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Volumn 36, Issue SUPPL. 3, 2009, Pages

Temsirolimus in Mantle Cell Lymphoma and Other Non-Hodgkin Lymphoma Subtypes

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ALPHA INTERFERON; ANTHRACYCLINE DERIVATIVE; CHLORAMBUCIL; CLADRIBINE; CYCLIN D1; CYCLOPHOSPHAMIDE; DEFOROLIMUS; ETOPOSIDE; EVEROLIMUS; FLUDARABINE; GEMCITABINE; LENALIDOMIDE; MAMMALIAN TARGET OF RAPAMYCIN; RITUXIMAB; TEMSIROLIMUS; THALIDOMIDE; VINBLASTINE;

EID: 72049112821     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2009.10.012     Document Type: Article
Times cited : (26)

References (45)
  • 1
    • 27244434474 scopus 로고    scopus 로고
    • Current treatment approaches for mantle-cell lymphoma
    • Witzig T.E. Current treatment approaches for mantle-cell lymphoma. J Clin Oncol 23 (2005) 6409-6414
    • (2005) J Clin Oncol , vol.23 , pp. 6409-6414
    • Witzig, T.E.1
  • 2
    • 50249129796 scopus 로고    scopus 로고
    • Incidence trends of mantle cell lymphoma in the United States between 1992 and 2004
    • Zhou Y., Wang H., Fang W., et al. Incidence trends of mantle cell lymphoma in the United States between 1992 and 2004. Cancer 113 (2008) 791-798
    • (2008) Cancer , vol.113 , pp. 791-798
    • Zhou, Y.1    Wang, H.2    Fang, W.3
  • 3
    • 39749091156 scopus 로고    scopus 로고
    • Therapeutic options in mantle cell lymphoma
    • Gill S., and Ritchie D. Therapeutic options in mantle cell lymphoma. Leuk Lymphoma 49 (2008) 398-409
    • (2008) Leuk Lymphoma , vol.49 , pp. 398-409
    • Gill, S.1    Ritchie, D.2
  • 5
    • 59149105528 scopus 로고    scopus 로고
    • Improvement of overall survival in advanced stage mantle cell lymphoma
    • Herrmann A., Hoster E., Zwingers T., et al. Improvement of overall survival in advanced stage mantle cell lymphoma. J Clin Oncol 27 (2009) 511-518
    • (2009) J Clin Oncol , vol.27 , pp. 511-518
    • Herrmann, A.1    Hoster, E.2    Zwingers, T.3
  • 6
    • 27244452464 scopus 로고    scopus 로고
    • High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine
    • Romaguera J.E., Fayad L., Rodriguez M.A., et al. High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine. J Clin Oncol 23 (2005) 7013-7023
    • (2005) J Clin Oncol , vol.23 , pp. 7013-7023
    • Romaguera, J.E.1    Fayad, L.2    Rodriguez, M.A.3
  • 7
    • 53449089095 scopus 로고    scopus 로고
    • Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group
    • Geisler C.H., Kolstad A., Laurell A., et al. Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group. Blood 112 (2008) 2687-2693
    • (2008) Blood , vol.112 , pp. 2687-2693
    • Geisler, C.H.1    Kolstad, A.2    Laurell, A.3
  • 8
    • 46249131868 scopus 로고    scopus 로고
    • Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma: overall survival exceeding 7 years with standard therapies
    • Martin P., Chadburn A., Christos P., et al. Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma: overall survival exceeding 7 years with standard therapies. Ann Oncol 19 (2008) 1327-1330
    • (2008) Ann Oncol , vol.19 , pp. 1327-1330
    • Martin, P.1    Chadburn, A.2    Christos, P.3
  • 9
    • 0034845543 scopus 로고    scopus 로고
    • Cyclophosphamide/fludarabine (CF) is active in the treatment of mantle cell lymphoma
    • Cohen B.J., Moskowitz C., Straus D., Noy A., Hedrick E., and Zelenetz A. Cyclophosphamide/fludarabine (CF) is active in the treatment of mantle cell lymphoma. Leuk Lymphoma 42 (2001) 1015-1022
    • (2001) Leuk Lymphoma , vol.42 , pp. 1015-1022
    • Cohen, B.J.1    Moskowitz, C.2    Straus, D.3    Noy, A.4    Hedrick, E.5    Zelenetz, A.6
  • 10
    • 47249112184 scopus 로고    scopus 로고
    • Long-term results of the treatment of patients with mantle cell lymphoma with cladribine (2-CDA) alone (95-80-53) or 2-CDA and rituximab (N0189) in the North Central Cancer Treatment Group
    • Inwards D.J., Fishkin P.A., Hillman D.W., et al. Long-term results of the treatment of patients with mantle cell lymphoma with cladribine (2-CDA) alone (95-80-53) or 2-CDA and rituximab (N0189) in the North Central Cancer Treatment Group. Cancer 113 (2008) 108-116
    • (2008) Cancer , vol.113 , pp. 108-116
    • Inwards, D.J.1    Fishkin, P.A.2    Hillman, D.W.3
  • 11
