메뉴 건너뛰기




Volumn 3, Issue 5, 2013, Pages 501-507

Impact of host and virus genome variability on HCV replication and response to interferon

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BOCEPREVIR; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 9; INTERLEUKIN 28B; INTERLEUKIN 6; NONSTRUCTURAL PROTEIN 5A; PEGINTERFERON ALPHA; RIBAVIRIN; RNA BINDING PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; TELAPREVIR; VIRUS RNA;

EID: 84885952071     PISSN: 18796257     EISSN: 18796265     Source Type: Journal    
DOI: 10.1016/j.coviro.2013.06.005     Document Type: Review
Times cited : (5)

References (76)
  • 1
    • 23944506014 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection
    • DOI 10.1016/S1473-3099(05)70216-4, PII S1473309905702164
    • C.W. Shepard, L. Finelli, and M.J. Alter Global epidemiology of hepatitis C virus infection Lancet Infect Dis 5 2005 558 567 (Pubitemid 41196755)
    • (2005) Lancet Infectious Diseases , vol.5 , Issue.9 , pp. 558-567
    • Shepard, C.W.1    Finelli, L.2    Alter, M.J.3
  • 3
    • 84860287080 scopus 로고    scopus 로고
    • Epidemiology of viral hepatitis and hepatocellular carcinoma
    • e1261
    • H.B. El-Serag Epidemiology of viral hepatitis and hepatocellular carcinoma Gastroenterology 142 2012 1264 1273 e1261
    • (2012) Gastroenterology , vol.142 , pp. 1264-1273
    • El-Serag, H.B.1
  • 4
    • 84877753528 scopus 로고    scopus 로고
    • Current and future therapies for hepatitis C virus infection
    • T.J. Liang, and M.G. Ghany Current and future therapies for hepatitis C virus infection N Engl J Med 368 2013 1907 1917
    • (2013) N Engl J Med , vol.368 , pp. 1907-1917
    • Liang, T.J.1    Ghany, M.G.2
  • 6
    • 0033594380 scopus 로고    scopus 로고
    • Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin
    • DOI 10.1056/NEJM199904223401602
    • E. Kenny-Walsh Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. Irish Hepatology Research Group N Engl J Med 340 1999 1228 1233 (Pubitemid 29181642)
    • (1999) New England Journal of Medicine , vol.340 , Issue.16 , pp. 1228-1233
    • Kenny-Walsh, E.1    Shanahan, F.2
  • 8
    • 77956268467 scopus 로고    scopus 로고
    • Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): An open-label, randomised, multicentre phase 2 trial
    • P.Y. Kwo, E.J. Lawitz, J. McCone, E.R. Schiff, J.M. Vierling, D. Pound, M.N. Davis, J.S. Galati, S.C. Gordon, and N. Ravendhran Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial Lancet 376 2010 705 716
    • (2010) Lancet , vol.376 , pp. 705-716
    • Kwo, P.Y.1    Lawitz, E.J.2    McCone, J.3    Schiff, E.R.4    Vierling, J.M.5    Pound, D.6    Davis, M.N.7    Galati, J.S.8    Gordon, S.C.9    Ravendhran, N.10
  • 9
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-α therapy
    • DOI 10.1126/science.282.5386.103
    • A.U. Neumann, N.P. Lam, H. Dahari, D.R. Gretch, T.E. Wiley, T.J. Layden, and A.S. Perelson Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy Science 282 1998 103 107 (Pubitemid 28471138)
    • (1998) Science , vol.282 , Issue.5386 , pp. 103-107
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3    Gretch, D.R.4    Wiley, T.E.5    Layden, T.J.6    Perelson, A.S.7
  • 10
    • 40849097775 scopus 로고    scopus 로고
    • Rates of evolutionary change in viruses: Patterns and determinants
    • DOI 10.1038/nrg2323, PII NRG2323
    • S. Duffy, L.A. Shackelton, and E.C. Holmes Rates of evolutionary change in viruses: patterns and determinants Nat Rev Genet 9 2008 267 276 (Pubitemid 351399833)
