Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia

Clinical Epigenetics

Volumn 5, Issue 1, 2013, Pages

  Sundrani, Deepali P ^a   Reddy, Umakar S ^c   Joshi, Asmita A ^a   Mehendale, Savita S ^b   Chavan Gautam, Preeti M ^a   Hardikar, Anandwardhan A ^d   Chandak, Giriraj R ^c   Joshi, Sadhana R ^a  

^a Bharati Vidyapeeth Deemed University   (India)

^b Bharati Vidyapeeth's Medical College   (India)

^c CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

APGAR SCORE; ARTICLE; BODY HEIGHT; BODY WEIGHT; CHEST CIRCUMFERENCE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DNA METHYLATION; FEMALE; FLT 1 GENE; GENE; GENE CONTROL; GENE EXPRESSION; GENETIC ASSOCIATION; GESTATIONAL AGE; HEAD CIRCUMFERENCE; HUMAN; HUMAN TISSUE; KDR GENE; MALE; NEWBORN; PREECLAMPSIA; PREMATURE LABOR; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; VEGF GENE;

EID: 84885794009     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/1868-7083-5-6     Document Type: Article

References (49)

1. Noori M, Donald AE, Angelakopoulou A, Hingorani AD, Williams DJ: Function before and after preeclampsia and gestational hypertension prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension. Circulation 2010, 122:478-487.
2. Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ: Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol 2002, 160:1405 -1423.
3. Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, Boland P, Leidich R, Hylton D, Burova E, Ioffe E, Huang T, Radziejewski C, Bailey K, Fandl JP, Daly T, Wiegand SJ, Yancopoulos GD, Rudge JS: VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 2002, 99:1393-1398.
4. Kumazaki K, Nakayama M, Suehara N, Wada Y: Expression of vascular endothelial growth factor, placental growth factor, and their receptors Flt-1 and KDR in human placenta under pathologic conditions. Hum Pathol 2002, 33:1069-1077. (Pubitemid 35416703)
5. Munaut C, Lorquet S, Pequeux C, Blacher S, Berndt S, Frankenne F, Foidart JM: Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast. Hum Reprod 2008, 23:1407-1415. (Pubitemid 351770590)
6. Lee GS, Joe YS, Kim SJ, Shin JC: Cytokine-related genes and oxidation-related genes detected in preeclamptic placentas. Arch Gynecol Obstet 2010, 282:363-369.
7. Kweider N, Fragoulis A, Rosen C, Pecks U, Rath W, Pufe T, Wruck CJ: Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia. J Biol Chem 2011, 286:423863-423872.
8. Lyall F, Young A, Boswell F, Kingdom JC, Greer IA: Placental expression of vascular endothelial growth factor in placentae from pregnancies complicated by pre-eclampsia and intrauterine growth restriction does not support placental hypoxia at delivery. Placenta 1997, 18:269-276. (Pubitemid 27214230)
9. Cooper JC, Sharkey AM, Charnock-Jones DS, Palmer CR, Smith SK: VEGF mRNA levels in placentae from pregnancies complicated by preeclampsia. Br J Obstet Gynaecol 1996, 103:1191-1196. (Pubitemid 26402883)
10. Kim SC, Park MJ, Joo BS, Joo JK, Suh DS, Lee KS: Decreased expressions of vascular endothelial growth factor and visfatin in the placental bed of pregnancies complicated by preeclampsia. J Obstet Gynaecol Res 2012, 38:665-673.
11. Toft JH, Lian IA, Tarca AL, Erez O, Espinoza J, Eide IP, Bjørge L, Draghici S, Romero R, Austgulen R: Whole-genome microarray and targeted analysis of angiogenesis regulating gene expression (ENG, FLT1, VEGF, PlGF) in placentas from pre-eclamptic and small-for-gestational-age pregnancies. J Matern Fetal Neonatal Med 2008, 21:267-273. (Pubitemid 351364243)
