The influence of cathelicidin LL37 in human anti-neutrophils cytoplasmic antibody (ANCA)-associated vasculitis

Arthritis Research and Therapy

Volumn 15, Issue 5, 2013, Pages

  Zhang, Ying ^a   Shi, Weiwei ^a   Tang, Sha ^a   Li, Jingyi ^a   Yin, Shiwei ^a   Gao, Xuejing ^a   Wang, Li ^a   Zou, Liyun ^a   Zhao, Jinghong ^a   Huang, Yunjian ^a   Shan, Lianyu ^b   Gounni, Abdelilah S ^b   Wu, Yuzhang ^a   Yuan, Fahuan ^a   Zhang, Jingbo ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; COMPLEMENT COMPONENT C3; CREATININE; CATHELICIDIN; CATHELICIDIN LL 37 (18 29), HUMAN; CATHELICIDIN LL-37 (18-29), HUMAN; NEUTROPHIL CYTOPLASMIC ANTIBODY; PEPTIDE FRAGMENT;

ADULT; ANCA ASSOCIATED VASCULITIS; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOKINE RELEASE; FEMALE; FROZEN SECTION; HUMAN; HUMAN TISSUE; INFLAMMATION; KIDNEY BIOPSY; MAJOR CLINICAL STUDY; MALE; ADOLESCENT; AGED; BIOPSY; BLOOD; CELL CULTURE; CHILD; CONFOCAL MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLOMERULONEPHRITIS; IMMUNOLOGY; KIDNEY; METABOLISM; MIDDLE AGED; NEUTROPHIL; PATHOLOGY; SCANNING ELECTRON MICROSCOPY; ULTRASTRUCTURE; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; BIOPSY; CATHELICIDINS; CELLS, CULTURED; CHILD; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULONEPHRITIS; HUMANS; INTERFERON-ALPHA; KIDNEY; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MIDDLE AGED; NEUTROPHILS; PEPTIDE FRAGMENTS; YOUNG ADULT;

EID: 84886007565     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4344     Document Type: Article

References (28)