    • (2008) Nature Reviews Genetics , vol.9 , Issue.4 , pp. 267-276
    • Duffy, S.1    Shackelton, L.A.2    Holmes, E.C.3
  • 11
    • 84455189499 scopus 로고    scopus 로고
    • New insights into the HCV quasispecies and compartmentalization
    • P. Farci New insights into the HCV quasispecies and compartmentalization Semin Liver Dis 31 2011 356 374
    • (2011) Semin Liver Dis , vol.31 , pp. 356-374
    • Farci, P.1
  • 15
    • 0033880575 scopus 로고    scopus 로고
    • Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein
    • R.G. Hope, and J. McLauchlan Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein J Gen Virol 81 2000 1913 1925 (Pubitemid 30599171)
    • (2000) Journal of General Virology , vol.81 , Issue.8 , pp. 1913-1925
    • Hope, R.G.1    McLauchlan, J.2
  • 17
    • 77955691994 scopus 로고    scopus 로고
    • Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin
    • N. Akuta, F. Suzuki, M. Hirakawa, Y. Kawamura, H. Yatsuji, H. Sezaki, Y. Suzuki, T. Hosaka, M. Kobayashi, and S. Saitoh Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin Hepatology 52 2010 421 429
    • (2010) Hepatology , vol.52 , pp. 421-429
    • Akuta, N.1    Suzuki, F.2    Hirakawa, M.3    Kawamura, Y.4    Yatsuji, H.5    Sezaki, H.6    Suzuki, Y.7    Hosaka, T.8    Kobayashi, M.9    Saitoh, S.10
  • 18
    • 79952679694 scopus 로고    scopus 로고
    • Mutations in the core and NS5A region of hepatitis C virus genotype 1b and correlation with response to pegylated-interferon-alpha 2b and ribavirin combination therapy
    • K. Hayashi, Y. Katano, M. Ishigami, A. Itoh, Y. Hirooka, I. Nakano, F. Urano, K. Yoshioka, H. Toyoda, and T. Kumada Mutations in the core and NS5A region of hepatitis C virus genotype 1b and correlation with response to pegylated-interferon-alpha 2b and ribavirin combination therapy J Viral Hepat 18 2011 280 286
    • (2011) J Viral Hepat , vol.18 , pp. 280-286
    • Hayashi, K.1    Katano, Y.2    Ishigami, M.3    Itoh, A.4    Hirooka, Y.5    Nakano, I.6    Urano, F.7    Yoshioka, K.8    Toyoda, H.9    Kumada, T.10
  • 20
    • 84869215141 scopus 로고    scopus 로고
    • NS5A sequence heterogeneity of hepatitis C virus genotype 4a predicts clinical outcome of pegylated-interferon-ribavirin therapy in Egyptian patients
    • A. El-Shamy, I. Shoji, W. El-Akel, S.E. Bilasy, L. Deng, M. El-Raziky, D.P. Jiang, G. Esmat, and H. Hotta NS5A sequence heterogeneity of hepatitis C virus genotype 4a predicts clinical outcome of pegylated-interferon-ribavirin therapy in Egyptian patients J Clin Microbiol 50 2012 3886 3892
    • (2012) J Clin Microbiol , vol.50 , pp. 3886-3892
    • El-Shamy, A.1    Shoji, I.2    El-Akel, W.3    Bilasy, S.E.4    Deng, L.5    El-Raziky, M.6    Jiang, D.P.7    Esmat, G.8    Hotta, H.9
  • 24
    • 3042740355 scopus 로고    scopus 로고
    • Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs
    • DOI 10.1002/jmv.20123
    • K. Melen, R. Fagerlund, M. Nyqvist, P. Keskinen, and I. Julkunen Expression of hepatitis C virus core protein inhibits interferon-induced nuclear import of STATs J Med Virol 73 2004 536 547 (Pubitemid 38857203)
    • (2004) Journal of Medical Virology , vol.73 , Issue.4 , pp. 536-547
    • Melen, K.1    Fagerlund, R.2    Nyqvist, M.3    Keskinen, P.4    Julkunen, I.5
  • 25
    • 33845724693 scopus 로고    scopus 로고
    • Repression of interferon regulatory factor 1 by hepatitis C virus core protein results in inhibition of antiviral and immunomodulatory genes
    • DOI 10.1128/JVI.01011-06
