메뉴 건너뛰기




Volumn 10, Issue 1, 2010, Pages 21-27

Optimal use of bendamustine in chronic lymphocytic leukemia, non-hodgkin lymphomas, and multiple myeloma: Treatment recommendations from an international consensus panel

Author keywords

Alkylating agent; Non Hodgkin's lymphoma; Phase I trial; Refractory; Relapsed; Rituximab

Indexed keywords

BENDAMUSTINE; BORTEZOMIB; FLUDARABINE; MITOXANTRONE; RITUXIMAB; ANTINEOPLASTIC AGENT; CHLORMETHINE DERIVATIVE;

EID: 77953670179     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.3816/CLML.2010.n.002     Document Type: Review
Times cited : (84)

References (35)
  • 1
    • 70349330220 scopus 로고    scopus 로고
    • Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia
    • Knauf WU, Lissichkov T, Aldaoud A, et al. Phase III randomized study of bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukemia. J Clin Oncol 2009; 27:4378-84.
    • (2009) J Clin Oncol , vol.27 , pp. 4378-4384
    • Knauf, W.U.1    Lissichkov, T.2    Aldaoud, A.3
  • 2
    • 38349119981 scopus 로고    scopus 로고
    • Bendamustine in patients with rituximab refractory and alkylator-refractory, indolent and transformed non-Hodgkin's lymphoma: Results from a phase II multicenter single-agent study
    • Friedberg JW, Cohen P, Chen L, et al. Bendamustine in patients with rituximab refractory and alkylator-refractory, indolent and transformed non-Hodgkin's lymphoma: Results from a phase II multicenter single-agent study. J Clin Oncol 2008; 28:204-10.
    • (2008) J Clin Oncol , vol.28 , pp. 204-210
    • Friedberg, J.W.1    Cohen, P.2    Chen, L.3
  • 3
    • 74549225036 scopus 로고    scopus 로고
    • Bendamustine is effective therapy in patients with rituximab-refractory, indolent B-cell non-Hodgkin lymphoma: Results from a multicenter study
    • Kahl BS, Bartlett NL, Leonard JP, et al. Bendamustine is effective therapy in patients with rituximab-refractory, indolent B-cell non-Hodgkin lymphoma: results from a multicenter study. Cancer 2009; 116:106-14.
    • (2009) Cancer , vol.116 , pp. 106-114
    • Kahl, B.S.1    Bartlett, N.L.2    Leonard, J.P.3
  • 4
    • 63049113411 scopus 로고    scopus 로고
    • Bendamustine: Rebirth of an old drug
    • Cheson BD, Rummel MJ. Bendamustine: rebirth of an old drug. J Clin Oncol 2009; 27:1492-1501.
    • (2009) J Clin Oncol , vol.27 , pp. 1492-1501
    • Cheson, B.D.1    Rummel, M.J.2
  • 8
    • 0033744194 scopus 로고    scopus 로고
    • Weekly administration of bendamustine: A phase i study in patients with advanced progresive solid tumors
    • Schoffski P, Seeland G, Engel H, et al. Weekly administration of bendamustine: a phase I study in patients with advanced progresive solid tumors. Ann Oncol 2000; 11:729-34.
    • (2000) Ann Oncol , vol.11 , pp. 729-734
    • Schoffski, P.1    Seeland, G.2    Engel, H.3
  • 10
    • 34247093863 scopus 로고    scopus 로고
    • A phase I study of bendamustine hydrochloride administered once every 3 weeks in patients with solid tumors
    • DOI 10.1097/CAD.0b013e3280149eb1, PII 0000181320070600000009
    • Rasschaert M, Schrijvers D, Van den Brande J, et al. A phase I study of bendamustine hydrochloride administered once every 3 weeks in patients with solid tumors. Anticancer Drugs 2007; 18:587-95. (Pubitemid 46597413)
    • (2007) Anti-Cancer Drugs , vol.18 , Issue.5 , pp. 587-595
    • Rasschaert, M.1    Schrijvers, D.2    Van Den Brande, J.3    Dyck, J.4    Bosmans, J.5    Merkle, K.6    Vermorken, J.B.7
  • 11
    • 0036449340 scopus 로고    scopus 로고
    • High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's-lymphomas
    • DOI 10.1007/s00432-002-0378-6
    • Bremer K. High rates of long-lasting remissions after 5-day bendamustine chemotherapy cycles in pre-treated low-grade non-Hodgkin's lymphomas. J Cancer Res Clin Oncol 2002; 128:603-9. (Pubitemid 35435557)
    • (2002) Journal of Cancer Research and Clinical Oncology , vol.128 , Issue.11 , pp. 603-609
    • Bremer, K.1
  • 12
    • 27144548424 scopus 로고    scopus 로고
    • Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: Results of a phase I/II study of the German CLL Study Group
