Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl) ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 22, 2013, Pages 6188-6191

  Wu, Yong Jin ^a   Conway, Charles M ^a   Sun, Li Qiang ^a   Machet, Frederic ^a   Chen, Jie ^a   Chen, Ping ^a   He, Huan ^a   Bourin, Clotilde ^a   Calandra, Vincenzo ^a   Polino, Joseph L ^a   Davis, Carl D ^a   Heman, Karen ^a   Gribkoff, Valentin K ^a   Boissard, Christopher G ^a   Knox, Ronald J ^a   Thompson, Mark W ^a   Fitzpatrick, William ^a   Weaver, David ^a   Harden, David G ^a   Natale, Joanne ^a   Dworetzky, Steven I ^a   Starrett, John E ^a   more..

^a BRISTOL MYERS SQUIBB RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Acrylamide; Diabetic neuropathy; KCNQ2; Kv7.2; Neuropathic pain

Indexed keywords

3 (2 FLUOROPHENYL) N (1 (3 (PYRIDIN 3 YLOXY) PHENYL)ETHYL) ACRYLAMIDE; ACRYLAMIDE DERIVATIVE; CHLORDIAZEPOXIDE; POTASSIUM CHANNEL KCNQ2; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; MEMBRANE POTENTIAL; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PATCH CLAMP; PERIPHERAL NEUROPATHY; RAT; SPINAL NERVE;

ACRYLAMIDE; DIABETIC NEUROPATHY; KCNQ2; KV7.2; NEUROPATHIC PAIN;

ACRYLAMIDES; ANIMALS; KCNQ2 POTASSIUM CHANNEL; MALE; NEURALGIA; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84885955785     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.092     Document Type: Article

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