    • A.R. Ciccaglione, E. Stellacci, C. Marcantonio, V. Muto, M. Equestre, G. Marsili, M. Rapicetta, and A. Battistini Repression of interferon regulatory factor 1 by hepatitis C virus core protein results in inhibition of antiviral and immunomodulatory genes J Virol 81 2007 202 214 (Pubitemid 44975161)
    • (2007) Journal of Virology , vol.81 , Issue.1 , pp. 202-214
    • Ciccaglione, A.R.1    Stellacci, E.2    Marcantonio, C.3    Muto, V.4    Equestre, M.5    Marsili, G.6    Rapicetta, M.7    Battistini, A.8
  • 27
    • 4544336360 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A: Tales of a promiscuous protein
    • DOI 10.1099/vir.0.80204-0
    • A. Macdonald, and M. Harris Hepatitis C virus NS5A: tales of a promiscuous protein J Gen Virol 85 2004 2485 2502 (Pubitemid 39214345)
    • (2004) Journal of General Virology , vol.85 , Issue.9 , pp. 2485-2502
    • Macdonald, A.1    Harris, M.2
  • 28
    • 0029161576 scopus 로고
    • Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region
    • N. Enomoto, I. Sakuma, Y. Asahina, M. Kurosaki, T. Murakami, C. Yamamoto, N. Izumi, F. Marumo, and C. Sato Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region J Clin Investig 96 1995 224 230
    • (1995) J Clin Investig , vol.96 , pp. 224-230
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3    Kurosaki, M.4    Murakami, T.5    Yamamoto, C.6    Izumi, N.7    Marumo, F.8    Sato, C.9
  • 30
  • 31
    • 0035215781 scopus 로고    scopus 로고
    • Statistical analysis of combined substitutions in nonstructural 5A region of hepatitis C virus and interferon response
    • G.W. Witherell, and P. Beineke Statistical analysis of combined substitutions in nonstructural 5A region of hepatitis C virus and interferon response J Med Virol 63 2001 8 16
    • (2001) J Med Virol , vol.63 , pp. 8-16
    • Witherell, G.W.1    Beineke, P.2
  • 32
    • 0034101768 scopus 로고    scopus 로고
    • Mutations in the protein kinase-binding domain of the NS5A protein in patients infected with hepatitis C virus type 1a are associated with treatment response
    • DOI 10.1086/315263
    • C. Sarrazin, T. Berg, J.H. Lee, B. Ruster, B. Kronenberger, W.K. Roth, and S. Zeuzem Mutations in the protein kinase-binding domain of the NS5A protein in patients infected with hepatitis C virus type 1a are associated with treatment response J Infect Dis 181 2000 432 441 (Pubitemid 30131807)
    • (2000) Journal of Infectious Diseases , vol.181 , Issue.2 , pp. 432-441
    • Sarrazin, C.1    Berg, T.2    Lee, J.-H.3    Ruster, B.4    Kronenberger, B.5    Roth, W.K.6    Zeuzem, S.7
  • 33
    • 1842327408 scopus 로고    scopus 로고
    • Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b
    • DOI 10.1002/(SICI)1096-9071(199710)53:2<118::AID-JMV3>3.0.CO;2-C
    • W.T. Hofgartner, S.J. Polyak, D.G. Sullivan, R.L. Carithers Jr., and D.R. Gretch Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b J Med Virol 53 1997 118 126 (Pubitemid 27445729)
    • (1997) Journal of Medical Virology , vol.53 , Issue.2 , pp. 118-126
    • Hofgartner, W.T.1    Polyak, S.J.2    Sullivan, D.G.3    Carithers Jr., R.L.4    Gretch, D.R.5
  • 34
    • 47149083069 scopus 로고    scopus 로고
    • Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy
    • DOI 10.1002/hep.22339
    • A. El-Shamy, M. Nagano-Fujii, N. Sasase, S. Imoto, S.R. Kim, and H. Hotta Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy Hepatology 48 2008 38 47 (Pubitemid 351975529)
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 38-47
    • El-Shamy, A.1    Nagano-Fujii, M.2    Sasase, N.3    Imoto, S.4    Kim, S.-R.5    Hotta, H.6
