Bupleurum Polysaccharides Attenuates Lipopolysaccharide-Induced Inflammation via Modulating Toll-Like Receptor 4 Signaling

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Wu, Jian ^a   Zhang, Yun Yi ^a   Guo, Li ^a   Li, Hong ^a   Chen, Dao Feng ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; INTERLEUKIN 12P40; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; POLYSACCHARIDE; PREDNISOLONE ACETATE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; CYTOKINE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; IRAK4 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; TLR4 PROTEIN, MOUSE; TLR4 PROTEIN, RAT;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BUPLEURUM; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOCYTOCHEMISTRY; IMMUNOMODULATION; LUNG HEMORRHAGE; MALE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PNEUMONIA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; IMMUNOLOGY; INFLAMMATION; METABOLISM; PATHOLOGY; PERITONEUM MACROPHAGE; TOXICITY; WISTAR RAT;

ANIMALS; ANTIGENS, CD14; BUPLEURUM; CYTOKINES; GENE EXPRESSION REGULATION; INFLAMMATION; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MAP KINASE KINASE 4; MICE; MICE, INBRED BALB C; NF-KAPPA B; PHAGOCYTOSIS; POLYSACCHARIDES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 4;

EID: 84886020564     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078051     Document Type: Article

References (40)

1. Heumann D, Glauser MP, Calandra T, (1998) Molecular basis of host-pathogen interaction in septic shock. Curr Opin Microbiol 1: 49-55. doi:10.1016/S1369-5274(98)80142-2. PubMed: 10066457.
2. Togbe D, Schnyder-Candrian S, Schnyder B, Couillin I, Maillet I, et al. (2006) TLR4 gene dosage contributes to endotoxin-induced acute respiratory inflammation. J Leukoc Biol 80: 451-457. doi:10.1189/jlb.0206099. PubMed: 16809643.
3. Pålsson-McDermott EM, O'Neill LAJ, (2004) Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 113: 153-162. doi:10.1111/j.1365-2567.2004.01976.x. PubMed: 15379975.
4. Akira S, Takeda K, (2004) Toll-like receptor signalling. Nat Rev Immunol 4: 499-511. doi:10.1038/nri1391. PubMed: 15229469.
5. Fujihara M, Muroi M, Tanamoto K, Suzuki T, Azuma H, et al. (2003) Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Therapeut 100: 171-194. doi:10.1016/j.pharmthera.2003.08.003. PubMed: 14609719.
6. Zhang GL, Ghosh S, (2001) Toll-like receptor-mediated NF-kappa B activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest 107: 13-19. doi:10.1172/JCI11837. PubMed: 11134172.
7. Holderness J, Schepetkin IA, Freedman B, Kirpotina LN, Quinn MT, et al. (2011) Polysaccharides Isolated from Acai Fruit Induce Innate Immune Responses. PLOS ONE 6: e17301. doi:10.1371/journal.pone.0017301. PubMed: 21386979.
8. Graff JC, Kimmel EM, Freedman B, Schepetkin IA, Holderness J, et al. (2009) Polysaccharides derived from Yamoa (TM) (Funtumia elastica) prime gamma delta T cells in vitro and enhance innate immune responses in vivo. Int Immunopharmacol 9: 1313-1322. doi:10.1016/j.intimp.2009.07.015. PubMed: 19671448.
9. Lee JS, Hong EK, (2011) Immunostimulating activity of the polysaccharides isolated from Cordyceps militaris. Int Immunopharmacol 11: 1226-1233. doi:10.1016/j.intimp.2011.04.001. PubMed: 21497206.
