The dinucleotide microsatellite polymorphism of the IFNAR1 gene promoter correlates with responsiveness of hepatitis C patients to interferon

Hepatology Research

Volumn 25, Issue 3, 2003, Pages 221-225

  Matsuyama, Noriko ^a   Mishiro, Shunji ^b   Sugimoto, Masanobu ^a   Furuichi, Yasuhiro ^a   Hashimoto, Michie ^b,c   Hijikata, Minako ^d   Ohta, Yasuhiko ^b  

^a GeneCare Research Institute   (Japan)

^b Shinagawa ku   (Japan)

^c TOSHIBA CORPORATION   (Japan)

^d NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

Chronic hepatitis C; Genetic polymorphism; IFNAR1 and IFNAR2; Interferon; Interferon receptor; Microsatellite

Indexed keywords

ALPHA INTERFERON; ALPHA INTERFERON RECEPTOR; BETA INTERFERON; BETA INTERFERON RECEPTOR; DINUCLEOTIDE; INTERFERON RECEPTOR; MICROSATELLITE DNA; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DINUCLEOTIDE REPEAT; DRUG RESPONSE; GENE SEQUENCE; GENETIC POLYMORPHISM; GENOTYPE; HEPATITIS C; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT OUTCOME;

EID: 0038071786     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(02)00269-3     Document Type: Article

References (5)

1. Gretch D. Mechanism of interferon resistance in hepatitis C. Lancet 2001;358:1662-3.
2. Matsushita M, Hijikata M, Matsushita M, Ohta Y, Mishiro S. Association of mannose-binding lectin gene haplotype LXPA and LYPB with interferon-resistant hepatitis C virus infection in Japanese patients. J Hepatol 1998;29:695-700.
3. Hijikata M, Ohta Y, Mishiro S. Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon. Intervirology 2000;43:124-7.
4. Hijikata M, Mishiro S, Miyamoto C, Furuichi Y, Hashimoto M, Ohta Y. Genetic polymorphism, of the MxA gene promoter and interferon-responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro. Intervirology 2001;44:379-82.
5. Muldoon J, Uriel A, Khoo S, Ollier WE, Hajeer AH. Novel IFN-α receptor promoter polymorphisms. Genes Immun 2001;2:159-60.