Interaction between BDNF Val66Met and childhood trauma on adult's violent suicide attempt

Genes, Brain and Behavior

Volumn 7, Issue 3, 2008, Pages 314-322

  Perroud, N ^a,g   Courtet, P ^b,c,d   Vincze, I ^a   Jaussent, I ^d   Jollant, F ^b,c,d   Bellivier, F ^e   Leboyer, M ^e   Baud, P ^a   Buresi, C ^a   Malafosse, A ^a,d,f  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIV MONTPELLIER   (France)

^c LAPEYRONIE HOSPITAL   (France)

^d INSERM   (France)

^e Section of Radiology   (France)

^f University Hospital and Faculty of Medicine   (Switzerland)

^g Departement de Psychiatrie   (Switzerland)

Author keywords

BDNF; Childhood trauma; Gene environment interaction; Sexual abuse; Suicide attempts; Val66Met

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ADULT; ARTICLE; CHILD SEXUAL ABUSE; CONTROLLED STUDY; FEMALE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PSYCHOTRAUMA; QUESTIONNAIRE; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT; VIOLENCE;

ADULT; AMINO ACID SUBSTITUTION; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; CHILD ABUSE, SEXUAL; FRANCE; GENE FREQUENCY; GENOTYPE; HUMANS; INTERVIEWS AS TOPIC; METHIONINE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; SUICIDE; SUICIDE, ATTEMPTED; SWITZERLAND; VALINE; VIOLENCE;

EID: 41749103978     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2007.00354.x     Document Type: Article

References (73)

