T cell receptor (TCR) signal strength controls arthritis severity in proteoglycan-specific TCR transgenic mice

Clinical and Experimental Immunology

Volumn 167, Issue 2, 2012, Pages 346-355

  Olasz, K ^a,b   Boldizsar, F ^a,b   Kis Toth, K ^a,c   Tarjanyi, O ^a,b   Hegyi, A ^a   van Eden, W ^d   Rauch, T A ^a   Mikecz, K ^a   Glant, T T ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF PÉCS   (Hungary)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Rheumatoid arthritis; TcR signalling; Transgenic mice

Indexed keywords

CD3 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; PROTEOGLYCAN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTHRITIS; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL COUNT; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HELPER CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AGGRECANS; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; EPITOPES, T-LYMPHOCYTE; GENE DOSAGE; HUMANS; IMMUNIZATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-TYROSINE KINASES; PROTEOGLYCANS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT PROTEINS;

EID: 84855802194     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04506.x     Document Type: Article

References (36)

1. Glant TT, Mikecz K, Arzoumanian A, Poole AR. Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology. Arthritis Rheum 1987; 30:201-12.
2. Mikecz K, Glant TT, Poole AR. Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan. Arthritis Rheum 1987; 30:306-18.
3. Glant TT, Buzas EI, Finnegan A, Negroiu G, Cs-Szabó G, Mikecz K. Critical role of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation. J Immunol 1998; 160:3812-19.
4. Glant TT, Finnegan A, Mikecz K. Proteoglycan-induced arthritis: immune regulation, cellular mechanisms and genetics. Crit Rev Immunol 2003; 23:199-250.
5. Finnegan A, Mikecz K, Tao P, Glant TT. Proteoglycan (aggrecan)-induced arthritis in BALB/c mice is a Th1-type disease regulated by Th2 cytokines. J Immunol 1999; 163:5383-90.
6. Bardos T, Mikecz K, Finnegan A, Zhang J, Glant TT. T and B cell recovery in arthritis adoptively transferred to SCID mice: antigen-specific activation is required for restoration of autopathogenic CD4+ Th1 cells in a syngeneic system. J Immunol 2002; 168:6013-21.
7. Boldizsar F, Tarjanyi O, Nemeth P, Mikecz K, Glant TT. Th1/Th17 polarization and acquisition of an arthritogenic phenotype in arthritis-susceptible BALB/c, but not in MHC-matched, arthritis-resistant DBA/2 mice. Int Immunol 2009; 21:511-22.
8. + T cells. Cell Immunol 1992; 144:347-57.
9. Mikecz K, Glant TT, Buzás E, Poole AR. Proteoglycan-induced polyarthritis and spondylitis adoptively transferred to naive (nonimmunized) BALB/c mice. Arthritis Rheum 1990; 33:866-76.
10. Szanto S, Bárdos T, Szabo Z etal. Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background. Arthritis Rheum 2004; 50:1984-95.
11. Buzas E, Vegvari A, Murad YM, Finnegan A, Mikecz K, Glant TT. T-cell recognition of differentially tolerated epitopes of cartilage proteoglycan aggrecan in arthritis. Cell Immunol 2005; 235:98-108.
12. Glant TT, Radacs M, Nagyeri G etal. Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two types of rheumatoid arthritis. Arthritis Rheum 2011; 63:1312-21.
13. Murad YM, Szabo Z, Ludanyi K, Glant TT. Molecular manipulation with the arthritogenic epitopes of the G1 domain of human cartilage proteoglycan aggrecan. Clin Exp Immunol 2005; 142:303-11.
14. Buzas EI, Brennan FR, Mikecz K etal. A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice. J Immunol 1995; 155:2679-87.
15. Berlo SE, Van Kooten PJ, ten Brink CB etal. Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis upon in vivo activation. J Autoimmun 2005; 25:172-80.
16. Berlo SE, Guichelaar T, ten Brink CB etal. Increased arthritis susceptibility in cartilage proteoglycan-specific T cell receptor-transgenic mice. Arthritis Rheum 2006; 54:2423-33.
17. Boldizsar F, Kis-Toth K, Tarjanyi O etal. Impaired activation-induced cell death promotes spontaneous arthritis in antigen (cartilage proteoglycan)-specific T cell receptor transgenic mice. Arthritis Rheum 2010; 62:2984-94.
18. Glant TT, Mikecz K. Proteoglycan aggrecan-induced arthritis. A murine autoimmune model of rheumatoid arthritis. Methods Mol Med 2004; 102:313-38.
19. Brennan FR, Negroiu G, Buzas EI, Fülöp C, Mikecz K, Glant TT. Presentation of cartilage proteoglycan to a T cell hybridoma derived from a mouse with proteoglycan-induced arthritis. Clin Exp Immunol 1995; 100:104-10.
20. Krutzik PO, Hale MB, Nolan GP. Characterization of the murine immunological signaling network with phosphospecific flow cytometry. J Immunol 2005; 175:2366-73.
21. Hsu HC, Scott DK, Mountz JD. Impaired apoptosis and immune senescence - cause or effect? Immunol Rev 2005; 205:130-46.
22. Wiczling P, Rosenzweig M, Vaickus L, Jusko WJ. Pharmacokinetics and pharmacodynamics of a chimeric/humanized anti-CD3 monoclonal antibody, otelixizumab (TRX4), in subjects with psoriasis and with type 1 diabetes mellitus. J Clin Pharmacol 2010; 50:494-506.
23. O'Neill SK, Shlomchik MJ, Glant TT, Cao Y, Doodes PD, Finnegan A. Antigen-specific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis. J Immunol 2005; 174:3781-8.
24. O'Neill SK, Glant TT, Finnegan A. The role of B cells in animal models of rheumatoid arthritis. Front Biosci 2007; 12:1722-36.
25. O'Neill SK, Cao Y, Hamel KM, Doodes PD, Hutas G, Finnegan A. Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis. J Immunol 2007; 179:5109-16.
26. Wilson EH, Zaph C, Mohrs M etal. B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses. J Immunol 2006; 177:2365-72.
27. Frey O, Meisel J, Hutloff A etal. Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis. Ann Rheum Dis 2010; 69:1495-501.
28. Frey O, Reichel A, Bonhagen K, Morawietz L, Rauchhaus U, Kamradt T. Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis. Ann Rheum Dis 2010; 48:345-53.
29. Kim YO, Kim HJ, Kim SK, Chung JH, Hong SJ. Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis. Clin Chem Lab Med 2010; 48:345-53.
30. Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000; 192:1553-62.
31. Linterman MA, Rigby RJ, Wong RK etal. Follicular helper T cells are required for systemic autoimmunity. J Exp Med 2009; 206:561-76.
32. Victoratos P, Kollias G. Induction of autoantibody-mediated spontaneous arthritis critically depends on follicular dendritic cells. Immunity 2009; 30:130-42.
33. She J, Matsui K, Terhorst C, Ju ST. Activation-induced apoptosis of mature T cells is dependent upon the level of surface TCR but not on the presence of the CD3 zeta ITAM. Int Immunol 1998; 10:1733-40.
34. Metz DP, Farber DL, Taylor T, Bottomly K. Differential role of CTLA-4 in regulation of resting memory versus naive CD4 T cell activation. J Immunol 1998; 161:5855-61.
35. Zhang J, Xu X, Liu Y. Activation-induced cell death in T cells and autoimmunity. Cell Mol Immunol 2004; 1:186-92.
36. Singh K, Deshpande P, Pryshchep S etal. ERK-dependent T cell receptor threshold calibration in rheumatoid arthritis. J Immunol 2009; 183:8258-67.