Shining a LAMP on pauci-immune focal segmental glomerulonephritis

Kidney International

Volumn 76, Issue 1, 2009, Pages 15-17

  Salama, Alan D ^a   Pusey, Charles D ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

ANCA; Glomerulonephritis; LAMP 2; Vasculitis

Indexed keywords

CROSS REACTING ANTIBODY; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2;

ANCA ASSOCIATED VASCULITIS; FIMBRIA; FOCAL GLOMERULOSCLEROSIS; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; MOLECULAR MIMICRY; PRIORITY JOURNAL; SHORT SURVEY;

EID: 67449146900     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.123     Document Type: Short Survey

References (20)

1. Davies DJ, Moran JE, Niall JF et al. Segmentai necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology? Br Med J (Clin Res Ed) 1982; 285: 606.
2. van der Woude FJ, Rasmussen N, Lobatto S et al. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity In Wegener's granulomatosis. Lancet 1985; 1: 425-429.
3. Jennette JC, Wilkman AS, Falk RJ. Antl-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and vasculitis. Am J Pathol 1989;135:921-930.
4. Goldschmeding R, van der Schoot CE, ten Bokkel Huinink D et al. Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils. J Clin Invest 1989; 84: 1577-1587.
5. Falk RJ, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988; 318: 1651-1657.
6. Hagen EC, Daha MR, Hermans J et al. Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC/BCR Project for ANCA Assay Standardization. Kidney lnt 1998; 53: 743-753.
7. Falk RJ, Terrell RS, Charles LA et al. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci USA 1990; 87: 4115-4119.
8. Xiao H, Heeringa P, Hu P et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest 2002; 110: 955-963.
9. Little MA, Smyth CL, Yadav R et al. Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions In vivo. Blood 2005; 106: 2050-2058.
10. Kain R, Matsui K, Exner M et al. A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: the lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. J Exp Med 1995; 181: 585-597.
11. Zhao MH, Jayne DR, Ardiles LG et al. Autoantibodies against bactericidal/ permeability-increasing protein in patients with cystic fibrosis. QJM 1996; 89: 259-265.
12. Seibold F, Weber P, Schoning A et al. Neutrophil antibodies (pANCA) In chronic liver disease and inflammatory bowel disease: do they react with different antigens? Eur J Gastroenterol Hepatol 1996; 8: 1095-1100.
13. Terjung B, Spengler U. Atypical p-ANCA in PSC and AIH: A Hint Toward a 'leaky gut'? Clin Rev Allergy Immunol 2009; 36: 40-51.
14. Binker MG, Cosen-Blnker LI, Tereblznik MR et al. Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosomeassociated membrane proteins, LAMP-I and LAMP-2. Cell Microbiol 2007; 9:2153-2166.
15. Rees AJ, Lockwood CM, Peters DK. Enhanced allergic tissue injury in Goodpasture's syndrome by Intercurrent bacterial infection. Br Med J 1977; 2: 723-726.
16. Pinching AJ, Rees AJ, Pussell BA et al. Relapses In Wegener's granulomatosis: the role of infection. Br Med J 1980; 281: 836-838.
17. Morgan MD, Harper L, Williams J et al. Anti-neutrophil cytoplasmassociated glomerulonephritis. J Am Soc Nephrol 2006; 17: 1224-1234.
18. Kain R, Exner M, Brandes Retal. Molecular mimicry In pauci-immune focal necrotizing glomerulonephritis. Nat Med 2008; 14: 1088-1096.
19. Popa ER, Stegeman CA, Kallenberg CG et al. Staphylococcus aureus and Wegener's granulomatosis. Arthritis Res 2002; 4: 77-79.
20. Pendergraft III WF, Preston GA, Shah RR et al. Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantlgen proteinase-3. Nat Med 2004; 10: 72-79.