Injectable microsphere/hydrogel hybrid system containing heat shock protein as therapy in a murine myocardial infarction model

Journal of Drug Targeting

Volumn 21, Issue 9, 2013, Pages 822-829

  Lee, Jangwook ^a   Cha, Min Ji ^b   Lim, Kwang Suk ^a   Kim, Jang Kyung ^a   Lee, Sang Kyung ^a   Kim, Yong Hee ^a   Hwang, Ki Chul ^b   Lee, Kuen Yong ^a  

^a Hanyang University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Heat shock protein; Microsphere hydrogel hybrid system; Myocardial infarction

Indexed keywords

ALGINIC ACID; HEAT SHOCK PROTEIN 27; POLYGLACTIN; POROUS POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG RELEASE; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE PRESSURE; HEART RIGHT VENTRICLE ENDSYSTOLIC VOLUME; HYDROGEL; IN VITRO STUDY; IN VIVO CULTURE; MALE; MURINE MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; SUSTAINED DRUG RELEASE; TREATMENT OUTCOME;

ALGINATES; ANIMALS; APOPTOSIS; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; GENE PRODUCTS, TAT; GLUCURONIC ACID; HEXURONIC ACIDS; HSP27 HEAT-SHOCK PROTEINS; HYDROGELS; IN SITU NICK-END LABELING; LACTIC ACID; MALE; MICROSPHERES; MYOCARDIAL INFARCTION; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS;

EID: 84885622831     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2013.829072     Document Type: Article

References (35)

