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Volumn 8, Issue 10, 2013, Pages

TGF-beta1 Does Not Induce Senescence of Multipotent Mesenchymal Stromal Cells and Has Similar Effects in Early and Late Passages

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1;

EID: 84885795846     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077656     Document Type: Article
Times cited : (29)

References (66)
  • 1
    • 58149260186 scopus 로고    scopus 로고
    • Smad3 mediates immediate early induction of Id1 by TGF-beta
    • doi:10.1038/cr.2008.321
    • Liang YY, Brunicardi FC, Lin X, (2009) Smad3 mediates immediate early induction of Id1 by TGF-beta. Cell Res 19: 140-148. doi:10.1038/cr.2008.321. PubMed: 19079362.
    • (2009) Cell Res , vol.19 , pp. 140-148
    • Liang, Y.Y.1    Brunicardi, F.C.2    Lin, X.3
  • 2
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-beta signals
    • doi:10.1038/35042034
    • Massagué J, (2000) How cells read TGF-beta signals. Nat Rev Mol Cell Biol 1: 169-178. doi:10.1038/35042034. PubMed: 11252892.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 169-178
    • Massagué, J.1
  • 3
    • 84859443358 scopus 로고    scopus 로고
    • Non-Smad signaling pathways
    • doi:10.1007/s00441-011-1201-y
    • Mu Y, Gudey SK, Landström M, (2012) Non-Smad signaling pathways. Cell Tissue Res 347: 11-20. doi:10.1007/s00441-011-1201-y. PubMed: 21701805.
    • (2012) Cell Tissue Res , vol.347 , pp. 11-20
    • Mu, Y.1    Gudey, S.K.2    Landström, M.3
  • 4
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • doi:10.1038/nrc1208
    • Siegel PM, Massagué J, (2003) Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 3: 807-821. doi:10.1038/nrc1208. PubMed: 14557817.
    • (2003) Nat Rev Cancer , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massagué, J.2
  • 5
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • doi:10.1242/jcs.02554
    • Moustakas A, Heldin CH, (2005) Non-Smad TGF-beta signals. J Cell Sci 118: 3573-3584. doi:10.1242/jcs.02554. PubMed: 16105881.
    • (2005) J Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 6
    • 0035951791 scopus 로고    scopus 로고
    • Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts
    • doi:10.1074/jbc.M006809200
    • Frippiat C, Chen QM, Zdanov S, Magalhaes JP, Remacle J, et al. (2001) Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J Biol Chem 276: 2531-2537. doi:10.1074/jbc.M006809200. PubMed: 11060295.
    • (2001) J Biol Chem , vol.276 , pp. 2531-2537
    • Frippiat, C.1    Chen, Q.M.2    Zdanov, S.3    Magalhaes, J.P.4    Remacle, J.5
  • 7
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-beta signaling
    • Massagué J, Chen YG, (2000) Controlling TGF-beta signaling. Genes Dev 14: 627-644. PubMed: 10733523.
    • (2000) Genes Dev , vol.14 , pp. 627-644
    • Massagué, J.1    Chen, Y.G.2
  • 8
    • 80051925342 scopus 로고    scopus 로고
    • Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells
    • doi:10.1074/jbc.M110.217745
    • Mizutani A, Koinuma D, Tsutsumi S, Kamimura N, Morikawa M, et al. (2011) Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells. J Biol Chem 286: 29848-29860. doi:10.1074/jbc.M110.217745. PubMed: 21646355.
    • (2011) J Biol Chem , vol.286 , pp. 29848-29860
    • Mizutani, A.1    Koinuma, D.2    Tsutsumi, S.3    Kamimura, N.4    Morikawa, M.5
  • 10
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • doi:10.1080/14653240600855905
    • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, et al. (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8: 315-317. doi:10.1080/14653240600855905. PubMed: 16923606.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.5
  • 11
    • 77950584190 scopus 로고    scopus 로고
    • Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin
    • Gao L, McBeath R, Chen CS, (2010) Stem cell shape regulates a chondrogenic versus myogenic fate through Rac1 and N-cadherin. Stem Cells 28: 564-572. PubMed: 20082286.