12. Ranheim T, Staff AC, Henriksen T: VEGF mRNA is unaltered in decidual and placental tissues in preeclampsia at delivery. Acta Obstet Gynecol Scand 2001, 80:93-98. (Pubitemid 32113460)
13. Sgambati E, Marini M, Zappoli Thyrion GD, Parretti E, Mello G, Orlando C, Simi L, Tricarico C, Gheri G, Brizzi E: VEGF expression in the placenta from pregnancies complicated by hypertensive disorders. Br J Obstet Gynaecol 2004, 111:564-570. (Pubitemid 38746240)
14. Heydarian M, McCaffrey T, Florea L, Yang Z, Ross MM, Zhou W, Maynard SE: Novel splice variants of sFlt1 are upregulated in preeclampsia. Placenta 2009, 30:250-255.
15. Rajakumar A, Powers RW, Hubel CA, Shibata E, von Versen-Höynck F, Plymire D, Jeyabalan A: Novel soluble Flt-1 isoforms in plasma and cultured placental explants from normotensive pregnant and preeclamptic women. Placenta 2009, 30:25-34.
16. Munaut C, Lorquet S, Pequeux C, Coulon C, Le Goarant J, Chantraine F, Noël A, Goffin F, Tsatsaris V, Subtil D, Foidart JM: Differential expression of Vegfr-2 and its soluble form in preeclampsia. PLoS One 2012, 7: e33475.
17. Tripathi R, Rath G, Jain A, Salhan S: Soluble and membranous vascular endothelial growth factor receptor-1 in pregnancies complicated by pre-eclampsia. Ann Anat 2008, 90:477-489.
18. Helske S, Vuorela P, Carpén O, Hornig C, Weich H, Halmesmäki E: Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies. Mol Hum Reprod 2001, 7:205-210. (Pubitemid 32148349)
19. Andraweera PH, Dekker GA, Laurence JA, Roberts CT: Placental expression of VEGF family mRNA in adverse pregnancy outcomes. Placenta 2012, 33:467-472.
20. Chavan-Gautam P, Sundrani D, Pisal H, Nimbargi V, Mehendale S, Joshi S: Gestation-dependant changes in human placental global DNA methylation levels. Mol Reprod Dev 2011, 78:150.
21. Hales CN, Barker DJ: The thrifty phenotype hypothesis. Br Med Bull 2001, 60:5-20. (Pubitemid 34123501)
22. Oyama S: The ontogeny of information. In Developmental systems and evolution. 2nd edition. Raleigh, NC: Duke University Press; 2000.
23. Lins RJ, Mitchell MD: Novel insights into the control of human pregnancy: potential role(s) for epigenetic regulation. Reproductive Biology Insights 2008, 1:3-8.
24. Zhang Y, Cui Y, Zhou Z, Sha J, Li Y, Liu J: Altered global gene expressions of human placentae subjected to assisted reproductive technology treatments. Placenta 2010, 31:251-258.
25. Alegría-Torres JA, Baccarelli A, Bollati V: Epigenetics and lifestyle. Epigenomics 2011, 3:267-277.
26. Kulkarni A, Mehendale S, Pisal H, Kilari A, Dangat K, Salunkhe S, Taralekar V, Joshi S: Association of omega 3 fatty acids and homocysteine concentrations in pre-eclampsia. Clin Nutr 2011, 30:60- 64.
27. Kulkarni A, Chavan-Gautam P, Mehendale S, Yadav H, Joshi S: Global DNA methylation patterns in placenta and its association with maternal hypertension in pre-eclampsia. DNA Cell Biol 2011, 30: 79 -84.
28. 12 and homocysteine concentrations in women delivering preterm. Ann Nutr Metab 2012, 61:7-14.
29. van Vliet J, Oates NA, Whitelaw E: Epigenetic mechanisms in the context of complex diseases. Cell Mol Life Sci 2007, 64:1531-1538. (Pubitemid 46954151)
30. Abdolmaleky HM, Cheng KH, Faraone SV, Wilcox M, Glatt SJ, Gao F, Smith CL, Shafa R, Aeali B, Carnevale J, Pan H, Papageorgis P, Ponte JF, Sivaraman V, Tsuang MT, Thiagalingam S: Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder. Hum Mol Genet 2006, 15:3132-3145. (Pubitemid 44607800)
31. Ball MP, Li JB, Gao Y, Lee JH, LeProust EM, Park IH, Xie B, Daley GQ, Church GM: Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol 2009, 27: 361-368.
