메뉴 건너뛰기




Volumn 18, Issue 10, 2013, Pages 1093-1100

Current understanding and management of medullary thyroid cancer

Author keywords

Familial medullary thyroid cancer (FMTC); Medullary thyroid cancer (MTC); Multiple endocrine neoplasia syndrome; Prophylactic surgery in MTC; RET proto oncogene; Serum calcitonin

Indexed keywords

AXITINIB; CABOZANTINIB; CALCITONIN; CAPECITABINE; CARCINOEMBRYONIC ANTIGEN; DACARBAZINE; DOXORUBICIN; FLUOROURACIL; IMATINIB; MOTESANIB; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB; VANDETANIB; PROTEIN RET; RET PROTEIN, HUMAN;

EID: 84886011426     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2013-0053     Document Type: Article
Times cited : (97)

References (65)
  • 2
    • 84886027791 scopus 로고    scopus 로고
    • Thyroid Cancer Treatment (PDQ®), Available at, Accessed July 29
    • Thyroid Cancer Treatment (PDQ®). Medullary Thyroid Cancer. Available at http://www. cancer.gov/cancertopics/pdq/treatment/thyroid/ HealthProfessional/page7. Accessed July 29, 2013.
    • (2013) Medullary Thyroid Cancer
  • 3
    • 4644256817 scopus 로고    scopus 로고
    • The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2 International RET mutation consortium analysis
    • Eng C, Clayton D, Schuffenecker I et al. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. JAMA 1996;276:1575-1579.
    • (1996) JAMA , vol.276 , pp. 1575-1579
    • Eng, C.1    Clayton, D.2    Schuffenecker, I.3
  • 4
    • 0028199074 scopus 로고
    • Specificmutations of the RET proto-oncogene are related to disease phenotype inMEN2A and FMTC
    • Mulligan LM, Eng C, Healey CS et al. Specificmutations of the RET proto-oncogene are related to disease phenotype inMEN2A and FMTC. Nat Genet 1994;6:70-74.
    • (1994) Nat Genet , vol.6 , pp. 70-74
    • Mulligan, L.M.1    Eng, C.2    Healey, C.S.3
  • 5
    • 80052599580 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia type 2: An overview
    • Moline J, Eng C. Multiple endocrine neoplasia type 2: An overview. Genet Med 2011;13:755-764.
    • (2011) Genet Med , vol.13 , pp. 755-764
    • Moline, J.1    Eng, C.2
  • 6
    • 0028174024 scopus 로고
    • A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma
    • Hofstra RM, Landsvater RM, Ceccherini I et al. A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature 1994;367:375-376.
    • (1994) Nature , vol.367 , pp. 375-376
    • Hofstra, R.M.1    Landsvater, R.M.2    Ceccherini, I.3
  • 7
    • 84924637584 scopus 로고
    • Medullary (solid) carcinoma of the thyroid a clinicopathologic entity
    • Hazard JB, Hawk WA, Crile G. Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity. J Clin Endocrinol Metab 1959;19:152-161.
    • (1959) J Clin Endocrinol Metab , vol.19 , pp. 152-161
    • Hazard, J.B.1    Hawk, W.A.2    Crile, G.3
  • 8
    • 0021746211 scopus 로고
    • Medullary carcinoma of the thyroid A study of the clinical features and prognostic factors in 161 patients
    • Saad MF, Ordonez NG, Rashid RK et al. Medullary carcinoma of the thyroid. A study of the clinical features and prognostic factors in 161 patients. Medicine (Baltimore) 1984;63:319-342.
    • (1984) Medicine (Baltimore) , vol.63 , pp. 319-342
    • Saad, M.F.1    Ordonez, N.G.2    Rashid, R.K.3
  • 9
    • 0029916917 scopus 로고    scopus 로고
    • Multivariate analysis of patients with medullary thyroid carcinoma Prognostic significance and impact on treatment of clinical and pathologic variables
    • Dottorini ME, Assi A, SironiMet al. Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathologic variables. Cancer 1996;77:1556-1565.
    • (1996) Cancer , vol.77 , pp. 1556-1565
    • Dottorini, M.E.1    Assi, A.2    Sironi, M.3
  • 10
    • 0029062898 scopus 로고
    • Cushing's syndrome in medullary thyroid carcinoma
    • Mure A, Gicquel C, Abdelmoumene N et al. Cushing's syndrome in medullary thyroid carcinoma. J Endocrinol Invest 1995;18:180-185.
