Autonomic modulation of repolarization instability in patients with heart failure prone to ventricular tachycardia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 305, Issue 8, 2013, Pages

  Nayyar, Sachin ^a   Roberts Thomson, Kurt C ^a   Hasan, Muhammad A ^b   Sullivan, Thomas ^b   Harrington, Judith ^a   Sanders, Prashanthan ^a   Baumert, Mathias ^a,b  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

blocker; Autonomic modulation; Ischemic cardiomyopathy; QT variability

Indexed keywords

ATROPINE; ESMOLOL; ISOPRENALINE;

ADULT; AGED; ANGIOCARDIOGRAPHY; ARTICLE; AUTONOMIC INNERVATION; AUTONOMIC NERVOUS SYSTEM; AUTONOMIC NERVOUS SYSTEM FUNCTION; CALCULATION; CARDIOVASCULAR RISK; CATHETER ABLATION; CLINICAL ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; FEMALE; HEART ATRIUM PACING; HEART BEAT; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART RATE VARIABILITY; HEART REPOLARIZATION; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE TACHYCARDIA; HUMAN; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; ISCHEMIC CARDIOMYOPATHY; MALE; PREDICTOR VARIABLE; PRIORITY JOURNAL; QT INTERVAL; RR INTERVAL; SUDDEN CARDIAC DEATH; SUPRAVENTRICULAR TACHYCARDIA; SYMPATHETIC BLOCKING; SYMPATHETIC TONE;

Β-BLOCKER; AUTONOMIC MODULATION; ISCHEMIC CARDIOMYOPATHY; QT VARIABILITY;

ADOLESCENT; ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ADRENERGIC BETA-AGONISTS; ADULT; AGED; AUTONOMIC NERVOUS SYSTEM; CARDIOMYOPATHIES; CASE-CONTROL STUDIES; ELECTROCARDIOGRAPHY; FEMALE; HEART FAILURE; HUMANS; ISOPROTERENOL; MALE; MIDDLE AGED; PROPANOLAMINES; TACHYCARDIA, VENTRICULAR; YOUNG ADULT;

EID: 84885620159     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00448.2013     Document Type: Article

References (56)

