-
1
-
-
0026922513
-
Studies of human tumors by MRS: a review
-
Negendank W. Studies of human tumors by MRS: a review. NMR Biomed. 1992; 5: 303-324.
-
(1992)
NMR Biomed.
, vol.5
, pp. 303-324
-
-
Negendank, W.1
-
2
-
-
1542315585
-
Structure and function of choline kinase isoforms in mammalian cells
-
Aoyama C, Liao H, Ishidate K. Structure and function of choline kinase isoforms in mammalian cells. Prog. Lipid Res. 2004; 43: 266-281.
-
(2004)
Prog. Lipid Res.
, vol.43
, pp. 266-281
-
-
Aoyama, C.1
Liao, H.2
Ishidate, K.3
-
3
-
-
0032893756
-
Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells
-
Aboagye EO, Bhujwalla ZM. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res. 1999; 59: 80-84.
-
(1999)
Cancer Res.
, vol.59
, pp. 80-84
-
-
Aboagye, E.O.1
Bhujwalla, Z.M.2
-
4
-
-
0035328487
-
Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells
-
Ackerstaff E, Pflug BR, Nelson JB, Bhujwalla ZM. Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells. Cancer Res. 2001; 61: 3599-3603.
-
(2001)
Cancer Res.
, vol.61
, pp. 3599-3603
-
-
Ackerstaff, E.1
Pflug, B.R.2
Nelson, J.B.3
Bhujwalla, Z.M.4
-
5
-
-
0037142610
-
Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy
-
Ramirez de Molina A, Gutierrez R, Ramos MA, Silva JM, Silva J, Bonilla F, Sanchez JJ, Lacal JC. Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Oncogene 2002; 21: 4317-4322.
-
(2002)
Oncogene
, vol.21
, pp. 4317-4322
-
-
Ramirez De Molina, A.1
Gutierrez, R.2
Ramos, M.A.3
Silva, J.M.4
Silva, J.5
Bonilla, F.6
Sanchez, J.J.7
Lacal, J.C.8
-
6
-
-
34748827371
-
Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study
-
Ramirez de Molina A, Sarmentero-Estrada J, Belda-Iniesta C, Taron M, Ramirez de Molina V, Cejas P, Skrzypski M, Gallego-Ortega D, de Castro J, Casado E, Garcia-Cabezas MA, Sanchez JJ, Nistal M, Rosell R, Gonzalez-Baron M, Lacal JC. Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study. Lancet Oncol. 2007; 8: 889-897.
-
(2007)
Lancet Oncol.
, vol.8
, pp. 889-897
-
-
Ramirez De Molina, A.1
Sarmentero-Estrada, J.2
Belda-Iniesta, C.3
Taron, M.4
Ramirez De Molina, V.5
Cejas, P.6
Skrzypski, M.7
Gallego-Ortega, D.8
de Castro, J.9
Casado, E.10
Garcia-Cabezas, M.A.11
Sanchez, J.J.12
Nistal, M.13
Rosell, R.14
Gonzalez-Baron, M.15
Lacal, J.C.16
-
7
-
-
67650064783
-
A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomas
-
Hernando E, Sarmentero-Estrada J, Koppie T, Belda-Iniesta C, Ramirez de Molina V, Cejas P, Ozu C, Le C, Sanchez JJ, Gonzalez-Baron M, Koutcher J, Cordon-Cardo C, Bochner BH, Lacal JC, Ramirez de Molina A. A critical role for choline kinase-alpha in the aggressiveness of bladder carcinomas. Oncogene 2009; 28: 2425-2435.
-
(2009)
Oncogene
, vol.28
, pp. 2425-2435
-
-
Hernando, E.1
Sarmentero-Estrada, J.2
Koppie, T.3
Belda-Iniesta, C.4
Ramirez De Molina, V.5
Cejas, P.6
Ozu, C.7
Le, C.8
Sanchez, J.J.9
Gonzalez-Baron, M.10
Koutcher, J.11
Cordon-Cardo, C.12
Bochner, B.H.13
Lacal, J.C.14
Ramirez De Molina, A.15
-
8
-
-
77950279249
-
Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cells
-
Iorio E, Ricci A, Bagnoli M, Pisanu ME, Castellano G, Di Vito M, Venturini E, Glunde K, Bhujwalla ZM, Mezzanzanica D, Canevari S, Podo F. Activation of phosphatidylcholine cycle enzymes in human epithelial ovarian cancer cells. Cancer Res. 2010; 70: 2126-2135.
-
(2010)
Cancer Res.