    • (1995) J Endocrinol Invest , vol.18 , pp. 180-185
    • Mure, A.1    Gicquel, C.2    Abdelmoumene, N.3
  • 11
    • 0242320447 scopus 로고    scopus 로고
    • Cushing's syndrome due to medullary thyroid carcinoma: Diagnosis by proopiomelanocortin messenger ribonucleic acid in situ hybridization
    • Smallridge RC, Bourne K, Pearson BW et al. Cushing's syndrome due to medullary thyroid carcinoma: Diagnosis by proopiomelanocortin messenger ribonucleic acid in situ hybridization. J Clin Endocrinol Metab 2003;88:4565-4568.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4565-4568
    • Smallridge, R.C.1    Bourne, K.2    Pearson, B.W.3
  • 12
    • 24944433989 scopus 로고    scopus 로고
    • Medullary thyroid carcinoma: Pitfalls in diagnosis by fine needle aspiration cytology and relationship of cytomorphology to RET proto-oncogene mutations
    • Chang TC, Wu SL, Hsiao YL. Medullary thyroid carcinoma: Pitfalls in diagnosis by fine needle aspiration cytology and relationship of cytomorphology to RET proto-oncogene mutations. Acta Cytol 2005;49: 477-482.
    • (2005) Acta Cytol , vol.49 , pp. 477-482
    • Chang, T.C.1    Wu, S.L.2    Hsiao, Y.L.3
  • 13
    • 0034086880 scopus 로고    scopus 로고
    • Cytologic diagnosis of medullary carcinoma of the thyroid gland
    • Papaparaskeva K, Nagel H, Droese M. Cytologic diagnosis of medullary carcinoma of the thyroid gland. Diagn Cytopathol 2000;22:351-358.
    • (2000) Diagn Cytopathol , vol.22 , pp. 351-358
    • Papaparaskeva, K.1    Nagel, H.2    Droese, M.3
  • 14
    • 77955214443 scopus 로고    scopus 로고
    • The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: Pheochromocytoma, paraganglioma, and medullary thyroid cancer
    • Chen H, Sippel RS, O'Dorisio MS et al. The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: Pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas 2010;39:775-783.
    • (2010) Pancreas , vol.39 , pp. 775-783
    • Chen, H.1    Sippel, R.S.2    O'Dorisio, M.S.3
  • 15
    • 34548153464 scopus 로고    scopus 로고
    • Diagnosis of medullary thyroid carcinoma by calcitonin measurement in fine-needle aspiration biopsy specimens
    • Kudo T, Miyauchi A, Ito Y et al. Diagnosis of medullary thyroid carcinoma by calcitonin measurement in fine-needle aspiration biopsy specimens. Thyroid 2007;17:635-638.
    • (2007) Thyroid , vol.17 , pp. 635-638
    • Kudo, T.1    Miyauchi, A.2    Ito, Y.3
  • 16
    • 34347215916 scopus 로고    scopus 로고
    • Calcitonin measurement in wash-out fluid from fine needle aspiration of neck masses in patients with primary and metastatic medullary thyroid carcinoma
    • Boi F, Maurelli I, Pinna G et al. Calcitonin measurement in wash-out fluid from fine needle aspiration of neck masses in patients with primary and metastatic medullary thyroid carcinoma. J Clin Endocrinol Metab 2007;92:2115-2118.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2115-2118
    • Boi, F.1    Maurelli, I.2    Pinna, G.3
  • 17
    • 17744381151 scopus 로고    scopus 로고
    • Preoperative calcitonin levels are predictive of tumor size and postoperative calcitonin normalization in medullary thyroid carcinoma
    • Groupe d'Etudes des Tumeurs a Calcitonine (GETC)
    • Cohen R, Campos JM, Salaün C et al. Preoperative calcitonin levels are predictive of tumor size and postoperative calcitonin normalization in medullary thyroid carcinoma. Groupe d'Etudes des Tumeurs a Calcitonine (GETC) J Clin Endocrinol Metab 2000;85:919-922.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 919-922
    • Cohen, R.1    Campos, J.M.2    Salaün, C.3
  • 18
    • 27744485886 scopus 로고    scopus 로고
    • Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma
    • Barbet J, Campion L, Kraeber-Bodéré F et al. Prognostic impact of serum calcitonin and carcinoembryonic antigen doubling-times in patients with medullary thyroid carcinoma. J Clin Endocrinol Metab 2005;90:6077-6084.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6077-6084
    • Barbet, J.1    Campion, L.2    Kraeber-Bodéré, F.3
  • 19
    • 70449370231 scopus 로고    scopus 로고
    • Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer
    • Cooper DS, Doherty GM, Haugen BR et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19:1167-1214.