1. Ajijola OA, Vaseghi M, Zhou W, Yamakawa K, Benharash P, Hadaya J, Lux RL, Mahajan A, Shivkumar K. Functional differences between junctional and extrajunctional adrenergic receptor activation in mammalian ventricle. Am J Physiol Heart Circ Physiol 304: H579-H588, 2013.
2. Akar FG, Wu RC, Juang GJ, Tian Y, Burysek M, Disilvestre D, Xiong W, Armoundas AA, Tomaselli GF. Molecular mechanisms underlying K current downregulation in canine tachycardia-induced heart failure. Am J Physiol Heart Circ Physiol 288: H2887-H2896, 2005.
3. Antzelevitch C, Dumaine R. Electrical heterogeneity in the heart: physiological, pharmacological and clinical implications. In: Handbook of Physiology. The Cardiovascular System. The Heart. New York: Oxford Univ. Press, 2002, sect. 2, vol. I, p. 654-692.
4. Antzelevitch C, Fish J. Electrical heterogeneity within the ventricular wall. Basic Res Cardiol 96: 517-527, 2001.
5. Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, Domanski M, Troutman C, Anderson J, Johnson G, McNulty SE, Clapp-Channing N, Davidson-Ray LD, Fraulo ES, Fishbein DP, Luceri RM, Ip JH. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 352: 225-237, 2005.
6. Baumert M, Lambert G, Dawood T, Lambert E, Esler M, McGrane M, Barton D, Nalivaiko E. QT interval variability and cardiac norepinephrine spillover in patients with depression and panic disorder. Am J Physiol Heart Circ Physiol 295: H962-H968, 2008.
7. Baumert M, Schlaich MP, Nalivaiko E, Lambert E, Sari CI, Kaye DM, Elser MD, Sanders P, Lambert G. Relation between QT interval variability and cardiac sympathetic activity in hypertension. Am J Physiol Heart Circ Physiol 300: H1412-H1417, 2011.
8. Berger R, Kasper E, Baughman K, Marban E, Calkins H, Tomaselli G. Beat-to-beat QT interval variability: novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation 96: 1557-1565, 1997.
9. Berglund H, Edlund A, Theodorsson E, Vallin H. Haemodynamic and hormonal responses to cardiac pacing in humans: influence of different stimulation sequences and rates. Clin Sci 88: 165-172, 1995.
10. Beuckelmann D, Nabauer M, Erdmann E. Alterations of K currents in isolated humanventricular myocytes from patients with terminal heart failure. Circulation 73: 379-385, 1993.
11. Beuckelmann D, Nabauer M, Erdmann E. Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation 85: 1046-1055, 1992.
12. Bristow MR. Adrenergic receptor blockade in chronic heart failure. Circulation 101: 558-569, 2000.
13. Brunton L, Chabner B, Knollman B. Goodman and Gilman's The Pharmacological Basis of Therapeutics (12 ed.). New York: McGrawHill, 2011, p. 1808.
14. Chatterjee S, Biondi-Zoccai G, Abbate A, D'Ascenzo F, Castagno D, Van Tassell B, Mukherjee D, Lichstein E. Benefits of blockers in patients with heart failure and reduced ejection fraction: network metaanalysis. BMJ 346: f55, 2013.
15. Chen X, Hu Y, Fetics BJ, Berger RD, Trayanova NA. Unstable QT interval dynamics precedes ventricular tachycardia onset in patients with acute myocardial infarction: a novel approach to detect instability in QT interval dynamics from clinical ECG. Circ Arrhythm Electrophysiol 4: 858-866, 2011.
16. Cheng A, Dalal D, Fetics BJ, Angkeow P, Spragg DD, Calkins H, Tomaselli GF, Berger RD. Ibutilide-induced changes in the temporal lability of ventricular repolarization in patients with and without structural heart disease. J Cardiovasc Electrophysiol 20: 873-879, 2009.
17. Chugh SS, Reinier K, Singh T, Uy-Evanado A, Socoteanu C, Peters D, Mariani R, Gunson K, Jui J. Determinants of prolonged QT interval and their contribution to sudden death risk in coronary artery disease: the Oregon Sudden Unexpected Death Study. Circulation 119: 663-670, 2009.
18. Desai N, Raghunandan DS, Mallavarapu M, Berger RD, Yeragani VK. Beat-to-beat heart rate and QT variability in patients with congestive cardiac failure: blunted response to orthostatic challenge. Ann Noninvasive Electrocardiol 9: 323-329, 2004.
19. Epstein AE, Dimarco JP, Ellenbogen KA, Estes NA, 3rd Freedman RA, Gettes LS, Gillinov AM, Gregoratos G, Hammill SC, Hayes DL, Hlatky MA, Newby LK, Page RL, Schoenfeld MH, Silka MJ, Stevenson LW, Sweeney MO. ACC/AHA/HRS 2008 guidelines for devicebased therapy of cardiac rhythm abnormalities: executive summary. Heart Rhythm 5: 934-955, 2008.
20. Fauchier L, Pierre B, de Labriolle A, Babuty D. Comparison of the beneficial effect of beta-blockers on mortality in patients with ischaemic or non-ischaemic systolic heart failure: a meta-analysis of randomised controlled trials. Eur J Heart Fail 9: 1136-1139, 2007.
21. Feldman DS, Carnes CA, Abraham WT, Bristow MR. Mechanisms of disease:-adrenergic receptors-alterations in signal transduction and pharmacogenomics in heart failure. Nat Clin Pract Cardiovasc Med 2: 475-483, 2005.
