Influence of obesity on the risk of esophageal disorders

Nature Reviews Gastroenterology and Hepatology

Volumn 8, Issue 6, 2011, Pages 340-347

  Lagergren, Jesper ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; LEPTIN; LEPTIN RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR GAMMA; SOMATOMEDIN; SOMATOMEDIN C RECEPTOR;

ABDOMINAL OBESITY; BARRETT ESOPHAGUS; BODY FAT DISTRIBUTION; BODY MASS; DIET THERAPY; DISEASE ASSOCIATION; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS DISEASE; GASTROESOPHAGEAL REFLUX; HUMAN; INTRAABDOMINAL FAT; LIFESTYLE MODIFICATION; MOLECULAR MECHANICS; PERITONEAL CAVITY; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT REDUCTION;

ADENOCARCINOMA; BARRETT ESOPHAGUS; BODY MASS INDEX; ESOPHAGEAL NEOPLASMS; GASTROESOPHAGEAL REFLUX; HUMANS; OBESITY; RISK FACTORS;

EID: 79958145651     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2011.73     Document Type: Review

References (74)

1. Vial, M., Grande, L. & Pera, M. Epidemiology of adenocarcinoma of the esophagus, gastric cardia, and upper gastric third. Recent Results Cancer Res. 182, 1-17 (2010).
2. Lagergren, J. & Lagergren, P. Oesophageal cancer. BMJ 341, c6280 (2010).
3. Sharma, P. Clinical practice. Barretts esophagus. N. Engl. J. Med. 361, 2548-2556 (2009).
4. Badreddine, R. J. & Wang, K. K. Barrett esophagus: an update. Nat. Rev. Gastroenterol. Hepatol. 7, 369-378 (2010).
5. Kahrilas, P. J. Clinical practice. Gastroesophageal reflux disease. N. Engl. J. Med. 359, 1700-1707 (2008).
6. WHO. Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation (Stationery Office Books, London, 2000).
7. Jaffrin, M. Y. Body composition determination by bioimpedance: an update. Curr. Opin. Clin. Nutr. Metab. Care 12, 482-486 (2009).
8. Andreoli, A., Scalzo, G., Masala, S., Tarantino, U. & Guglielmi, G. Body composition assessment by dual-energy X-ray absorptiometry (DXA). Radiol. Med. 114, 286-300 (2009).
9. Brown, L. M., et al. Adenocarcinoma of the esophagus: role of obesity and diet. J. Natl Cancer Inst. 87, 104-109 (1995).
10. Vaughan, T. L., Davis, S., Kristal, A. & Thomas, D. B. Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev. 4, 85-92 (1995).
11. Chow, W. H., et al. Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia. J. Natl Cancer Inst. 90, 150-155 (1998).
12. Whiteman, D. C., et al. Combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the oesophagus. Gut 57, 173-180 (2008). (Pubitemid 351158042)
13. Lindblad, M., Rodrguez, L. A. & Lagergren, J. Body mass, tobacco and alcohol and risk of esophageal, gastric cardia, and gastric non-cardia adenocarcinoma among men and women in a nested case-control study. Cancer Causes Control 16, 285-294 (2005). (Pubitemid 40897847)
14. Engeland, A., Tretli, S. & Bjrge, T. Height and body mass index in relation to esophageal cancer; 23-year follow-up of two million Norwegian men and women. Cancer Causes Control 15, 837-843 (2004). (Pubitemid 39335580)
15. Merry, A. H., Schouten, L. J., Goldbohm, R. A. & van den Brandt, P. A. Body mass index, height and risk of adenocarcinoma of the oesophagus and gastric cardia: a prospective cohort study. Gut 56, 1503-1511 (2007). (Pubitemid 350033186)
16. Abnet, C. C., et al. A prospective study of BMI and risk of oesophageal and gastric adenocarcinoma. Eur. J. Cancer 44, 465-471 (2008).
17. Löfdahl, H. E., Lu, Y. & Lagergren, J. Sex-specific risk factor profile in oesophageal adenocarcinoma. Br. J. Cancer 99, 1506-1510 (2008).
