Cytometric profiling of CD133+ cells in human colon carcinoma cell lines identifies a common core phenotype and cell type-specific mosaics

International Journal of Biological Markers

Volumn 28, Issue 3, 2013, Pages 267-273

  Gemei, Marica ^a   Di Noto, Rosa ^a,b   Mirabelli, Peppino ^c   Del Vecchio, Luigi ^a,b  

^a CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c IRCCS SDN   (Italy)

Author keywords

Cancer stem cells; CD133; Colorectal carcinoma; Flow cytometry; Surface markers

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALPHA2 INTEGRIN; ALPHA6 INTEGRIN; BETA1 INTEGRIN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; CD133 ANTIGEN; CD151 ANTIGEN; CD164 ANTIGEN; CD200 ANTIGEN; CD24 ANTIGEN; CD34 ANTIGEN; CD47 ANTIGEN; CD56 ANTIGEN; CD59 ANTIGEN; CD81 ANTIGEN; CD9 ANTIGEN; CD99 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; DECAY ACCELERATING FACTOR; DIPEPTIDYL PEPTIDASE IV; EPITHELIAL CELL ADHESION MOLECULE; HERMES ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; LEUKOSIALIN; MICROSOMAL AMINOPEPTIDASE; NECTIN 2; THY 1 ANTIGEN; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE; TUMOR MARKER;

ARTICLE; CELL MATURATION; COLON CARCINOMA; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOPHENOTYPING; PHENOTYPE; PROTEIN EXPRESSION; CANCER STEM CELL; COLON TUMOR; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTIGENS, CD; BIOMARKERS, TUMOR; CELL LINE, TUMOR; COLONIC NEOPLASMS; FLOW CYTOMETRY; GLYCOPROTEINS; HUMANS; NEOPLASTIC STEM CELLS; PEPTIDES; PHENOTYPE;

EID: 84885926442     PISSN: 03936155     EISSN: 17246008     Source Type: Journal    
DOI: 10.5301/JBM.5000020     Document Type: Article

References (39)

1. Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008; 8: 755-68.
2. Dalerba P, Dylla SJ, Park IK, et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 2007; 104: 10158-63.
3. Vermeulen L, Todaro M, de Sousa Mello F, et al. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc Natl Acad Sci USA 2008; 105: 13427-32.
4. Galizia G, Gemei M, Del Vecchio L, et al. Combined expression of cancer stem cell markers CD133 and CD44 is an independent prognostic indicator of disease-free survival in colo-rectal cancer patients undergoing potentially curative surgery. Ann Surg 2012; 147: 18-24.
5. Yin AH, Miraglia, S, Zanjani, Almeida-Porada ED, Ogawa GM, Leary AG. AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 1997; 90: 5002-12.
6. Uchida N, Buck DW, He D, et al. Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci USA 2000; 97: 14720-5.
7. Gemei M, Mirabelli P, Di Noto R, Fortunato G, Del Vecchio L. Divergent expression of CD133 in different studies on HCT-116 cell line. International Journal of Cancer 2010; 128: 998-1000.
8. + sector is enlarged by hypoxia. Int J Radiat Oncol Biol Phys 2007; 67: 1-5.
9. Mariotti E, Gemei M, Mirabelli P, et al. The percentage of CD133+ cells in human colorectal cancer cell lines is influenced by Mycoplasma hyorhinis infection. BMC Cancer 2009; 10: 120.
10. - metastatic colon cancer cells initiate tumors. J Clin Invest 2008; 118: 2111-20.
11. Du L, Wang H, He L, et al. CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 2008; 14: 6751-60.
12. Yeung TM, Gandhi SC, Wilding JL, Muschel R, Bodmer WF. Cancer stem cells from colorectal cancer-derived cell lines. Proc Natl Acad Sci USA 2010; 107: 3722-7.
13. + colon cancer cells indicates activation of the Wnt pathway and up-regulation of SRp20 that is potentially involved in tumorigenicity. Proteomics 2012; 12: 2045-59.
14. Gemei M, Mirabelli P, Di Noto R, et al. CD66c is a novel marker for colorectal cancer stem cell isolation and its silencing halts tumor growth in vivo. Cancer 2012; 119: 729-38.
15. Flatmark K, Maelandsmo GM, Martinsen M, Rasmussen H, Fodstad Ø. Twelve colorectal cancer cell lines exhibit highly variable growth and metastatic capacities in an orthotopic model in nude mice. Eur J Cancer 2004; 40: 1593-8.
16. Hamada K, Monnai M, Kawai K, et al. Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rgammanull (NOG) mice. Int J Oncol 2008; 32: 153-9.
17. Rose RJ, Wang J, Hu P, Le Vea C, Brattain MG, Rajput A. Characterization of the GEO human colon cancer cell line in an orthotopic model of colon cancer. Journal of Surgical Research 2006; 130: 258.
18. de Vries JE, Dinjens WN, De Bruyne GK, et al. In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells. Br J Cancer 1995; 71: 271-7.
19. Nakamura Y, Chang CC, Mori T, et al. Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells. Carcinogenesis 2005; 26: 665-71.
20. Fitzgerald RC, Omary MB, Triadafilopoulos G. Acid modulation of HT29 cell growth and differentiation. An in vitro model for Barrett's esophagus. J Cell Sci 1997; 110: 663-71.
21. Sambuy Y, De Angelis I, Ranaldi G, Scarino ML, Stammati A, Zucco F. The Caco2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco2 cell functional characteristics. Cell Biol Toxicol 2005; 21: 1-26.
22. Boyd D, Florent G, Chakrabarty S, Brattain D, Brattain MG. Alterations of the biological characteristics of a colon carcinoma cell line by colon derived substrata material. Cancer Res 1988; 48: 2825-31.
23. Richardson MM, Jennings LK, Zhang XA. Tetraspanins and tumor progression. Clin Exp Metastasis 2011; 28: 261-70.
24. Zöller M. Tetraspanins: push and pull in suppressing and promoting metastasis. Nat Rev Cancer 2009; 9: 40-55.
25. Osta WA, Chen Y, Mikhitarian K, et al. EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res 2004; 64: 5818-24.
26. Yang GY, Xu KS, Pan ZQ, et al. Integrin alpha v beta 6 mediates the potential for colon cancer cells to colonize in and metastasize to the liver. Cancer Sci 2008; 99: 879-87.
27. Ovalle S, Gutierrez-Lopez MD, Olmo N, et al. The tetraspanin CD9 inhibits the proliferation and tumorigenicity of human colon carcinoma cells. Int J Cancer 2007; 121: 2140-52.
28. Hasegawa M, Furuya M, Kasuya Y, et al. CD151 dynamics in carcinoma-stroma interaction: integrin expression, adhesion strength and proteolytic activity. Lab Invest 2007; 87: 882-92.
29. Ravindranath NM, Shuler C. Cell-surface density of complement restriction factors (CD46, CD55, and CD59): oral squamous cell carcinoma versus other solid tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 103: 231-9.
30. Silk AW, Schoen RE, Potter DM, Finn OJ. Humoral immune response to abnormal MUC1 in subjects with colorectal adenoma and cancer. Mol Immunol 2009; 47: 52-6.
31. Majeti R, Chao MP, Alizadeh AA, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 2009; 138: 286-99.
32. Zhu Z, Hao X, Yan M, et al. Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma. Int J Cancer 2010; 126: 2067-78.
33. Kawasaki BT, Mistree T, Hurt EM, Kalathur M, Farrar WL. Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells. Biochem Biophys Res Commun 2007; 364: 778-82.
34. Pang R, Law WL, Chu AC, et al. A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer. Cell Stem Cell 2010; 6: 603-15.
35. Conrad F, Zhu X, Zhang X, et al. Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion. J Mol Med 2009; 87: 507-14.
36. Mazzocca A, Liotta F, Carloni V. Tetraspanin CD81-regulated cell motility plays a critical role in intrahepatic metastasis of hepatocellular carcinoma. Gastroenterology 2008; 135: 244-56.
37. Matsui T, Kurosawa N, Hibi K, et al. The ratio of splicing variants of MGC-24/CD164, a sialomucin, correlates with the metastatic potential of colorectal carcinomas. J Biochem 2000; 127: 1103-7.
38. Strickland LA, Ross J, Williams S, et al. Preclinical evaluation of carcinoembryonic cell adhesion molecule (CEACAM) 6 as potential therapy target for pancreatic adenocarcinoma. J Pathol 2009; 218: 380-90.
39. Sun YF, Yang XR, Zhou J, Qiu SJ, Fan J, Xu Y. Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance. J Cancer Res Clin Oncol 2011; 137: 1151-73.