메뉴 건너뛰기




Volumn 6, Issue 5, 2013, Pages 525-537

Bendamustine for indolent non-Hodgkin lymphoma in the front-line or relapsed setting: A review of pharmacokinetics and clinical trial outcomes

Author keywords

bendamustine; follicular lymphoma; indolent; mantle cell lymphoma; non Hodgkin lymphoma

Indexed keywords

ANTIINFECTIVE AGENT; BENDAMUSTINE; BORTEZOMIB; CARFILZOMIB; CARMUSTINE; CYCLOPHOSPHAMIDE; CYTARABINE; DOXORUBICIN; ELOTUZUMAB; ETOPOSIDE; IDELALISIB; LENALIDOMIDE; MELPHALAN; MITOXANTRONE; PREDNISONE; RITUXIMAB; VINCRISTINE;

EID: 84885914365     PISSN: 17474086     EISSN: 17474094     Source Type: Journal    
DOI: 10.1586/17474086.2013.841538     Document Type: Review
Times cited : (7)

References (56)
  • 2
    • 84871763008 scopus 로고    scopus 로고
    • Curability of advanced indolent or low-grade follicular lymphomas: Time for a new paradigm?
    • Cabanillas F. Curability of advanced indolent or low-grade follicular lymphomas: time for a new paradigm? J. Clin. Oncol. 31, 14-16 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 14-16
    • Cabanillas, F.1
  • 3
    • 21444451109 scopus 로고    scopus 로고
    • Advances in molecular biology diagnostic and treatment of B-cell malignancies: Indolent B-cell lymphoma
    • Dreyling M, Buske C, Hiddemann W. Advances in molecular biology diagnostic and treatment of B-cell malignancies: indolent B-cell lymphoma. Ann. Oncol. 16 (Suppl. 2), ii99-ii104 (2005).
    • (2005) Ann. Oncol. , vol.16 , Issue.SUPPL. 2
    • Dreyling, M.1    Buske, C.2    Hiddemann, W.3
  • 4
    • 0042385037 scopus 로고    scopus 로고
    • ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of newly diagnosed follicular lymphoma
    • Hiddemann W; European Society for Medical Oncology. ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of newly diagnosed follicular lymphoma. Ann. Oncol. 14, 1163-1164 (2003).
    • (2003) Ann. Oncol. , vol.14 , pp. 1163-1164
    • Hiddemann, W.1
  • 5
    • 41149129462 scopus 로고    scopus 로고
    • Chemotherapy combinations with monoclonal antibodies in non-Hodgkin's lymphoma
    • Kahl B. Chemotherapy combinations with monoclonal antibodies in non-Hodgkin's lymphoma. Semin. Hematol. 45, 90-94 (2008).
    • (2008) Semin. Hematol. , vol.45 , pp. 90-94
    • Kahl, B.1
  • 6
    • 84875594520 scopus 로고    scopus 로고
    • ESMO Consensus conferences: Guidelines on malignant lymphoma part 2: Marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma
    • Dreyling M, Thieblemont C, Gallamini A et al. ESMO Consensus conferences: guidelines on malignant lymphoma part 2: marginal zone lymphoma, mantle cell lymphoma, peripheral T-cell lymphoma. Ann. Oncol. 24(4), 857-877 (2013)
    • (2013) Ann. Oncol. , vol.24 , Issue.4 , pp. 857-877
    • Dreyling, M.1    Thieblemont, C.2    Gallamini, A.3
  • 7
    • 33646894078 scopus 로고    scopus 로고
    • Mantle cell lymphoma: An update on management
    • Zelenetz AD. Mantle cell lymphoma: an update on management. Ann. Oncol. 17 (Suppl. 4), iv12-iv14 (2006).