1. Park H-J, Yang F, Cho S-W. Nonviral delivery of genetic medicine for therapeutic angiogenesis. Adv Drug Deliv Rev 2012;64:40-52
2. Lange R, Weipert J, Homann M, et al. Performance of allografts and xenografts for right ventricular outflow tract reconstruction. Ann Thorac Surg 2001;71:S365-7
3. Cao L, Mooney DJ. Spatiotemporal control over growth factor signaling for therapeutic neovascularization. Adv Drug Deliv Rev 2007;59:1340-50
4. Garbern JC, Hoffman AS, Stayton PS. Injectable pHand temperature- responsive poly(N-isopropylacrylamide-copropylacrylic acid) copolymers for delivery of angiogenic growth factors. Biomacromolecules 2010;11:1833-9
5. Novosel EC, Kleinhans C, Kluger PJ. Vascularization is the key challenge in tissue engineering. Adv Drug Deliv Rev 2011;63: 300-11
6. Asoh S, Ohta S. PTD-mediated delivery of anti-cell death proteins/ peptides and therapeutic enzymes. Adv Drug Deliv Rev 2008;60: 499-516
7. Li Z, Guo X, Guan JA. Thermosensitive hydrogel capable of releasing bFGF for enhanced differentiation of mesenchymal stem cell into cardiomyocyte-like cells under ischemic conditions. Biomacromolecules 2012;13:1956-64
8. Acunzo J, Katsogiannou M, Rocchi P. Small heat shock proteins HSP27 (HspB1), aB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death. Int J Biochem Cell Biol 2012;44:1622-31
9. Benjamin IJ, McMillan DR. Stress (heat shock) proteins: Molecular chaperones in cardiovascular biology and disease. Circ Res 1998; 83:117-32
10. Kalmar B, Greensmith L. Induction of heat shock proteins for protection against oxidative stress. Adv Drug Deliv Rev 2009;61: 310-18.
11. Gupta B, Levchenko TS, Torchilin VP. Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides. Adv Drug Deliv Rev 2005;57:637-51
12. Nasrollahi SA, Taghibiglou C, Azizi E, et al. Cell-penetrating peptides as a novel transdermal drug delivery system. Chem Biol Drug Des 2012;80:639-46
13. Zhang X, Zhang X, Wang F. Intracellular transduction and potential of Tat PTD and its analogs: From basic drug delivery mechanism to application. Expert Opin Drug Deliv 2012;9:457-72
14. Kwon JH, Kim JB, Lee K-H, et al. Protective effect of heat shock protein 27 using protein transduction domain-mediated delivery on ischemia/reperfusion heart injury. Biochem Biophys Res Commun 2007;363:399-404
15. Tan C, Ban H, Kim Y-H, et al. The heat shock protein 27 (Hsp27) operates predominantly by blocking the mitochondrialindependent/ extrinsic pathway of cellular apoptosis. Mol Cells 2009;27:533-8
16. Lee J, Lee KY. Injectable microsphere/hydrogel combination systems for localized protein delivery. Macromol Biosci 2009;9: 671-6
17. Lee J, Bhang S, Park H, et al. Active blood vessel formation in the ischemic hindlimb mouse model using a microsphere/hydrogel combination system. Pharm Res 2010;27:767-74
18. Shin S-H, Lee J, Lim KS, et al. Sequential delivery of TAT-HSP27 and VEGF using microsphere/hydrogel hybrid systems for therapeutic angiogenesis. J Control Release 2012;166:38-45
19. Lee J, Tan CY, Lee S-K, et al. Controlled delivery of heat shock protein using an injectable microsphere/hydrogel combination system for the treatment of myocardial infarction. J Control Release 2009;137:196-202
20. Lee J, Oh YJ, Lee SK, et al. Facile control of porous structures of polymer microspheres using an osmotic agent for pulmonary delivery. J Control Release 2010;146:61-7
21. Konecny F, Zou J, Husain M, et al. Post-myocardial infarct p27 fusion protein intravenous delivery averts adverse remodelling and improves heart function and survival in rodents. Cardiovasc Res 2012;94:492-500
22. Koneru S, Varma Penumathsa S, Thirunavukkarasu M, et al. Sildenafil-mediated neovascularization and protection against myocardial ischaemia reperfusion injury in rats: Role of VEGF/ angiopoietin-1. J Cell Mol Med 2008;12:2651-64
23. Lam CK, Zhao W, Cai W, et al. Novel role of HAX-1 in ischemic injury protection involvement of heat shock protein 90. Circ Res 2013;112:79-89
24. Cai B, Lin Y, Xue X-H, et al. TAT-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice. Exp Neurol 2011;227:224-31
25. Paul A, Binsalamah ZM, Khan AA, et al. A nanobiohybrid complex of recombinant baculovirus and Tat/DNA nanoparticles for delivery of Ang-1 transgene in myocardial infarction therapy. Biomaterials 2011;32:8304-18
26. Kong HJ, Lee KY, Mooney DJ. Decoupling the dependence of rheological/mechanical properties of hydrogels from solids concentration. Polymer 2002;43:6239-46
27. Drury JL, Mooney DJ. Hydrogels for tissue engineering: Scaffold design variables and applications. Biomaterials 2003;24:4337-51
28. Tønnesen HH, Karlsen J. Alginate in drug delivery systems. Drug Dev Ind Pharm 2002;28:621-30
29. Gombotz WR, Wee S. Protein release from alginate matrices. Adv Drug Deliv Rev 1998;31:267-85
30. Lee KY, Mooney DJ. Alginate: Properties and biomedical applications. Prog Polym Sci 2012;32:106-26
31. Won YW, Kim JK., Cha MJ, et al. Prolongation and enhancement of the anti-Apoptotic effects of PTD-Hsp27 fusion proteins using an injectable thermo-reversible gel in a rat myocardial infarction model. J Control Release 2010;144:181-9
32. Shi C, Li Q, Zhao Y, et al. Stem-cell-capturing collagen scaffold promotes cardiac tissue regeneration. Biomaterials 2011;32: 2508-15
33. Shimizu T, Sekine H, Yamato M, et al. Cell sheet-based myocardial tissue engineering: New hope for damaged heart rescue. Curr Pharm Design 2009;15:2807-14
34. Xiong Q, Hill KL, Li Q, et al. A fibrin patch-based enhanced delivery of human embryonic stem cell-derived vascular cell transplantation in a porcine model of postinfarction left ventricular remodeling. Stem Cells 2011;29:367-75
35. Vunjak-Novakovic G, Lui KO, Tandon N, et al. Bioengineering heart muscle: A paradigm for regenerative medicine. Annu Rev Biomed Eng 2011;13:245-67