The incidence and prevalence of Huntington's disease: A systematic review and meta-analysis

Movement Disorders

Volumn 27, Issue 9, 2012, Pages 1083-1091

  Pringsheim, Tamara ^a   Wiltshire, Katie ^a   Day, Lundy ^a   Dykeman, Jonathan ^a   Steeves, Thomas ^b   Jette, Nathalie ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Epidemiology; Huntington's disease; Incidence; Prevalence

Indexed keywords

HUNTINGTIN;

ASIAN; AUSTRALIA; EMBASE; EUROPE; GENE EXPRESSION; HAPLOTYPE; HUMAN; HUNTINGTON CHOREA; INCIDENCE; MEDLINE; META ANALYSIS; META ANALYSIS (TOPIC); NORTH AMERICA; PREVALENCE; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; SYSTEMATIC REVIEW (TOPIC);

ASIAN CONTINENTAL ANCESTRY GROUP; AUSTRALIA; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; HAPLOTYPES; HUMANS; HUNTINGTON DISEASE; INCIDENCE; NORTH AMERICA; PREVALENCE; UNITED STATES;

EID: 84864749266     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.25075     Document Type: Review

References (35)

1. Shoulson I, Young A. Milestones in Huntington Disease. Mov Disord 2011; 26: 1127-1133.
2. Falush D, Almqvist EW, Brinkmann RR, Iwasa Y, Hayden MR. Measurement of mutational flow implies both a high new-mutation rate for Huntington disease and substantial underascertainment of late-onset cases. Am J Hum Genet 2001; 68: 373-385.
3. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50: 1088-1101.
4. Egger M, Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Br Med J 1997; 315: 629-634.
5. R: a language and environment for statistical computing [program]. Vienna, Austria, 2011.
6. meta: meta-Analysis with R [program]. 1.6-1. version, 2010.
7. Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw 2010; 36: 1-48.
8. Almqvist EW, Elterman DS, MacLeod PM, Hayden MR. High incidence rate and absent family histories in one quarter of patients newly diagnosed with Huntington disease in British Columbia. Clin Genet 2001; 60: 198-205.
9. Mercy L, Hodges JR, Dawson K, Barker RA, Brayne C. Incidence of early-onset dementias in Cambridgeshire, United Kingdom. Neurology 2008; 71: 1496-1499.
10. Ramos-Arroyo MA, Moreno S, Valiente A. Incidence and mutation rates of Huntington's disease in Spain: experience of 9 years of direct genetic testing. J Neurol Neurosurg Psychiatry 2005; 76: 337-342.
11. James CM, Houlihan GD, Snell RG, Cheadle JP, Harper PS. Late-onset Huntington's disease: a clinical and molecular study. Age Ageing 1994; 23: 445-448.
12. Kandil MR, Tohamy SA, Fattah MA, Ahmed HN, Farwiez HM. Prevalence of chorea, dystonia, and athetosis in Assiut, Egypt: a clinical and epidemiological study. Neuroepidemiology 1994; 13: 202-210.
13. Morrison PJ, Nevin NC. Huntington disease in County Donegal: epidemiological trends over four decades. Ulster Med J 1993; 62: 141-144.
14. Morrison PJ, Johnston WP, Nevin NC. The epidemiology of Huntington's disease in Northern Ireland. J Med Genet 1995; 32: 524-530.
15. Morrison PJ. Accurate prevalence and uptake of testing for Huntington's disease. Lancet Neurol 2010; 9: 1147.
16. Nakashima K, Watanabe Y, Kusumi M, et al. Epidemiological and genetic studies of Huntington's disease in the San-in area of Japan. Neuroepidemiology 1996; 15: 126-131.
17. Peterlin B, Kobal J, Teran N, Flisar D, Lovrecic L. Epidemiology of Huntington's disease in Slovenia. Acta Neurol Scand 2009; 119: 371-375.
18. Pridmore SA. The prevalence of Huntington's disease in Tasmania. Med J Aust 1990; 153: 133-134.
19. Shiwach RS. Prevalence of Huntington's disease in the Oxford region. Br J Psychiatry 1994; 165: 414-415.
20. Warren G, Yellowlees P. The prevalence of Huntington's disease. Med J Aust 1990; 153: 629.
21. Watt DC, Seller A. A clinico-genetic study of psychiatric disorder in Huntington's chorea. Psychol Med 1993; 23( Suppl. 23): 1-46.
22. Chang CM, Yu YL, Fong KY, et al. Huntington's disease in Hong Kong Chinese: epidemiology and clinical picture. Clin Exp Neurol 1994; 31: 43-51.
23. Chen YY, Lai CH. Nationwide population-based epidemiologic study of Huntington's disease in Taiwan. Neuroepidemiology 2010; 35: 250-254.
24. Kokmen E, Ozekmekç FS, Beard CM, O'Brien PC, Kurland LT. Incidence and prevalence of Huntington's disease in Olmsted County, Minnesota (1950 through 1989). Arch Neurol 1994; 51: 696-698.
25. McCusker EA, Casse RF, Graham SJ, Williams DB, Lazarus R. Prevalence of Huntington disease in New South Wales in 1996. Med J Aust 2000; 173: 187-190.
26. Pavoni M, Granieri E, Govoni V, Pavoni V, Del Senno L, Mapelli G. Epidemiologic approach to Huntington's disease in northern Italy (Ferrara area). Neuroepidemiology 1990; 9: 306-314.
27. Shiwach RS, Lindenbaum RH. Prevalence of Huntington's disease among UK immigrants from the Indian subcontinent. Br J Psychiatry 1990; 157: 598-599.
28. Schneider SA, Walker RH, Bhatia KP. The Huntington's disease-like syndromes: what to consider in patients with a negative Huntington's disease gene test. Nat Clin Pract Neurol 2007; 3: 517-525.
29. Stevanin G, Camuzat A, Holmes SE, et al. CAG/CTG repeat expansions at the Huntington's disease like 2 locus are rare in Huntington's disease patients. Neurology 2002; 58: 965-967.
30. Squitieri F, Andrew SE, Goldberg YP, et al. DNA haplotype analysis of Huntington disease reveals clues to the origins and mechanisms of CAG expansion and reasons for geographic variations of prevalence. Hum Mol Genet 1994; 3: 2103-2114.
31. Warby SC, Montpetit A, Hayden AR, et al. CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup. Am J Hum Genet 2009; 84: 351-366.
32. Rubinsztein DC, Amos W, Leggo J, et al. Mutational bias provides a model for the evolution of Huntington's disease and predicts a general increase in disease prevalence. Nat Genet 1994; 7: 525-530.
33. Pecheux C, Mouret JF, Durr A, et al. Sequence analysis of the CCG polymorphic region adjacent to the CAG triplet repeat of the HD gene in normal and HD chromosomes. J Med Genet 1995; 32: 399-400.
34. Masuda N, Goto J, Murayama N, Watanabe M, Kondo I, Kanazawa I. Analysis of triplet repeats in the huntington gene in Japanese families affected with Huntington's disease. J Med Genet 1995; 32: 701-705.
35. Ma M, Yang Y, Shang H, et al. Evidence for a predisposing background for CAG expansion leading to HTT mutation in a Chinese population. J Neurol Sci 2010; 298: 57-60.