Allele-specific imbalance mapping identifies HDAC9 as a candidate gene for cutaneous squamous cell carcinoma

International Journal of Cancer

Volumn 134, Issue 1, 2014, Pages 244-248

  Fleming, Jessica L ^a,b   Dworkin, Amy M ^c   Allain, Dawn C ^b,d   Fernandez, Soledad ^e   Wei, Lai ^e   Peters, Sara B ^e   Iwenofu, O Hans ^e   Ridd, Katie ^f,g   Bastian, Boris C ^f,g   Toland, Amanda Ewart ^a,b,d  

^a 998 Biomedical Research Tower ^*  (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^e OHIO STATE UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

allelic specific imbalance; cutaneous squamous cell carcinoma; HDAC9; Skts5

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; DNA; HISTONE DEACETYLASE;

ALLELIC IMBALANCE; ARTICLE; BASE PAIRING; CARCINOGENESIS; CONTROLLED STUDY; GENE DOSAGE; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENETIC VARIABILITY; GENOTYPE; HDAC9 GENE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MICROSATELLITE MARKER; MOUSE; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN CARCINOMA; SKTS5 GENE; SOMATIC MUTATION;

ALLELIC-SPECIFIC IMBALANCE; CUTANEOUS SQUAMOUS CELL CARCINOMA; HDAC9; SKTS5;

ALLELIC IMBALANCE; CARCINOMA, SQUAMOUS CELL; CHROMOSOME MAPPING; GENOTYPE; HISTONE DEACETYLASES; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRESSOR PROTEINS; SKIN NEOPLASMS;

EID: 84885947801     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28339     Document Type: Article

References (24)

1. www.skincancer.org.
2. Rogers HW, Weinstock MA, Harris AR, et al. Incidence estimate of nonmelanoma skin cancer in the United States. Arch Dermatol 2006; 146: 283-7.
3. Boukamp P,. UV-induced skin cancer: similarities - variations. J Dtsch Dermatol Ges 2005; 3: 493-503.
4. Hemminki K, Zhang H, Czene K,. Familial invasive and in situ squamous cell carcinoma of the skin. Br J Cancer 2003; 88: 1375-80.
5. Lindstrom LS, Yip B, Lichtenstein P, et al. Etiology of familial aggregation in melanoma and squamous cell carcinoma of the skin. Cancer Epidemiol Biomarkers Prev 2007; 16: 1639-43.
6. Nagase H, Mao JH, Balmain A,. A subset of skin tumor modifier loci determines survival time of tumor-bearing mice. Proc Natl Acad Sci U S A 1999; 96: 15032-7.
7. Ewart-Toland A, Briassouli P, de Koning JP, et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet 2003; 34: 403-12.
8. Mahler KL, Fleming JL, Dworkin AM, et al. Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus. BMC Genomics 2008; 9: 1-12.
9. Nagase H, Mao JH, Balmain A,. Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice. Cancer Res 2003; 63: 4849-53.
10. Ewart-Toland A, Dai Q, Gao YT, et al. Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis 2005; 26: 1368-73.
11. Tuupanen S, Turunen M, Lehtonen R, et al. The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat Genet 2009; 41: 885-90.
12. Dworkin AM, Ridd K, Bautista D, et al. Germline variation controls the architecture of somatic alterations in tumors. PLoS Genet 2010; 6: e1001136.
13. Camargo A, Azuaje F, Wang H, et al. Permutation-based statistical tests for multiple hypotheses. Source Code Biol Med 2008; 3: 15.
14. Skeeles LE, Fleming JL, Mahler KL, et al. The impact of 3'UTR variants on differential expression of candidate cancer susceptibility genes. Plos One 2013; 8: e58609.
15. George RE, Attiyeh EF, Li S, et al. Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays. PLoS One 2007; 2: e255.
16. Purdie KJ, Lambert SR, Teh MT, et al. Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer 2007; 46: 661-9.
17. Milde T, Oehme I, Korshunov A, et al. HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth. Clin Cancer Res 2010; 16: 3240-52.
18. Moreno DA, Scrideli CA, Cortez MA, et al. Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia. Br J Haematol 2010; 150: 665-73.
19. Choi YW, Bae SM, Kim YW, et al. Gene expression profiles in squamous cell cervical carcinoma using array-based comparative genomic hybridization analysis. Int J Gynecol Cancer 2007; 17: 687-96.
20. Tao R, de Zoeten EF, Ozkaynak E, et al. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med 2007; 13: 1299-307.
21. Clocchiatti A, Florean C, Brancolini C,. Class IIa HDACs: from important roles in differentiation to possible implications in tumourigenesis. J Cell Mol Med 2011; 15: 1833-46.
22. Morrison BE, D'Mello SR,. Polydactyly in mice lacking HDAC9/HDRP. Exp Biol Med 2008; 233: 980-8.
23. Nishikawa H, Sakaguchi S,. Regulatory T cells in tumor immunity. Int J Cancer 2010; 127: 759-67.
24. Brockschmidt FF, Heilmann S, Ellis JA, et al. Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness. Br J Dermatol 2011; 165: 1293-302.