Ice fog as a means to induce uniform ice nucleation during lyophilization

BioPharm International

Volumn 25, Issue 1, 2012, Pages 33-38

  Chakravarty, Prerona ^a   Lee, Ron ^a   Demarco, Frank ^b   Renzi, Ernesto ^b  

^a Fine and Specialty Chemicals in Linde Gases Division   (United States)

^b IMA LIFE North America   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ICE;

ARTICLE; CHEMICAL MODIFICATION; COOLING; CRYSTAL STRUCTURE; DRUG INDUSTRY; FOG; FREEZE DRYING; ICE NUCLEATION; LARGE SCALE PRODUCTION; PHASE TRANSITION; PROCESS DESIGN; PRODUCT DEVELOPMENT; TEMPERATURE SENSITIVITY;

EID: 84859088928     PISSN: 1542166X     EISSN: 19391862     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (4)

1. M.L. Roy and M.J. Pikal, J. Parenter. Sci. Technol. 43, 60-66 (1989).
2. J.A. Searles, J. F. Carpenter, and T.W. Randolph, J. Pharm. Sci. 90, 860-871 (2001).
3. S. Rambhatla et al., AAPS PharmSciTech 5 (4), 54-62 (2004).
4. T. D. Rowe, presentation at International Symposium on Biological Product Freeze-Drying and Formulation (Geneva, 1990).