    • Bergmann MA, Goebeler ME, Herold M, et al. Efficacy of bendamustine in patients with relapsed or refractory chronic lymphocytic leukemia: results of a phase I/II study of the German CLL Study Group. Haematologica 2005; 90:1357-64. (Pubitemid 41503651)
    • (2005) Haematologica , vol.90 , Issue.10 , pp. 1357-1364
    • Bergmann, M.A.1    Goebeler, M.E.2    Herold, M.3    Emmerich, B.4    Wilhelm, M.5    Ruelfs, C.6    Boening, L.7    Hallek, M.J.8
  • 13
    • 0034773457 scopus 로고    scopus 로고
    • Efficacy and toxicity of bendamustine in patients with relapsed low-grade non-Hodgkin's lymphomas
    • DOI 10.1097/00001813-200110000-00003
    • Heider A, Niederle N. Efficacy and toxicity of bendamustine in patients with relapsed low-grade non-Hodgkin's lymphomas. Anticancer Drugs 2001; 12:725-9. (Pubitemid 33001185)
    • (2001) Anti-Cancer Drugs , vol.12 , Issue.9 , pp. 725-729
    • Heider, A.1    Niederle, N.2
  • 14
    • 67650419706 scopus 로고    scopus 로고
    • Bendamustine vs. fludarabine as second-line treatment for patients with chronic lymphocytic leukemia - First interim results of a randomized study
    • (abstract 379)
    • Niederle N, Balleisen L, Heit W, et al, et al. Bendamustine vs. fludarabine as second-line treatment for patients with chronic lymphocytic leukemia - first interim results of a randomized study. Ann Oncol 2008; 19(suppl 4): (abstract 379).
    • (2008) Ann Oncol , vol.19 , Issue.SUPPL. 4
    • Niederle, N.1    Balleisen, L.2    Heit, W.3
  • 15
    • 0034744322 scopus 로고    scopus 로고
    • Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia
    • Kath R, Blumenstengel K, Fricke HJ, et al. Bendamustine monotherapy in advanced and refractory chronic lymphocytic leukemia. J Cancer Res Clin Oncol 2001; 127:48-54.
    • (2001) J Cancer Res Clin Oncol , vol.127 , pp. 48-54
    • Kath, R.1    Blumenstengel, K.2    Fricke, H.J.3
  • 16
    • 28644433498 scopus 로고    scopus 로고
    • Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine HCl in pre-treated patients with B-chronic lymphocytic leukaemia (Binet stages B and C) requiring therapy
    • DOI 10.1007/s00432-005-0050-z
    • Lissitchkov T, Arnaudov G, Peytchev D, et al. Phase-I/II study to evaluate dose limiting toxicity, maximum tolerated dose, and tolerability of bendamustine HCL in pre-treated patients with B-chronic lymphocytic leukaemia (Binet stages B and C) requiring therapy. J Cancer Res Clin Oncol 2006; 132:99-104. (Pubitemid 41752051)
    • (2006) Journal of Cancer Research and Clinical Oncology , vol.132 , Issue.2 , pp. 99-104
    • Lissitchkov, T.1    Arnaudov, G.2    Peytchev, D.3    Merkle, Kh.4
  • 18
    • 25444512381 scopus 로고    scopus 로고
    • The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy
    • Knop S, Straka C, Haen M, et al. The efficacy and toxicity of bendamustine in recurrent multiple myeloma after high-dose chemotherapy. Haematologica 2005; 90:1287-8. (Pubitemid 41375295)
    • (2005) Haematologica , vol.90 , Issue.9 , pp. 1287-1288
    • Knop, S.1    Straka, C.2    Haen, M.3    Schwedes, R.4    Hebart, H.5    Einsele, H.6
  • 19
    • 64249170013 scopus 로고    scopus 로고
    • Population pharmacokinetics of bendamustine and metabolites in patients with indolent non-Hodgkin's lymphoma (NHL)
    • Owen JS, Melhem M, D'Andrea D, et al. Population pharmacokinetics of bendamustine and metabolites in patients with indolent non-Hodgkin's lymphoma (NHL). Proc Am Soc Clin Pharm Ther 2008; 83(suppl 1):S54-5.
    • (2008) Proc Am Soc Clin Pharm Ther , vol.83 , Issue.SUPPL. 1
    • Owen, J.S.1    Melhem, M.2    D'Andrea, D.3
  • 20
    • 65749110753 scopus 로고    scopus 로고
    • Bendamustine in combination with rituximab (BR) for patients with relapsed chronic lymphocyic leukemia (CLL): A multicentre phase II trial of the German CLL Study Group (GCLLSG)
    • (abstract 330)
    • Fischer K, Stilgenbauer S, Schweighofer CD, et al. Bendamustine in combination with rituximab (BR) for patients with relapsed chronic lymphocyic leukemia (CLL): a multicentre phase II trial of the German CLL Study Group (GCLLSG). Blood 2008; 112:128 (abstract 330).
