Discovery, synthesis, and structure-activity relationship of a series of N -aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener

ACS Chemical Neuroscience

Volumn 2, Issue 10, 2011, Pages 572-577

  Yu, Haibo ^a   Wu, Meng ^a,b   Townsend, Steven D ^c,e   Zou, Beiyan ^a   Long, Shunyou ^a   Daniels, J Scott ^c,d   McManus, Owen B ^a,b   Li, Min ^a,b   Lindsley, Craig W ^c,d,e   Hopkins, Corey R ^c,d,e  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

activator; ion channels; KCNQ2; KCNQ4; Kv7; ML218; MLPCN probe

Indexed keywords

BICYCLO COMPOUND; ML 213; N MESITYLBICYCLO[2.2.1]HEPTANE 2 CARBOXAMIDE; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ2 STIMULATING AGENT; POTASSIUM CHANNEL KCNQ4; POTASSIUM CHANNEL KCNQ4 STIMULATING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 80054878125     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn200065b     Document Type: Article

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