18. Chak, A., et al. Assessment of familiality, obesity, and other risk factors for early age of cancer diagnosis in adenocarcinomas of the esophagus and gastroesophageal junction. Am. J. Gastroenterol. 104, 1913-1921 (2009).
19. Calle, E. E., Rodriguez, C., Walker-Thurmond, K. & Thun, M. J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of, U. S. adults. N. Engl. J. Med. 348, 1625-1638 (2003). (Pubitemid 36459468)
20. Renehan, A. G., Tyson, M., Egger, M., Heller, R. F. & Zwahlen, M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371, 569-578 (2008). (Pubitemid 351232031)
21. Lagergren, J., Bergström, R. & Nyrén, O. Association between body mass and adenocarcinoma of the esophagus and gastric cardia. Ann. Intern. Med. 130, 883-890 (1999). (Pubitemid 29239582)
22. Samanic, C., Chow, W. H., Gridley, G., Jarvholm, B. & Fraumeni, J. F. Jr Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control 17, 901-909 (2006). (Pubitemid 44078281)
23. Nordenstedt, H. & El-Serag, H. The influence of age, sex, and race on the incidence of esophageal cancer in the United States (1992-2006). Scand. J. Gastroenterol. doi:10.3109/00365521.2011.551890.
24. Lagergren, J. & Mattsson, F. No further increase in the incidence of esophageal adenocarcinoma in Sweden. Int. J. Cancer doi:10.1002/ijc.25701.
25. Lagergren, J., Bergström, R., Lindgren, A. & Nyrén, O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N. Engl. J. Med. 340, 825-831 (1999). (Pubitemid 29142625)
26. MacInnis, R. J., English, D. R., Hopper, J. L. & Giles, G. G. Body size and composition and the risk of gastric and oesophageal adenocarcinoma. Int. J. Cancer 118, 2628-2631 (2006).
27. Steffen, A., et al. Anthropometry and esophageal cancer risk in the European prospective investigation into cancer and nutrition. Cancer Epidemiol. Biomarkers Prev. 18, 2079-2089 (2009).
28. Corley, D. A., Kubo, A. & Zhao, W. Abdominal obesity and the risk of esophageal and gastric cardia carcinomas. Cancer Epidemiol. Biomarkers Prev. 17, 352-358 (2008). (Pubitemid 351272786)
29. Beddy, P., et al. Association of visceral adiposity with oesophageal and junctional adenocarcinomas. Br. J. Surg. 97, 1028-1034 (2010).
30. Lagergren, J., Ye, W., Bergström, R. & Nyrén, O. Utility of endoscopic screening for upper gastrointestinal adenocarcinoma. JAMA 284, 961-962 (2000). (Pubitemid 30659125)
31. Ortiz, V., et al. Value of heartburn for diagnosing gastroesophageal reflux disease in severely obese patients. Obesity (Silver Spring) 14, 696-700 (2006). (Pubitemid 46219745)
32. Küper, M. A., et al. Dysfunction of the lower esophageal sphincter and dysmotility of the tubular esophagus in morbidly obese patients. Obes. Surg. 19, 1143-1149 (2009).
33. McElholm, A. R., et al. A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence. Gastroenterology 139, 204-212 (2010).
34. MacDonald, K., Porter, G. A., Guernsey, D. L., Zhao, R. & Casson, A. G. A polymorphic variant of the insulin-like growth factor type I receptor gene modifies risk of obesity for esophageal adenocarcinoma. Cancer Epidemiol. 33, 37-40 (2009).
35. Ogunwobi, O. O. & Beales, I. L. Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgf? mediated transactivation of the epidermal growth factor receptor. Br. J. Biomed. Sci. 65, 121-127 (2008).
36. Brochu-Gaudreau, K., et al. Adiponectin action from head to toe. Endocrine 37, 11-32 (2010).