    • (2009) Thyroid , vol.19 , pp. 1167-1214
    • Cooper, D.S.1    Doherty, G.M.2    Haugen, B.R.3
  • 20
    • 67749130797 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Management guidelines of the American Thyroid Association
    • Kloos RT, Eng C, Evans DB et al. Medullary thyroid cancer: Management guidelines of the American Thyroid Association. Thyroid 2009;19:565-612.
    • (2009) Thyroid , vol.19 , pp. 565-612
    • Kloos, R.T.1    Eng, C.2    Evans, D.B.3
  • 21
    • 33745943870 scopus 로고    scopus 로고
    • Pretargeted anti-carcinoembryonic-antigen radioimmunotherapy for medullary thyroid carcinoma
    • author reply e38
    • Machens A, Dralle H. Pretargeted anti-carcinoembryonic-antigen radioimmunotherapy for medullary thyroid carcinoma. J Clin Oncol 2006:24: e37; author reply e38.
    • (2006) J Clin Oncol , vol.24
    • Machens, A.1    Dralle, H.2
  • 22
    • 52249115588 scopus 로고    scopus 로고
    • Serum calcitonin-negative medullary thyroid carcinoma: Role ofCgAandCEAascomplementarymarkers
    • Giovanella L, Crippa S, Cariani L. Serum calcitonin-negative medullary thyroid carcinoma: Role ofCgAandCEAascomplementarymarkers. Int J Biol Markers 2008;23:129-131.
    • (2008) Int J Biol Markers , vol.23 , pp. 129-131
    • Giovanella, L.1    Crippa, S.2    Cariani, L.3
  • 23
    • 20044380561 scopus 로고    scopus 로고
    • High frequency of bone/bone marrow involvement in advanced medullary thyroid cancer
    • Mirallié E, Vuillez JP, Bardet S et al. High frequency of bone/bone marrow involvement in advanced medullary thyroid cancer. J Clin Endocrinol Metab 2005;90:779-788.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 779-788
    • Mirallié, E.1    Vuillez, J.P.2    Bardet, S.3
  • 24
    • 36849090954 scopus 로고    scopus 로고
    • Sensitivity and prognostic value of positron emission tomography with F-18-fluorodeoxyglucose and sensitivity of immunoscintigraphy in patients with medullary thyroid carcinoma treated with anticarcinoembryonic antigen-targeted radioimmunotherapy
    • Oudoux A, Salaun PY, Bournaud C et al. Sensitivity and prognostic value of positron emission tomography with F-18-fluorodeoxyglucose and sensitivity of immunoscintigraphy in patients with medullary thyroid carcinoma treated with anticarcinoembryonic antigen-targeted radioimmunotherapy. J Clin Endocrinol Metab 2007;92:4590-4597.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4590-4597
    • Oudoux, A.1    Salaun, P.Y.2    Bournaud, C.3
  • 25
    • 35948994121 scopus 로고    scopus 로고
    • Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels
    • Giraudet AL, Vanel D, Leboulleux S et al. Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels. J Clin Endocrinol Metab 2007;92:4185-4190.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4185-4190
    • Giraudet, A.L.1    Vanel, D.2    Leboulleux, S.3
  • 26
    • 34248594179 scopus 로고    scopus 로고
    • Diagnostic accuracy of 18F-FDG PET in restaging patients with medullary thyroid carcinoma and elevated calcitonin levels
    • Ong SC, Schöder H, Patel SG et al. Diagnostic accuracy of 18F-FDG PET in restaging patients with medullary thyroid carcinoma and elevated calcitonin levels. J Nucl Med 2007;48:501-507.