    • (2006) Ann. Oncol. , vol.17 , Issue.SUPPL. 4
    • Zelenetz, A.D.1
  • 8
    • 72049112821 scopus 로고    scopus 로고
    • Temsirolimus in mantle cell lymphoma and other non-Hodgkin lymphoma subtypes
    • Hess G, Smith SM, Berkenblit A, Coiffier B. Temsirolimus in mantle cell lymphoma and other non-Hodgkin lymphoma subtypes. Semin. Oncol. 36 (Suppl. 36), S37-S45 (2009).
    • (2009) Semin. Oncol. , vol.36 , Issue.SUPPL. 36
    • Hess, G.1    Smith, S.M.2    Berkenblit, A.3    Coiffier, B.4
  • 9
    • 84860158536 scopus 로고    scopus 로고
    • Bortezomib: A proteasome inhibitor with an evolving role in select subtypes of B-cell non-Hodgkin's lymphoma
    • Koprivnikar JL, Cheson BD. Bortezomib: a proteasome inhibitor with an evolving role in select subtypes of B-cell non-Hodgkin's lymphoma. Future Oncol. 8, 359-371 (2012).
    • (2012) Future Oncol. , vol.8 , pp. 359-371
    • Koprivnikar, J.L.1    Cheson, B.D.2
  • 10
    • 84871806385 scopus 로고    scopus 로고
    • Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies
    • Advani RH, Buggy JJ, Sharman JP et al. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies. J. Clin. Oncol. 31, 88-94 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 88-94
    • Advani, R.H.1    Buggy, J.J.2    Sharman, J.P.3
  • 11
    • 28544435078 scopus 로고    scopus 로고
    • Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: Results of a prospective randomized study of the German Low-Grade L ymphoma Study Group
    • Hiddemann W, Kneba M, Dreyling M et al. Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: results of a prospective randomized study of the German Low-Grade L ymphoma Study Group. Blood 106, 3725-3732 (2005).
    • (2005) Blood , vol.106 , pp. 3725-3732
    • Hiddemann, W.1    Kneba, M.2    Dreyling, M.3
  • 12
    • 13244270361 scopus 로고    scopus 로고
    • CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma
    • Marcus R, Imrie K, Belch A et al. CVP chemotherapy plus rituximab compared with CVP as first-line treatment for advanced follicular lymphoma. Blood 105, 1417-1423 (2005).
    • (2005) Blood , vol.105 , pp. 1417-1423
    • Marcus, R.1    Imrie, K.2    Belch, A.3
  • 13
    • 20144376591 scopus 로고    scopus 로고
    • Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: Results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG)
    • Lenz G, Dreyling M, Hoster E et al. Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG). J. Clin. Oncol. 23, 1984-1992 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 1984-1992
    • Lenz, G.1    Dreyling, M.2    Hoster, E.3
  • 14
    • 67651159290 scopus 로고    scopus 로고
    • R-CHOP versus R-CVP in the treatment of follicular lymphoma: A meta-analysis and critical appraisal of current literature
    • Siddhartha G, Vijay P. R-CHOP versus R-CVP in the treatment of follicular lymphoma: a meta-analysis and critical appraisal of current literature. J. Hematol Oncol. 2, 14 (2009).
    • (2009) J. Hematol Oncol. , vol.2 , pp. 14
    • Siddhartha, G.1    Vijay, P.2
  • 15
    • 74549225036 scopus 로고    scopus 로고
    • Bendamustine is effective therapy in patients with rituximab-refractory, indolent B-cell non-Hodgkin lymphoma: Results from a multicenter study
    • Kahl BS, Bartlett NL, Leonard JP et al Bendamustine is effective therapy in patients with rituximab-refractory, indolent B-cell non-Hodgkin lymphoma: results from a multicenter study. Cancer 116, 106-114 (2010).