1. Agerbo, E., Nordentoft, M. Mortensen, P.B 2002) Familial, psychiatric, and socioeconomic risk factors for suicide in young people: nested case-control study. BMJ 325, 74.
2. Altar, C.A., Boylan, C.B., Fritsche, M., Jackson, C., Hyman, C. Lindsay, R.M 1994) The neurotrophins NT-4/5 and BDNF augment serotonin, dopamine, and GABAergic systems during behaviorally effective infusions to the substantia nigra. Exp Neurol 130, 31 40.
3. Altar, C.A., Cai, N., Bliven, T., Juhasz, M., Conner, J.M., Acheson, A.L., Lindsay, R.M. Wieqand, S.J 1997) Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature 389, 856 860.
4. Anguelova, M., Benkelfat, C. Turecki, G 2003) A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 8, 646 653.
5. Asberg, M., Traskman, L. Thoren, P 1976) 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33, 1193 1197.
6. Barr, C.S., Newman, T.K., Becker, M.L., Parker, C.C., Champoux, M., Lesch, K.P., Goldman, D., Suomi, S.J. Higley, J.D 2003) The utility of the non-human primate: model for studying gene by environment interactions in behavioral research. Genes Brain Behav 2, 336 340.
7. Beautrais, A.L., Joyce, P.R. Mulder, R.T 1996) Risk factors for serious suicide attempts among youths aged 13 through 24 years. J Am Acad Child Adolesc Psychiatry 35, 1174 1182.
8. Bellivier, F., Chaste, P. Malafosse, A 2004) Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. Am J Med Genet B Neuropsychiatr Genet 124, 87 91.
9. Bennett, A.J., Lesch, K.P., Heils, A., Long, J.C., Lorenz, J.G., Shoaf, S.E., Champoux, M., Suomi, S.J., Linnoila, M.V. Higley, J.D 2002) Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 7, 118 122.
10. Bernstein, D.P. Fink, L 1998) Childhood Trauma Questionnaire. A Retrospective Self-Report. The Psychological Corporation, San Antonio.
11. Bernstein, D.P., Fink, L., Handelsman, L., Foote, J., Lovejoy, M., Wenzel, K., Sapareto, E. Ruggiero, J 1994) Initial reliability and validity of a new retrospective measure of child abuse and neglect. Am J Psychiatry 151, 1132 1136.
12. Bernstein, D.P., Ahluvalia, T., Pogge, D. Handelsman, L 1997) Validity of the childhood trauma questionnaire in an adolescent psychiatric population. J Am Acad Child Adolesc Psychiatry 36, 340 348.
13. Berton, O., McClung, C.A., Dileone, R.J., Krishnan, V., Renthal, W., Russo, S.J., Graham, D., Tsankova, N.M., Bolanos, C.A., Rios, M., Monteggia, L.M., Self, D.W. Nestler, E.J 2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311, 864 868.
14. Bondy, B., Buettner, A. Zill, P 2006) Genetics of suicide. Mol Psychiatry 11, 336 351.
15. Brent, D.A., Baugher, M., Bridge, J., Chen, T. Chiappetta, L 1999) Age- and sex-related risk factors for adolescent suicide. J Am Acad Child Adolesc Psychiatry 38, 1497 1505.
16. Brent, D.A., Oquendo, M., Birmaher, B., Greenhill, L., Kolko, D., Stanley, B., Zelazny, J., Brodsky, B., Bridge, J., Ellis, S., Salazar, J.O. Mann, J.J 2002) Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempters. Arch Gen Psychiatry 59, 801 807.
17. Brodsky, B.S., Oquendo, M., Ellis, S.P., Haas, G.L., Malone, K.M. Mann, J.J 2001) The relationship of childhood abuse to impulsivity and suicidal behavior in adults with major depression. Am J Psychiatry 158, 1871 1877.
18. Brown, J., Cohen, P., Johnson, J.G. Smailes, E.M 1999) Childhood abuse and neglect: specificity of effects on adolescent and young adult depression and suicidality. J Am Acad Child Adolesc Psychiatry 38, 1490 1496.
19. Caspi, A. Moffitt, T.E 2006) Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat Rev Neurosci 7, 583 590.
20. Chen, Z.Y., Patel, P.D., Sant, G., Meng, C.X., Teng, K.K., Hempstead, B.L. Lee, F.S 2004) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24, 4401 4411.
21. Courtet, P., Jollant, F., Castelnau, D., Buresi, C. Malafosse, A 2005) Suicidal behavior: relationship between phenotype and serotonergic genotype. Am J Med Genet C Semin Med Genet 133, 25 33.
22. Dube, S.R., Anda, R.F., Felitti, V.J., Chapman, D.P., Williamson, D.F. Giles, W.H 2001) Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: findings from the Adverse Childhood Experiences Study. JAMA 286, 3089 3096.
23. Dwivedi, Y., Rizavi, H.S., Conley, R.R., Roberts, R.C., Tamminga, C.A. Pandey, G.N 2003) Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 60, 804 815.
24. Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana, B.S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., Lu, B. Weinberger, D.R 2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257 269.