  • 35
    • 80855133484 scopus 로고    scopus 로고
    • Polymorphisms of hepatitis C virus non-structural protein 5A and core protein and clinical outcome of pegylated-interferon/ribavirin combination therapy
    • A. El-Shamy, S.R. Kim, Y.H. Ide, N. Sasase, S. Imoto, L. Deng, I. Shoji, and H. Hotta Polymorphisms of hepatitis C virus non-structural protein 5A and core protein and clinical outcome of pegylated-interferon/ribavirin combination therapy Intervirology 55 2012 1 11
    • (2012) Intervirology , vol.55 , pp. 1-11
    • El-Shamy, A.1    Kim, S.R.2    Ide, Y.H.3    Sasase, N.4    Imoto, S.5    Deng, L.6    Shoji, I.7    Hotta, H.8
  • 36
    • 84866624182 scopus 로고    scopus 로고
    • Mutations in non-structural 5A and rapid viral response to pegylated interferon-alpha-2b plus ribavirin therapy are associated with therapeutic efficacy in patients with genotype 1b chronic hepatitis C
    • Y. Yano, Y. Seo, A. Miki, M. Saito, H. Kato, K. Hamano, M. Oya, S. Ouchi, T. Fujisawa, and H. Yamada Mutations in non-structural 5A and rapid viral response to pegylated interferon-alpha-2b plus ribavirin therapy are associated with therapeutic efficacy in patients with genotype 1b chronic hepatitis C Int J Mol Med 30 2012 1048 1052
    • (2012) Int J Mol Med , vol.30 , pp. 1048-1052
    • Yano, Y.1    Seo, Y.2    Miki, A.3    Saito, M.4    Kato, H.5    Hamano, K.6    Oya, M.7    Ouchi, S.8    Fujisawa, T.9    Yamada, H.10
  • 37
    • 0343924357 scopus 로고    scopus 로고
    • Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
    • DOI 10.1006/viro.1997.8493
    • M.J. Gale Jr., M.J. Korth, N.M. Tang, S.L. Tan, D.A. Hopkins, T.E. Dever, S.J. Polyak, D.R. Gretch, and M.G. Katze Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein Virology 230 1997 217 227 (Pubitemid 27211852)
    • (1997) Virology , vol.230 , Issue.2 , pp. 217-227
    • Gale Jr., M.J.1    Korth, M.J.2    Tang, N.M.3    Tan, S.-L.4    Hopkins, D.A.5    Dever, T.E.6    Polyak, S.J.7    Gretch, D.R.8    Katze, M.G.9
  • 39
    • 34548288928 scopus 로고    scopus 로고
    • Hepatitis C virus non-structural 5A abrogates signal transducer and activator of transcription-1 nuclear translocation induced by IFN-α through dephosphorylation
    • G.Z. Gong, J. Cao, Y.F. Jiang, Y. Zhou, and Liu B Hepatitis C virus non-structural 5A abrogates signal transducer and activator of transcription-1 nuclear translocation induced by IFN-alpha through dephosphorylation World J Gastroenterol: WJG 13 2007 4080 4084 (Pubitemid 47323160)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.30 , pp. 4080-4084
    • Gong, G.-Z.1    Cao, J.2    Jiang, Y.-F.3    Zhou, Y.4    Liu, B.5
  • 40
    • 34047174776 scopus 로고    scopus 로고
    • HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines
    • K.H. Lan, K.L. Lan, W.P. Lee, M.L. Sheu, M.Y. Chen, Y.L. Lee, S.H. Yen, F.Y. Chang, and S.D. Lee HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines J Hepatol 46 2007 759 767
    • (2007) J Hepatol , vol.46 , pp. 759-767
    • Lan, K.H.1    Lan, K.L.2    Lee, W.P.3    Sheu, M.L.4    Chen, M.Y.5    Lee, Y.L.6    Yen, S.H.7    Chang, F.Y.8    Lee, S.D.9
  • 41
    • 18844369121 scopus 로고    scopus 로고
    • Nonstructural protein 5A does not contribute to the resistance of hepatitis C virus replication to interferon alpha in cell culture
    • DOI 10.1016/j.virol.2005.03.012, PII S0042682205001698