1. Jennette JC, Falk RJ. Small-vessel vasculitis. N Engl J Med 1997, 337:1512-1523. 10.1056/NEJM199711203372106, 9366584.
2. Kain R, Tadema H, McKinney EF, Benharkou A, Brandes R, Peschel A, Hubert V, Feenstra T, Sengolge G, Stegeman C, Heeringa P, Lyons PA, Smith KG, Kallenberg C, Rees AJ. High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis. J Am Soc Nephrol 2012, 23:556-566. 10.1681/ASN.2011090920, 3294304, 22323643.
3. Kain R, Exner M, Brandes R, Ziebermayr R, Cunningham D, Alderson CA, Davidovits A, Raab I, Jahn R, Ashour O, Spitzauer S, Sunder-Plassmann G, Fukuda M, Klemm P, Rees AJ, Kerjaschki D. Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis. Nat Med 2008, 14:1088-1096. 10.1038/nm.1874, 2751601, 18836458.
4. Salama AD, Pusey CD. Shining a LAMP on pauci-immune focal segmental glomerulonephritis. Kidney Int 2009, 76:15-17. 10.1038/ki.2009.123, 19387471.
5. Frasca L, Lande R. Role of defensins and cathelicidin LL37 in auto-immune and auto-inflammatory diseases. Curr Pharm Biotechnol 2012, 13:1882-1897. 10.2174/138920112802273155, 22250708.
6. Garcia-Romo GS, Caielli S, Vega B, Connolly J, Allantaz F, Xu Z, Punaro M, Baisch J, Guiducci C, Coffman RL, Barrat FJ, Banchereau J, Pascual V. Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci Transl Med 2011, 3:73ra20. 10.1126/scitranslmed.3001201, 3143837, 21389264.
7. Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Su B, Nestle FO, Zal T, Mellman I, Schroder JM, Liu YJ, Gilliet M. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 2007, 449:564-569. 10.1038/nature06116, 17873860.
8. Kessenbrock K, Krumbholz M, Schonermarck U, Back W, Gross WL, Werb Z, Grone HJ, Brinkmann V, Jenne DE. Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 2009, 15:623-625. 10.1038/nm.1959, 2760083, 19448636.
9. Nizet V, Ohtake T, Lauth X, Trowbridge J, Rudisill J, Dorschner RA, Pestonjamasp V, Piraino J, Huttner K, Gallo RL. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 2001, 414:454-457. 10.1038/35106587, 11719807.
10. Knight JS, Kaplan MJ. Lupus neutrophils: 'NET' gain in understanding lupus pathogenesis. Curr Opin Rheumatol 2012, 24:441-450. 10.1097/BOR.0b013e3283546703, 22617827.
11. Chamilos G, Gregorio J, Meller S, Lande R, Kontoyiannis DP, Modlin RL, Gilliet M. Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37. Blood 2012, 120:3699-3707. 10.1182/blood-2012-01-401364, 3488884, 22927244.
12. Jennette JC, Falk RJ, Andrassy K, Bacon PA, Churg J, Gross WL, Hagen EC, Hoffman GS, Hunder GG, Kallenberg CG, et al. Nomenclature of systemic vasculitides, Proposal of an international consensus conference. Arthritis Rheum 1994, 37:187-192. 10.1002/art.1780370206, 8129773.
13. Brinkmann V, Laube B, Abu Abed U, Goosmann C, Zychlinsky A. Neutrophil extracellular traps: how to generate and visualize them. J Vis Exp 2010, 36:1724. 3125121, 20182410.
14. Bosch X. LAMPs and NETs in the pathogenesis of ANCA vasculitis. J Am Soc Nephrol 2009, 20:1654-1656. 10.1681/ASN.2009060616, 19608698.
15. Bosch X, Mirapeix E. Vasculitis syndromes: LAMP-2 illuminates pathogenesis of ANCA glomerulonephritis. Nat Rev Nephrol 2009, 5:247-249. 10.1038/nrneph.2009.51, 19384321.
16. Abdulahad DA, Westra J, Bijzet J, Dolff S, van Dijk MC, Limburg PC, Kallenberg CG, Bijl M. Urine levels of HMGB1 in systemic lupus erythematosus patients with and without renal manifestations. Arthritis Res Ther 2012, 14:R184. 10.1186/ar4015, 3580580, 22892043.
17. Abdulahad DA, Westra J, Bijzet J, Limburg PC, Kallenberg CG, Bijl M. High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus. Arthritis Res Ther 2011, 13:R71. 10.1186/ar3332, 3218880, 21548924.
18. Riboldi E, Daniele R, Cassatella MA, Sozzani S, Bosisio D. Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. Immunobiology 2009, 214:868-876. 10.1016/j.imbio.2009.06.016, 19577819.
19. Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 2011, 11:519-531. 10.1038/nri3024, 21785456.
20. Tillack K, Breiden P, Martin R, Sospedra M. T lymphocyte priming by neutrophil extracellular traps links innate and adaptive immune responses. J Immunol 2012, 188:3150-3159. 10.4049/jimmunol.1103414, 22351936.
21. Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD. Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost 2012, 10:136-144. 10.1111/j.1538-7836.2011.04544.x, 3319651, 22044575.
22. Kambas K, Mitroulis I, Apostolidou E, Girod A, Chrysanthopoulou A, Pneumatikos I, Skendros P, Kourtzelis I, Koffa M, Kotsianidis I, Ritis K. Autophagy mediates the delivery of thrombogenic tissue factor to neutrophil extracellular traps in human sepsis. PLoS One 2012, 7:e45427. 10.1371/journal.pone.0045427, 3446899, 23029002.
23. Leffler J, Martin M, Gullstrand B, Tyden H, Lood C, Truedsson L, Bengtsson AA, Blom AM. Neutrophil extracellular traps that are not degraded in systemic lupus erythematosus activate complement exacerbating the disease. J Immunol 2012, 188:3522-3531. 10.4049/jimmunol.1102404, 22345666.
24. Megens RT, Vijayan S, Lievens D, Doring Y, van Zandvoort MA, Grommes J, Weber C, Soehnlein O. Presence of luminal neutrophil extracellular traps in atherosclerosis. Thromb Haemost 2012, 107:597-598. 10.1160/TH11-09-0650, 22318427.
25. Sangaletti S, Tripodo C, Chiodoni C, Guarnotta C, Cappetti B, Casalini P, Piconese S, Parenza M, Guiducci C, Vitali C, Colombo MP. Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. Blood 2012, 120:3007-3018. 10.1182/blood-2012-03-416156, 22932797.
26. Thornton RB, Wiertsema SP, Kirkham LA, Rigby PJ, Vijayasekaran S, Coates HL, Richmond PC. Neutrophil extracellular traps and bacterial biofilms in middle ear effusion of children with recurrent acute otitis media - a potential treatment target. PLoS One 2013, 8:e53837. 10.1371/journal.pone.0053837, 3564866, 23393551.
27. Summers SA, van der Veen BS, O'Sullivan KM, Gan PY, Ooi JD, Heeringa P, Satchell SC, Mathieson PW, Saleem MA, Visvanathan K, Holdsworth SR, Kitching AR. Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney Int 2010, 78:1263-1274. 10.1038/ki.2010.327, 20844472.
28. Yang D, de la Rosa G, Tewary P, Oppenheim JJ. Alarmins link neutrophils and dendritic cells. Trends Immunol 2009, 30:531-537. 10.1016/j.it.2009.07.004, 2767430, 19699678.