    • 54449095901 scopus 로고    scopus 로고
    • Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma
    • Wiernik P.H., Lossos I.S., Tuscano J.M., et al. Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma. J Clin Oncol 26 (2008) 4952-4957
    • (2008) J Clin Oncol , vol.26 , pp. 4952-4957
    • Wiernik, P.H.1    Lossos, I.S.2    Tuscano, J.M.3
  • 12
    • 4944229959 scopus 로고    scopus 로고
    • Antitumor activity of rituximab plus thalidomide in patients with relapsed/refractory mantle cell lymphoma
    • Kaufmann H., Raderer M., Wohrer S., et al. Antitumor activity of rituximab plus thalidomide in patients with relapsed/refractory mantle cell lymphoma. Blood 104 (2004) 2269-2271
    • (2004) Blood , vol.104 , pp. 2269-2271
    • Kaufmann, H.1    Raderer, M.2    Wohrer, S.3
  • 13
    • 20644469242 scopus 로고    scopus 로고
    • Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma
    • Rummel M.J., Al-Batran S.E., Kim S.Z., et al. Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma. J Clin Oncol 23 (2005) 3383-3389
    • (2005) J Clin Oncol , vol.23 , pp. 3383-3389
    • Rummel, M.J.1    Al-Batran, S.E.2    Kim, S.Z.3
  • 14
    • 34848870352 scopus 로고    scopus 로고
    • Bortezomib for the treatment of mantle cell lymphoma
    • Kane R.C., Dagher R., Farrell A., et al. Bortezomib for the treatment of mantle cell lymphoma. Clin Cancer Res 13 (2007) 5291-5294
    • (2007) Clin Cancer Res , vol.13 , pp. 5291-5294
    • Kane, R.C.1    Dagher, R.2    Farrell, A.3
  • 15
    • 33846530661 scopus 로고    scopus 로고
    • A phase II study of bortezomib in mantle cell lymphoma: the National Cancer Institute of Canada Clinical Trials Group trial IND.150
    • Belch A., Kouroukis C.T., Crump M., et al. A phase II study of bortezomib in mantle cell lymphoma: the National Cancer Institute of Canada Clinical Trials Group trial IND.150. Ann Oncol 18 (2007) 116-121
    • (2007) Ann Oncol , vol.18 , pp. 116-121
    • Belch, A.1    Kouroukis, C.T.2    Crump, M.3
  • 16
    • 33750625445 scopus 로고    scopus 로고
    • Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma
    • Fisher R.I., Bernstein S.H., Kahl B.S., et al. Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma. J Clin Oncol 24 (2006) 4867-4874
    • (2006) J Clin Oncol , vol.24 , pp. 4867-4874
    • Fisher, R.I.1    Bernstein, S.H.2    Kahl, B.S.3
  • 17
    • 23944481410 scopus 로고    scopus 로고
    • Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
    • Witzig T.E., Geyer S.M., Ghobrial I., et al. Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J Clin Oncol 23 (2005) 5347-5356
    • (2005) J Clin Oncol , vol.23 , pp. 5347-5356
    • Witzig, T.E.1    Geyer, S.M.2    Ghobrial, I.3
  • 18
    • 49049087320 scopus 로고    scopus 로고
    • Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the North Central Cancer Treatment Group
    • Ansell S.M., Inwards D.J., Rowland Jr. K.M., et al. Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the North Central Cancer Treatment Group. Cancer 113 (2008) 508-514
    • (2008) Cancer , vol.113 , pp. 508-514
    • Ansell, S.M.1    Inwards, D.J.2    Rowland Jr., K.M.3
  • 19
    • 68949102180 scopus 로고    scopus 로고
    • Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
    • Hess G., Herbrecht R., Romaguera J., et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol 27 (2009) 3822-3829
    • (2009) J Clin Oncol , vol.27 , pp. 3822-3829
    • Hess, G.1    Herbrecht, R.2    Romaguera, J.3
  • 20
    • 72049083386 scopus 로고    scopus 로고
    • Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies
    • [Epub ahead of print]
    • Coiffier B., and Ribrag V. Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies. Leuk Lymphoma (2009 Sep 8) [Epub ahead of print]
    • (2009) Leuk Lymphoma
    • Coiffier, B.1    Ribrag, V.2
  • 21
    • 34547935219 scopus 로고    scopus 로고
    • Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway
    • Marzec M., Kasprzycka M., Liu X., et al. Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway. Oncogene 26 (2007) 5606-5614
    • (2007) Oncogene , vol.26 , pp. 5606-5614
    • Marzec, M.1    Kasprzycka, M.2    Liu, X.3
  • 22
    • 33845500278 scopus 로고    scopus 로고
    • Syk-dependent mTOR activation in follicular lymphoma cells
