A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment

Neuropsychologia

Volumn 51, Issue 12, 2013, Pages 2442-2449

  Stark, Shauna M ^a   Yassa, Michael A ^b   Lacy, Joyce W ^c   Stark, Craig E L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c AZUSA PACIFIC UNIVERSITY   (United States)

Author keywords

Dentate gyrus (DG); Healthy aging; MCI; Pattern separation

Indexed keywords

ADULT; AGED; AGING; ARTICLE; BEHAVIOR; BEHAVIORAL PATTERN SEPARATION; BEHAVIORAL PATTERN SEPARATION TASK OBJECT VERSION; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; EARLY DIAGNOSIS; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; LIFESPAN; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; MENTAL PERFORMANCE; MENTAL TASK; META ANALYSIS; MILD COGNITIVE IMPAIRMENT; RECOGNITION; TASK PERFORMANCE; WORD LIST RECALL;

DENTATE GYRUS (DG); HEALTHY AGING; MCI; PATTERN SEPARATION;

ADULT; AGED; AGED, 80 AND OVER; AGING; FEMALE; HUMANS; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TESTS; PATTERN RECOGNITION, VISUAL; PHOTIC STIMULATION; RECOGNITION (PSYCHOLOGY); YOUNG ADULT;

EID: 84885951316     PISSN: 00283932     EISSN: 18733514     Source Type: Journal    
DOI: 10.1016/j.neuropsychologia.2012.12.014     Document Type: Article

References (36)