    • (2010) Stem Cells , vol.28 , pp. 564-572
    • Gao, L.1    McBeath, R.2    Chen, C.S.3
  • 12
    • 6344281040 scopus 로고    scopus 로고
    • Proteomic profiling of bone marrow mesenchymal stem cells upon transforming growth factor beta1 stimulation
    • doi:10.1074/jbc.M407368200
    • Wang D, Park JS, Chu JS, Krakowski A, Luo K, et al. (2004) Proteomic profiling of bone marrow mesenchymal stem cells upon transforming growth factor beta1 stimulation. J Biol Chem 279: 43725-43734. doi:10.1074/jbc.M407368200. PubMed: 15302865.
    • (2004) J Biol Chem , vol.279 , pp. 43725-43734
    • Wang, D.1    Park, J.S.2    Chu, J.S.3    Krakowski, A.4    Luo, K.5
  • 13
    • 50949092167 scopus 로고    scopus 로고
    • Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells
    • doi:10.1016/j.bone.2008.06.016
    • Koli K, Ryynänen MJ, Keski-Oja J, (2008) Latent TGF-beta binding proteins (LTBPs)-1 and-3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells. Bone 43: 679-688. doi:10.1016/j.bone.2008.06.016. PubMed: 18672106.
    • (2008) Bone , vol.43 , pp. 679-688
    • Koli, K.1    Ryynänen, M.J.2    Keski-Oja, J.3
  • 14
    • 84455188376 scopus 로고    scopus 로고
    • TGF-beta mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction
    • doi:10.1210/en.2011-1169
    • Kumar A, Ruan M, Clifton K, Syed F, Khosla S, et al. (2012) TGF-beta mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction. Endocrinology 153: 254-263. doi:10.1210/en.2011-1169. PubMed: 22067314.
    • (2012) Endocrinology , vol.153 , pp. 254-263
    • Kumar, A.1    Ruan, M.2    Clifton, K.3    Syed, F.4    Khosla, S.5
  • 15
    • 84863229849 scopus 로고    scopus 로고
    • Matrix rigidity regulates a switch between TGF-beta1-induced apoptosis and epithelial-mesenchymal transition
    • doi:10.1091/mbc.E11-06-0537
    • Leight JL, Wozniak MA, Chen S, Lynch ML, Chen CS, (2012) Matrix rigidity regulates a switch between TGF-beta1-induced apoptosis and epithelial-mesenchymal transition. Mol Cell Biol 23: 781-791. doi:10.1091/mbc.E11-06-0537.
    • (2012) Mol Cell Biol , vol.23 , pp. 781-791
    • Leight, J.L.1    Wozniak, M.A.2    Chen, S.3    Lynch, M.L.4    Chen, C.S.5
  • 16
    • 79953025653 scopus 로고    scopus 로고
    • The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-beta
    • doi:10.1016/j.biomaterials.2011.02.019
    • Park JS, Chu JS, Tsou AD, Diop R, Tang Z, et al. (2011) The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-beta. Biomaterials 32: 3921-3930. doi:10.1016/j.biomaterials.2011.02.019. PubMed: 21397942.
    • (2011) Biomaterials , vol.32 , pp. 3921-3930
    • Park, J.S.1    Chu, J.S.2    Tsou, A.D.3    Diop, R.4    Tang, Z.5
  • 17
    • 47649121002 scopus 로고    scopus 로고
    • PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages
    • doi:10.1182/blood-2007-07-103697
    • Ng F, Boucher S, Koh S, Sastry KS, Chase L, et al. (2008) PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages. Blood 112: 295-307. doi:10.1182/blood-2007-07-103697. PubMed: 18332228.
    • (2008) Blood , vol.112 , pp. 295-307
    • Ng, F.1    Boucher, S.2    Koh, S.3    Sastry, K.S.4    Chase, L.5
  • 18
    • 0035136844 scopus 로고    scopus 로고
    • TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)
    • doi:10.1046/j.1523-1755.2001.059002579.x
    • Strutz F, Zeisberg M, Renziehausen A, Raschke B, Becker V, et al. (2001) TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2). Kidney Int 59: 579-592. doi:10.1046/j.1523-1755.2001.059002579.x. PubMed: 11168939.
