-
1
-
-
54249155522
-
Network pharmacology: The next paradigm in drug discovery
-
Hopkins, A. L. (2008), Network pharmacology: The next paradigm in drug discovery, Nature Chem. Biol. 4(11), 682-690.
-
(2008)
Nature Chem. Biol.
, vol.4
, Issue.11
, pp. 682-690
-
-
Hopkins, A.L.1
-
2
-
-
39049161143
-
2007 FDA drug approvals: A year of flux
-
Hughes, B. (2008), 2007 FDA drug approvals: A year of flux, Nature Rev. Drug Discov. 7 (2), 107-109.
-
(2008)
Nature Rev. Drug Discov.
, vol.7
, Issue.2
, pp. 107-109
-
-
Hughes, B.1
-
3
-
-
33847377573
-
A robustness-based approach to systems-oriented drug design
-
Kitano, H. (2007), A robustness-based approach to systems-oriented drug design, Nature Rev. Drug Discov. 6(3), 202-210.
-
(2007)
Nature Rev. Drug Discov.
, vol.6
, Issue.3
, pp. 202-210
-
-
Kitano, H.1
-
4
-
-
12144258457
-
Multicomponent therapeutics for networked systems
-
Keith, C. T.; Borisy, A. A.; Stockwell, B. R. (2005), Multicomponent therapeutics for networked systems, Nature Rev. Drug Discov. 4(1), 71-78.
-
(2005)
Nature Rev. Drug Discov.
, vol.4
, Issue.1
, pp. 71-78
-
-
Keith, C.T.1
Borisy, A.A.2
Stockwell, B.R.3
-
5
-
-
0038610570
-
Systematic discovery of multicomponent therapeutics
-
Borisy, A. A.; Elliott, P. J.; Hurst, N.W.; Lee, M. S.; Lehár, J.; Price, E. R.; Serbedzija, G.; Zimmermann, G. R.; Foley, M. A.; Stockwell, B. R.; et al. (2003), Systematic discovery of multicomponent therapeutics, Proc. Natl. Acad. Sci. USA 100(13), 7977-7982.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, Issue.13
, pp. 7977-7982
-
-
Borisy, A.A.1
Elliott, P.J.2
Hurst, N.W.3
Lee, M.S.4
Lehár, J.5
Price, E.R.6
Serbedzija, G.7
Zimmermann, G.R.8
Foley, M.A.9
Stockwell, B.R.10
-
6
-
-
10744230485
-
Global mapping of the yeast genetic interaction network
-
Tong, A. H.; Lesage, G.; Bader, G. D.; Ding, H.; Xu, H.; Xin, X.; Young, J.; Berriz, G. F.; Brost, R. L.; Chang, M.; et al. (2004), Global mapping of the yeast genetic interaction network, Science 303(5659), 808-813.
-
(2004)
Science
, vol.303
, Issue.5659
, pp. 808-813
-
-
Tong, A.H.1
Lesage, G.2
Bader, G.D.3
Ding, H.4
Xu, H.5
Xin, X.6
Young, J.7
Berriz, G.F.8
Brost, R.L.9
Chang, M.10
-
7
-
-
33847643207
-
Chemical combination effects predict connectivity in biological systems
-
Lehár, J.; Zimmermann, G. R.; Krueger, A. S.; Molnar, R. A.; Ledell, J. T.; Heilbut, A. M.; Short, G. F., 3rd; Giusti, L. C.; Nolan, G. P.; Magid, O. A.; et al. (2007), Chemical combination effects predict connectivity in biological systems, Mol. Syst. Biol. 3, 80.
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 80
-
-
Lehár, J.1
Zimmermann, G.R.2
Krueger, A.S.3
Molnar, R.A.4
Ledell, J.T.5
Heilbut, A.M.6
Short, 3rdG.F.7
Giusti, L.C.8
Nolan, G.P.9
Magid, O.A.10
-
8
-
-
0029036955
-
The search for synergy: A critical review from a response surface perspective
-
Greco, W. R.; Bravo, G.; Parsons, J. C. (1995), The search for synergy: A critical review from a response surface perspective, Pharmacol. Rev. 47(2), 331-385.
-
(1995)
Pharmacol. Rev.
, vol.47
, Issue.2
, pp. 331-385
-
-
Greco, W.R.1
Bravo, G.2
Parsons, J.C.3
-
9
-
-
84960590019
-
How and when should combination therapy be used? The role of an anchor drug
-
Farr, M.; Bacon, P. A. (1995), How and when should combination therapy be used? The role of an anchor drug, Br. J. Rheumatol. 34 (Suppl. 2); 100-3.
-
(1995)
Br. J. Rheumatol.
, vol.34
, Issue.SUPPL. 2
, pp. 100-103
-
-
Farr, M.1
Bacon, P.A.2
-
10
-
-
67650488269
-
Synergistic drug combinations tend to improve therapeutically relevant selectivity
-
Lehár, J.; Krueger, A. S.; Avery,W.; Heilbut, A. M.; Johansen, L. M.; Price, E. R.; Rickles, R. J.; Short, G. F., 3rd; Staunton, J. E.; Jin, X.; et al. (2009), Synergistic drug combinations tend to improve therapeutically relevant selectivity, Nature Biotechnol. 27(7), 659-666.