1. Bakker A., Kirwan C.B., Miller M.I., Stark C.E.L. Pattern separation in the human hippocampal CA3 and dentate gyrus. Science 2008, 319:1640-1642.
2. Bakker A., Krauss G.L., Albert M.S., Speck C.L., Jones L.R., Stark C.E., Gallagher M. Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron 2012, 74(3):467-474. 10.1016/j.neuron.2012.03.023.
3. Chen J., Olsen R.K., Preston A.R., Glover G.H., Wagner A.D. Associative retrieval processes in the human medial temporal lobe: hippocampal retrieval success and CA1 mismatch detection. Learning and Memory 2011, 18(8):523-528.
4. Crum R.M., Anthony J.C., Bassett S.S., Folstein M.F. Population-based norms for the Mini-Mental State Examination by age and educational level. JAMA 1993, 269(18):2386-2391.
5. Ferguson S.A., Hashtroudi S., Johnson M.K. Age differences in using source-relevant cues. Psychology and Aging 1992, 7(3):443. Retrieved from.
6. Gallagher M., Colantuoni C., Eichenbaum H., Haberman R.P., Rapp P.R., Tanila H., et al. Individual differences in neurocognitive aging of the medial temporal lobe. Age (Dordrecht) 2006, 28(3):221-233. 10.1007/s11357-006-9017-5.
7. Geinisman Y. deToledo-Morrell, L., Morrell F., Persina I.S., Rossi M. Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique. Hippocampus Hippocampus 1992, 2(4):437-444.
8. Holdstock J.S., Mayes A.R., Robert N., Cezayirli E., Isaac C.L., O'Reilly R.C., Norman K.A. Under what conditions is recognition spared relative to recall after selective hippocampal damage in humans?. Hippocampus 2002, 12(3):341-351.
9. Hughes C.P., Berg L., Danziger W.L., Coben L.A., Martin R.L. A new clinical scale for the staging of dementia. British Journal of Psychiatry 1982, 140:566-572.
10. Kirwan B.C, Hartshorn A., Stark S.M., Goodrich-Hunsaker N.J., Stark C.E. Pattern separation deficits following damage to the hippocampus. Neuropsychologia 2012, 50(10):2408-2414.
11. Kirwan C.B., Jones C.K., Miller M.I., Stark C.E. High-resolution fMRI investigation of the medial temporal lobe. Human Brain Mapping 2007, 28(10):959-966.
12. Koutstaal W., Schacter D.L., Galluccio L., Stofer K.A. Reducing gist-based false recognition in older adults: encoding and retrieval manipulations. Psychology and Aging 1999, 14(2):220-237. Retrieved from.
13. Kumaran D., Maguire E.A. Match mismatch processes underlie human hippocampal responses to associative novelty. The Journal of Neuroscience 2007, 27(32):8517-8524.
14. Lacy J.W., Yassa M.A., Stark S.M., Muftuler L.T., Stark C.E. Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity. Learning & Memory 2011, 18(1):15-18. 10.1101/lm.1971111.
15. Leutgeb J.K., Leutgeb S., Moser M.B., Moser E.I. Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science (New York, N.Y.) Science 2007, 315(5814):961-966.
16. McClelland J.L., McNaughton B.L, O.Reilly R.C. Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory. Psychological Reviews 1995, 102(3):419-457.
17. Norman K.A., O'Reilly R.C. Modeling hippocampal and neocortical contributions to recognition memory: A complementary-learning-systems approach. Psychological Review 2003, 110(4):611-646.
18. Petersen R.C., Smith G.E., Waring S.C., Ivnik R.J., Tangalos E.G., Kokmen E. Mild cognitive impairment: Clinical characterization and outcome. Archives of Neurology 1999, 56(3):303-308.
19. Rey A. L'examen psychologique dans les cas d'encephalopathie traumatique. Archives of Psychology 1941, 28:286-340.
20. Salthouse T.A. Decomposing age correlations on neuropsychological and cognitive variables. Journal of the International Neuropsychological Society 2009, 15(5):650-661. 10.1017/S1355617709990385.
21. Segal S.K., Stark S.M., Kattan D., Stark C.E., Yassa M.A. Norepinephrine-mediated emotional arousal facilitates subsequent pattern separation. Neurobiology of Learning and Memory 2012, 97(4):465-469. 10.1016/j.nlm.2012.03.010.
22. Stark S.M., Yassa M.A., Stark C.E.L. Individual differences in spatial pattern separation performance associated with healthy aging in humans. Learning and Memory 2010, 17(6):284-288.
23. Tombaugh T.N. Trail Making Test A and B: Normative data stratified by age and education. Archives of Clinical Neuropsychology 2004, 19(2):203-214. 10.1016/S0887-6177(03)00039-8.
24. Tombaugh T.N., Kozak J., Rees L. Normative data stratified by age and education for two measures of verbal fluency: FAS and animal naming. Archives of Clinical Neuropsychology 1999, 14(2):167-177.
25. Toner C.K., Pirogovsky E., Kirwan C.B., Gilbert P.E. Visual object pattern separation deficits in nondemented older adults. Learning & Memory (Cold Spring Harbor, N.Y.) 2009, 16(5):338-342.
26. Treves A., Rolls E.T. Computational constraints suggest the need for two distinct input systems to the hippocampal CA3 network. Hippocampus 1992, 2(2):189-199.
27. Wechsler D Wechsler Adult Instelligence Scale (WAIS-III): Administration and scoring manual 1997, The Psychological Corporation, San Antonio, TX.
28. Wechsler D Wechsler Memory Scale-Third Edition (WMS-III) 1997, The Psychological Corporation, San Antonio, TX.
29. Wilson I.A., Gallagher M., Eichenbaum H., Tanila H. Neurocognitive aging: Prior memories hinder new hippocampal encoding. Trends in Neurosciences 2006, 29(12):662-670.
30. Wilson I.A., Ikonen S., Gallagher M., Eichenbaum H., Tanila H. Age-associated alterations of hippocampal place cells are subregion specific. The Journal of Neuroscience: The official Journal of the Society for Neuroscience 2005, 25(29):6877-6886.
31. Wilson I.A., Ikonen S., Gureviciene I., McMahan R.W., Gallagher M., Eichenbaum H., et al. Cognitive aging and the hippocampus: How old rats represent new environments. The Journal of Neuroscience: The official Journal of the Society for Neuroscience 2004, 24(15):3870-3878.
32. Yassa M.A., Lacy J.W., Stark S.M., Albert M.S., Gallagher M., Stark C.E.L Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus 2010, E-pub. ahead of print: 2010: doi: 10.1002/hipo.20808.
33. Yassa M.A., Mattfeld A.T., Stark S.M., Stark C.E. Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America 2011, 108(21):8873-8878. 10.1073/pnas.1101567108.
34. Yassa M.A., Muftuler L.T., Stark C.E.L. Ultrahigh-resolution microstructural diffusion tensor imaging (msDTI) reveals perforant path degradation in aged humans in vivo. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(28):12687-12691.
35. Yassa M.A., Stark C.E. Pattern separation in the hippocampus. Trends in Neurosciences 2011, 34(10):515-525. 10.1016/j.tins.2011.06.006.
36. Yassa M.A., Stark S.M., Bakker A., Albert M.S., Gallagher M., Stark C.E.L. High-resolution functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic mild cognitive impairment. NeuroImage 2010, 51:1242-1252.