    • (2010) Cancer , vol.116 , pp. 106-114
    • Kahl, B.S.1    Bartlett, N.L.2    Leonard, J.P.3
  • 16
    • 38349119981 scopus 로고    scopus 로고
    • Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: Results from a Phase II multicenter, single-agent study
    • Friedberg JW, Cohen P, Chen L et al Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: results from a Phase II multicenter, single-agent study. J. Clin. Oncol. 26, 204-210 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 204-210
    • Friedberg, J.W.1    Cohen, P.2    Chen, L.3
  • 17
    • 84874568508 scopus 로고    scopus 로고
    • ESMO Guidelines consensus conference on malignant lymphoma (2011) part 1: Diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL)
    • Ghielmini M, Vitolo U, Kimby E et al. ESMO Guidelines consensus conference on malignant lymphoma (2011) part 1: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL). Ann. Oncol. 24, 561-576 (2013).
    • (2013) Ann. Oncol. , vol.24 , pp. 561-576
    • Ghielmini, M.1    Vitolo, U.2    Kimby, E.3
  • 18
    • 84885932251 scopus 로고    scopus 로고
    • Different safety profiles of first-line bendamustine-rituximab (BR), R-CHOP, and R-CVP in an open-label, randomized study of indolent non-Hodgkin lymphoma (NHL) and mantle cell lymphoma (MCL): The BRIGHT study. Presented at: American Society of Clinical Oncology Annual Meeting. Chicago, IL, USA, 31 May-4 June 2013
    • Abstract 8565
    • MacDonald D, Van der Jagt RH, Burke JM et al. Different safety profiles of first-line bendamustine-rituximab (BR), R-CHOP, and R-CVP in an open-label, randomized study of indolent non-Hodgkin lymphoma (NHL) and mantle cell lymphoma (MCL): The BRIGHT study. Presented at: American Society of Clinical Oncology Annual Meeting. Chicago, IL, USA, 31 May-4 June 2013. J Clin Oncol. 31 (15 Suppl.), Abstract 8565 (2013).
    • (2013) J Clin Oncol. , vol.31 , Issue.15 SUPPL.
    • MacDonald, D.1    Van Der Jagt, R.H.2    Burke, J.M.3
  • 19
    • 40749085662 scopus 로고    scopus 로고
    • Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents
    • Leoni LM, Bailey B, Reifert J et al Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin. Cancer Res. 14, 309-317 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 309-317
    • Leoni, L.M.1    Bailey, B.2    Reifert, J.3
  • 20
    • 0036340122 scopus 로고    scopus 로고
    • Metabolism and mechanisms of action of bendamustine: Rationales for combination therapies
    • Gandhi V. Metabolism and mechanisms of action of bendamustine: rationales for combination therapies. Semin. Oncol. 29, 4-11 (2002).
    • (2002) Semin. Oncol. , vol.29 , pp. 4-11
    • Gandhi, V.1
  • 21
    • 34249795785 scopus 로고    scopus 로고
    • A Phase i study of bendamustine hydrochloride administered day 1+2 every 3 weeks in patients with solid tumours
    • Rasschaert M, Schrijvers D, Van den Brande J et al. A Phase I study of bendamustine hydrochloride administered day 1+2 every 3 weeks in patients with solid tumours. Br. J. Cancer 96, 1692-1698 (2007).
    • (2007) Br. J. Cancer , vol.96 , pp. 1692-1698
    • Rasschaert, M.1    Schrijvers, D.2    Van Den Brande, J.3
  • 22
    • 78149406113 scopus 로고    scopus 로고
    • Bendamustine pharmacokinetic profile and exposure-response relationships in patients with indolent non-Hodgkin's lymphoma
    • Owen JS, Melhem M, Passarell JA et al. Bendamustine pharmacokinetic profile and exposure-response relationships in patients with indolent non-Hodgkin's lymphoma. Cancer Chemother. Pharmacol. 66, 1039-1049 (2010).
