Vasculitis syndromes: LAMP-2 illuminates pathogenesis of ANCA glomerulonephritis

Nature Reviews Nephrology

Volumn 5, Issue 5, 2009, Pages 247-249

  Bosch, Xavier ^a,b   Mirapeix, Eduard ^c  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Department of Internal Medicine ^*  (Spain)

^c HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL ANTIGEN; COTRIMOXAZOLE; GLUCOCORTICOID; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; LAMP2 PROTEIN, HUMAN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN;

ANCA ASSOCIATED VASCULITIS; CELLULAR IMMUNITY; CROSS REACTION; FOCAL GLOMERULONEPHRITIS; HUMAN; ILLUMINATION; KIDNEY BIOPSY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REMISSION; SHORT SURVEY; UNSPECIFIED SIDE EFFECT; WEGENER GRANULOMATOSIS; ANIMAL; GLOMERULONEPHRITIS; IMMUNOLOGY; NOTE; VASCULITIS;

ANIMALS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; GLOMERULONEPHRITIS; HUMANS; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; VASCULITIS;

EID: 67650361085     PISSN: 17595061     EISSN: 1759507X     Source Type: Journal    
DOI: 10.1038/nrneph.2009.51     Document Type: Short Survey

References (8)

1. Kain, R. et al. Molecular mimicry in pauciimmune focal necrotizing glomerulonephritis. Nat. Med. 14, 1088-1096 (2008).
2. Falk, R. J., Terrell, R. S., Charles, L. A. & Jennette, J. C. Antineutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc. Natl Acad. Sci. UsA 87, 4115-4119 (1990).
3. Bosch, X., Guilabert, A. & Font, J. Antineutrophil cytoplasmic antibodies. Lancet 368, 404-418 (2006).
4. Xiao, H. et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J. Clin. Invest. 110, 955-963 (2002).
5. Bosch, X., Guilabert, A., espinosa, G. & Mirapeix, e. immunotherapy for antineutrophil cytoplasmic antibody-associated vasculitis: challenging the therapeutic status quo? Trends Immunol. 29, 280-289 (2008).
6. Pendergraft, w. F. 3rd et al. Autoimmunity is triggered by cPR-3105-201, a protein complementary to human autoantigen proteinase-3. Nat. Med. 10, 72-79 (2004).
7. Stegeman, C. A., Tervaert, J. W, De Jong, P. E. & Kallenberg, C. G. Trimethoprim- sulfamethoxazole (co-trimoxazole) for the prevention of relapses of wegener's granulomatosis. Dutch Co-Trimoxazole wegener study Group. N. Engl. J. Med. 335, 16-20 (1996).
8. Kain, R. et al. A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. J. Exp. Med. 181, 585-597 (1995).