    • (2007) J Nucl Med , vol.48 , pp. 501-507
    • Ong, S.C.1    Schöder, H.2    Patel, S.G.3
  • 27
    • 0028876004 scopus 로고
    • Laparoscopic detection of hepatic metastases in patients with residual or recurrent medullary thyroid cancer
    • discussion 1029-1030
    • Tung WS, Vesely TM, Moley JF. Laparoscopic detection of hepatic metastases in patients with residual or recurrent medullary thyroid cancer. Surgery 1995;118:1024-1029, discussion 1029-1030.
    • (1995) Surgery , vol.118 , pp. 1024-1029
    • Tung, W.S.1    Vesely, T.M.2    Moley, J.F.3
  • 28
    • 75749095615 scopus 로고    scopus 로고
    • Familial associations in medullarythyroidcarcinomawith Hirschsprung disease: The role of the RET-C620 "Janus" genetic variation
    • Moore SW, Zaahl M. Familial associations in medullarythyroidcarcinomawith Hirschsprung disease: The role of the RET-C620 "Janus" genetic variation. J Pediatr Surg 2010;45:393-396.
    • (2010) J Pediatr Surg , vol.45 , pp. 393-396
    • Moore, S.W.1    Zaahl, M.2
  • 29
    • 38149073937 scopus 로고    scopus 로고
    • RET proto-oncogene testing in infants presenting with Hirschsprung disease identifies 2 new multiple endocrine neoplasia 2A kindreds
    • Fialkowski EA, DeBenedetti MK, Moley JF et al. RET proto-oncogene testing in infants presenting with Hirschsprung disease identifies 2 new multiple endocrine neoplasia 2A kindreds. J Pediatr Surg 2008;43:188-190.
    • (2008) J Pediatr Surg , vol.43 , pp. 188-190
    • Fialkowski, E.A.1    DeBenedetti, M.K.2    Moley, J.F.3
  • 30
    • 33845925574 scopus 로고    scopus 로고
    • Prophylactic thyroidectomy in pediatric carriers of multiple endocrine neoplasia type 2A or familial medullary thyroid carcinoma: Mutation in C620 is associated with Hirschsprung's disease
    • Bütter A, Gagné J, Al-Jazaeri A et al. Prophylactic thyroidectomy in pediatric carriers of multiple endocrine neoplasia type 2A or familial medullary thyroid carcinoma: Mutation in C620 is associated with Hirschsprung's disease. J Pediatr Surg 2007;42: 203-206.
    • (2007) J Pediatr Surg , vol.42 , pp. 203-206
    • Bütter, A.1    Gagné, J.2    Al-Jazaeri, A.3
  • 31
    • 0024958177 scopus 로고
    • Familial cutaneous lichen amyloidosis in association with multiple endocrine neoplasia type 2A: A new variant
    • Donovan DT, Levy ML, Furst EJ et al. Familial cutaneous lichen amyloidosis in association with multiple endocrine neoplasia type 2A: A new variant. Henry Ford Hosp Med J 1989;37:147-150.
    • (1989) Henry Ford Hosp Med J , vol.37 , pp. 147-150
    • Donovan, D.T.1    Levy, M.L.2    Furst, E.J.3
  • 32
    • 0043167812 scopus 로고    scopus 로고
    • Frequent association between MEN 2A and cutaneous lichen amyloidosis
    • Verga U, Fugazzola L, Cambiaghi S et al. Frequent association between MEN 2A and cutaneous lichen amyloidosis. Clin Endocrinol (Oxf) 2003;59: 156-161.
    • (2003) Clin Endocrinol (Oxf) , vol.59 , pp. 156-161
    • Verga, U.1    Fugazzola, L.2    Cambiaghi, S.3
  • 33
    • 0028850669 scopus 로고
    • Multiple endocrine neoplasia type 2B:Morethan an endocrine disorder
    • O'Riordain DS, O'Brien T, Crotty TB et al. Multiple endocrine neoplasia type 2B:Morethan an endocrine disorder. Surgery 1995;118:936-942.
    • (1995) Surgery , vol.118 , pp. 936-942
    • O'Riordain, D.S.1    O'Brien, T.2    Crotty, T.B.3
  • 34
    • 0027303248 scopus 로고
    • Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC
    • Donis-Keller H, Dou S, Chi D et al. Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Hum Mol Genet 1993;2:851-856.