    • (2010) Cancer Chemother. Pharmacol. , vol.66 , pp. 1039-1049
    • Owen, J.S.1    Melhem, M.2    Passarell, J.A.3
  • 23
    • 33947305075 scopus 로고    scopus 로고
    • Characterization of two Phase i metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride
    • Teichert J, Baumann F, Chao Q et al Characterization of two Phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride. Cancer Chemother. Pharmacol. 59, 759-770 (2007).
    • (2007) Cancer Chemother. Pharmacol. , vol.59 , pp. 759-770
    • Teichert, J.1    Baumann, F.2    Chao, Q.3
  • 24
    • 84876209316 scopus 로고    scopus 로고
    • Pharmacokinetics and excretion of C-bendamustine in patients with relapsed or refractory malignancy
    • Dubbelman AC, Rosing H, Darwish M et al. Pharmacokinetics and excretion of C-bendamustine in patients with relapsed or refractory malignancy. Drugs R.D. 13(1), 17-28 (2013).
    • (2013) Drugs R.D. , vol.13 , Issue.1 , pp. 17-28
    • Dubbelman, A.C.1    Rosing, H.2    Darwish, M.3
  • 25
    • 0036340334 scopus 로고    scopus 로고
    • Phase i studies with bendamustine: An update
    • Schrijvers D, Vermorken JB. Phase I studies with bendamustine: an update. Semin. Oncol. 29, 15-18 (2002).
    • (2002) Semin. Oncol. , vol.29 , pp. 15-18
    • Schrijvers, D.1    Vermorken, J.B.2
  • 26
    • 0033986945 scopus 로고    scopus 로고
    • Repeated administration of short infusions of bendamustine: A Phase i study in patients with advanced progressive solid tumours
    • Schoffski P, Hagedorn T, Grunwald V et al Repeated administration of short infusions of bendamustine: a Phase I study in patients with advanced progressive solid tumours. J. Cancer Res. Clin. Oncol. 126, 41-47 (2000).
    • (2000) J. Cancer Res. Clin. Oncol. , vol.126 , pp. 41-47
    • Schoffski, P.1    Hagedorn, T.2    Grunwald, V.3
  • 27
    • 0033744194 scopus 로고    scopus 로고
    • Weekly administration of bendamustine: A Phase i study in patients with advanced progressive solid tumours
    • Schoffski P, Seeland G, Engel H et al. Weekly administration of bendamustine: a Phase I study in patients with advanced progressive solid tumours. Ann. Oncol. 11, 729-734 (2000).
    • (2000) Ann. Oncol. , vol.11 , pp. 729-734
    • Schoffski, P.1    Seeland, G.2    Engel, H.3
  • 28
    • 77955937622 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of bendamustine hydrochloride in relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma
    • Ogura M, Uchida T, Taniwaki M et al. Phase I and pharmacokinetic study of bendamustine hydrochloride in relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma. Cancer Sci. 101, 2054-2058 (2010).
    • (2010) Cancer Sci. , vol.101 , pp. 2054-2058
    • Ogura, M.1    Uchida, T.2    Taniwaki, M.3
  • 29
    • 77953670179 scopus 로고    scopus 로고
    • Optimal use of bendamustine in chronic lymphocytic leukemia, non-Hodgkin lymphomas, and multiple myeloma: Treatment recommendations from an international consensus panel
    • Cheson BD, Wendtner CM, Pieper A et al. Optimal use of bendamustine in chronic lymphocytic leukemia, non-Hodgkin lymphomas, and multiple myeloma: treatment recommendations from an international consensus panel. Clin. Lymphoma Myeloma Leuk. 10, 21-27 (2010).
