychiatry 2007, 164:493-499.
    • (2007) Am J Psychiatry , vol.164 , pp. 493-499
    • Samuels, J.1    Shugart, Y.Y.2    Grados, M.A.3
  • 37
    • 44949228148 scopus 로고    scopus 로고
    • Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories
    • Pinto A, Greenberg BD, Grados MA, et al.: Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories. Psychiatry Res 2008, 160:83-93.
    • (2008) Psychiatry Res , vol.160 , pp. 83-93
    • Pinto, A.1    Greenberg, B.D.2    Grados, M.A.3
  • 39
    • 51449108080 scopus 로고    scopus 로고
    • Evidence for a heritable unidimensional symptom factor underlying obsessionality
    • Mathews CA, Greenwood T, Wessel J, et al.: Evidence for a heritable unidimensional symptom factor underlying obsessionality. Am J Med Genet B Neuropsychiatr Genet 2008, 147B:676-685.
    • (2008) Am J Med Genet B Neuropsychiatr Genet , vol.147 B , pp. 676-685
    • Mathews, C.A.1    Greenwood, T.2    Wessel, J.3
  • 40
    • 36749001585 scopus 로고    scopus 로고
    • Neurocognitive endophenotypes of obsessive-compulsive disorder
    • Menzies L, Achard S, Chamberlain SR, et al.: Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain 2007, 130:3223-3236.
    • (2007) Brain , vol.130 , pp. 3223-3236
    • Menzies, L.1    Achard, S.2    Chamberlain, S.R.3
  • 41
    • 54349128080 scopus 로고    scopus 로고
    • White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives
    • Menzies L, Williams GB, Chamberlain SR, et al.: White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives. Am J Psychiatry 2008, 165:1308-1315.
    • (2008) Am J Psychiatry , vol.165 , pp. 1308-1315
    • Menzies, L.1    Williams, G.B.2    Chamberlain, S.R.3
  • 42
    • 47749116024 scopus 로고    scopus 로고
    • Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives
    • Chamberlain SR, Menzies L, Hampshire A, et al.: Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 2008, 321:421-422.
    • (2008) Science , vol.321 , pp. 421-422
    • Chamberlain, S.R.1    Menzies, L.2    Hampshire, A.3
  • 43
    • 63449088196 scopus 로고    scopus 로고
    • Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessivecompulsive disorder
    • Arnold PD, Macmaster FP, Richter MA, et al.: Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessivecompulsive disorder. Psychiatry Res 2009, 172:136-139.
    • (2009) Psychiatry Res , vol.172 , pp. 136-139
    • Arnold, P.D.1    Macmaster, F.P.2    Richter, M.A.3
  • 45
    • 49049110785 scopus 로고    scopus 로고
    • Gene expression in the etiology of schizophrenia
    • Bray NJ: Gene expression in the etiology of schizophrenia. Schizophr Bull 2008, 34:412-418.
    • (2008) Schizophr Bull , vol.34 , pp. 412-418
    • Bray, N.J.1
  • 46
    • 43449117811 scopus 로고    scopus 로고
    • Psychiatric research: Psychoproteomics, degradomics and systems biology
    • Kobeissy FH, Sadasivan S, Liu J, et al.: Psychiatric research: psychoproteomics, degradomics and systems biology. Expert Rev Proteomics 2008, 5:293-314.
    • (2008) Expert Rev Proteomics , vol.5 , pp. 293-314
    • Kobeissy, F.H.1    Sadasivan, S.2    Liu, J.3


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