The R740S mutation in the V-ATPase a3 subunit results in osteoclast apoptosis and defective early-stage autophagy

Journal of Cellular Biochemistry

Volumn 114, Issue 12, 2013, Pages 2823-2833

  Ochotny, Noelle ^a   Voronov, Irina ^a   Owen, Celeste ^a,b   Aubin, Jane E ^a   Manolson, Morris F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

BONE BIOLOGY; OSTEOCLAST; PROTON TRANSPORT; VACUOLAR H+ ATPASE

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; PROTEIN; PROTEIN LC3II; PROTEIN P62; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; VACUOLAR PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE A3;

ACIDIFICATION; ALBERS SCHOENBERG DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL GROWTH; CELL MATURATION; CELL PH; CELL POLARITY; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; DISEASE SEVERITY; ENZYME LOCALIZATION; ENZYME SUBUNIT; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HOMOZYGOTE; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NEWBORN; NONHUMAN; OSTEOCLAST; OSTEOCYTE; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; WILD TYPE;

BONE BIOLOGY; OSTEOCLAST; PROTON TRANSPORT; VACUOLAR H+-ATPASE;

ANIMALS; APOPTOSIS; AUTOPHAGY; CELL DIFFERENTIATION; CYTOPLASM; LYSOSOMES; MICE; MUTATION; OSTEOCLASTS; OSTEOPETROSIS; PROTEIN SUBUNITS; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84885671482     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24630     Document Type: Article

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