    • (2010) Clin. Lymphoma Myeloma Leuk. , vol.10 , pp. 21-27
    • Cheson, B.D.1    Wendtner, C.M.2    Pieper, A.3
  • 30
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • Knauf WU, Lissichkov T, Aldaoud A et al Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J. Clin. Oncol. 27, 4378-4384 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4378-4384
    • Knauf, W.U.1    Lissichkov, T.2    Aldaoud, A.3
  • 31
    • 84866531516 scopus 로고    scopus 로고
    • Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: A multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group
    • Fischer K, Cramer P, Busch R et al Bendamustine in combination with rituximab for previously untreated patients with chronic lymphocytic leukemia: a multicenter phase II trial of the German Chronic Lymphocytic Leukemia Study Group. J. Clin. Oncol. 30, 3209-3216 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 3209-3216
    • Fischer, K.1    Cramer, P.2    Busch, R.3
  • 32
    • 52649177173 scopus 로고    scopus 로고
    • Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma
    • Robinson KS, Williams ME, van der Jagt RH et al. Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma. J. Clin. Oncol. 26, 4473-4479 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , pp. 4473-4479
    • Robinson, K.S.1    Williams, M.E.2    Van Der Jagt, R.H.3
  • 33
    • 34447549127 scopus 로고    scopus 로고
    • High anti-lymphoma activity of bendamustine/mitoxantrone/rituximab in rituximab pretreated relapsed or refractory indolent lymphomas and mantle cell lymphomas. A multicenter Phase II study of the German Low Grade Lymphoma Study Group (GLSG)
    • Weide R, Hess G, Koppler H et al. High anti-lymphoma activity of bendamustine/mitoxantrone/rituximab in rituximab pretreated relapsed or refractory indolent lymphomas and mantle cell lymphomas. A multicenter Phase II study of the German Low Grade Lymphoma Study Group (GLSG). Leuk. Lymphoma 48, 1299-1306 (2007).
    • (2007) Leuk. Lymphoma , vol.48 , pp. 1299-1306
    • Weide, R.1    Hess, G.2    Koppler, H.3
  • 34
    • 79953077610 scopus 로고    scopus 로고
    • The combination of bendamustine, bortezomib, and rituximab for patients with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma
    • Friedberg JW, Vose JM, Kelly JL et al. The combination of bendamustine, bortezomib, and rituximab for patients with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma. Blood. 117, 2807-12 (2011).
    • (2011) Blood. , vol.117 , pp. 2807-2812
    • Friedberg, J.W.1    Vose, J.M.2    Kelly, J.L.3
  • 35
    • 80052746696 scopus 로고    scopus 로고
    • Bortezomib, bendamustine, and rituximab in patients with relapsed or refractory follicular lymphoma: The Phase II VERTICAL study
    • Fowler N, Kahl BS, Lee P et al. Bortezomib, bendamustine, and rituximab in patients with relapsed or refractory follicular lymphoma: the Phase II VERTICAL study. J. Clin. Oncol. 29, 3389-3395 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3389-3395
    • Fowler, N.1    Kahl, B.S.2    Lee, P.3
  • 36
    • 84875606235 scopus 로고    scopus 로고
    • Combination of rituximab, bendamustine, and cytarabine for patients with mantle-cell non-Hodgkin lymphoma ineligible for intensive regimens or autologous transplantation
    • Visco C, Finotto S, Zambello R et al. Combination of rituximab, bendamustine, and cytarabine for patients with mantle-cell non-Hodgkin lymphoma ineligible for intensive regimens or autologous transplantation. J. Clin. Oncol. 31, 1442-1449 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 1442-1449
    • Visco, C.1    Finotto, S.2    Zambello, R.3
  • 37
    • 33646986211 scopus 로고    scopus 로고
    • Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin's lymphoma and mantle cell lymphoma: Results of a randomised phase III trial (OSHO# 19)
    • Herold M, Schulze A, Niederwieser D et al. Bendamustine, vincristine and prednisone (BOP) versus cyclophosphamide, vincristine and prednisone (COP) in advanced indolent non-Hodgkin's lymphoma and mantle cell lymphoma: results of a randomised phase III trial (OSHO# 19). J. Cancer Res. Clin. Oncol. 132, 105-112 (2006).
