Design and development of multiple emulsion for enhancement of oral bioavailability of acyclovir

Drug Development and Industrial Pharmacy

Volumn 39, Issue 11, 2013, Pages 1809-1817

  Paul, Sumita ^a   Kumar, Abhinesh ^a   Yedurkar, Pramod ^a   Sawant, Krutika ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Acyclovir; Bioavailability; Pharmacokinetics; Rheology; W o w multiple emulsion

Indexed keywords

ACICLOVIR; POLIDOCANOL; SORBITAN OLEATE; SPAN 83; SURFACTANT; UNCLASSIFIED DRUG; WATER OIL CREAM;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CENTRIFUGATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DOSAGE FORM COMPARISON; DRUG RELEASE; DRUG STABILITY; EX VIVO STUDY; FEMALE; FLOW KINETICS; FREEZING; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PHASE SEPARATION; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; RAT; ROOM TEMPERATURE; TIME TO MAXIMUM PLASMA CONCENTRATION; VISCOSITY;

ACYCLOVIR; ADMINISTRATION, ORAL; ANIMALS; ANTIVIRAL AGENTS; BIOLOGICAL AVAILABILITY; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STABILITY; DRUG STORAGE; EMULSIONS; EXCIPIENTS; HEXOSES; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MALE; PARTICLE SIZE; PHYSICOCHEMICAL PHENOMENA; POLYETHYLENE GLYCOLS; RATS; SURFACE-ACTIVE AGENTS; VISCOSITY;

EID: 84885652843     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.738682     Document Type: Article

References (44)