    • (2001) Kidney Int , vol.59 , pp. 579-592
    • Strutz, F.1    Zeisberg, M.2    Renziehausen, A.3    Raschke, B.4    Becker, V.5
  • 19
    • 33645007189 scopus 로고    scopus 로고
    • Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells
    • doi:10.1101/gad.1388806
    • Jian H, Shen X, Liu I, Semenov M, He X, et al. (2006) Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. Genes Dev 20: 666-674. doi:10.1101/gad.1388806. PubMed: 16543220.
    • (2006) Genes Dev , vol.20 , pp. 666-674
    • Jian, H.1    Shen, X.2    Liu, I.3    Semenov, M.4    He, X.5
  • 20
    • 34249661093 scopus 로고    scopus 로고
    • FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2
    • doi:10.1016/j.bbrc.2007.05.067
    • Ito T, Sawada R, Fujiwara Y, Seyama Y, Tsuchiya T, (2007) FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2. Biochem Biophys Res Commun 359: 108-114. doi:10.1016/j.bbrc.2007.05.067. PubMed: 17532297.
    • (2007) Biochem Biophys Res Commun , vol.359 , pp. 108-114
    • Ito, T.1    Sawada, R.2    Fujiwara, Y.3    Seyama, Y.4    Tsuchiya, T.5
  • 21
    • 20144362952 scopus 로고    scopus 로고
    • Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway
    • doi:10.1242/jcs.01651
    • Debacq-Chainiaux F, Borlon C, Pascal T, Royer V, Eliaers F, et al. (2005) Repeated exposure of human skin fibroblasts to UVB at subcytotoxic level triggers premature senescence through the TGF-beta1 signaling pathway. J Cell Sci 118: 743-758. doi:10.1242/jcs.01651. PubMed: 15671065.
    • (2005) J Cell Sci , vol.118 , pp. 743-758
    • Debacq-Chainiaux, F.1    Borlon, C.2    Pascal, T.3    Royer, V.4    Eliaers, F.5
  • 22
    • 38949186562 scopus 로고    scopus 로고
    • Mesenchymal stem cell preparations-comparing apples and oranges
    • Wagner W, Ho AD, (2007) Mesenchymal stem cell preparations-comparing apples and oranges. Stem. Cell Res 3: 239-248.
    • (2007) Stem Cell Res , vol.3 , pp. 239-248
    • Wagner, W.1    Ho, A.D.2
  • 23
    • 47249166372 scopus 로고    scopus 로고
    • Replicative Senescence of Mesenchymal Stem Cells - a Continuous and Organized Process
    • Wagner W, Horn P, Castoldi M, Diehlmann A, Bork S, et al. (2008) Replicative Senescence of Mesenchymal Stem Cells- a Continuous and Organized Process. PLOS ONE 5: e2213.
    • (2008) PLOS ONE , vol.5
    • Wagner, W.1    Horn, P.2    Castoldi, M.3    Diehlmann, A.4    Bork, S.5
  • 24
    • 84858661300 scopus 로고    scopus 로고
    • Population dynamics of mesenchymal stromal cells during culture expansion
    • doi:10.3109/14653249.2011.640669
    • Schellenberg A, Stiehl T, Horn P, Joussen S, Pallua N, et al. (2012) Population dynamics of mesenchymal stromal cells during culture expansion. Cytotherapy 14: 401-411. doi:10.3109/14653249.2011.640669. PubMed: 22149184.
    • (2012) Cytotherapy , vol.14 , pp. 401-411
    • Schellenberg, A.1    Stiehl, T.2    Horn, P.3    Joussen, S.4    Pallua, N.5
  • 25
    • 76249107254 scopus 로고    scopus 로고
    • DNA Methylation Pattern Changes upon Long-Term Culture and Aging of Human Mesenchymal Stromal Cells
    • doi:10.1111/j.1474-9726.2009.00535.x
    • Bork S, Pfister S, Witt H, Horn P, Korn B, et al. (2010) DNA Methylation Pattern Changes upon Long-Term Culture and Aging of Human Mesenchymal Stromal Cells. Aging Cell 9: 54-63. doi:10.1111/j.1474-9726.2009.00535.x. PubMed: 19895632.