    • (2006) J. Cancer Res. Clin. Oncol. , vol.132 , pp. 105-112
    • Herold, M.1    Schulze, A.2    Niederwieser, D.3
  • 38
    • 84885921804 scopus 로고    scopus 로고
    • An open-label, randomized study of bendamustine and rituximab (BR) compared with rituximab, cyclophosphamide, vincristine, and prednisone (R-CVP) or rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in first-line treatment of patients with advanced indolent non-Hodgkin's lymphoma (NHL) or mantle cell lymphoma (MCL): The Bright Study
    • Abstract 902
    • Flinn IW, Van der Jagt RH, Kahl BS et al. An open-label, randomized study of bendamustine and rituximab (BR) compared with rituximab, cyclophosphamide, vincristine, and prednisone (R-CVP) or rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in first-line treatment of patients with advanced indolent non-Hodgkin's lymphoma (NHL) or mantle cell lymphoma (MCL): The Bright Study. Blood 120, Abstract 902 (2012).
    • (2012) Blood , vol.120
    • Flinn, I.W.1    Van Der Jagt, R.H.2    Kahl, B.S.3
  • 39
    • 84875840492 scopus 로고    scopus 로고
    • Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: An open-label, multicentre, randomised, Phase 3 non-inferiority trial
    • Rummel MJ, Niederle N, Maschmeyer G et al. Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, Phase 3 non-inferiority trial. Lancet 381(9873), 1203-1210 (2013).
    • (2013) Lancet , vol.381 , Issue.9873 , pp. 1203-1210
    • Rummel, M.J.1    Niederle, N.2    Maschmeyer, G.3
  • 40
    • 84885905113 scopus 로고    scopus 로고
    • Secondary efficacy subanalysis by histology from the Phase III BRIGHT study: First-line bendamustine-rituximab (BR) compared with standard R-CHOP/R-CVP for patients with advanced indolent non-Hodgkin lymphoma (NHL) or mantle cell lymphoma (MCL)
    • Abstract 8537
    • Flinn IW, Van der Jagt RH, Kahl B et al. Secondary efficacy subanalysis by histology from the Phase III BRIGHT study: First-line bendamustine-rituximab (BR) compared with standard R-CHOP/R-CVP for patients with advanced indolent non-Hodgkin lymphoma (NHL) or mantle cell lymphoma (MCL). J. Clin. Oncol. 31(Suppl.), Abstract 8537 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.SUPPL.
    • Flinn, I.W.1    Van Der Jagt, R.H.2    Kahl, B.3
  • 41
    • 20644469242 scopus 로고    scopus 로고
    • Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma
    • Rummel MJ, Al-Batran SE, Kim SZ et al. Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma. J. Clin. Oncol. 23, 3383-3389 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 3383-3389
    • Rummel, M.J.1    Al-Batran, S.E.2    Kim, S.Z.3
  • 42
    • 4043087953 scopus 로고    scopus 로고
    • Chemotherapy-induced alopecia: Psychosocial impact and therapeutic approaches
    • Hesketh PJ, Batchelor D, Golant M et al. Chemotherapy-induced alopecia: psychosocial impact and therapeutic approaches. Support Care Cancer 12, 543-549 (2004).
    • (2004) Support Care Cancer , vol.12 , pp. 543-549
    • Hesketh, P.J.1    Batchelor, D.2    Golant, M.3
  • 43
    • 84885917208 scopus 로고    scopus 로고
    • Differences in quality of life between bendamustine plus rituximab compared with standard first-line treatments in patients with previously untreated advanced indolent non-Hodgkin's lymphoma or mantle cell lymphoma
    • Abstract 155
    • Burke JM, Van der Jagt RH, Kahl BS et al. Differences in quality of life between bendamustine plus rituximab compared with standard first-line treatments in patients with previously untreated advanced indolent non-Hodgkin's lymphoma or mantle cell lymphoma. Blood 120, Abstract 155 (2012).