    • Leseux L., Hamdi S.M., Al S.T., et al. Syk-dependent mTOR activation in follicular lymphoma cells. Blood 108 (2006) 4156-4162
    • (2006) Blood , vol.108 , pp. 4156-4162
    • Leseux, L.1    Hamdi, S.M.2    Al, S.T.3
  • 23
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: a target for cancer therapy
    • Bjornsti M.A., and Houghton P.J. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4 (2004) 335-348
    • (2004) Nat Rev Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 24
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin D.A., and Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 12 (2007) 9-22
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 25
    • 1642539982 scopus 로고    scopus 로고
    • Molecular basis of mantle cell lymphoma
    • Bertoni F., Zucca E., and Cotter F.E. Molecular basis of mantle cell lymphoma. Br J Haematol 124 (2004) 130-140
    • (2004) Br J Haematol , vol.124 , pp. 130-140
    • Bertoni, F.1    Zucca, E.2    Cotter, F.E.3
  • 26
    • 33745909399 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies
    • Witzig T.E., and Kaufmann S.H. Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies. Curr Treat Options Oncol 7 (2006) 285-294
    • (2006) Curr Treat Options Oncol , vol.7 , pp. 285-294
    • Witzig, T.E.1    Kaufmann, S.H.2
  • 27
    • 33846396190 scopus 로고    scopus 로고
    • Aspects of mTOR biology and the use of mTOR inhibitors in non-Hodgkin's lymphoma
    • Costa L.J. Aspects of mTOR biology and the use of mTOR inhibitors in non-Hodgkin's lymphoma. Cancer Treat Rev 33 (2007) 78-84
    • (2007) Cancer Treat Rev , vol.33 , pp. 78-84
    • Costa, L.J.1
  • 28
    • 33747846726 scopus 로고    scopus 로고
    • Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma
    • Rudelius M., Pittaluga S., Nishizuka S., et al. Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood 108 (2006) 1668-1676
    • (2006) Blood , vol.108 , pp. 1668-1676
    • Rudelius, M.1    Pittaluga, S.2    Nishizuka, S.3
  • 29
    • 34248647440 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma
    • Peponi E., Drakos E., Reyes G., Leventaki V., Rassidakis G.Z., and Medeiros L.J. Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma. Am J Pathol 169 (2006) 2171-2180
    • (2006) Am J Pathol , vol.169 , pp. 2171-2180
    • Peponi, E.1    Drakos, E.2    Reyes, G.3    Leventaki, V.4    Rassidakis, G.Z.5    Medeiros, L.J.6
  • 30
    • 40749094917 scopus 로고    scopus 로고
    • Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma
    • Yazbeck V.Y., Buglio D., Georgakis G.V., et al. Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma. Exp Hematol 36 (2008) 443-450
    • (2008) Exp Hematol , vol.36 , pp. 443-450
    • Yazbeck, V.Y.1    Buglio, D.2    Georgakis, G.V.3
  • 31
    • 33846516354 scopus 로고    scopus 로고
    • Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma
    • Haritunians T., Mori A., O'Kelly J., Luong Q.T., Giles F.J., and Koeffler H.P. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia 21 (2007) 333-339
    • (2007) Leukemia , vol.21 , pp. 333-339
    • Haritunians, T.1    Mori, A.2    O'Kelly, J.3    Luong, Q.T.4    Giles, F.J.5    Koeffler, H.P.6
  • 32
    • 33749002279 scopus 로고    scopus 로고
    • Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
    • Yee K.W., Zeng Z., Konopleva M., et al. Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 12 (2006) 5165-5173
    • (2006) Clin Cancer Res , vol.12 , pp. 5165-5173
    • Yee, K.W.1    Zeng, Z.2    Konopleva, M.3
  • 33
    • 0042449063 scopus 로고    scopus 로고
    • Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group
    • Cheson B.D., Horning S.J., Coiffier B., et al. Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group. J Clin Oncol 17 (1999) 1244-1253
    • (1999) J Clin Oncol , vol.17 , pp. 1244-1253
    • Cheson, B.D.1    Horning, S.J.2    Coiffier, B.3
  • 34
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins M.B., Hidalgo M., Stadler W.M., et al. Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 22 (2004) 909-918
    • (2004) J Clin Oncol , vol.22 , pp. 909-918
    • Atkins, M.B.1    Hidalgo, M.2    Stadler, W.M.3
  • 35
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G., Carducci M., Tomczak P., et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 356 (2007) 2271-2281