32. Torry DS, Torry RJ: Angiogenesis and the expression of vascular endothelial growth factor in endometrium and placenta. Am J Reprod Immunol 1997, 37: 21-29. (Pubitemid 27075965)
33. Sun Z, Asmann YW, Kalari KR, Bot B, Eckel-Passow JE, Baker TR, Carr JM, Khrebtukova I, Luo S, Zhang L, Schroth GP, Perez EA, Thompson EA: Integrated Analysis of Gene Expression, CpG Island Methylation, and Gene Copy Number in Breast Cancer Cells by Deep Sequencing. PLoS One 2011, 6:e17490.
34. Reik W: Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 2007, 447:425-432.
35. Roberts JM, Catov JM: Preeclampsia more than 1 disease: or is it? Hypertension 2008, 51:989-990.
36. Phillips JK, Janowiak M, Badger GJ, Bernstein IM: Evidence for distinct preterm and term phenotypes of preeclampsia. J Matern Fetal Neonatal Med 2010, 23:622-626.
37. 12 and docosahexaenoic acid and increased homocysteine and cortisol in nevermedicated schizophrenia patients: implications for altered one-carbon metabolism. Psychiatry Res 2010, 175:47-53.
38. 12 and docosahexaenoic acid on placental global DNA methylation patterns in wistar rats. PLoS One 2011, 6:e17706.
39. Sharma RP: Schizophrenia, epigenetics and ligand-activated nuclear receptors: a framework for chromatin therapeutics. Schizophr Res 2005, 72:79-90.
40. Novakovic B, Sibson M, Ng HK, Manuelpillai U, Rakyan V, Down T, Beck S, Fournier T, Evain-Brion D, Dimitriadis E, Craig JM, Morley R, Saffery R: Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J Biol Chem 2009, 284: 14838-14848.
41. Bell JT, Pai AA, Pickrell JK, Gaffney DJ, Pique-Regi R, Degner JF, Gilad Y, Pritchard JK: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol 2011, 12:R10.
42. Gibbs JR, van der Brug MP, Hernandez DG, Traynor BJ, Nalls MA, Lai SL, Arepalli S, Dillman A, Rafferty IP, Troncoso J, Johnson R, Zielke HR, Ferrucci L, Longo DL, Cookson MR, Singleton AB: Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet 2010, 6:e1000952.
43. Zhang D, Cheng L, Badner JA, Chen C, Chen Q, Luo W, Craig DW, Redman M, Gershon ES, Liu C: Genetic control of individual differences in gene-specific methylation in human brain. Am J Hum Genet 2010, 86: 411-419.
44. Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D'souza C, Fouse SD, Johnson BE, Hong C, Nielsen C, Zhao Y, Turecki G, Delaney A, Varhol R, Thiessen N, Shchors K, Heine VM, Rowitch DH, Xing X, Fiore C, Schillebeeckx M, Jones SJ, Haussler D, Marra MA, Hirst M, Wang T, Costello JF: Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 2010, 466:253-257.
45. Kulkarni AV, Mehendale SS, Yadav HR, Kilari AS, Taralekar VS, Joshi SR: Circulating angiogenic factors and their association with birth outcomes in preeclampsia. Hypertens Res 2010, 33:561-567.
46. Kilari A, Mehendale S, Pisal H, Panchanadikar T, Kale A, Joshi S: Nerve growth factor, birth outcome and pre-eclampsia. Int J Dev Neurosci 2011, 29:71-75.
47. Dangat K, Kilari A, Mehendale S, Lalwani S, Joshi S: Higher levels of brain derived neurotrophic factor but similar nerve growth factor in human milk in women with preeclampsia. Int J Dev Neurosci 2013, 31:209-213.
48. Messeguer X, Escudero R, Farré D, Nuñez O, Martínez J, Albà MM: PROMO: detection of known transcription regulatory elements using speciestailored searches. Bioinformatics 2002, 18:333-334. (Pubitemid 34183117)
49. Farré D, Roset R, Huerta M, Adsuara JE, Roselló L, Albà MM, Messeguer X: Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN. Nucleic Acids Res 2003, 31:3651-3653. (Pubitemid 37442215)