25. Fergusson, D.M., Horwood, L.J. Lynskey, M.T 1996) Childhood sexual abuse and psychiatric disorder in young adulthood: II. Psychiatric outcomes of childhood sexual abuse. J Am Acad Child Adolesc Psychiatry 35, 1365 1374.
26. Fergusson, D.M., Woodward, L.J. Horwood, L.J 2000) Risk factors and life processes associated with the onset of suicidal behaviour during adolescence and early adulthood. Psychol Med 30, 23 39.
27. Fink, L.A., Bernstein, D., Handelsman, L., Foote, J. Lovejoy, M 1995) Initial reliability and validity of the childhood trauma interview: a new multidimensional measure of childhood interpersonal trauma. Am J Psychiatry 152, 1329 1335.
28. Gaspar, P., Cases, O. Maroteaux, L 2003) The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4, 1002 1012.
29. Gladstone, G., Parker, G., Wilhelm, K., Mitchell, P. Austin, M.P 1999) Characteristics of depressed patients who report childhood sexual abuse. Am J Psychiatry 156, 431 437.
30. Gladstone, G.L., Parker, G.B., Mitchell, P.B., Malhi, G.S., Wilhelm, K. Austin, M.P 2004) Implications of childhood trauma for depressed women: an analysis of pathways from childhood sexual abuse to deliberate self-harm and revictimization. Am J Psychiatry 161, 1417 1425.
31. Gratacos, M., Gonzalez, J.R., Mercader, J.M., de Cid, R., Urretavizcaya, M. Estivill, X 2007) Brain-derived neurotrophic factor val66met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol Psychiatry 61, 911 922.
32. Hariri, A.R., Mattay, V.S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M.F. Weinberger, D.R 2002) Serotonin transporter genetic variation and the response of the human amygdala. Science 297, 400 403.
33. Harrington, R., Pickles, A., Aglan, A., Harrington, V., Burroughs, H. Kerfoot, M 2006) Early adult outcomes of adolescents who deliberately poisoned themselves. J Am Acad Child Adolesc Psychiatry 45, 337 345.
34. Hong, C.J., Huo, S.J., Yen, F.C., Tung, C.L., Pan, G.M. Tsai, S.J 2003) Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 48, 186 189.
35. Hunter, D.J 2005) Gene-environment interactions in human diseases. Nat Rev Genet 6, 287 298.
36. Hwang, J.P., Tsai, S.J., Hong, C.J., Yang, C.H., Lirng, J.F. Yang, Y.M 2006) The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol Aging 27, 1834 1837.
37. Iga, J.I., Ueno, S.I., Yamauchi, K., Numata, S., Tayoshi-Shibuya, S., Kinouchi, S., Nakataki, M., Song, H., Hokoishi, K., Tanabe, H., Sano, A. Ohmori, T in press) The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients. Am J Med Genet B Neuropsychiatr Genet.
38. Jaffee, S.R. Price, T.S 2007) Gene-environment correlations: a review of the evidence and implications for prevention of mental illness. Mol Psychiatry 12, 432 442.
39. Johnson, J.G., Cohen, P., Gould, M.S., Kasen, S., Brown, J. Brook, J.S 2002) Childhood adversities, interpersonal difficulties, and risk for suicide attempts during late adolescence and early adulthood. Arch Gen Psychiatry 59, 741 749.
40. Kaplan, S.J., Pelcovitz, D., Salzinger, S., Mandel, F. Weiner, M 1997) Adolescent physical abuse and suicide attempts. J Am Acad Child Adolesc Psychiatry 36, 799 808.
41. Karege, F., Vaudan, G., Schwald, M., Perroud, N. La Harpe, R 2005) Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res Mol Brain Res 136, 29 37.
42. Kim, Y.K., Lee, H.P., Won, S.D., Park, E.Y., Lee, H.Y., Lee, B.H., Lee, S.W., Yoon, D., Han, C., Kim, D.J. Choi, S.H 2007) Low plasma BDNF is associated with suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry 31, 78 85.
43. Kimata, H 2005) Differential modulation of cerebrospinal fluid neurotrophins in patients with atopic dermatitis who attempted suicide. J Clin Psychiatry 66, 1193 1194.
44. Lange, A., de Beurs, E., Dolan, C., Lachnit, T., Sjollema, S. Hanewald, G 1999) Long-term effects of childhood sexual abuse: objective and subjective characteristics of the abuse and psychopathology in later life. J Nerv Ment Dis 187, 150 158.
45. Lesch, K.P 2004) Gene-environment interaction and the genetics of depression. J Psychiatry Neurosci 29, 174 184.
46. Li, D. He, L 2007) Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior. Mol Psychiatry 12, 47 54.
47. Lin, P.Y. Tsai, G 2004) Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis. Biol Psychiatry 55, 1023 1030.
48. Lyons, W.E., Mamounas, L.A., Ricaurte, G.A., Coppola, V., Reid, S.W., Bora, S.H., Wihler, C., Koliatsos, V.E. Tessarollo, L 1999) Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci U S A 96, 15239 15244.