    • (2010) Aging Cell , vol.9 , pp. 54-63
    • Bork, S.1    Pfister, S.2    Witt, H.3    Horn, P.4    Korn, B.5
  • 26
    • 84858342860 scopus 로고    scopus 로고
    • Monitoring of cellular senescence by DNA-methylation at specific CpG sites
    • doi:10.1111/j.1474-9726.2011.00784.x
    • Koch CM, Joussen S, Schellenberg A, Lin Q, Zenke M, et al. (2012) Monitoring of cellular senescence by DNA-methylation at specific CpG sites. Aging Cell 11: 366-369. doi:10.1111/j.1474-9726.2011.00784.x. PubMed: 22221451.
    • (2012) Aging Cell , vol.11 , pp. 366-369
    • Koch, C.M.1    Joussen, S.2    Schellenberg, A.3    Lin, Q.4    Zenke, M.5
  • 27
    • 80855163623 scopus 로고    scopus 로고
    • Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks
    • Schellenberg A, Lin Q, Schüler H, Koch CM, Joussen S, et al. (2011) Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks. Aging (Albany NY) 3: 873-888. PubMed: 22025769.
    • (2011) Aging (Albany NY) , vol.3 , pp. 873-888
    • Schellenberg, A.1    Lin, Q.2    Schüler, H.3    Koch, C.M.4    Joussen, S.5
  • 28
    • 0034596230 scopus 로고    scopus 로고
    • Age-related effects of TGF-beta on proteoglycan synthesis in equine articular cartilage
    • doi:10.1006/bbrc.2000.3167
    • Iqbal J, Dudhia J, Bird JL, Bayliss MT, (2000) Age-related effects of TGF-beta on proteoglycan synthesis in equine articular cartilage. Biochem Biophys Res Commun 274: 467-471. doi:10.1006/bbrc.2000.3167. PubMed: 10913361.
    • (2000) Biochem Biophys Res Commun , vol.274 , pp. 467-471
    • Iqbal, J.1    Dudhia, J.2    Bird, J.L.3    Bayliss, M.T.4
  • 29
    • 0028128443 scopus 로고
    • In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences
    • doi:10.1136/ard.53.9.593
    • van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB, (1994) In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences. Ann Rheum Dis 53: 593-600. doi:10.1136/ard.53.9.593. PubMed: 7979598.
    • (1994) Ann Rheum Dis , vol.53 , pp. 593-600
    • van Beuningen, H.M.1    van der Kraan, P.M.2    Arntz, O.J.3    van den Berg, W.B.4
  • 30
    • 0027529271 scopus 로고
    • Evidence for an age-related dysfunction in the antiproliferative response to transforming growth factor-beta in vascular smooth muscle cells
    • doi:10.1091/mbc.4.3.315
    • McCaffrey TA, Falcone DJ, (1993) Evidence for an age-related dysfunction in the antiproliferative response to transforming growth factor-beta in vascular smooth muscle cells. Mol Cell Biol 4: 315-322. doi:10.1091/mbc.4.3.315. PubMed: 8387357.
    • (1993) Mol Cell Biol , vol.4 , pp. 315-322
    • McCaffrey, T.A.1    Falcone, D.J.2
  • 31
    • 80855150910 scopus 로고    scopus 로고
    • Expansion of adipose mesenchymal stromal cells is affected by human platelet lysate and plating density
    • doi:10.3727/096368910X557218
    • Cholewa D, Stiehl T, Schellenberg A, Bokermann G, Joussen S, et al. (2011) Expansion of adipose mesenchymal stromal cells is affected by human platelet lysate and plating density. Cell Transplant 20: 1409-1422. doi:10.3727/096368910X557218. PubMed: 21396157.
    • (2011) Cell Transplant , vol.20 , pp. 1409-1422
    • Cholewa, D.1    Stiehl, T.2    Schellenberg, A.3    Bokermann, G.4    Joussen, S.5
  • 32
    • 77958015845 scopus 로고    scopus 로고
    • Comparison of Individual Platelet Lysates for Isolation of Human Mesenchymal Stromal Cells
    • doi:10.3109/14653249.2010.501788
    • Horn P, Bokermann G, Cholewa D, Bork S, Walenda T, et al. (2010) Comparison of Individual Platelet Lysates for Isolation of Human Mesenchymal Stromal Cells. Cytotherapy 12: 888-898. doi:10.3109/14653249.2010.501788. PubMed: 20662607.
