Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol

Experimental and Toxicologic Pathology

Volumn 65, Issue 7-8, 2013, Pages 1091-1100

  Monga, Jitender ^a   Pandit, Saurabh ^a   Chauhan, Chetan Singh ^b   Sharma, Manu ^a  

^a JAYPEE UNIVERSITY OF INFORMATION TECHNOLOGY   (India)

^b Bhupal Noble's College of Pharmacy   (India)

Author keywords

(+) Cyanidan 3 ol; Apoptosis; Breast cancer; Cytotoxicity

Indexed keywords

1,2 DIBROMOETHANE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ACRIDINE ORANGE; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYANIDAN 3 OL; DNA; FLAVONOID; LACTATE DEHYDROGENASE; MESSENGER RNA; POLYPHENOL DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN C FOS; PROTEIN C JUN; PROTEIN MDM2; PROTEIN P53; SULFORHODAMINE B; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CELL ASSAY; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

(+)-CYANIDAN-3-OL; APOPTOSIS; BREAST CANCER; CYTOTOXICITY;

ADENOCARCINOMA; APOPTOSIS; BREAST NEOPLASMS; CATECHIN; CELL PROLIFERATION; CELL SURVIVAL; DNA FRAGMENTATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MCF-7 CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84885835242     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2013.04.005     Document Type: Article

References (37)