, vol.70
, pp. 2126-2135
-
-
Iorio, E.1
Ricci, A.2
Bagnoli, M.3
Pisanu, M.E.4
Castellano, G.5
Di Vito, M.6
Venturini, E.7
Glunde, K.8
Bhujwalla, Z.M.9
Mezzanzanica, D.10
Canevari, S.11
Podo, F.12
-
9
-
-
3042562283
-
Molecular causes of the aberrant choline phospholipid metabolism in breast cancer
-
Glunde K, Jie C, Bhujwalla ZM. Molecular causes of the aberrant choline phospholipid metabolism in breast cancer. Cancer Res. 2004; 64: 4270-4276.
-
(2004)
Cancer Res.
, vol.64
, pp. 4270-4276
-
-
Glunde, K.1
Jie, C.2
Bhujwalla, Z.M.3
-
10
-
-
73849098309
-
Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling
-
Yalcin A, Clem B, Makoni S, Clem A, Nelson K, Thornburg J, Siow D, Lane AN, Brock SE, Goswami U, Eaton JW, Telang S, Chesney J. Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling. Oncogene 2010; 29: 139-149.
-
(2010)
Oncogene
, vol.29
, pp. 139-149
-
-
Yalcin, A.1
Clem, B.2
Makoni, S.3
Clem, A.4
Nelson, K.5
Thornburg, J.6
Siow, D.7
Lane, A.N.8
Brock, S.E.9
Goswami, U.10
Eaton, J.W.11
Telang, S.12
Chesney, J.13
-
11
-
-
28244464886
-
RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation
-
Glunde K, Raman V, Mori N, Bhujwalla ZM. RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation. Cancer Res. 2005; 65: 11 034-11 043.
-
(2005)
Cancer Res.
, vol.65
-
-
Glunde, K.1
Raman, V.2
Mori, N.3
Bhujwalla, Z.M.4
-
12
-
-
33947127063
-
Phosphocholine as a biomarker of breast cancer: molecular and biochemical studies
-
Eliyahu G, Kreizman T, Degani H. Phosphocholine as a biomarker of breast cancer: molecular and biochemical studies. Int. J. Cancer. 2007; 120: 1721-1730.
-
(2007)
Int. J. Cancer
, vol.120
, pp. 1721-1730
-
-
Eliyahu, G.1
Kreizman, T.2
Degani, H.3
-
13
-
-
0001715433
-
Choline kinase: a novel target for antitumor drugs
-
Lacal JC. Choline kinase: a novel target for antitumor drugs. IDrugs. 2001; 4: 419-426.
-
(2001)
IDrugs
, vol.4
, pp. 419-426
-
-
Lacal, J.C.1
-
14
-
-
0038089964
-
In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery
-
Hernandez-Alcoceba R, Fernandez F, Lacal JC. In vivo antitumor activity of choline kinase inhibitors: a novel target for anticancer drug discovery. Cancer Res. 1999; 59: 3112-3118.
-
(1999)
Cancer Res.
, vol.59
, pp. 3112-3118
-
-
Hernandez-Alcoceba, R.1
Fernandez, F.2
Lacal, J.C.3
-
15
-
-
4644284916
-
Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression
-
Ramirez de Molina A, Banez-Coronel M, Gutierrez R, Rodriguez-Gonzalez A, Olmeda D, Megias D, Lacal JC. Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression. Cancer Res. 2004; 64: 6732-6739.
-
(2004)
Cancer Res.
, vol.64
, pp. 6732-6739
-
-
Ramirez De Molina, A.1
Banez-Coronel, M.2
Gutierrez, R.3
Rodriguez-Gonzalez, A.4
Olmeda, D.5
Megias, D.6
Lacal, J.C.7
-
16
-
-
17944389830
-
Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells
-
Rodriguez-Gonzalez A, Ramirez de Molina A, Fernandez F, Ramos MA, del Carmen Nunez M, Campos J, Lacal JC. Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells. Oncogene 2003; 22: 8803-8812.
-
(2003)
Oncogene
, vol.22
, pp. 8803-8812
-
-
Rodriguez-Gonzalez, A.1
Ramirez De Molina, A.2
Fernandez, F.3
Ramos, M.A.4
Del Carmen Nunez, M.5
Campos, J.6
Lacal, J.C.7
-
17
-
-
4644270297
-
Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action
-
Rodriguez-Gonzalez A, Ramirez de Molina A, Fernandez F. Lacal JC. Choline kinase inhibition induces the increase in ceramides resulting in a highly specific and selective cytotoxic antitumoral strategy as a potential mechanism of action. Oncogene 2004; 23: 8247-8259.
-
(2004)
Oncogene
, vol.23
, pp. 8247-8259
-
-
Rodriguez-Gonzalez, A.1
Ramirez De Molina, A.2
Fernandez, F.3
Lacal, J.C.4
-
18
-
-
65949102790
-
Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft
-
Krishnamachary B, Glunde K, Wildes F, Mori N, Takagi T, Raman V, Bhujwalla ZM. Noninvasive detection of lentiviral-mediated choline kinase targeting in a human breast cancer xenograft. Cancer Res. 2009; 69: 3464-3471.
