Lynch syndrome-associated colorectal carcinoma: Frequent involvement of the left colon and rectum and late-onset presentation supports a universal screening approach

Human Pathology

Volumn 44, Issue 11, 2013, Pages 2518-2528

  Hartman, Douglas J ^a   Brand, Randall E ^b   Hu, Huankai ^a   Bahary, Nathan ^b   Dudley, Beth ^b   Chiosea, Simon I ^a   Nikiforova, Marina N ^a   Pai, Reetesh K ^a  

^a PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

BRAF; Colorectal carcinoma; Lynch syndrome; MLH1; MSI; Screening

Indexed keywords

DNA; MISMATCH REPAIR PROTEIN; MISMATCH REPAIR PROTEIN PMS2; PROTEIN MLH1; PROTEIN MSH6;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER LOCALIZATION; COLON CARCINOGENESIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA METHYLATION; FEMALE; GENE MUTATION; GENETIC SCREENING; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HISTOLOGY; HUMAN; HUMAN CELL; LYNCH SYNDROME ASSOCIATED COLORECTAL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; PROMOTER REGION; PROTEIN DEFECT; PROTEIN EXPRESSION; RECTUM CARCINOMA; TUMOR ASSOCIATED LEUKOCYTE;

BRAF; COLORECTAL CARCINOMA; LYNCH SYNDROME; MLH1; MSI; SCREENING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; COLON; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA METHYLATION; DNA MISMATCH REPAIR; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; EARLY DETECTION OF CANCER; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTATION; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS B-RAF; RECTUM;

EID: 84885634188     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.06.012     Document Type: Article

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