10. Bendjeddou D, Lalaoui K, Satta D, (2003) Immuno stimulating activity of the hot water-soluble polysaccharide extracts of Anacyclus pyrethrum, Alpinia galanga and Citrullus colocynthis. J Ethnopharmacol 88: 155-160. doi:10.1016/S0378-8741(03)00226-5. PubMed: 12963136.
11. Li SY, Yang D, Yeung CM, Yu WY, Chang RCC, et al. (2011) Lycium Barbarum Polysaccharides Reduce Neuronal Damage, Blood-Retinal Barrier Disruption and Oxidative Stress in Retinal Ischemia/Reperfusion Injury. PLOS ONE 6: e16380. doi:10.1371/journal.pone.0016380. PubMed: 21298100.
12. Navarro P, Giner RM, Recio MC, Máñez S, Cerdá-Nicolás M, et al. (2001) In vivo anti-inflammatory activity of saponins from Bupleurum rotundifolium. Life Sci 68: 1199-1206. doi:10.1016/S0024-3205(00)01019-5. PubMed: 11228104.
13. Ushio Y, Oda Y, Abe H, (1991) Effect of saikosaponin on the immune-reponses in mice. Int J Immunopharmacol 13: 501-508. doi:10.1016/0192-0561(91)90069-J. PubMed: 1783462.
14. Wang Z, Li H, Xu H, Yue XL, Cheng XQ, et al. (2009) Beneficial effect of Bupleurum polysaccharides on autoimmune disease induced by Campylobacter jejuni in BALB/c mice. J Ethnopharmacol 124: 481-487. doi:10.1016/j.jep.2009.05.013. PubMed: 19467314.
15. Cheng XQ, Song LJ, Li H, Di HY, Zhang YY, et al. (2012) Beneficial Effect of the Polysaccharides from Bupleurum smithii var. parvifolium on "Two-Hit" Acute Lung Injury in Rats. Inflammation 35: 1715-1722. doi:10.1007/s10753-012-9489-7. PubMed: 22763771.
16. Cheng XQ, Li H, Yue XL, Xie JY, Zhang YY, et al. (2010) Macrophage immunomodulatory activity of the polysaccharides from the roots of Bupleurum smithii var. parvifolium. J Ethnopharmacol 130: 363-368. doi:10.1016/j.jep.2010.05.019. PubMed: 20546871.
17. Chang HS, Sack DA, (2001) Detection of anti-lipopolysaccharide antibodies to Vibrio cholerae O1 and O139 using a novel microtiter limulus amebocyte lysate (LAL) assay. Clin Chim Acta 312: 49-54. doi:10.1016/S0009-8981(01)00588-5. PubMed: 11580909.
18. Manna SK, Mukhopadhyay A, Aggarwal BB, (2000) IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis. J Immunol 165: 4927-4934. PubMed: 11046018.
19. Bakker AD, da Silva VC, Krishnan R, Bacabac RG, Blaauboer ME, et al. (2009) Tumor Necrosis Factor alpha and Interleukin-1 beta Modulate Calcium and Nitric Oxide Signaling in Mechanically Stimulated Osteocytes. Arthritis Rheum 60: 3336-3345. doi:10.1002/art.24920. PubMed: 19877030.
20. de las Heras B, Hortelano S, Girón N, Bermejo P, Rodríguez B, et al. (2007) Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages. Br J Pharmacol 152: 249-255. doi:10.1038/sj.bjp.0707382. PubMed: 17618303.
21. Fan J, Kapus A, Marsden PA, Li YH, Oreopoulos G, et al. (2002) Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol 168: 5252-5259. PubMed: 11994482.
22. Medvedev AE, Kopydlowski KM, Vogel SN, (2000) Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: Dysregulation of cytokine, chemokine, and Toll-like receptor 2 and 4 gene expression. J Immunol 164: 5564-5574. PubMed: 10820230.
23. Johnson GL, Lapadat R, (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298: 1911-1912. doi:10.1126/science.1072682. PubMed: 12471242.
24. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, et al. (2001) Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Resfund Mol M 480: 243-268. PubMed: 11506818.
25. Smiley ST, King JA, Hancock WW, (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 167: 2887-2894. PubMed: 11509636.