    • (2008) Blood , vol.112 , pp. 128
    • Fischer, K.1    Stilgenbauer, S.2    Schweighofer, C.D.3
  • 21
    • 0037220152 scopus 로고    scopus 로고
    • Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: Results from cancer and leukemia group B 9712 (CALGB 9712)
    • DOI 10.1182/blood-2002-04-1258
    • Byrd JC, Peterson B, Morrison VA, et al. Randomized phase 2 study of fludarabine with concurrent versus sequential treatment with rituximab in symptomatic, untreated patients with B-cell chronic lymphocytic leukemia: results from Cancer and Leukemia Group B 9712 (CALGB 9712). Blood 2003; 101:6-14. (Pubitemid 36025880)
    • (2003) Blood , vol.101 , Issue.1 , pp. 6-14
    • Byrd, J.C.1    Peterson, B.L.2    Morrison, V.A.3    Park, K.4    Jacobson, R.5    Hoke, E.6    Vardiman, J.W.7    Rai, K.8    Schiffer, C.A.9    Larson, R.A.10
  • 22
    • 77953654537 scopus 로고    scopus 로고
    • Bendamustine produces durable responses with an acceptable long-term safety profile in patients with rituximabrefractory non-Hodgkin's lymphoma. A pooled analysis
    • (abstract 268)
    • Cheson BD, Friedberg J, Kahl BS, et al. Bendamustine produces durable responses with an acceptable long-term safety profile in patients with rituximabrefractory non-Hodgkin's lymphoma. A pooled analysis. Blood 2009; 114:1049 (abstract 268).
    • (2009) Blood , vol.114 , pp. 1049
    • Cheson, B.D.1    Friedberg, J.2    Kahl, B.S.3
  • 23
    • 20644469242 scopus 로고    scopus 로고
    • Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma
    • Rummel MJ, Al-Batran S, Kim SZ, et al. Bendamustine plus rituximab is effective and has a favorable toxicity profile in the treatment of mantle cell and low-grade non-Hodgkin's lymphoma. J Clin Oncol 2005; 23:3383-9.
    • (2005) J Clin Oncol , vol.23 , pp. 3383-3389
    • Rummel, M.J.1    Al-Batran, S.2    Kim, S.Z.3
  • 24
    • 52649177173 scopus 로고    scopus 로고
    • Bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma: A phase II multicenter study
    • Robinson KS, Williams ME, van der Jagt RH, et al. Bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma: a phase II multicenter study. J Clin Oncol 2008; 26:4473-9.
    • (2008) J Clin Oncol , vol.26 , pp. 4473-4479
    • Robinson, K.S.1    Williams, M.E.2    Van Der Jagt, R.H.3
  • 25
    • 77950488976 scopus 로고    scopus 로고
    • Bendamustine plus rituximab is superior in respect of progression free survival and CR rate when compared to CHOP plus rituximab as first-line treatment of patients with advanced follicular, indolent, and mantle cell lymphomas: Final results of a randomized phase III study of the StiL (Study Group Indolent Lymphomas, Germany)
    • (abstract 405)
    • Rummel MJ, Niederle N, Maschmeye G, et al. Bendamustine plus rituximab is superior in respect of progression free survival and CR rate when compared to CHOP plus rituximab as first-line treatment of patients with advanced follicular, indolent, and mantle cell lymphomas: final results of a randomized phase III study of the StiL (Study Group Indolent Lymphomas, Germany). Blood 2009; 114:168-9 (abstract 405).
    • (2009) Blood , vol.114 , pp. 168-169
    • Rummel, M.J.1    Niederle, N.2    Maschmeye, G.3
  • 27
    • 34447549127 scopus 로고    scopus 로고
    • High anti-lymphoma activity of bendamustine/mitoxantrone/rituximab in rituximab pretreated relapsed or refractory indolent lymphomas and mantle cell lymphomas. A multicenter phase II study of the German Low Grade Lymphoma Study Group (GLSG)
    • DOI 10.1080/10428190701361828, PII 780394368
    • Weide R, Hess G, Koppler H, et al. High anti-lymphoma activity of bendamustine/ mitoxantrone/rituximab in reituximab pretreated relapsed or refractory indolent lymphomas and mantle cell lymphomas. A multicenter phase II study of the German Low Grade Lymphoma Study Group (GLSG). Leuk Lymphoma 2007; 48:1299-306. (Pubitemid 47082223)
    • (2007) Leukemia and Lymphoma , vol.48 , Issue.7 , pp. 1299-1306
    • Weide, R.1    Hess, G.2    Koppler, H.3    Heymanns, J.4    Thomalla, J.5    Aldaoud, A.6    Losem, C.7    Schmitz, S.8    Haak, U.9    Huber, C.10    Unterhalt, M.11    Hiddemann, W.12    Dreyling, M.13