37. Howard, J. M., et al. Associations between leptin and adiponectin receptor upregulation, visceral obesity and tumour stage in oesophageal and junctional adenocarcinoma. Br. J. Surg. 97, 1020-1027 (2010).
38. Doecke, J. D., et al. Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. Cancer Epidemiol. Biomarkers Prev. 17, 1007-1012 (2008). (Pubitemid 351536439)
39. Stein, D. J., El-Serag, H. B., Kuczynski, J., Kramer, J. R. & Sampliner, R. E. The association of body mass index with Barretts oesophagus. Aliment. Pharmacol. Ther. 22, 1005-1010 (2005). (Pubitemid 41634883)
40. Smith, K. J., et al. Interactions among smoking, obesity, and symptoms of acid reflux in Barretts esophagus. Cancer Epidemiol. Biomarkers Prev. 14, 2481-2486 (2005). (Pubitemid 41752705)
41. Healy, L. A., Ryan, A. M., Pidgeon, G., Ravi, N. & Reynolds, J. V. Lack of differential pattern in central adiposity and metabolic syndrome in Barretts esophagus and gastroesophageal reflux disease. Dis. Esophagus 23, 386-391 (2010).
42. Gerson, L. B., et al. Does body mass index differ between patients with Barretts oesophagus and patients with chronic gastro-oesophageal reflux disease? Aliment. Pharmacol. Ther. 25, 1079-1086 (2007).
43. Corley, D. A., et al. Abdominal obesity and body mass index as risk factors for Barretts esophagus. Gastroenterology 133, 34-41 (2007). (Pubitemid 47031134)
44. Smith, K. J., et al. Current and past smoking significantly increase risk for Barretts esophagus. Clin. Gastroenterol. Hepatol. 7, 840-848 (2009).
45. Edelstein, Z. R., Farrow, D. C., Bronner, M. P., Rosen, S. N. & Vaughan, T. L. Central adiposity and risk of Barretts esophagus. Gastroenterology 133, 403-411 (2007). (Pubitemid 47187351)
46. Caygill, C. P., et al. Lifestyle factors and Barretts esophagus. Am. J. Gastroenterol. 97, 1328-1331 (2002).
47. El-Serag, H. B., Kvapil, P., Hacken-Bitar, J. & Kramer, J. R. Abdominal obesity and the risk of Barretts esophagus. Am. J. Gastroenterol. 100, 2151-2156 (2005).
48. Akiyama, T., et al. Visceral obesity and the risk of Barretts esophagus in Japanese patients with non-alcoholic fatty liver disease. BMC Gastroenterol. 9, 56 (2009).
49. Rubenstein, J. H., et al. A pilot study of the association of low plasma adiponectin and Barretts esophagus. Am. J. Gastroenterol. 103, 1358-1364 (2008). (Pubitemid 351813912)
50. Sowers, J. R. Endocrine functions of adipose tissue: focus on adiponectin. Clin. Cornerstone 9, 32-38 (2008).
51. Rubenstein, J. H., et al. Association of adiponectin multimers with Barretts oesophagus. Gut 58, 1583-1589 (2009).
52. Ryan, A. M., et al. Barrett esophagus: prevalence of central adiposity, metabolic syndrome, and a proinflammatory state. Ann. Surg. 247, 909-915 (2008). (Pubitemid 351770409)
53. Kendall, B. J., et al. Leptin and the risk of Barretts oesophagus. Gut 57, 448-454 (2008).
54. Lagergren, J., Bergström, R. & Nyrén, O. No relation between body mass and gastro-oesophageal reflux symptoms in a Swedish population based study. Gut 47, 26-29 (2000). (Pubitemid 30430407)
55. Nilsson, M., Johnsen, R., Ye, W., Hveem, K. & Lagergren, J. Obesity and estrogen as risk factors for gastroesophageal reflux symptoms. JAMA 290, 66-72 (2003). (Pubitemid 37432867)
56. Jacobson, B. C., Somers, S. C., Fuchs, C. S., Kelly, C. P. & Camargo, C. A. Jr. Body-mass index and symptoms of gastroesophageal reflux in women. N. Engl. J. Med. 354, 2340-2348 (2006). (Pubitemid 43801279)