    • (1993) Hum Mol Genet , vol.2 , pp. 851-856
    • Donis-Keller, H.1    Dou, S.2    Chi, D.3
  • 35
    • 33747633366 scopus 로고    scopus 로고
    • Long-term outcomein46genecarriers of hereditarymedullary thyroid carcinoma after prophylactic thyroidectomy: Impact of individual RET genotype
    • Frank-Raue K, Buhr H, DralleHet al. Long-term outcomein46genecarriers of hereditarymedullary thyroid carcinoma after prophylactic thyroidectomy: Impact of individual RET genotype. Eur J Endocrinol 2006;155:229-236.
    • (2006) Eur J Endocrinol , vol.155 , pp. 229-236
    • Frank-Raue, K.1    Buhr, H.2    Dralle, H.3
  • 36
    • 84880067672 scopus 로고    scopus 로고
    • Hereditary medullary thyroid cancer: Age-appropriate thyroidectomy improves disease-free survival
    • Shepet K, Alhefdhi A, Lai N et al. Hereditary medullary thyroid cancer: Age-appropriate thyroidectomy improves disease-free survival. Ann Surg Oncol 2013;20:1451-1455.
    • (2013) Ann Surg Oncol , vol.20 , pp. 1451-1455
    • Shepet, K.1    Alhefdhi, A.2    Lai, N.3
  • 37
    • 0033503932 scopus 로고    scopus 로고
    • Patterns of nodal metastases in palpable medullary thyroid carcinoma: Recommendations for extent of node dissection
    • discussion 887-888
    • Moley JF, DeBenedetti MK. Patterns of nodal metastases in palpable medullary thyroid carcinoma: Recommendations for extent of node dissection. Ann Surg 1999;229:880-887, discussion 887-888.
    • (1999) Ann Surg , vol.229 , pp. 880-887
    • Moley, J.F.1    DeBenedetti, M.K.2
  • 38
    • 34249672300 scopus 로고    scopus 로고
    • Initial lymph node dissection increases cure rates in patients with medullary thyroid cancer
    • Greenblatt DY, Elson D, Mack E et al. Initial lymph node dissection increases cure rates in patients with medullary thyroid cancer. Asian J Surg 2007;30:108-112.
    • (2007) Asian J Surg , vol.30 , pp. 108-112
    • Greenblatt, D.Y.1    Elson, D.2    Mack, E.3
  • 39
    • 0038369070 scopus 로고    scopus 로고
    • Rationale for central and bilateral lymph node dissection in sporadic and hereditary medullary thyroid cancer
    • Scollo C, Baudin E, Travagli JP et al. Rationale for central and bilateral lymph node dissection in sporadic and hereditary medullary thyroid cancer. J Clin Endocrinol Metab 2003;88:2070-2075.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2070-2075
    • Scollo, C.1    Baudin, E.2    Travagli, J.P.3
  • 40
    • 34548688232 scopus 로고    scopus 로고
    • Increased risk of lymph node metastasis in multifocal hereditary and sporadic medullary thyroid cancer
    • Machens A, Hauptmann S, Dralle H. Increased risk of lymph node metastasis in multifocal hereditary and sporadic medullary thyroid cancer. World J Surg 2007;31:1960-1965.
    • (2007) World J Surg , vol.31 , pp. 1960-1965
    • Machens, A.1    Hauptmann, S.2    Dralle, H.3
  • 41
  • 42
    • 0029772557 scopus 로고    scopus 로고
    • Medullary thyroid cancer: Analyses of survival and prognostic factors and the role of radiation therapy in local control
    • Brierley J, Tsang R, Simpson WJ et al. Medullary thyroid cancer: Analyses of survival and prognostic factors and the role of radiation therapy in local control. Thyroid 1996;6:305-310.
    • (1996) Thyroid , vol.6 , pp. 305-310
    • Brierley, J.1    Tsang, R.2    Simpson, W.J.3
  • 44
    • 84859827825 scopus 로고    scopus 로고
    • Recent advances in the molecular pathogenesis and targeted therapies of medullary thyroid carcinoma
    • Almeida MQ, Hoff AO. Recent advances in the molecular pathogenesis and targeted therapies of medullary thyroid carcinoma. Curr Opin Oncol 2012;24:229-234.