    • M. Aus dem Siepen, V. Lohmann, M. Wiese, S. Ross, M. Roggendorf, and S. Viazov Nonstructural protein 5A does not contribute to the resistance of hepatitis C virus replication to interferon alpha in cell culture Virology 336 2005 131 136 (Pubitemid 40693947)
    • (2005) Virology , vol.336 , Issue.2 , pp. 131-136
    • Aus Dem Siepen, M.1    Lohmann, V.2    Wiese, M.3    Ross, S.4    Roggendorf, M.5    Viazov, S.6
  • 42
    • 84860389491 scopus 로고    scopus 로고
    • IL28B single nucleotide polymorphisms in the treatment of hepatitis C
    • C.M. Lange, and S. Zeuzem IL28B single nucleotide polymorphisms in the treatment of hepatitis C J Hepatol 55 2011 692 701
    • (2011) J Hepatol , vol.55 , pp. 692-701
    • Lange, C.M.1    Zeuzem, S.2
  • 43
    • 21144438856 scopus 로고    scopus 로고
    • SNPs in the promoter region of the osteopontin gene as a marker predicting the efficacy of interferon-based therapies in patients with chronic hepatitis C
    • DOI 10.1007/s00535-005-1558-3
    • M. Naito, A. Matsui, M. Inao, S. Nagoshi, M. Nagano, N. Ito, T. Egashira, M. Hashimoto, S. Mishiro, and S. Mochida SNPs in the promoter region of the osteopontin gene as a marker predicting the efficacy of interferon-based therapies in patients with chronic hepatitis C J Gastroenterol 40 2005 381 388 (Pubitemid 40723929)
    • (2005) Journal of Gastroenterology , vol.40 , Issue.4 , pp. 381-388
    • Naito, M.1    Matsui, A.2    Inao, M.3    Nagoshi, S.4    Nagano, M.5    Ito, N.6    Egashira, T.7    Hashimoto, M.8    Mishiro, S.9    Mochida, S.10    Fujiwara, K.11
  • 45
    • 0038071786 scopus 로고    scopus 로고
    • The dinucleotide microsatellite polymorphism of the IFNAR1 gene promoter correlates with responsiveness of hepatitis C patients to interferon
    • DOI 10.1016/S1386-6346(02)00269-3, PII S1386634602002693
    • N. Matsuyama, S. Mishiro, M. Sugimoto, Y. Furuichi, M. Hashimoto, M. Hijikata, and Y. Ohta The dinucleotide microsatellite polymorphism of the IFNAR1 gene promoter correlates with responsiveness of hepatitis C patients to interferon Hepatol Res: Off J Jpn Soc Hepatol 25 2003 221 225 (Pubitemid 36546347)
    • (2003) Hepatology Research , vol.25 , Issue.3 , pp. 221-225
    • Matsuyama, N.1    Mishiro, S.2    Sugimoto, M.3    Furuichi, Y.4    Hashimoto, M.5    Hijikata, M.6    Ohta, Y.7
  • 49
    • 67349284651 scopus 로고    scopus 로고
    • Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection
    • L.J. Yee, K. Im, B. Borg, H. Yang, and T.J. Liang Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection Genes Immun 10 2009 365 372
    • (2009) Genes Immun , vol.10 , pp. 365-372
    • Yee, L.J.1    Im, K.2    Borg, B.3    Yang, H.4    Liang, T.J.5
  • 55
    • 84866178019 scopus 로고    scopus 로고
    • The impact of interferon lambda 3 gene polymorphism on natural course and treatment of hepatitis C
    • F. Bellanti, G. Vendemiale, E. Altomare, and G. Serviddio The impact of interferon lambda 3 gene polymorphism on natural course and treatment of hepatitis C Clin Dev Immunol 2012 2012 849373
    • (2012) Clin Dev Immunol , vol.2012 , pp. 849373
    • Bellanti, F.1    Vendemiale, G.2    Altomare, E.3    Serviddio, G.4
  • 62
    • 19044361835 scopus 로고    scopus 로고
    • Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection
    • DOI 10.1053/j.gastro.2005.01.059, PII S0016508505003999
    • L. Chen, I. Borozan, J. Feld, J. Sun, L.L. Tannis, C. Coltescu, J. Heathcote, A.M. Edwards, and I.D. McGilvray Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection Gastroenterology 128 2005 1437 1444 (Pubitemid 40712193)
    • (2005) Gastroenterology , vol.128 , Issue.5 , pp. 1437-1444