57. Murray, L., et al. Relationship between body mass and gastro-oesophageal reflux symptoms: the Bristol Helicobacter Project. Int. J. Epidemiol. 32, 645-650 (2003). (Pubitemid 37039024)
58. Nandurkar, S., et al. Relationship between body mass index, diet, exercise and gastro-oesophageal reflux symptoms in a community. Aliment. Pharmacol. Ther. 20, 497-505 (2004). (Pubitemid 39243895)
59. Hampel, H., Abraham, N. S. & El-Serag, H. B. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann. Intern. Med. 143, 199-211 (2005). (Pubitemid 41076753)
60. Corley, D. A. & Kubo, A. Body mass index and gastroesophageal reflux disease: a systematic review and meta-analysis. Am. J. Gastroenterol. 101, 2619-2628 (2006). (Pubitemid 44665262)
61. Solhpour, A., et al. Gastro-esophageal reflux symptoms and body mass index: no relation among the Iranian population. Indian J. Gastroenterol. 27, 153-155 (2008).
62. Corley, D. A., Kubo, A. & Zhao, W. Abdominal obesity, ethnicity and gastro-oesophageal reflux symptoms. Gut 56, 756-762 (2007). (Pubitemid 46854187)
63. Gunji, T., et al. Risk factors for erosive esophagitis: a cross-sectional study of a large number of Japanese males. J. Gastroenterol. doi:10.1007/s00535-010-0359-0355.
64. Zheng, Z., et al. Effects of estrogen with and without progestin and obesity on symptomatic gastroesophageal reflux. Gastroenterology 135, 72-81 (2008). (Pubitemid 351899017)
65. Chung, S. J., et al. Metabolic syndrome and visceral obesity as risk factors for reflux oesophagitis: a cross-sectional case-control study of 7078 Koreans undergoing health check-ups. Gut 57, 1360-1365 (2008).
66. Nam, S. Y., et al. Abdominal visceral adipose tissue volume is associated with increased risk of erosive esophagitis in men and women. Gastroenterology 139, 1902-1911 (2010).
67. de Vries, D. R., van Herwaarden, M. A., Smout, A. J. & Samsom, M. Gastroesophageal pressure gradients in gastroesophageal reflux disease: relations with hiatal hernia, body mass index, and esophageal acid exposure. Am. J. Gastroenterol. 103, 1349-1354 (2008). (Pubitemid 351813940)
68. Crowell, M. D., et al. Obesity is associated with increased 48-h esophageal acid exposure in patients with symptomatic gastroesophageal reflux. Am. J. Gastroenterol. 104, 553-559 (2009).
69. Ayazi, S., et al. Obesity and gastroesophageal reflux: quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptoms. J. Gastrointest. Surg. 13, 1440-1447 (2009).
70. Menon, S. & Trudgill, N. Risk factors in the aetiology of hiatus hernia: a meta-analysis. Eur. J. Gastroenterol. Hepatol. 23, 133-138 (2011).
71. Nilsson, M., Lundegårdh, G., Carling, L., Ye, W. & Lagergren, J. Body mass and reflux oesophagitis: an oestrogen-dependent association? Scand. J. Gastroenterol. 37, 626-630 (2002). (Pubitemid 34620921)
72. Nordenstedt, H., et al. Postmenopausal hormone therapy as a risk factor for gastroesophageal reflux symptoms among female twins. Gastroenterology 134, 921-928 (2008). (Pubitemid 351451964)
73. De Groot, N. L., et al. Systematic review: the effects of conservative and surgical treatment for obesity on gastro-oesophageal reflux disease. Aliment. Pharmacol. Ther. 30, 1091-1102 (2009).
74. Flegal, K. M., Carroll, M. D., Ogden, C. L. & Curtin, L. R. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 303, 235-241 (2010).