49. Mamounas, L.A., Blue, M.E., Siuciak, J.A. Altar, C.A 1995) Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. J Neurosci 15, 7929 7939.
50. Mann, J.J 2003) Neurobiology of suicidal behaviour. Nat Rev Neurosci 4, 819 828.
51. Mann, J.J., Bortinger, J., Oquendo, M.A., Currier, D., Li, S. Brent, D.A 2005) Family history of suicidal behavior and mood disorders in probands with mood disorders. Am J Psychiatry 162, 1672 1679.
52. Martin, G., Bergen, H.A., Richardson, A.S., Roeger, L. Allison, S 2004) Sexual abuse and suicidality: gender differences in a large community sample of adolescents. Child Abuse Negl 28, 491 503.
53. McHolm, A.E., MacMillan, H.L. Jamieson, E 2003) The relationship between childhood physical abuse and suicidality among depressed women: results from a community sample. Am J Psychiatry 160, 933 938.
54. Moffitt, T.E., Caspi, A. Rutter, M 2005) Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry 62, 473 481.
55. Molnar, B.E., Berkman, L.F. Buka, S.L 2001) Psychopathology, childhood sexual abuse and other childhood adversities: relative links to subsequent suicidal behaviour in the US. Psychol Med 31, 965 977.
56. Murakami, S., Imbe, H., Morikawa, Y., Kubo, C. Senba, E 2005) Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly. Neurosci Res 53, 129 139.
57. Nelson, E.C., Heath, A.C., Madden, P.A., Cooper, M.L., Dinwiddie, S.H., Bucholz, K.K., Glowinski, A., McLaughlin, T., Dunne, M.P., Statham, D.J. Martin, N.G 2002) Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study. Arch Gen Psychiatry 59, 139 145.
58. Neves-Pereira, M., Mundo, E., Muglia, P., King, N., Macciardi, F. Kennedy, J.L 2002) The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet 71, 651 655.
59. Neves-Pereira, M., Cheung, J.K., Pasdar, A., Zhang, F., Breen, G., Yates, P., Sinclair, M., Crombie, C., Walker, N. St Clair, D.M 2005) BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiatry 10, 208 212.
60. Nurnberger, J.I., Blehar, M.C., Kaufmann, C.A., York-Cooler, C., Simpson, S.G., Harkavy-Friedman, J., Severe, J.B., Malaspina, D. Reich, T 1994) Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 51, 849 864.
61. Pizarro, J.M., Lumley, L.A., Medina, W., Robison, C.L., Chang, W.E., Alagappan, A., Bah, M.J., Dawood, M.Y., Shah, J.D., Mark, B., Kendall, N., Smith, M.A., Saviolakis, G.A. Meyerhoff, J.L 2004) Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice. Brain Res 1025, 10 20.
62. Plomin, R. Bergeman, C.S 1991) The nature of nurture: genetic influence on environmental measures. Behav Brain Sci 14, 373 427.
63. Preisig, M., Fenton, B.T., Matthey, M.L., Berney, A. Ferrero, F 1999) Diagnostic interview for genetic studies (DIGS): inter-rater and test-retest reliability of the French version. Eur Arch Psychiatry Clin Neurosci 249, 174 179.
64. Romans, S.E., Martin, J.L., Anderson, J.C., Herbison, G.P. Mullen, P.E 1995) Sexual abuse in childhood and deliberate self-harm. Am J Psychiatry 152, 1336 1342.
65. Roy, A 2004) Relationship of childhood trauma to age of first suicide attempt and number of attempts in substance dependent patients. Acta Psychiatr Scand 109, 121 125.
66. Roy, A. Janal, M 2005) Family history of suicide, female sex, and childhood trauma: separate or interacting risk factors for attempts at suicide? Acta Psychiatr Scand 112, 367 371.
67. Rujescu, D., Giegling, I., Sato, T., Hartmann, A.M. Moller, H.J 2003) Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis. Biol Psychiatry 54, 465 473.
68. Savitz, J., van der Merwe, L., Stein, D.J., Solms, M. Ramesar, R in press) Genotype and childhood sexual trauma moderate neurocognitive performance: a possible role for brain-derived neurotrophic factor and apolipoprotein E variants. Biol Psychiatry.
69. Scaccianoce, S., Del Bianco, P., Caricasole, A., Nicoletti, F. Catalani, A 2003) Relationship between learning, stress and hippocampal brain-derived neurotrophic factor. Neuroscience 121, 825 828.
70. Sheehan, D., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J., Weiller, E., Hergueta, T., Baker, R. Dunbar, G.C 1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59, 22 33.
71. Siuciak, J.A., Boylan, C., Fritsche, M., Altar, C.A. Lindsay, R.M 1996) BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration. Brain Res 710, 11 20.
72. Tsankova, N.M., Berton, O., Renthal, W., Kumar, A., Neve, R.L. Nestler, E.J 2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9, 519 525.
73. Ullman, S.E. Brecklin, L.R 2002) Sexual assault history and suicidal behavior in a national sample of women. Suicide Life Threat Behav 32, 117 130.