    • Chen, L.1    Borozan, I.2    Feld, J.3    Sun, J.4    Tannis, L.-L.5    Coltescu, C.6    Heathcote, J.7    Edwards, A.M.8    McGilvray, I.D.9
  • 63
    • 36348960622 scopus 로고    scopus 로고
    • Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response
    • DOI 10.1002/hep.21853
    • J.J. Feld, S. Nanda, Y. Huang, W. Chen, M. Cam, S.N. Pusek, L.M. Schweigler, D. Theodore, S.L. Zacks, and T.J. Liang Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response Hepatology 46 2007 1548 1563 (Pubitemid 350155537)
    • (2007) Hepatology , vol.46 , Issue.5 , pp. 1548-1563
    • Feld, J.J.1    Nanda, S.2    Huang, Y.3    Chen, W.4    Cam, M.5    Pusek, S.N.6    Schweigler, L.M.7    Theodore, D.8    Zacks, S.L.9    Liang, T.J.10    Fried, M.W.11
  • 68
    • 77957348326 scopus 로고    scopus 로고
    • In the absence of HCV infection, interferon stimulated gene expression in liver is not associated with IL28B genotype
    • F.M. Shebl, D. Maeder, Y. Shao, L. Prokunina-Olsson, E.E. Schadt, and T.R. O'Brien In the absence of HCV infection, interferon stimulated gene expression in liver is not associated with IL28B genotype Gastroenterology 139 2010 1422 1424
    • (2010) Gastroenterology , vol.139 , pp. 1422-1424
    • Shebl, F.M.1    Maeder, D.2    Shao, Y.3    Prokunina-Olsson, L.4    Schadt, E.E.5    O'Brien, T.R.6
  • 71
    • 84856964947 scopus 로고    scopus 로고
    • Hepatitis C in 2011: A new standard of care and the race towards IFN-free therapy
    • W.P. Hofmann, and S. Zeuzem Hepatitis C in 2011: a new standard of care and the race towards IFN-free therapy Nat Rev Gastroenterol Hepatol 9 2012 67 68
    • (2012) Nat Rev Gastroenterol Hepatol , vol.9 , pp. 67-68
    • Hofmann, W.P.1    Zeuzem, S.2
  • 73
    • 84873987251 scopus 로고    scopus 로고
    • IL28B in the era of direct-acting antivirals for hepatitis C
    • A.J. Muir IL28B in the era of direct-acting antivirals for hepatitis C J Clin Gastroenterol 47 2013 222 227
    • (2013) J Clin Gastroenterol , vol.47 , pp. 222-227
    • Muir, A.J.1
  • 74
    • 84857919608 scopus 로고    scopus 로고
    • Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy
    • N. Akuta, F. Suzuki, M. Hirakawa, Y. Kawamura, H. Sezaki, Y. Suzuki, T. Hosaka, M. Kobayashi, S. Saitoh, and Y. Arase Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy Intervirology 55 2012 231 241
    • (2012) Intervirology , vol.55 , pp. 231-241
    • Akuta, N.1    Suzuki, F.2    Hirakawa, M.3    Kawamura, Y.4    Sezaki, H.5    Suzuki, Y.6    Hosaka, T.7    Kobayashi, M.8    Saitoh, S.9    Arase, Y.10
  • 75
    • 79957963815 scopus 로고    scopus 로고
    • IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C
    • K. Chayama, C.N. Hayes, H. Abe, D. Miki, H. Ochi, Y. Karino, J. Toyota, Y. Nakamura, N. Kamatani, and H. Sezaki IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C J Infect Dis 204 2011 84 93
    • (2011) J Infect Dis , vol.204 , pp. 84-93
    • Chayama, K.1    Hayes, C.N.2    Abe, H.3    Miki, D.4    Ochi, H.5    Karino, Y.6    Toyota, J.7    Nakamura, Y.8    Kamatani, N.9    Sezaki, H.10
  • 76
    • 80053339008 scopus 로고    scopus 로고
    • An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases
    • M.G. Ghany, D.R. Nelson, D.B. Strader, D.L. Thomas, and L.B. Seeff An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases Hepatology 54 2011 1433 1444
    • (2011) Hepatology , vol.54 , pp. 1433-1444
    • Ghany, M.G.1    Nelson, D.R.2    Strader, D.B.3    Thomas, D.L.4    Seeff, L.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.