Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Wang, Yufei ^a   Broderick, Peter ^a   Matakidou, Athena ^b   Eisen, Timothy ^b   Houlston, Richard S ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALLELE; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENIC ACTIVITY; CHRNA3 CHRNA5 GENE; CHROMOSOME 15Q; CIGARETTE SMOKING; CONTROLLED STUDY; CORRELATIONAL STUDY; FEMALE; GENE DOSAGE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; ONCOGENE; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; CHROMOSOME 15; GENETIC PREDISPOSITION; GENETICS; LUNG TUMOR; MIDDLE AGED; RISK; SMOKING;

CHRNA5 PROTEIN, HUMAN; NERVE PROTEIN; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR SUBUNIT ALPHA3;

AGED; ALLELES; CHROMOSOMES, HUMAN, PAIR 15; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; ODDS RATIO; RECEPTORS, NICOTINIC; RISK; SMOKING;

EID: 79955725571     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019085     Document Type: Article

References (31)

1. Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, et al. (2008) Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet 40: 616-622.
2. Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, et al. (2008) A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452: 633-637.
3. Thorgeirsson TE, Geller F, Sulem P, Rafnar T, Wiste A, et al. (2008) A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452: 638-642.
4. Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, et al. (2007) Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet 16: 36-49.
5. Saccone NL, Culverhouse RC, Schwantes-An TH, Cannon DS, Chen X, et al. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet 6.
6. Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 42: 436-440.
7. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 42: 441-447.
8. Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 42: 448-453.
9. Lips EH, Gaborieau V, McKay JD, Chabrier A, Hung RJ, et al. Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. Int J Epidemiol 39: 563-577.
10. Spitz MR, Amos CI, Dong Q, Lin J, Wu X, (2008) The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. J Natl Cancer Inst 100: 1552-1556.
11. Falvella FS, Galvan A, Frullanti E, Spinola M, Calabro E, et al. (2009) Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk. Clin Cancer Res 15: 1837-1842.
12. Broderick P, Wang Y, Vijayakrishnan J, Matakidou A, Spitz MR, et al. (2009) Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. Cancer Res 69: 6633-6641.
13. Wang Y, Broderick P, Webb E, Wu X, Vijayakrishnan J, et al. (2008) Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat Genet 40: 1407-1409.
14. Eisen T, Matakidou A, Houlston R, (2008) Identification of low penetrance alleles for lung cancer: the GEnetic Lung CAncer Predisposition Study (GELCAPS). BMC Cancer 8: 244.
15. Lorenzo Bermejo J, Hemminki K, (2005) Familial lung cancer and aggregation of smoking habits: a simulation of the effect of shared environmental factors on the familial risk of cancer. Cancer Epidemiol Biomarkers Prev 14: 1738-1740.
16. Pettiti D, (1994) Meta-analysis Decision Analysis and Cost effectiveness Analysis. Oxford University Press, Oxford, New York.
17. Higgins JP, Thompson SG, (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539-1558.
18. Shiraishi K, Kohno T, Kunitoh H, Watanabe S, Goto K, et al. (2009) Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. Carcinogenesis 30: 65-70.
19. Truong T, Hung RJ, Amos CI, Wu X, Bickeboller H, et al. Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst 102: 959-971.
20. Doll R, Peto R, (1978) Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers. J Epidemiol Community Health 32: 303-313.
21. Flanders WD, Lally CA, Zhu BP, Henley SJ, Thun MJ, (2003) Lung cancer mortality in relation to age, duration of smoking, and daily cigarette consumption: results from Cancer Prevention Study II. Cancer Res 63: 6556-6562.
22. Weiss RB, Baker TB, Cannon DS, von Niederhausern A, Dunn DM, et al. (2008) A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet 4: e1000125.
23. Freathy RM, Ring SM, Shields B, Galobardes B, Knight B, et al. (2009) A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. Hum Mol Genet 18: 2922-2927.
24. Broms U, Silventoinen K, Madden PA, Heath AC, Kaprio J, (2006) Genetic architecture of smoking behavior: a study of Finnish adult twins. Twin Res Hum Genet 9: 64-72.
25. Peto R, Darby S, Deo H, Silcocks P, Whitley E, et al. (2000) Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ 321: 323-329.
26. Li X, Hemminki K, (2005) Familial multiple primary lung cancers: a population-based analysis from Sweden. Lung Cancer 47: 301-307.
27. Gorber SC, Schofield-Hurwitz S, Hardt J, Levasseur G, Tremblay M, (2009) The accuracy of self-reported smoking: a systematic review of the relationship between self-reported and cotinine-assessed smoking status. Nicotine Tob Res 11: 12-24.
28. Le Marchand L, Derby KS, Murphy SE, Hecht SS, Hatsukami D, et al. (2008) Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer Res 68: 9137-9140.
29. Falvella FS, Galvan A, Colombo F, Frullanti E, Pastorino U, et al. Promoter polymorphisms and transcript levels of nicotinic receptor CHRNA5. J Natl Cancer Inst 102: 1366-1370.
30. Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Grucza RA, et al. (2008) Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry 165: 1163-1171.
31. Galvan A, Dragani TA, Nicotine dependence may link the 15q25 locus to lung cancer risk. Carcinogenesis 31: 331-333.