Antioxidants may protect cancer cells from apoptosis signals and enhance cell viability

Asian Pacific Journal of Cancer Prevention

Volumn 14, Issue 8, 2013, Pages 4611-4614

  Akan, Zafer ^a   Garip, Ayse Inhan ^b  

^a YUZUNCU YIL UNIVERSITY   (Turkey)

^b MARMARA UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Cancer; Cell viability; Prevention; Quercetin

Indexed keywords

ANTIOXIDANT; HYDROGEN PEROXIDE; OXIDIZING AGENT; QUERCETIN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; DRUG EFFECT; ERYTHROLEUKEMIA; HUMAN; METABOLISM; PATHOLOGY; TUMOR CELL CULTURE;

ANTIOXIDANTS; APOPTOSIS; CELL PROLIFERATION; HUMANS; HYDROGEN PEROXIDE; LEUKEMIA, ERYTHROBLASTIC, ACUTE; OXIDANTS; QUERCETIN; TUMOR CELLS, CULTURED;

EID: 84885812530     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2013.14.8.4611     Document Type: Article

References (25)

1. Bayir H (2005). Reactive oxygen species. Crit Care Med, 33, 498-501.
2. Benkovic V, Knezevic AH, Dikic D, et al (2009). Radioprotective effects of quercetin and ethanolic extract of propolis in gamma-irradiated mice. Arh Hig Rada Toksikol, 60, 129-38.
3. Cao XG, Li XX, Bao YZ, et al (2007). Responses of human lens epithelial cells to quercetin and DMSO. Invest Ophthalmol Vis Sci, 48, 3714-8.
4. Chamond RR, Anon JC, Guerra P, et al (1999). Apoptosis and disease. Alergol Immunol Clin, 14, 367-74.
5. 2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Pharmacol, 69, 1839-51.
6. Davis JM, Murphy EA, Carmichael MD (2009). Effects of the dietary flavonoid quercetin upon performance and health. Curr Sports Med Rep, 8, 206-13.
7. Formica JV, Regelson W (1995). Review of the biology of Quercetin and related bioflavonoids. Food Chem Toxicol, 33, 1061-80.
8. Gerhauser C (2008). Cancer chemopreventive potential of apples, apple juice, and apple components. Planta Med, 74, 1608-24.
9. Hertog MG, Hollman PC (1996). Potential health effects of the dietary flavonol quercetin. Eur J Clin Nutr, 50, 63-71.
10. Hultqvist M, Olsson LM, Gelderman KA, et al (2009). The protective role of ROS in autoimmune disease. Trends Immunol, 30, 201-8.
11. Ishikawa Y, Kitamura M (2000). Anti-apoptotic effect of quercetin; intervention in the JNK-and ERK-mediated apoptotic pathways. Kidney Int, 58, 1078-87.
12. Jung JH, Lee JO, Kim JH, et al (2010). Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation. J Cell Physiol, 223, 408-14.
13. Kopani M, Celec P, Danisovic L, et al (2006). Oxidative stress and electron spin resonance. Clin Chim Acta, 364, 61-6.
14. Kulbacka J, Saczko J, Chwilkowska A (2009). Oxidative stress in cells damage processes. Pol Merkur Lekarski, 27, 44-7.
15. Murakami A, Ashida H, Terao J (2008). Multitargeted cancer prevention by quercetin. Cancer Lett, 269, 315-25.
16. Nguyen TT, Tran E, Nguyen TH, et al (2004). The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis, 25, 647-59.
17. Orsolic N, Benkovic V, Horvat-Knezevic A, et al (2007). Assessment by survival analysis of the radioprotective properties of propolis and its polyphenolic compounds. Biol Pharm Bull, 30, 946-51.
18. Park C, So HS, Shin CH, et al (2003). Quercetin protects the hydrogen peroxide-induced apoptosis via inhibition of mitochondrial dysfunction in H9c2 cardiomyoblast cells. Biochem Pharmacol, 66, 1287-95.
19. Rinaldi S, Landucci F, De Gaudio AR (2009). Antioxidant therapy in critically septic patients. Curr Drug Targets, 10, 872-80.
20. Richter M, Ebermann R, Marian B (1999). Quercetin-induced apoptosis in colorectal tumor cells; possible role of EGF receptor signaling. Nutr Cancer, 34, 88-99.
21. Schafer FQ, Buettner GR (2001). Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med, 30, 1191-212.
22. Siu D (2010). A new way of targeting to treat coronary artery disease. J Cardiovasc Med (Hagerstown), 11, 1-6.
23. Terao J (2009). Dietary flavonoids as antioxidants. Forum Nutr, 61, 87-94.
24. Ueno I, Kohno M, Haraikawa K, et al (1984). Interaction between quercetin and superoxide radicals. Reduction of the quercetin mutagenicity. J Pharmacobiodyn, 7, 798-803.
25. Van Erk MJ, Roepman P, van der Lende TR, et al (2005). Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr, 44, 143-56.