  • 28
    • 70349641636 scopus 로고    scopus 로고
    • Bortezomib (V), bendamustine (B), and rituximab (R) in patients (pts) with relapsed (rel) or refractory (ref) follicular lymphoma (FL): Dose finding results of the VERTICAL study
    • (abstract 8535)
    • Matous J, Letzer J, Rosen P, et al. Bortezomib (V), bendamustine (B), and rituximab (R) in patients (pts) with relapsed (rel) or refractory (ref) follicular lymphoma (FL): dose finding results of the VERTICAL study. J Clin Oncol 2009; 27(suppl):442s (abstract 8535).
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Matous, J.1    Letzer, J.2    Rosen, P.3
  • 29
    • 52649146310 scopus 로고    scopus 로고
    • Combined bendamustine, prednisolone and thalidomide for refractory or relapsede multiple myeloma after autologous stem-cell transplantation or conventional chemotherapy: Results of a phase i clinical trial
    • Ponisch W, Rozanski M, Goldschmidt H, et al. Combined bendamustine, prednisolone and thalidomide for refractory or relapsede multiple myeloma after autologous stem-cell transplantation or conventional chemotherapy: results of a phase I clinical trial. Br J Haematol 2008; 143:191-200.
    • (2008) Br J Haematol , vol.143 , pp. 191-200
    • Ponisch, W.1    Rozanski, M.2    Goldschmidt, H.3
  • 31
    • 0031831522 scopus 로고    scopus 로고
    • Tumor lysis syndrome as a rare complication of fludarabine therapy in chronic lymphocytic leukemia
    • Cheson BD, Frame J, Vena D, et al. Tumor lysis syndrome as a rare complication of fludarabine therapy in chronic lymphocytic leukemia. J Clin Oncol 1998; 16:2305-12.
    • (1998) J Clin Oncol , vol.16 , pp. 2305-2312
    • Cheson, B.D.1    Frame, J.2    Vena, D.3
  • 32
    • 28044443646 scopus 로고    scopus 로고
    • Recurrent chemotherapy-induced tumor lysis syndrome (TLS) with renal failure in a patient with chronic lymphocytic leukemia - Successful treatment and prevention of TLS with low-dose rasburicase
    • DOI 10.1111/j.1600-0609.2005.00550.x
    • Hummel M, Buchheidt D, Reiter S, et al. Recurrent chemotherapy-induced tumor lysis syndrome (TLS) with renal failure in a patient with chronic lymphocytic leukemia - successful treatment and prevention of TLS with low-dose rasburicase. Eur J Haematol 2005; 75:518-21. (Pubitemid 41687787)
    • (2005) European Journal of Haematology , vol.75 , Issue.6 , pp. 518-521
    • Hummel, M.1    Buchheidt, D.2    Reiter, S.3    Bergmann, J.4    Adam, K.5    Hehlmann, R.6
  • 33
    • 84860637955 scopus 로고    scopus 로고
    • Bendamustine pharmacokinetics and safety are not afflicted by impaired renal function in patients with multiple myeloma
    • (abstract 5254)
    • Preiss R, Teichert J, Poenisch W, et al. Bendamustine pharmacokinetics and safety are not afflicted by impaired renal function in patients with multiple myeloma. Blood 2003; 102:381-2b (abstract 5254).
    • (2003) Blood , vol.102
    • Preiss, R.1    Teichert, J.2    Poenisch, W.3
  • 34
    • 85031182880 scopus 로고    scopus 로고
    • [prescribing information]: Frazer, PA: Cephalon;
    • Treanda (bendamustine hydrochloride) [prescribing information]: Frazer, PA: Cephalon; 2008.
    • (2008) Treanda (Bendamustine Hydrochloride)
  • 35
    • 77953453940 scopus 로고    scopus 로고
    • Peripheral blood stem cell mobilization after bendamustine containing chemotherapy in indolent lymphomas is possible. Results from the phase III study off B-R vs CHOP-R (NHL 1-2003 trial) of the StiL (Study Group Indolent Lymphomas, Germany)
    • (abstract 2679)
    • Burchardt CA, Brugger W, Maschmeyer G, et al. Peripheral blood stem cell mobilization after bendamustine containing chemotherapy in indolent lymphomas is possible. Results from the phase III study off B-R vs CHOP-R (NHL 1-2003 trial) of the StiL (Study Group Indolent Lymphomas, Germany). Blood 2009; 114:1048-9 (abstract 2679).
    • (2009) Blood , vol.114 , pp. 1048-1049
    • Burchardt, C.A.1    Brugger, W.2    Maschmeyer, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.