    • (2012) Blood , vol.120
    • Burke, J.M.1    Van Der Jagt, R.H.2    Kahl, B.S.3
  • 44
    • 79953681626 scopus 로고    scopus 로고
    • Bendamustine therapy in patients with relapsed or refractory Waldenstrom's macroglobulinemia
    • Treon SP, Hanzis C, Tripsas C et al. Bendamustine therapy in patients with relapsed or refractory Waldenstrom's macroglobulinemia. Clin. Lymphoma Myeloma Leuk. 11, 133-135 (2011).
    • (2011) Clin. Lymphoma Myeloma Leuk. , vol.11 , pp. 133-135
    • Treon, S.P.1    Hanzis, C.2    Tripsas, C.3
  • 45
    • 84880290654 scopus 로고    scopus 로고
    • Bendamustin-rituximab induction followed by observation or rituximab maintenance for newly diagnosed patients with Waldenström's macroglobulinemia: Results from a prospective, randomized, multicenter study (StiL)
    • Abstract 2739
    • Rummel M, Lerchenmuller C, Greil R et al. Bendamustin-rituximab induction followed by observation or rituximab maintenance for newly diagnosed patients with Waldenström's macroglobulinemia: results from a prospective, randomized, multicenter study (StiL). Blood 120, Abstract 2739 (2012).
    • (2012) Blood , vol.120
    • Rummel, M.1    Lerchenmuller, C.2    Greil, R.3
  • 46
    • 84877733170 scopus 로고    scopus 로고
    • Rituximab maintenance therapy until progression after rituximab and chemotherapy induction in patients with follicular lymphoma
    • Yared J, Kimball A, Baer MR et al. Rituximab maintenance therapy until progression after rituximab and chemotherapy induction in patients with follicular lymphoma. Clin. Lymphoma Myeloma Leuk. 13, 253-257 (2013).
    • (2013) Clin. Lymphoma Myeloma Leuk. , vol.13 , pp. 253-257
    • Yared, J.1    Kimball, A.2    Baer, M.R.3
  • 47
    • 84885918118 scopus 로고    scopus 로고
    • A Phase i trial of the Bruton's tyrosine kinase (BTK) inhibitor, ibrutinib (PCI-32765), in combination with rituximab (R) and bendamustine in patients with relapsed/refractory non-Hodgkin's lymphoma (NHL)
    • Abstract 1643
    • Blum KA, Christian B, Flynn JM et al. A Phase I trial of the Bruton's tyrosine kinase (BTK) inhibitor, ibrutinib (PCI-32765), in combination with rituximab (R) and bendamustine in patients with relapsed/refractory non-Hodgkin's lymphoma (NHL). Blood 120, Abstract 1643 (2012).
    • (2012) Blood , vol.120
    • Blum, K.A.1    Christian, B.2    Flynn, J.M.3
  • 48
    • 84885935024 scopus 로고    scopus 로고
    • A phase III study of ibrutinib in combination with bendamustine and rituximab (BR) in elderly patients with newly diagnosed mantle cell lymphoma (MCL)
    • Abstract TPS8613
    • Wang M, Gordon L, Rule S et al. A phase III study of ibrutinib in combination with bendamustine and rituximab (BR) in elderly patients with newly diagnosed mantle cell lymphoma (MCL). J. Clin. Oncol. 31(Suppl.), Abstract TPS8613 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.SUPPL.
    • Wang, M.1    Gordon, L.2    Rule, S.3
  • 50
    • 84885922837 scopus 로고    scopus 로고
    • A phase III, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of idelalisib (GS-1101) in combination with rituximab for previously treated indolent non-Hodgkin lymphomas (iNHL)
    • Abstract 554
    • Salles GA, Zinzani PL, Jurczak W et al. A phase III, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of idelalisib (GS-1101) in combination with rituximab for previously treated indolent non-Hodgkin lymphomas (iNHL). Hematol. Oncol. 1(Suppl.), Abstract 554 (2013).
