The ratio of splicing variants of MGC-24/CD164, a sialomucin, correlates with the metastatic potential of colorectal carcinomas

Journal of Biochemistry

Volumn 127, Issue 6, 2000, Pages 1103-1107

  Matsui, Takanori ^a   Kurosawa, Nobuyuki ^a   Hibi, Kenji ^a   Akiyama, Seiji ^a   Kasai, Yasushi ^a   Sakamoto, Junichi ^b   Ito, Katsuki ^a   Nakao, Akimasa ^a   Muramatsu, Takashi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI PREFECTURAL UNIVERSITY   (Japan)

Author keywords

CD164; Colorectal carcinomas; Metastasis; Sialomucin; Vascular invasion

Indexed keywords

RNA; SIALOMUCIN;

ALTERNATIVE RNA SPLICING; ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; MOLECULAR RECOGNITION; PROTEIN EXPRESSION; RIBONUCLEASE PROTECTION ASSAY;

EID: 0033933512     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022704     Document Type: Article

References (16)

1. Lasky, L.A., Singer, M.S., Dewbenko, D., Imai, Y., Henzel, W.J., Grimley, C., Fennie, C., Gillett, N., Watson, S.R., and Rosen, S.D. (1992) An endothelial ligand for L-selectin is a novel mucin-like molecule. Cell 69, 927-938
2. Briskin, M., McEvoy, L.M., and Butcher, E.G. (1993) MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. Nature 363, 461-464
3. Shimizu, Y. and Shaw, S. (1993) Cell adhesion. Mucins in the mainstream. Nature 366, 630-631
4. Nakamori, S., Ota, D.M., Cleary, K.R., Shirotani, K., and Irimura, T. (1994) MUC 1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma. Gastroenterology 106, 353-361
5. Utsunomiya, T., Yonezawa, S., Sakamoto, H., Kitamura, H., Hokita, S., Aiko, T., Tanaka, S., Irimura, T., Kim, Y.S., and Sato, E. (1998) Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients. Clin. Cancer Res. 4, 2605-2614
6. Hilkens, J., Ligtenberg, M.J., Vos, H.L., and Litvinov, S.V. (1992) Cell membrance-associated mucins and their adhesion-modulating property. Trends Biochem. Sci. 17, 359-363
7. Wesseling, J., van der Valk, S.W., Vos, H.L., Sonneberg, A., and Hilkens, J. (1995) Episialin (MUC 1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J. Cell Biol. 129, 255-265
8. Hanski, C., Riede, E., Gratchev, A., Foss, H.D., Bohm, C., Klussmann, E., Hummel, M., Mann, B., Buhr, H.J., Stein, H., Kim, Y.S., Gum, J., and Riecken, E.O. (1997) MUC2 gene suppression in human colorectal carcinomas and their metastasis: in vivo evidence for the modulatory role of DNA methylation. Lab. Invest. 17, 685-695
9. Muramatsu, T. (1993) Carbohydrate signals in metastasis and prognosis of human carcinomas. Glycobiology 3, 294-296
10. Masuzawa, Y., Miyauchi, T., Hamanoue, M., Ando, S., Yoshida, J., Takao, S., Shimazu, H., and Adachi, T. (1992) A novel core protein as well as polymorphic epithelial mucin carry peanut agglutinin binding sites in human gastric carcinoma cells: sequence analysis and examination of gene expression. J. Biochem. 112, 609-615
11. Zannettino, A.C., Buhring, H.J., Niutta, S., Watt, S.M., Benton, M.A., and Simmons, P.J. (1998) The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. Blood 92, 2613-2628
12. Watt, S.M., Buhring, H.J., Rappold, I., Chan, J.Y., Lee-prudhoe, J., Jones, T., Zannettino, A.C., Simmons, P.J., Doyonnas, R., Sheer, D., and Butler, L.H. (1998) CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21. Blood 92, 849-866
13. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159
14. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
15. Kurosawa, N., Kanemitsu, Y., Matsui, T., Shimada, K., Ishihama, H., and Muramatsu, T. (1999) Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164. Eur. J. Biochem. 265, 466-472
16. Japanese society for Cancer of the Colon and Rectum (1996) General Rules for Clinical and Pathological Studies on Cancer the Colon, Rectum and Anus (6th ed.), Kanehara, Tokyo