-
(2009)
Cancer Res.
, vol.69
, pp. 3464-3471
-
-
Krishnamachary, B.1
Glunde, K.2
Wildes, F.3
Mori, N.4
Takagi, T.5
Raman, V.6
Bhujwalla, Z.M.7
-
19
-
-
37049027725
-
Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells
-
Mori N, Glunde K, Takagi T, Raman V, Bhujwalla ZM. Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells. Cancer Res. 2007; 67: 11 284-11 290.
-
(2007)
Cancer Res.
, vol.67
-
-
Mori, N.1
Glunde, K.2
Takagi, T.3
Raman, V.4
Bhujwalla, Z.M.5
-
20
-
-
0025141337
-
What is the evidence that tumors are angiogenesis dependent?
-
Folkman J. What is the evidence that tumors are angiogenesis dependent?. J. Natl. Cancer Inst. 1990; 82: 4-6.
-
(1990)
J. Natl. Cancer Inst.
, vol.82
, pp. 4-6
-
-
Folkman, J.1
-
21
-
-
85013312416
-
Tumor angiogenesis: therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 1971; 285: 1182-1186.
-
(1971)
N. Engl. J. Med.
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
22
-
-
41049094181
-
Judah Folkman, a pioneer in the study of angiogenesis
-
Ribatti D. Judah Folkman, a pioneer in the study of angiogenesis. Angiogenesis 2008; 11: 3-10.
-
(2008)
Angiogenesis
, vol.11
, pp. 3-10
-
-
Ribatti, D.1
-
23
-
-
38349168406
-
Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis
-
Wu G, Aoyama C, Young SG, Vance DE. Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis. J. Biol. Chem. 2008; 283: 1456-1462.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 1456-1462
-
-
Wu, G.1
Aoyama, C.2
Young, S.G.3
Vance, D.E.4
-
24
-
-
64749088438
-
Understanding the muscular dystrophy caused by deletion of choline kinase beta in mice
-
Wu G, Sher RB, Cox GA, Vance DE. Understanding the muscular dystrophy caused by deletion of choline kinase beta in mice. Biochim. Biophys. Acta 2009; 1791: 347-356.
-
(2009)
Biochim. Biophys. Acta
, vol.1791
, pp. 347-356
-
-
Wu, G.1
Sher, R.B.2
Cox, G.A.3
Vance, D.E.4
-
25
-
-
33646205344
-
A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis
-
Sher RB, Aoyama C, Huebsch KA, Ji S, Kerner J, Yang Y, Frankel WN, Hoppel CL, Wood PA, Vance DE, Cox GA. A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis. J. Biol. Chem. 2006; 281: 4938-4948.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 4938-4948
-
-
Sher, R.B.1
Aoyama, C.2
Huebsch, K.A.3
Ji, S.4
Kerner, J.5
Yang, Y.6
Frankel, W.N.7
Hoppel, C.L.8
Wood, P.A.9
Vance, D.E.10
Cox, G.A.11
-
26
-
-
33750435528
-
Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism
-
Glunde K, Serkova NJ. Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism. Pharmacogenomics 2006; 7: 1109-1123.
-
(2006)
Pharmacogenomics
, vol.7
, pp. 1109-1123
-
-
Glunde, K.1
Serkova, N.J.2
-
27
-
-
70649104039
-
Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment
-
Gallego-Ortega D, Ramirez de Molina A, Ramos MA, Valdes-Mora F, Barderas MG, Sarmentero-Estrada J, Lacal JC. Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. PLoS One 2009; 4: e7819.
-
(2009)
PLoS One
, vol.4
-
-
Gallego-Ortega, D.1
Ramirez De Molina, A.2
Ramos, M.A.3
Valdes-Mora, F.4
Barderas, M.G.5
Sarmentero-Estrada, J.6
Lacal, J.C.7
-
28
-
-
0041473368
-
Choline phospholipid metabolites of human vascular endothelial cells altered by cyclooxygenase inhibition, growth factor depletion, and paracrine factors secreted by cancer cells
-
Mori N, Natarajan K, Chacko VP, Artemov D, Bhujwalla ZM. Choline phospholipid metabolites of human vascular endothelial cells altered by cyclooxygenase inhibition, growth factor depletion, and paracrine factors secreted by cancer cells. Mol. Imaging, 2003; 2: 124-130.
-
(2003)
Mol. Imaging
, vol.2
, pp. 124-130
-
-
Mori, N.1
Natarajan, K.2
Chacko, V.P.3
Artemov, D.4
Bhujwalla, Z.M.5
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