    • (2013) Hematol. Oncol. , vol.1 , Issue.SUPPL.
    • Salles, G.A.1    Zinzani, P.L.2    Jurczak, W.3
  • 51
    • 84885900276 scopus 로고    scopus 로고
    • A dose-finding study of bendamustine, rituximab and lenalidomide in relapsed and refractory lymphoma
    • Abstract 289
    • Cheson BD, Crawford JG. A dose-finding study of bendamustine, rituximab and lenalidomide in relapsed and refractory lymphoma. Hematol. Oncol. 1(Suppl.), Abstract 289 (2013).
    • (2013) Hematol. Oncol. , vol.1 , Issue.SUPPL.
    • Cheson, B.D.1    Crawford, J.G.2
  • 52
    • 84885928286 scopus 로고    scopus 로고
    • Tolerability and activity of combinations of the PI3Kd inhibitor idelalisib (GS-1101) with rituximab and/or bendamustine in patients with previously treated indolent non-Hodgkin lymphoma (iNHL): Updated results from a phase i study
    • Abstract 8500
    • Leonard J, Wagner-Johnston ND, Coutre SE et al. Tolerability and activity of combinations of the PI3Kd inhibitor idelalisib (GS-1101) with rituximab and/or bendamustine in patients with previously treated, indolent non-Hodgkin lymphoma (iNHL): Updated results from a phase I study. J. Clin. Oncol. 31(Suppl.), Abstract 8500 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , Issue.SUPPL.
    • Leonard, J.1    Wagner-Johnston, N.D.2    Coutre, S.E.3
  • 53
    • 84871758096 scopus 로고    scopus 로고
    • Results from a prospective, open-label, phase II trial of bendamustine in refractory or relapsed T-cell lymphomas: The BENTLY trial
    • Damaj G, Gressin R, Bouabdallah K et al. Results from a prospective, open-label, phase II trial of bendamustine in refractory or relapsed T-cell lymphomas: the BENTLY trial. J. Clin. Oncol. 31, 104-110 (2013).
    • (2013) J. Clin. Oncol. , vol.31 , pp. 104-110
    • Damaj, G.1    Gressin, R.2    Bouabdallah, K.3
  • 54
    • 80053185604 scopus 로고    scopus 로고
    • BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma patients
    • Visani G, Malerba L, Stefani PM et al. BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma patients. Blood 118, 3419-3425 (2011).
    • (2011) Blood , vol.118 , pp. 3419-3425
    • Visani, G.1    Malerba, L.2    Stefani, P.M.3
  • 55
    • 84872512168 scopus 로고    scopus 로고
    • Phase I/II trial assessing bendamustine plus bortezomib combination therapy for the treatment of patients with relapsed or refractory multiple myeloma
    • Berenson JR, Yellin O, Bessudo A et al. Phase I/II trial assessing bendamustine plus bortezomib combination therapy for the treatment of patients with relapsed or refractory multiple myeloma. Br. J. Haematol. 160, 321-3230 (2013).
    • (2013) Br. J. Haematol. , vol.160 , pp. 321-3230
    • Berenson, J.R.1    Yellin, O.2    Bessudo, A.3
  • 56
    • 31344443373 scopus 로고    scopus 로고
    • Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone-a randomized Phase III study of the East German Study Group of Hematology and Oncology (OSHO)
    • Ponisch W, Mitrou PS, Merkle K et al. Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone-a randomized Phase III study of the East German Study Group of Hematology and Oncology (OSHO). J. Cancer Res. Clin. Oncol. 132, 205-212 (2006).
    • (2006) J. Cancer Res. Clin. Oncol. , vol.132 , pp. 205-212
    • Ponisch, W.1    Mitrou, P.S.2    Merkle, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.