    • (2010) Cytotherapy , vol.12 , pp. 888-898
    • Horn, P.1    Bokermann, G.2    Cholewa, D.3    Bork, S.4    Walenda, T.5
  • 33
    • 74949127989 scopus 로고    scopus 로고
    • Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo
    • doi:10.1038/nprot.2009.191
    • Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O, (2009) Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc 4: 1798-1806. doi:10.1038/nprot.2009.191. PubMed: 20010931.
    • (2009) Nat Protoc , vol.4 , pp. 1798-1806
    • Debacq-Chainiaux, F.1    Erusalimsky, J.D.2    Campisi, J.3    Toussaint, O.4
  • 34
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • doi:10.1126/science.284.5411.143
    • Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, et al. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-147. doi:10.1126/science.284.5411.143. PubMed: 10102814.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3    Jaiswal, R.K.4    Douglas, R.5
  • 35
    • 79951563440 scopus 로고    scopus 로고
    • Specific age-associated DNA methylation changes in human dermal fibroblasts
    • doi:10.1371/journal.pone.0016679
    • Koch CM, Suschek CV, Lin Q, Bork S, Goergens M, et al. (2011) Specific age-associated DNA methylation changes in human dermal fibroblasts. PLOS ONE 6: e16679. doi:10.1371/journal.pone.0016679. PubMed: 21347436.
    • (2011) PLOS ONE , vol.6
    • Koch, C.M.1    Suschek, C.V.2    Lin, Q.3    Bork, S.4    Goergens, M.5
  • 36
    • 84934442123 scopus 로고    scopus 로고
    • Epigenetic Biomarker to Determine Replicative Senescence of in vitro-Cultured Cells
    • in press
    • Koch CM, Wagner W, (2013) Epigenetic Biomarker to Determine Replicative Senescence of in vitro-Cultured Cells. Methods Mol Biol (in press).
    • (2013) Methods Mol Biol
    • Koch, C.M.1    Wagner, W.2
  • 37
    • 84873394089 scopus 로고    scopus 로고
    • Pluripotent stem cells escape from senescence-associated DNA methylation changes
    • doi:10.1101/gr.141945.112
    • Koch CM, Reck K, Shao K, Lin Q, Joussen S, et al. (2013) Pluripotent stem cells escape from senescence-associated DNA methylation changes. Genome Res 23: 248-259. doi:10.1101/gr.141945.112. PubMed: 23080539.
    • (2013) Genome Res , vol.23 , pp. 248-259
    • Koch, C.M.1    Reck, K.2    Shao, K.3    Lin, Q.4    Joussen, S.5
  • 38
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: open software development for computational biology and bioinformatics
    • doi:10.1186/gb-2004-5-10-r80
    • Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, et al. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80. doi:10.1186/gb-2004-5-10-r80. PubMed: 15461798.
    • (2004) Genome Biol , vol.5
    • Gentleman, R.C.1    Carey, V.J.2    Bates, D.M.3    Bolstad, B.4    Dettling, M.5
  • 39
    • 33645823677 scopus 로고    scopus 로고
    • A new summarization method for Affymetrix probe level data
    • doi:10.1093/bioinformatics/btl033
    • Hochreiter S, Clevert DA, Obermayer K, (2006) A new summarization method for Affymetrix probe level data. Bioinformatics 22: 943-949. doi:10.1093/bioinformatics/btl033. PubMed: 16473874.
    • (2006) Bioinformatics , vol.22 , pp. 943-949
    • Hochreiter, S.1    Clevert, D.A.2    Obermayer, K.3
  • 41
    • 0001677717 scopus 로고
    • Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
    • Benjamini Y, Hochberg Y, (1995) Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J R Stat Soc B Stat Methodol) 57: 289-300.
    • (1995) J R Stat Soc B Stat Methodol) , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 42
    • 74049143556 scopus 로고    scopus 로고
    • An improved empirical bayes approach to estimating differential gene expression in microarray time-course data: BETR (Bayesian Estimation of Temporal Regulation
    • doi:10.1186/1471-2105-10-409
    • Aryee MJ, Gutiérrez-Pabello JA, Kramnik I, Maiti T, Quackenbush J, (2009) An improved empirical bayes approach to estimating differential gene expression in microarray time-course data: BETR (Bayesian Estimation of Temporal Regulation. BMC Bioinformatics 10: 409. doi:10.1186/1471-2105-10-409. PubMed: 20003283.
