Can controlled ice nucleation improve freeze-drying of highly-concentrated protein formulations?

Journal of Pharmaceutical Sciences

Volumn 102, Issue 11, 2013, Pages 3915-3919

  Geidobler, Raimund ^a   Konrad, Ilona ^a   Winter, Gerhard ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Controlled ice nucleation; Dissolution; Freeze drying; Lyophilization; Proteins; Wetting

Indexed keywords

BOVINE SERUM ALBUMIN; MONOCLONAL ANTIBODY;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED ICE NUCLEATION; DRUG FORMULATION; FREEZE DRYING; LOW TEMPERATURE PROCEDURES; MOISTURE; SURFACE PROPERTY; TEMPERATURE;

CONTROLLED ICE NUCLEATION; DISSOLUTION; FREEZE-DRYING; LYOPHILIZATION; PROTEINS; WETTING;

ANIMALS; ANTIBODIES, MONOCLONAL; CATTLE; CRYSTALLIZATION; EXCIPIENTS; FREEZE DRYING; ICE; PROTEIN STABILITY; SERUM ALBUMIN, BOVINE; SOLUBILITY;

EID: 84885860995     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23704     Document Type: Article

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