Medullary thyroid carcinoma: Pitfalls in diagnosis by fine needle aspiration cytology and relationship of cytomorphology to RET proto-oncogene mutations

Acta Cytologica

Volumn 49, Issue 5, 2005, Pages 477-482

  Chang, Tien Chun ^a   Wu, Shih Lu ^b   Hsiao, Yung Lien ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Aspiration biopsy, fine needle; Carcinoma, medullary; Proto oncogenes; Thyroid cancer

Indexed keywords

PROTEIN RET;

ADOLESCENT; ADULT; AGED; ASPIRATION BIOPSY; CANCER CYTODIAGNOSIS; CELL STRUCTURE; CLINICAL ARTICLE; CODON; DIAGNOSTIC ACCURACY; DIAGNOSTIC ERROR; DIAGNOSTIC VALUE; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTO ONCOGENE; REVIEW; SOMATIC MUTATION; SPINDLE CELL; THYROID MEDULLARY CARCINOMA;

EID: 24944433989     PISSN: 00015547     EISSN: 19382650     Source Type: Journal    
DOI: 10.1159/000326191     Document Type: Review

References (22)

1. Gilliland FD, Hunt WG, Morris DM, Kent CR: Prognostic factors for thyroid carcinoma. Cancer 1997;79:564-573
2. Modigliani E, Franc B, Niccoli-sire P: Diagnosis and treatment of medullary thyroid cancer. Baillieres Clin Endocrinol Metab 2000;14:631-649
3. Forrest CH, Frost FA, de Boer WB, Spagnolo DV, Whitaker D, Sterrett GF: Medullary carcinoma of the thyroid: Accuracy of diagnosis by fine-needle aspiration cytology. Cancer Cytopathol 1998;84:295-302
4. Collins BT, Cramer HM, Tabatowski K, Hearn S, Raminhos A, Lampe H: Fine needle aspiration of medullary carcinoma of the thyroid: Cytomorphology, immunocytochemistry and electron microscopy. Acta Cytol 1995;39:920-930
5. Söderström N, Telenius-Berg M, Åkerman M: Diagnosis of medullary carcinoma of the thyroid by fine needle aspiration biopsy. Acta Med Scand 1975;197:71-76
6. Bose S, Kapila K, Verma K: Medullary carcinoma of the thyroid: A cytological, immunocytochemical and ultrastructural study. Diagn Cytopathol 1992;8:28-32
7. Zeppa P, Vetrani A, Marino M, Fulciniti F, Boschi R, Derosa D, Palombini L: Fine needle aspiration cytology of medullary thyroid carcinoma: A review of 18 cases. Cytopathology 1990; 1:35-44
8. Pacini F, Fontanelli M, Fugazzola L, Elisei R, Romei C, Di Coscio G, Miccoli P, Pinchera A: Routine measurement of serum calcitonin in nodular thyroid disease allows the preoperative diagnosis of unsuspected sporadic medullary thyroid carcinoma. J Clin Endocrinol Metab 1994;78:826-829
9. Henry JF, Denizot A, Puccini M, Gramatica L, Kvachenyuk A, Devolx BC, De Micco C: Latent subclinical medullary thyroid carcinoma: Diagnosis and treatment. World J Surg 1998; 22:752-757
10. Hahm JR, Lee MS, Min YK, Lee MK, Kim KW, Nam SJ, Yang JH, Chung JH: Routine measurement of serum calcitonin is useful for early detection of medullary thyroid carcinoma in patients with nodular thyroid diseases. Thyroid 2001;11:73-80
11. Riu CH: On the studies of the methods of staining blood film (Romanowsky's system). J Niigata Med Assoc 1956;70:635-643
12. Kini SR: Thyroid. New York, Igaku-Shoin, 1987, p 210
13. Huang CN, Wu SL, Chang TC, Huang SH, Chang TJ: RET proto-oncogene mutations in patients with apparently sporadic medullary thyroid carcinoma. J Formos Med Assoc 1998;97: 541-546
14. Kwok JB, Gardner E, Warner JP, Ponder BA, Mulligan LM: Structural analysis of the human RET proto-oncogene using exon trapping. Oncogene 1993;8:2575-2582
15. Komminoth P, Roth J, Muletta-Feurer S, Saremaslani P, Seelentag WK, Heitz PU: RET proto-oncogene point mutations in sporadic neuroendocrine tumors. J Clin Endocrinol Metab 1996;81:2041-2046
16. Geddie WR, Bedard YC, Strawbridge HTG: Medullary carcinoma of the thyroid in fine-needle aspiration biopsies. Am J Clin Pathol 1984;82:552-558
17. Das A, Gupta SK, Banerjee AK, Srinivasan R, Radotra BD, Nijhawan R, Dey P, Rajwanshi A: Atypical cytologic features of medullary carcinoma of the thyroid: A review of 12 cases. Acta Cytol 1992;36:137-141
18. Kinjo M, Yohena C, Kunishima N: Intracytoplasmic lumina in medullary carcinoma of the thyroid gland: Report of a case with cytologic and immunocytochemical features. Acta Cytol 2003; 47:663-667
19. Bourtsos EP, Bedrossian CWM, De Frias DVS, Nayar R: Thyroid plasmacytoma mimicking medullary carcinoma: A potential pitfall in aspiration cytology. Diagn Cytopathol 2000;23: 354-358
20. Rastad J, Wilander E, Lindgren PG, Ljunghall S, Stenkvist BG, Akerström G: Cytologic diagnosis of a medullary carcinoma of the thyroid by Sevier-Munger silver staining and calcitonin immunocytochemistry. Acta Cytol 1987;31:45-47
21. Schäffer R, Müller HA, Pfeifer U, Ormanns W: Cytological findings in medullary carcinoma of the thyroid. Pathol Res Pract 1984;178:461-466
22. Chang TC, Lai SM, Wen CY, Hsiao YL, Huang SH: Three-dimensional cytomorphology in fine needle aspiration biopsy of medullary thyroid carcinoma. Acta Cytol 2001;45:980-984