    • (2012) Curr Opin Oncol , vol.24 , pp. 229-234
    • Almeida, M.Q.1    Hoff, A.O.2
  • 45
    • 77649214078 scopus 로고    scopus 로고
    • Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Wells SA, Gosnell JE, GagelRFet al. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Oncol 2010;28:767-772.
    • (2010) J Clin Oncol , vol.28 , pp. 767-772
    • Wells, S.A.1    Gosnell, J.E.2    Gagel, R.F.3
  • 46
    • 77954478933 scopus 로고    scopus 로고
    • Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Robinson BG, Paz-Ares L, Krebs A et al. Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Endocrinol Metab 2010;95:2664-2671.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2664-2671
    • Robinson, B.G.1    Paz-Ares, L.2    Krebs, A.3
  • 47
    • 84655175698 scopus 로고    scopus 로고
    • Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, doubleblind phase III trial
    • Wells SA, Robinson BG, Gagel RF et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, doubleblind phase III trial. J Clin Oncol 2012;30:134-141.
    • (2012) J Clin Oncol , vol.30 , pp. 134-141
    • Wells, S.A.1    Robinson, B.G.2    Gagel, R.F.3
  • 48
    • 84886018677 scopus 로고    scopus 로고
    • Cabozantinib approved for rare thyroid cancer
    • OF7
    • Cabozantinib approved for rare thyroid cancer. Cancer Discov 2013:3:OF7.
    • (2013) Cancer Discov , vol.3
  • 49
    • 84873883043 scopus 로고    scopus 로고
    • Profile of cabozantinib and its potential in the treatment of advanced medullary thyroid cancer
    • Hart CD, De Boer RH. Profile of cabozantinib and its potential in the treatment of advanced medullary thyroid cancer. Onco Targets Ther 2013;6: 1-7.
    • (2013) Onco Targets Ther , vol.6 , pp. 1-7
    • Hart, C.D.1    De Boer, R.H.2
  • 50
    • 84872310356 scopus 로고    scopus 로고
    • Cabozantinib approved for advanced medullary thyroid cancer
    • Traynor K. Cabozantinib approved for advanced medullary thyroid cancer. Am J Health Syst Pharm 2013;70:88.
    • (2013) Am J Health Syst Pharm , vol.70 , pp. 88
    • Traynor, K.1
  • 51
    • 79960179069 scopus 로고    scopus 로고
    • Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: A phase II study in a UK based population
    • Ahmed M, Barbachano Y, Riddell A et al. Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: A phase II study in a UK based population. Eur J Endocrinol 2011;165:315-322.
    • (2011) Eur J Endocrinol , vol.165 , pp. 315-322
    • Ahmed, M.1    Barbachano, Y.2    Riddell, A.3
  • 52
    • 77952468875 scopus 로고    scopus 로고
    • Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
    • Lam ET, Ringel MD, Kloos RT et al. Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. J Clin Oncol 2010;28:2323-2330.
    • (2010) J Clin Oncol , vol.28 , pp. 2323-2330
    • Lam, E.T.1    Ringel, M.D.2    Kloos, R.T.3
  • 53
    • 78049462514 scopus 로고    scopus 로고
    • Phase II study of daily sunitinib in FDG-PET-positive, iodinerefractory differentiated thyroid cancer and meta-static medullary carcinoma of the thyroid with functional imaging correlation
    • Carr LL, Mankoff DA, Goulart BH et al. Phase II study of daily sunitinib in FDG-PET-positive, iodinerefractory differentiated thyroid cancer and meta-static medullary carcinoma of the thyroid with functional imaging correlation. Clin Cancer Res 2010;16:5260-5268.
    • (2010) Clin Cancer Res , vol.16 , pp. 5260-5268
    • Carr, L.L.1    Mankoff, D.A.2    Goulart, B.H.3
  • 54
    • 68949108390 scopus 로고    scopus 로고
    • Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer
    • Schlumberger MJ, Elisei R, Bastholt L et al. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J Clin Oncol 2009;27:3794-3801.
    • (2009) J Clin Oncol , vol.27 , pp. 3794-3801
    • Schlumberger, M.J.1    Elisei, R.2    Bastholt, L.3
  • 55
    • 50649095801 scopus 로고    scopus 로고
    • Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study
    • Cohen EE, Rosen LS, Vokes EE et al. Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study. J Clin Oncol 2008;26:4708-4713.