    • (2009) BMC Bioinformatics , vol.10 , pp. 409
    • Aryee, M.J.1    Gutiérrez-Pabello, J.A.2    Kramnik, I.3    Maiti, T.4    Quackenbush, J.5
  • 43
    • 77956604125 scopus 로고    scopus 로고
    • Multidimensional gene set analysis of genomic data
    • doi:10.1371/journal.pone.0010348
    • Montaner D, Dopazo J, (2010) Multidimensional gene set analysis of genomic data. PLOS ONE 5: e10348. doi:10.1371/journal.pone.0010348. PubMed: 20436964.
    • (2010) PLOS ONE , vol.5
    • Montaner, D.1    Dopazo, J.2
  • 44
    • 0035733108 scopus 로고    scopus 로고
    • The Control of the False Discovery Rate in Multiple Testing under Dependency
    • doi:10.1214/aos/1013699998
    • Benjamini Y, Yekutieli D, (2001) The Control of the False Discovery Rate in Multiple Testing under Dependency. Ann Statist 29: 1165-1188. doi:10.1214/aos/1013699998.
    • (2001) Ann Statist , vol.29 , pp. 1165-1188
    • Benjamini, Y.1    Yekutieli, D.2
  • 45
    • 77958498535 scopus 로고    scopus 로고
    • Depletion of TGF-beta from fetal bovine serum
    • doi:10.1016/j.jim.2010.09.008
    • Oida T, Weiner HL, (2010) Depletion of TGF-beta from fetal bovine serum. J Immunol Methods 362: 195-198. doi:10.1016/j.jim.2010.09.008. PubMed: 20837018.
    • (2010) J Immunol Methods , vol.362 , pp. 195-198
    • Oida, T.1    Weiner, H.L.2
  • 46
    • 0038369998 scopus 로고    scopus 로고
    • A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    • doi:10.1016/S1097-2765(03)00109-6
    • Kang Y, Chen CR, Massagué J, (2003) A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 11: 915-926. doi:10.1016/S1097-2765(03)00109-6. PubMed: 12718878.
    • (2003) Mol Cell , vol.11 , pp. 915-926
    • Kang, Y.1    Chen, C.R.2    Massagué, J.3
  • 47
    • 77953206944 scopus 로고    scopus 로고
    • Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions
    • doi:10.3324/haematol.2009.011692
    • Schallmoser K, Bartmann C, Rohde E, Bork S, Guelly C, et al. (2010) Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions. Haematologica 95: 867-874. doi:10.3324/haematol.2009.011692. PubMed: 20053868.
    • (2010) Haematologica , vol.95 , pp. 867-874
    • Schallmoser, K.1    Bartmann, C.2    Rohde, E.3    Bork, S.4    Guelly, C.5
  • 48
    • 0036076884 scopus 로고    scopus 로고
    • Regulation of smooth muscle actin expression and contraction in adult human mesenchymal stem cells
    • doi:10.1006/excr.2002.5561
    • Kinner B, Zaleskas JM, Spector M, (2002) Regulation of smooth muscle actin expression and contraction in adult human mesenchymal stem cells. Exp Cell Res 278: 72-83. doi:10.1006/excr.2002.5561. PubMed: 12126959.
    • (2002) Exp Cell Res , vol.278 , pp. 72-83
    • Kinner, B.1    Zaleskas, J.M.2    Spector, M.3
  • 49
    • 0029981772 scopus 로고    scopus 로고
    • Differential activation of adipogenesis by multiple PPAR isoforms
    • doi:10.1101/gad.10.8.974
    • Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, et al. (1996) Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev 10: 974-984. doi:10.1101/gad.10.8.974. PubMed: 8608944.
    • (1996) Genes Dev , vol.10 , pp. 974-984
    • Brun, R.P.1    Tontonoz, P.2    Forman, B.M.3    Ellis, R.4    Chen, J.5
  • 50
    • 0028362420 scopus 로고
    • Role of active and latent transforming growth factor beta in bone formation
    • doi:10.1002/jcb.240550312
    • Bonewald LF, Dallas SL, (1994) Role of active and latent transforming growth factor beta in bone formation. J Cell Biochem 55: 350-357. doi:10.1002/jcb.240550312. PubMed: 7962167.