-
(2009)
Nature Biotechnol.
, vol.27
, Issue.7
, pp. 659-666
-
-
Lehár, J.1
Krueger, A.S.2
Avery, W.3
Heilbut, A.M.4
Johansen, L.M.5
Price, E.R.6
Rickles, R.J.7
Short, 3rdG.F.8
Staunton, J.E.9
Jin, X.10
-
11
-
-
3843128481
-
Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model
-
Duarte, N. C.; Herrgard, M. J.; Palsson, B. O. (2004), Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model, Genome Res. 14(7), 1298-1309.
-
(2004)
Genome Res.
, vol.14
, Issue.7
, pp. 1298-1309
-
-
Duarte, N.C.1
Herrgard, M.J.2
Palsson, B.O.3
-
12
-
-
24144457593
-
Effect of endogenous catecholamines in lymphocytes on lymphocyte function
-
Qiu, Y. H.; Cheng, C.; Dai, L.; Peng, Y. P. (2005), Effect of endogenous catecholamines in lymphocytes on lymphocyte function, J. Neuroimmunol. 167(1-2), 45-52.
-
(2005)
J. Neuroimmunol.
, vol.167
, Issue.1-2
, pp. 45-52
-
-
Qiu, Y.H.1
Cheng, C.2
Dai, L.3
Peng, Y.P.4
-
13
-
-
11144358198
-
A gene atlas of the mouse and human protein-encoding transcriptomes
-
Su, A. I.;Wiltshire, T.; Batalov, S.; Lapp, H.; Ching, K. A.; Block, D.; Zhang, J. H.; Soden, R.; Hayakawa, M.; Kreiman, G.; et al. (2004), A gene atlas of the mouse and human protein-encoding transcriptomes, Proc. Natl. Acid. Sci. USA 101(16), 6062-6067.
-
(2004)
Proc. Natl. Acid. Sci. USA
, vol.101
, Issue.16
, pp. 6062-6067
-
-
Su, A.I.1
Wiltshire, T.2
Batalov, S.3
Lapp, H.4
Ching, K.A.5
Block, D.6
Zhang, J.H.7
Soden, R.8
Hayakawa, M.9
Kreiman, G.10
-
14
-
-
46849091405
-
Efficacy and safety of a novel synergistic drug candidate-CRx-102-in hand osteoarthritis
-
Jul, Epub 2007 Oct 25
-
Kvien, T. K.; Fjeld, E.; Slatkowsky-Christensen, B.; Nichols, M.; Zhang, Y.; Proven, A.; Mikkelsen, K.; Palm, O.; Borisy, A. A.; Lessem, J. (2007), Efficacy and safety of a novel synergistic drug candidate-CRx-102-in hand osteoarthritis, Ann. Rheum. Dis. 2008 Jul; 67(7):942-948. Epub 2007 Oct 25.
-
(2007)
Ann. Rheum. Dis.
, vol.67
, Issue.7
, pp. 942-948
-
-
Kvien, T.K.1
Fjeld, E.2
Slatkowsky-Christensen, B.3
Nichols, M.4
Zhang, Y.5
Proven, A.6
Mikkelsen, K.7
Palm, O.8
Borisy, A.A.9
Lessem, J.10
-
15
-
-
60849108323
-
Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination drug
-
Zimmermann, G. R.; Avery, W.; Finelli, A. L.; Farwell, M.; Fraser, C. C.; Borisy, A. A. (2009), Selective amplification of glucocorticoid anti-inflammatory activity through synergistic multi-target action of a combination drug, Arthritis Res. Ther. 11(1), R12.
-
(2009)
Arthritis Res. Ther.
, vol.11
, Issue.1
-
-
Zimmermann, G.R.1
Avery, W.2
Finelli, A.L.3
Farwell, M.4
Fraser, C.C.5
Borisy, A.A.6
-
16
-
-
18144381611
-
Dissociated glucocorticoid receptor ligands: Compounds with an improved therapeutic index
-
Schäcke, H.; Rehwinkel, H.; Asadullah, K. (2005), Dissociated glucocorticoid receptor ligands: Compounds with an improved therapeutic index, Curr. Opin. Invest. Drugs 6(5), 503-507.
-
(2005)
Curr. Opin. Invest. Drugs
, vol.6
, Issue.5
, pp. 503-507
-
-
Schäcke, H.1
Rehwinkel, H.2
Asadullah, K.3
-
17
-
-
49449101097
-
High-order combination effects and biological robustness
-
Lehár, J.; Krueger, A.; Zimmermann, G.; Borisy, A. (2008), High-order combination effects and biological robustness, Mol. Syst. Biol. 4, 215.
-
(2008)
Mol. Syst. Biol.
, vol.4
, pp. 215
-
-
Lehár, J.1
Krueger, A.2
Zimmermann, G.3
Borisy, A.4
|