    • (2008) J Clin Oncol , vol.26 , pp. 4708-4713
    • Cohen, E.E.1    Rosen, L.S.2    Vokes, E.E.3
  • 56
    • 34548452775 scopus 로고    scopus 로고
    • Tumorsuppressor role ofNotch-1signaling in neuroendocrine tumors
    • KunnimalaiyaanM, ChenH. Tumorsuppressor role ofNotch-1signaling in neuroendocrine tumors. The Oncologist 2007;12:535-542.
    • (2007) The Oncologist , vol.12 , pp. 535-542
    • Kunnimalaiyaan, M.1    Chen, H.2
  • 57
    • 40349091384 scopus 로고    scopus 로고
    • Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells
    • Ning L, Greenblatt DY, KunnimalaiyaanMet al. Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells. The Oncologist 2008;13:98-104.
    • (2008) The Oncologist , vol.13 , pp. 98-104
    • Ning, L.1    Greenblatt, D.Y.2    Kunnimalaiyaan, M.3
  • 58
    • 33748132208 scopus 로고    scopus 로고
    • In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer
    • Vaccaro A, Chen H, Kunnimalaiyaan M. In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer. Anticancer Drugs 2006;17:849-853.
    • (2006) Anticancer Drugs , vol.17 , pp. 849-853
    • Vaccaro, A.1    Chen, H.2    Kunnimalaiyaan, M.3
  • 59
    • 34147168760 scopus 로고    scopus 로고
    • Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells
    • KunnimalaiyaanM, VaccaroAM, NdiayeMAet al. Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells. Mol Cancer Ther 2007;6:1151-1158.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1151-1158
    • Kunnimalaiyaan, M.1    Vaccaro, A.M.2    Ndiaye, M.A.3
  • 60
    • 33845626635 scopus 로고    scopus 로고
    • Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002
    • Kunnimalaiyaan M, Ndiaye M, Chen H. Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery 2006;140:1009-1014.
    • (2006) Surgery , vol.140 , pp. 1009-1014
    • Kunnimalaiyaan, M.1    Ndiaye, M.2    Chen, H.3
  • 61
    • 33845987566 scopus 로고    scopus 로고
    • Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells
    • Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA et al. Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells. J Biol Chem 2006;281:39819-39830.
    • (2006) J Biol Chem , vol.281 , pp. 39819-39830
    • Kunnimalaiyaan, M.1    Vaccaro, A.M.2    Ndiaye, M.A.3
  • 62
    • 66449115520 scopus 로고    scopus 로고
    • Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta
    • Adler JT, Cook M, Luo Y et al. Tautomycetin and tautomycin suppress the growth of medullary thyroid cancer cells via inhibition of glycogen synthase kinase-3beta. Mol Cancer Ther 2009;8: 914-920.
    • (2009) Mol Cancer Ther , vol.8 , pp. 914-920
    • Adler, J.T.1    Cook, M.2    Luo, Y.3
  • 63
    • 77949490246 scopus 로고    scopus 로고
    • Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitorsandlithium chloride
    • Adler JT, Hottinger DG, Kunnimalaiyaan M et al. Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitorsandlithium chloride. J Surg Res 2010;159:640-644.
    • (2010) J Surg Res , vol.159 , pp. 640-644
    • Adler, J.T.1    Hottinger, D.G.2    Kunnimalaiyaan, M.3
  • 64
    • 77649300540 scopus 로고    scopus 로고
    • Xanthohumol inhibits the neuroendocrine transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in medullary thyroid cancer
    • discussion 318
    • Cook MR, Luo J, NdiayeMet al. Xanthohumol inhibits the neuroendocrine transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in medullary thyroid cancer. Am J Surg 2010;199:315-318, discussion 318.
    • (2010) Am J Surg , vol.199 , pp. 315-318
    • Cook, M.R.1    Luo, J.2    Ndiaye, M.3
  • 65
    • 79955824831 scopus 로고    scopus 로고
    • Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer
    • Truong M, Cook MR, Pinchot SN et al. Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer. Ann Surg Oncol 2011;18:1506-1511.
    • (2011) Ann Surg Oncol , vol.18 , pp. 1506-1511
    • Truong, M.1    Cook, M.R.2    Pinchot, S.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.