    • (1994) J Cell Biochem , vol.55 , pp. 350-357
    • Bonewald, L.F.1    Dallas, S.L.2
  • 51
    • 77049089562 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces osteogenic differentiation of murine bone marrow stromal cells
    • doi:10.1089/ten.tea.2009.0495
    • Zhao L, Jiang S, Hantash BM, (2010) Transforming growth factor beta1 induces osteogenic differentiation of murine bone marrow stromal cells. Tissue Eng A 16: 725-733. doi:10.1089/ten.tea.2009.0495. PubMed: 19769530.
    • (2010) Tissue Eng A , vol.16 , pp. 725-733
    • Zhao, L.1    Jiang, S.2    Hantash, B.M.3
  • 53
    • 77956629716 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth
    • doi:10.1002/hep.23769
    • Senturk S, Mumcuoglu M, Gursoy-Yuzugullu O, Cingoz B, Akcali KC, et al. (2010) Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth. Hepatology 52: 966-974. doi:10.1002/hep.23769. PubMed: 20583212.
    • (2010) Hepatology , vol.52 , pp. 966-974
    • Senturk, S.1    Mumcuoglu, M.2    Gursoy-Yuzugullu, O.3    Cingoz, B.4    Akcali, K.C.5
  • 54
    • 78650104210 scopus 로고    scopus 로고
    • TGFbeta-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas
    • doi:10.4161/cc.9.23.14211
    • Müller J, Samans B, van RJ, Fagà G, Peh KR, et al. (2010) TGFbeta-dependent gene expression shows that senescence correlates with abortive differentiation along several lineages in Myc-induced lymphomas. Cell Cycle 9: 4622-4626. doi:10.4161/cc.9.23.14211. PubMed: 21127397.
    • (2010) Cell Cycle , vol.9 , pp. 4622-4626
    • Müller, J.1    Samans, B.2    van, R.J.3    Fagà, G.4    Peh, K.R.5
  • 55
    • 36248976097 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    • doi:10.1038/ni1536
    • Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ, (2007) CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol 8: 1353-1362. doi:10.1038/ni1536. PubMed: 17982458.
    • (2007) Nat Immunol , vol.8 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 56
    • 0036136943 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta-mediated apoptosis
    • doi:10.1007/s00441-001-0479-6
    • Schuster N, Krieglstein K, (2002) Mechanisms of TGF-beta-mediated apoptosis. Cell Tissue Res 307: 1-14. doi:10.1007/s00441-001-0479-6. PubMed: 11810309.
    • (2002) Cell Tissue Res , vol.307 , pp. 1-14
    • Schuster, N.1    Krieglstein, K.2
  • 57
    • 0028180133 scopus 로고
    • TGF-beta promotes proliferation of cultured SMC via both PDGF-AA-dependent and PDGF-AA-independent mechanisms
    • doi:10.1172/JCI117199
    • Stouffer GA, Owens GK, (1994) TGF-beta promotes proliferation of cultured SMC via both PDGF-AA-dependent and PDGF-AA-independent mechanisms. J Clin Invest 93: 2048-2055. doi:10.1172/JCI117199. PubMed: 8182136.
    • (1994) J Clin Invest , vol.93 , pp. 2048-2055
    • Stouffer, G.A.1    Owens, G.K.2
  • 58
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • doi:10.1016/j.cell.2008.07.001
    • Massagué J, (2008) TGFbeta in Cancer. Cell 134: 215-230. doi:10.1016/j.cell.2008.07.001. PubMed: 18662538.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagué, J.1
  • 59
    • 77955077191 scopus 로고    scopus 로고
    • Different Facets of Aging in Human Mesenchymal Stem Cells
    • doi:10.1089/ten.teb.2009.0825
    • Wagner W, Ho AD, Zenke M, (2010) Different Facets of Aging in Human Mesenchymal Stem Cells. Tissue Eng B Rev 16: 445-453. doi:10.1089/ten.teb.2009.0825. PubMed: 20196648.
    • (2010) Tissue Eng B Rev , vol.16 , pp. 445-453
    • Wagner, W.1    Ho, A.D.2    Zenke, M.3
  • 60
    • 77953169806 scopus 로고    scopus 로고
    • How to track cellular aging of mesenchymal stromal cells?
    • Wagner W, Bork S, Lepperdinger G, Joussen S, Ma N, et al. (2010) How to track cellular aging of mesenchymal stromal cells? Aging (Albany NY) 2: 224-230. PubMed: 20453259.