26. Jenkins SJ, Hewitson JP, Ferret-Bernard S, Mountford AP, (2005) Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and-independent pathways. Int Immunol 17: 1409-1418. doi:10.1093/intimm/dxh319. PubMed: 16186163.
27. Guo TJ, Matsumoto T, Kikuchi Y, Ikejima T, Wang BX, et al. (2000) Effects of a pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. on interleukin 6 production of murine B cells and B cell lines. J Immunopharmacol 49: 307-316. doi:10.1016/S0162-3109(00)00245-9.
28. Komatsu H, Shimose A, Shimizu T, Mukai Y, Kobayashi J, et al. (2012) Trypsin inhibits lipopolysaccharide signaling in macrophages via toll-like receptor 4 accessory molecules. Life Sci 91: 143-150. doi:10.1016/j.lfs.2012.06.030. PubMed: 22771700.
29. Hennessy EJ, Parker AE, O'Neill LAJ, (2010) Targeting Toll-like receptors: emerging therapeutics? Nat Rev Drug Discov 9: 293-307. doi:10.1038/nrd3203. PubMed: 20380038.
30. Kim JH, Lee G, Cho YL, Kim CK, Han S, et al. (2009) Desmethylanhydroicaritin inhibits NF-kappa B-regulated inflammatory gene expression by modulating the redox-sensitive PI3K/PTEN/Akt pathway. Eur J Pharmacol 602: 422-431. doi:10.1016/j.ejphar.2008.10.062. PubMed: 19027002.
31. Pruett SB, Fan R, (2009) Ethanol inhibits LPS-induced signaling and modulates cytokine production in peritoneal macrophages in vivo in a model for binge drinking. BMC Immunol 10.
32. Zhou R, Zheng SX, Tang W, He PL, Li XY, et al. (2006) Inhibition of inducible nitric-oxide synthase expression by (5R)-5-hydroxytriptolide in interferon-gamma- and bacterial lipopolysaccharide- stimulated macrophages. J Pharmacol Exp Ther 316: 121-128. PubMed: 16166270.
33. Sato TA, Keelan JA, Mitchell MD, (2003) Critical paracrine interactions between TNF-alpha and IL-10 regulate lipopolysaccharide-stimulated human choriodecidual cytokine and prostaglandin E-2 production. J Immunol 170: 158-166. PubMed: 12496396.
34. Lee JK, Kim SY, Kim YS, Lee W-H, Hwang DH, et al. (2009) Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochem Pharmacol 77: 1391-1400. doi:10.1016/j.bcp.2009.01.009. PubMed: 19426678.
35. de Santana-Filho AP, Noleto GR, Gorin James, de Souza LM, Iacomini Met al. (2012) GC-MS detection and quantification of lipopolysaccharides in polysaccharides through 3-O-acetyl fatty acid methyl esters. Carbohydr Polym 87: 2730-2734. doi:10.1016/j.carbpol.2011.11.073.
36. Sullivan AM, Laba JG, Moore JA, Lee TDG, (2008) Echinacea-induced macrophage activation. Immunopharmacol Immunotoxicol 30: 553-574. doi:10.1080/08923970802135534. PubMed: 18618312.
37. Heumann D, Adachi Y, Le Roy D, Ohno N, Yadomae T, et al. (2001) Role of plasma, lipopolysaccharide-binding protein, and CD14 in response of mouse peritoneal exudate macrophages to endotoxin. Infect Immun 69: 378-385. doi:10.1128/IAI.69.1.378-385.2001. PubMed: 11119527.
38. Jeyaseelan S, Chu HW, Young SK, Freeman MW, Worthen GS, (2005) Distinct roles of pattern recognition receptors CD14 and toll-like receptor 4 in acute lung injury. Infect Immun 73: 1754-1763. doi:10.1128/IAI.73.3.1754-1763.2005. PubMed: 15731076.
39. Wang N, Gates KL, Trejo H, Favoreto S Jr., Schleimer RP, et al. (2010) Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage. FASEB J 24: 2178-2190. doi:10.1096/fj.09-136895. PubMed: 20181940.
40. Barsness KA, Arcaroli J, Harken AH, Abraham E, Banerjee A, et al. (2004) Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiolreg I287:: R592-R599. PubMed: 15072965.