1. Angel P., Karin M. The role of jun, fos, and the AP-1 complex in cell-proliferation and transformation. Biochimica et Biophysica Acta 1991, 1072:129-157.
2. Ariffin S.H.Z., Wan Omar W.H., Ariffin Z.Z., Safian M.F., Senafi S., Abdul Wahab R.M. Intrinsic anticarcinogenic effects of Piper sarmentosum ethanolic extract on a human hepatoma cell line. Cancer Cell International 2009, 9:6.
3. Ashkenazi A., Herbst R.S. To kill a tumor cell: the potential of proapoptotic receptor agonists. Journal of Clinical Investigation 2008, 118:1979-1990.
4. Barnes S., Prasain J. Current progress in the use of traditional medicine and nutraceuticals. Current Opinion in Plant Biology 2005, 8:324-328.
5. Beg A.A., Sha W.C., Bronson R.T., Ghosh S., Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 1995, 376:167-170.
6. Bellas R.E., FitzGerald M.J., Fausto N., Sonenshein G.E. Inhibition of NF-κB activity induces apoptosis in murine hepatocytes. American Journal of Pathology 1997, 151:891-896.
7. Brekman A., Singh K.E., Polotskaia A., Kundu N., Bargonetti J. A p53-independent role of Mdm2 in estrogen mediated activation of breast cancer cell proliferation. Breast Cancer Research 2011, 13:R3.
8. Denizot F., Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. Journal of Immunological Methods 1986, 89:271-277.
9. Fink S.L., Cookson B.T. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infection and Immunity 2005, 73:1907-1916.
10. Ghavami S., Hashemi M., Ande S.R., Yeganeh B., Xiao W., Eshraghi M., et al. Apoptosis and cancer: mutations within caspase genes. Journal of Medical Genetics 2009, 46:497-510.
11. Guruvayoorappan C., Kuttan G. (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-α in LPS-stimulated macrophages. Innate Immunity 2008, 14:160-174.
12. Hengartner M.O. The biochemistry of apoptosis. Nature 2007, 407:770-776.
13. Jeong S.Y., Seol D.W. The role of mitochondria in apoptosis. BMB Reports 2008, 41:11-22.
14. Jimenez P.C., Wilke D.V., Takeara R., Lotufo T.M., Pessoa C., de Moraes M.O., et al. Cytotoxicity activity of a dichloromethane extract and fractions obtained from Eudistoma vannamei (Tunicata: Ascidiacea). Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology 2008, 151:391-398.
15. Jordan V.C., O'Malley B.W. Selective estrogen-receptor modulators and antihormonal resistance in breast cancer. Journal of Clinical Oncology 2007, 25:5815-5824.
16. Karin M., Liu Z.G., Zandi E. AP-1 function and regulation. Current Opinion in Cell Biology 1997, 9:240-246.
17. Khan M.R., Mlungwana S.M. c-Sitosterol, a cytotoxic sterol from Markhamia zanzibarica and Kigelia africana. Fitoterapia 1999, 70:96-97.
18. Kurita-Ochiai T., Fukushima K., Ochiai K. Lipopolysaccharide stimulates butyric acid-induced apoptosis in human peripheral blood mononuclear cells. Infection and Immunity 1999, 67:22-29.
19. Lotito B.S., Fraga C.G. (+)-Catechin prevents human plasma oxidation. Free Radical Biology and Medicine 1998, 24:435-441.
20. Maximov G.K., Maximov K.G. The role of p53 tumor-suppressor protein in apoptosis and carcinogenesis. Biotechnology and Biotechnological Equipment 2008, 22:664-668.
21. Monga J., Chauhan C.S., Sharma M. Human epithelial carcinoma cytotoxicity and inhibition of DMBA/TPA induced squamous cell carcinoma in Balb/c mice by Acacia catechu heartwood. Journal of Pharmacy and Pharmacology 2011, 63:1470-1482.
22. Monga J., Chauhan C.S., Sharma M. Human breast adenocarcinoma cytotoxicity and modulation of 7,12-dimethylbenz[a]anthracene-induced mammary carcinoma in Balb/c mice by Acacia catechu heartwood. Integrative Cancer Therapies 2012, (November). [E-pub ahead].
23. Nukumi N., Iwamori T., Kano K., Naito K., Tojo H. Reduction of tumorigenesis and invasion of human breast cancer cells by whey acidic protein (WAP). Cancer Letters 2007, 252:65-74.
24. Panchal R.G. Novel therapeutic strategies to selectively kill cancer cells. Biochemical Pharmacology 1998, 55:247-252.
25. Perandones C.E., Illera V.A., Peckham D., Stunz L., Ashman R.F. Regulation of apoptosis in vitro in mature spleen T cells. Journal of Immunology 1993, 151:3521-3529.
26. Saad S., Dakwar O., Said G., Abu-Hijleh G., Battah F.A., Kmeel A., et al. Evaluation of medicinal plant hepatotoxicity in co-cultures of hepatocytes and monocytes. Evidence-Based Complementary and Alternative Medicine 2006, 3:93-98.
27. Shangary S., Wang S. Targeting the MDM2-p53 interaction for cancer therapy. Clinical Cancer Research 2008, 14:5318-5324.
28. Shankar S., Ganapathy G., Shrivastava R.K. Green tea polyphenols: biology and therapeutic implications in cancer. Frontiers in Bioscience 2007, 12:4881-4899.
29. Shanmugam M.K., Nguyen A.H., Kumar A.P., Tan B.K., Sethi G. Targeted inhibition of tumor proliferation, survival and metastasis by pentacyclic triterpenoids: potential role in prevention and therapy of cancer. Cancer Letters 2012, 320:158-170.
30. Shaulian E., Karin M. AP-1 in cell proliferation and survival. Oncogene 2001, 20:2390-2400.
31. Thomas A., Giesler T., White E. p53 mediated Bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway. Oncogene 2000, 19:5259-5269.
32. Van Antwerp D.J., Martin S.J., Kafri T., Green D.R., Verma I.M. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 1996, 274:787-789.
33. Vanicha V., Kanyawim K. Sulforhodamine B colorimetric assay for cytotoxicity screening. Nature 2006, 1:1112-1116.
34. Vazquez A., Bond E.E., Levine A.J., Bond G.L. The genetics of the p53 pathway, apoptosis and cancer therapy. Nature Reviews Drug Discovery 2008, 7:979-987.
35. Walker P.R., Kokileva L., LeBlanc J., Sikorska M. Detection of the initial stages of DNA fragmentation in apoptosis. Biotechniques 1993, 15:1032-1040.
36. Weyant M.J., Carothers A.M., Dannenberg A.J., Bertagnolli M.M. (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the Min/1 mouse. Cancer Research 2001, 61:118-125.
37. Wylie A.H., Morris R.G., Smith A.L., Dunlop D. Chromatin cleavage in apoptosis; association with condensed chromatin morphology and dependence on macromolecular synthesis. Journal of Pathology 1984, 142:62-67.