    • (2010) Aging (Albany NY) , vol.2 , pp. 224-230
    • Wagner, W.1    Bork, S.2    Lepperdinger, G.3    Joussen, S.4    Ma, N.5
  • 61
    • 84873038745 scopus 로고    scopus 로고
    • Effects of medium supplements on proliferation, differentiation potential, and in vitro expansion of mesenchymal stem cells. Stem Cells
    • Gharibi B, Hughes FJ, (2012) Effects of medium supplements on proliferation, differentiation potential, and in vitro expansion of mesenchymal stem cells. Stem Cells. J Transl Med 1: 771-782.
    • (2012) J Transl Med , vol.1 , pp. 771-782
    • Gharibi, B.1    Hughes, F.J.2
  • 62
    • 80051878794 scopus 로고    scopus 로고
    • Epidermal growth factor, basic fibroblast growth factor and platelet-derived growth factor-bb can substitute for fetal bovine serum and compete with human platelet-rich plasma in the ex vivo expansion of mesenchymal stromal cells derived from adipose tissue
    • doi:10.3109/14653249.2011.583232
    • Chieregato K, Castegnaro S, Madeo D, Astori G, Pegoraro M, et al. (2011) Epidermal growth factor, basic fibroblast growth factor and platelet-derived growth factor-bb can substitute for fetal bovine serum and compete with human platelet-rich plasma in the ex vivo expansion of mesenchymal stromal cells derived from adipose tissue. Cytotherapy 13: 933-943. doi:10.3109/14653249.2011.583232. PubMed: 21623669.
    • (2011) Cytotherapy , vol.13 , pp. 933-943
    • Chieregato, K.1    Castegnaro, S.2    Madeo, D.3    Astori, G.4    Pegoraro, M.5
  • 63
    • 79951904225 scopus 로고    scopus 로고
    • A novel serum-free medium for the expansion of human mesenchymal stem cells
    • doi:10.1186/scrt8
    • Chase LG, Lakshmipathy U, Solchaga LA, Rao MS, Vemuri MC, (2010) A novel serum-free medium for the expansion of human mesenchymal stem cells. Stem Cell Res Ther 1: 8. doi:10.1186/scrt8. PubMed: 20504289.
    • (2010) Stem Cell Res Ther , vol.1 , pp. 8
    • Chase, L.G.1    Lakshmipathy, U.2    Solchaga, L.A.3    Rao, M.S.4    Vemuri, M.C.5
  • 64
    • 84859439644 scopus 로고    scopus 로고
    • TGF-beta signal transduction spreading to a wider field: a broad variety of mechanisms for context-dependent effects of TGF-beta
    • doi:10.1007/s00441-011-1179-5
    • Ikushima H, Miyazono K, (2012) TGF-beta signal transduction spreading to a wider field: a broad variety of mechanisms for context-dependent effects of TGF-beta. Cell Tissue Res 347: 37-49. doi:10.1007/s00441-011-1179-5. PubMed: 21618142.
    • (2012) Cell Tissue Res , vol.347 , pp. 37-49
    • Ikushima, H.1    Miyazono, K.2
  • 65
    • 0642306119 scopus 로고    scopus 로고
    • Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line
    • doi:10.1186/bcr640
    • Xie L, Law BK, Aakre ME, Edgerton M, Shyr Y, et al. (2003) Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Res 5: R187-R198. doi:10.1186/bcr640. PubMed: 14580254.
    • (2003) Breast Cancer Res , vol.5
    • Xie, L.1    Law, B.K.2    Aakre, M.E.3    Edgerton, M.4    Shyr, Y.5
  • 66
    • 24144475045 scopus 로고    scopus 로고
    • Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines
    • doi:10.1093/carcin/bgi110
    • Kloth JN, Fleuren GJ, Oosting J, de Menezes RX, Eilers PH, et al. (2005) Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines. Carcinogenesis 26: 1493-1502. doi:10.1093/carcin/bgi110. PubMed: 15878915.
    • (2005) Carcinogenesis , vol.26 , pp. 1493-1502
    • Kloth, J.N.1    Fleuren, G.J.2    Oosting, J.3    de Menezes, R.X.4    Eilers, P.H.5


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