1. Florence AT, Omotosho JA, Whateley TL. (1989). Multiple w/o/w emulsions as drug vehicles. In: Rosoff M, ed. Controlled release of drugs: Polymers and aggregate systems. VCH Publishers, Marcel Dekker, 163-184
2. Koga K, Takarada N, Takada K. (2010). Nano-sized water-in-oilin-water emulsion enhances intestinal absorption of calcein, a high solubility and low permeability compound. Eur J Pharm Biopharm, 74:223-232
3. Onuki Y, Morishita M, Takayama K. (2004). Formulation optimization of water-in-oil-water multiple emulsion for intestinal insulin delivery. J Control Release, 97:91-99
4. Nakhare S, Vyas SP. (1995). Prolonged release multiple emulsion based system bearing rifampicin: In vitro characterisation. Drug Dev Ind Pharm, 21(7):869-878
5. Tang SY, Sivakumar M. (2012). Design and evaluation of aspirinloaded water-in-oil-in-water submicron multiple emulsions generated using two-stage ultrasonic cavitational emulsification technique. Asia-Pacific J Chem Eng, 7(S1):S145-S156
6. Ghosh LK, Ghosh NC, Thakur RS, Pal M, Gupta BK (1997). Design and evaluation of controlled-release W/O/W multiple-emulsion oral liquid delivery system of chlorpheniramine maleate. Drug Dev Ind Pharm, 23(11):1131-1134
7. Sharma G, Wilson K, van Der Walle CF, Sattar N, Petrie JR, Ravi Kumar MN. (2010). Microemulsions for oral delivery of insulin: Design, development and evaluation in streptozotocin induced diabetic rats. Eur J Pharm Biopharm, 76:159-169
8. Morishita M, Matsuzawa A, Takaynama K, Isowa K, Nagai T. (1998). Improving insulin enteral absorption using w/o/w emulsion. Int J Pharm, 172:189-198
9. Shively ML, Thompson DC. (1995). Oral bioavailability of vancomycin solid emulsion. Int J Pharm, 117:119-122
10. Wang Y, Shan C, Ming S, Liu Y, Du Y, Jiang G. (2009). Immunoadjuvant effects of bacterial genomic DNA and CpG oligodeoxynucleotides on avian influenza virus subtype H5N1 inactivated oil emulsion vaccine in chicken. Res Vet Sci, 86:399-405
11. Bozkir A, Hayta G. (2004). Preparation and evaluation of multiple emulsions water-in-oil-in-water (w/o/w) as delivery system for influenza virus antigens. J Drug Target, 12:157-164
12. Taylor PJ, Miller CL, Pollock TM, Perkins FT, Westwood MA. (1969). Antibody response and reaction to aqueous influenza vaccine, simple emulsion vaccine and multiple emulsion vaccine. J Hyg, 67:485-490
13. Jiao J, Rhodes DG, Burgess DJ. (2002). Multiple emulsion stability: Pressure balance and interfacial film strength. J Colloid Interface Sci, 250:444-450
14. Chiang CW, Fuller GC, Frankenfeld JW, Rhodes CT. (1978). Potential of liquid membranes for drug overdose treatment: In vitro studies. J Pharm Sci, 67:63-66
15. Garti N, Benichou A. (2004). Recent developments in double emulsions for food applications. In: Friberg S, Larsson K, Sjoblom J, eds. Food Emulsions, 4th edn. New York: Marcel Dekker, 353-412
16. Sohi H, Sultana Y, Khar RK. (2004). Taste masking technologies in oral pharmaceuticals: Recent developments and approaches. Drug Dev Ind Pharm, 30:429-448
17. Oh C, Lee JH, Lee YG, Lee YH, Kim JW, Kang HH et al. (2006). New approach to the immobilization of glucose oxidase on nonporous silica microspheres functionalized by (3-aminopropyl) trimethoxysilane (APTMS). Colloids Surf B Biointerfaces, 53:225-232
18. May SW, Li NN. (1972). The immobilization of urease using liquid-surfactant membranes. Biochem Biophys Res Commun, 47:1179-1185
19. Omotosho JA, Florence AT, Whateley TL. (1990). Absorption and lymphatic uptake of 5-FU in the rat following oral administration of w/o/w multiple emulsion. Int J Pharm, 61:51-56
20. Florence AT, Whitehill D. (1982). The formulation and stability of multiple emulsions. Int J Pharm, 11:277-308
21. Araya H, Tomita M, Hayashi M. (2005). The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds. Int J Pharm, 305:61-74
22. Tolle-Sander S, Lentz KA, Maeda DY, Coop A, Polli JE. (2004). Increased acyclovir oral bioavailability via a bile acid conjugate. Mol Pharm, 1:40-48
23. De Miranda P, Blum MR. (1983). Pharmacokinetics of acyclovir after intravenous and oral administration. J Antimicrob Chemother, 12 SupplB:29-37
24. Freeman DJ, Sheth NV, Spruance SL. (1986). Failure of topical acyclovir in ointment to penetrate human skin. Antimicrob Agents Chemother, 29:730-732
25. Jain SK, Jain RK, Chourasia MK, Jain AK, Chalasani KB, Soni V et al. (2005). Design and development of multivesicular liposomal depot delivery system for controlled systemic delivery of acyclovir sodium. AAPS PharmSciTech, 6:E35-E41
26. Han H, De Vrueh RL, Rhie JK, Covitz KM, Smith PL, Lee CP et al.(1998). 5-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharm Res, 15:1154-1159
27. Bundgaard H, Jensen E, Falch E. (1991). Water-soluble, solutionstable, and biolabile N-substituted (aminomethyl)benzoate ester prodrugs of acyclovir. Pharm Res, 8:1087-1093
28. Shao Z, Park GB, Krishnamoorthy R, Mitra AK. (1994). The physicochemical properties, plasma enzymatic hydrolysis, and nasal absorption of acyclovir and its 2-ester prodrugs. Pharm Res, 11:237-242
29. Chikhale PJ, Venkatraghavan V, Bodor NS. (1996). Improved delivery through biological membranes LX: Intradermal targeting of acyclovir using redox-based chemical drug delivery systems. Drug Delivery, 3:17-26
30. Krenitsky TA, Hall WW, De Miranda P, Beauchamp LM, Schaeffer HJ, Whiteman PD. (1984). 6-Deoxyacyclovir: A xanthine oxidase-activated prodrug of acyclovir. Proc Natl Acad Sci USA, 81:3209-3213
31. Smiley ML. (1993). Valciclovir and acyclovir for the treatment of recurrent genital herpes simplex infections. Intersci Conf Antimicrob Chemother, 33:1210
32. Rossi S. (2006). Australian Medicines Handbook. Adelaide: Australian Medicines
33. Shojaei AH, Zhuo SL, Li X. (1998). Transbuccal delivery of acyclovir (II): Feasibility, system design, and in vitro permeation studies. J Pharm Pharm Sci, 1:66-73
34. Law SL, Huang KJ, Chiang CH. (2000). Acyclovir-containing liposomes for potential ocular delivery. Corneal penetration and absorption. J Control Release, 63:135-140
35. Gandhi P, Momin N, Kharade S, Konapure NP, Kuchekar BS. (2006). Spectrophotometric estimation of acyclovir in pharmaceutical dosage forms. Indian J Pharm Sci, 68(4):516-517
36. Hino T, Takeuchi H, Niwa T, Kitagawa M, Kawashima Y. (1995). The analysis of drug release from diluted w/o/w emulsions by a model of the rupture of oil membrane. J Pharm Pharmacol, 47:1-7
37. Bangaru RA, Bansal YK, Rao AR, Gandhi TP. (2000). Rapid, simple and sensitive high-performance liquid chromatographic method for detection and determination of acyclovir in human plasma and its use in bioavailability studies. J Chromatogr B Biomed Sci Appl, 739:231-237
38. Zambaux MF, Bonneaux F, Gref R, Maincent P, Dellacherie E, Alonso MJ et al. (1998). Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method. J Control Release, 50:31-40
39. Geiger S, Tokgoz S, Fructus A, Jager-Lezer N, Seiller M, Lacombe C et al. (1998). Kinetics of swelling-breakdown of a W/O/W multiple emulsion: Possible mechanisms for the lipophilic surfactant effect. J Control Release, 52:99-107
40. Tirnaksiz F, Kalsin O. (2005). A topical w/o/w multiple emulsions prepared with Tetronic 908 as a hydrophilic surfactant: Formulation, characterization and release study. J Pharm Pharm Sci, 8:299-315
41. Terrisse I, Seiller M, Rabaron A, Grossiord JL, Magnet A, Hen-Ferrenbach C. (1993). Rheology: How to characterize and to predict the evolution of W/O/W multiple emulsions. Int J Cosmet Sci, 15:53-62
42. Fredro-Kumbaradzi E, Popovska-Pavlovska F, Simov A, Goracinova K, Glavas M, Mladenovska K. (1998). Formulation and release of lidocaine HCl from multiple w/o/w emulsions. Glas Hem Tehnol Maked 17(2):119-123
43. Adeyeye CM, Price JC. (1990). Effect of dextrose in the internal aqueous phase on formation and stability of w/o/w multiple emulsion. Drug Dev Ind Pharm, 16(6):1053-1071
44. Pays K, Giermanska-Kahn J, Pouligny B, Bibette J, Leal-Calderon F. (2002). Double emulsions: How does release occuróf J Control Release, 79:193-205