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 36
    • 57449107677 scopus 로고    scopus 로고
    • A phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed aggressive non-Hodgkin lymphoma (NHL) [abstract 121]
    • Reeder C.B., Gornet M.K., and Habermann T.M. A phase II trial of the oral mTOR inhibitor everolimus (RAD001) in relapsed aggressive non-Hodgkin lymphoma (NHL) [abstract 121]. Blood 110 (2007) 44a
    • (2007) Blood , vol.110
    • Reeder, C.B.1    Gornet, M.K.2    Habermann, T.M.3
  • 37
    • 1642586272 scopus 로고    scopus 로고
    • Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
    • Wendel H.G., De S.E., Fridman J.S., et al. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428 (2004) 332-337
    • (2004) Nature , vol.428 , pp. 332-337
    • Wendel, H.G.1    De, S.E.2    Fridman, J.S.3
  • 38
    • 24744435392 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum
    • Wlodarski P., Kasprzycka M., Liu X., et al. Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum. Cancer Res 65 (2005) 7800-7808
    • (2005) Cancer Res , vol.65 , pp. 7800-7808
    • Wlodarski, P.1    Kasprzycka, M.2    Liu, X.3
  • 39
    • 33947497552 scopus 로고    scopus 로고
    • mTOR inhibition in lymphoma: a rational and promising strategy
    • Smith S.M., and van Besien K. mTOR inhibition in lymphoma: a rational and promising strategy. Lett Drug Design Discov 4 (2007) 224-231
    • (2007) Lett Drug Design Discov , vol.4 , pp. 224-231
    • Smith, S.M.1    van Besien, K.2
  • 40
    • 34248641157 scopus 로고    scopus 로고
    • Clinical development of mTOR inhibitors: a focus on lymphoma
    • Smith S.M. Clinical development of mTOR inhibitors: a focus on lymphoma. Rev Recent Clin Trials 2 (2007) 103-110
    • (2007) Rev Recent Clin Trials , vol.2 , pp. 103-110
    • Smith, S.M.1
  • 41
    • 61649117233 scopus 로고    scopus 로고
    • Activity of single agent temsirolimus (CCI-779) in non-mantle cell non-Hodgkin lymphoma subtypes [abstract 8514]
    • part I
    • Smith S.M., Pro B., Cisneros A., et al. Activity of single agent temsirolimus (CCI-779) in non-mantle cell non-Hodgkin lymphoma subtypes [abstract 8514]. J Clin Oncol, 2008 ASCO Annual Meeting Proceedings 26 suppl 15S (2008) 457s part I
    • (2008) J Clin Oncol, 2008 ASCO Annual Meeting Proceedings , vol.26 , Issue.SUPPL. 15S
    • Smith, S.M.1    Pro, B.2    Cisneros, A.3
  • 42
    • 53749107701 scopus 로고    scopus 로고
    • Phase II trial of the oral mTOR inhibitor everolimus (RAD001) for patients with relapsed or refractory lymphoma [abstract 8055]
    • part I
    • Johnston P.B., Ansell S.M., Colgan J.P., et al. Phase II trial of the oral mTOR inhibitor everolimus (RAD001) for patients with relapsed or refractory lymphoma [abstract 8055]. J Clin Oncol, 2007 ASCO Annual Meeting Proceedings Part I 25 suppl 18S (2007) part I
    • (2007) J Clin Oncol, 2007 ASCO Annual Meeting Proceedings Part I , vol.25 , Issue.SUPPL. 18S
    • Johnston, P.B.1    Ansell, S.M.2    Colgan, J.P.3
  • 43
    • 38649140450 scopus 로고    scopus 로고
    • Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies
    • Mita M.M., Mita A.C., Chu Q.S., et al. Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies. J Clin Oncol 26 (2008) 361-367
    • (2008) J Clin Oncol , vol.26 , pp. 361-367
    • Mita, M.M.1    Mita, A.C.2    Chu, Q.S.3
  • 44
    • 51449096670 scopus 로고    scopus 로고
    • A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
    • Rizzieri D.A., Feldman E., Dipersio J.F., et al. A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 14 (2008) 2756-2762
    • (2008) Clin Cancer Res , vol.14 , pp. 2756-2762
    • Rizzieri, D.A.1    Feldman, E.2    Dipersio, J.F.3
  • 45
    • 59049091983 scopus 로고    scopus 로고
    • A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL
    • Decker T., Sandherr M., Goetze K., Oelsner M., Ringshausen I., and Peschel C. A pilot trial of the mTOR (mammalian target of rapamycin) inhibitor RAD001 in patients with advanced B-CLL. Ann Hematol 88 (2008) 221-227
    • (2008) Ann Hematol , vol.88 , pp. 221-227
    • Decker, T.1    Sandherr, M.2    Goetze, K.3    Oelsner, M.4    Ringshausen, I.5    Peschel, C.6


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