22. Franz MR, Swerdlow CD, Liem LB, Schaefer J. Cycle length dependence of human action potential duration in vivo. Effects of single extrastimuli, sudden sustained rate acceleration and deceleration, and different steady-state frequencies. J Clin Invest 82: 972-979, 1988.
23. Haigney M, Zareba W, Gentlesk P, Goldstein R, Illovsky M, McNitt S, Andrews M, Moss A. QT interval variability and spontaneous ventricular tachycardia or fibrillation in the Multi-center Automatic Defibrillator Implantation Trial (MADIT) II patients. J Am Coll Cardiol 44: 1481-1487, 2004.
24. Hasan MA, Abbott D, Baumert M. Relation between beat-to-beat QT interval variability and T-wave amplitude in healthy subjects. Ann Noninvasive Electrocardiol 17: 195-203, 2012.
25. Hinterseer M, Beckmann BM, Thomsen MB, Pfeufer A, Ulbrich M, Sinner MF, Perz S, Wichmann HE, Lengyel C, Schimpf R, Maier SK, Varro A, Vos MA, Steinbeck G, Kaab S. Usefulness of short-term variability of QT intervals as a predictor for electrical remodeling and proarrhythmia in patients with nonischemic heart failure. Am J Cardiol 106: 216-220, 2010.
26. Jensen BT, Larroude CE, Rasmussen LP, Holstein-Rathlou NH, Hojgaard MV, Agner E, Kanters JK. Beat-to-beat QT dynamics in healthy subjects. Ann Noninvasive Electrocardiol 9: 3-11, 2004.
27. Karwatowska-Prokopczuk E, Wang W, Cheng ML, Zeng D, Schwartz PJ, Belardinelli L. The risk of sudden cardiac death in patients with non-ST elevation acute coronary syndrome and prolonged QTc interval: effect of ranolazine. Europace 15: 429-436, 2013.
28. Kaye D, Lefkovits J, Jennings G, Bergin P, Broughton A, Esler M. Adverse consequences of high sympathetic nervous activity in the failing human heart. J Am Coll Cardiol 26: 1257-1263, 1995.
29. Krauss TT, Mauser W, Reppel M, Schunkert H, Bonnemeier H. Gender effects on novel time domain parameters of ventricular repolarization inhomogeneity. Pacing Clin Electrophysiol 32, Suppl 1: S167-S172, 2009.
30. Lengyel C, Varro A, Tabori K, Papp JG, Baczko I. Combined pharmacological block of IKr and IKs increases short-term QT interval variability and provokes torsades de pointes. Br J Pharmacol 151: 941-951, 2007.
31. Lombardi F, Malliani A, Pagani M, Cerutti S. Heart rate variability and its sympatho-vagal modulation. Cardiovasc Res 32: 208-216, 1996.
32. Lombardi F, Sandrone G, Porta A, Torzillo D, Terranova G, Baselli G, Cerutti S, Malliani A. Spectral analysis of short term R-Tapex interval variability during sinus rhythm and fixed atrial rate. Eur Heart J 17: 769-778, 1996.
33. Mine T, Shimizu H, Hiromoto K, Furukawa Y, Kanemori T, Nakamura H, Masuyama T, Ohyanagi M. Beat-to-beat QT interval variability is primarily affected by the autonomic nervous system. Ann Noninvasive Electrocardiol 13: 228-233, 2008.
34. Murabayashi T, Fetics B, Kass D, Nevo E, Gramatikov B, Berger R. Beat-to-beat QT interval variability associated with acute myocardial ischemia. J Electrocardiol 35: 19-25, 2002.
35. Nakagawa M, Ooie T, Ou B, Ichinose M, Takahashi N, Hara M, Yonemochi H, Saikawa T. Gender differences in autonomic modulation of ventricular repolarization in humans. J Cardiovasc Electrophysiol 16: 278-284, 2005.
36. Oosterhoff P, Tereshchenko LG, van der Heyden MAG, Ghanem RN, Fetics BJ, Berger RD, Vos MA. Short-term variability of repolarization predicts ventricular tachycardia and sudden cardiac death in patients with structural heart disease: a comparison to QT variability index. Heart Rhythm 8: 1584-1590, 2011.
37. Orejarena LA, Vidaillet H Jr, DeStefano F, Nordstrom DL, Vierkant RA, Smith PN, Hayes JJ. Paroxysmal supraventricular tachycardia in the general population. J Am Coll Cardiol 31: 150-157, 1998.
38. Ouellet G, Huang DT, Moss AJ, Hall WJ, Barsheshet A, McNitt S, Klein H, Zareba W, Goldenberg I. Effect of cardiac resynchronization therapy on the risk of first and recurrent ventricular tachyarrhythmic events in MADIT-CRT. J Am Coll Cardiol 60: 1809-1816, 2012.
39. Piccirillo G, Magnanti M, Matera S, Di Carlo S, De Laurentis T, Torrini A, Marchitto N, Ricci R, Magrí D. Age and QT variability index during free breathing, controlled breathing and tilt in patients with chronic heart failure and healthy control subjects. Transl Res 148: 72-78, 2006.
40. Piccirillo G, Magri D, Matera S, Magnanti M, Torrini A, Pasquazzi E, Schifano E, Velitti S, Marigliano V, Quaglione R, Barillà F. QT variability strongly predicts sudden cardiac death in asymptomatic subjects with mild or moderate left ventricular systolic dysfunction: a prospective study. Eur Heart J 28: 1344-1350, 2007.
41. Piccirillo G, Magri D, Ogawa M, Song J, Chong V, Han S, Joung B, Choi E, Hwang S, Chen L, Lin S, Chen P. Autonomic nervous system activity measured directly and QT interval variability in normal and pacing-induced tachycardia heart failure dogs. J Am Coll Cardiol 54: 840-850, 2009.
42. Piccirillo G, Quaglione R, Nocco M, Naso C, Moise A, Lionetti M, Di Carlo S, Marigliano V. Effects of long-term-blocker (metoprolol or carvedilol) therapy on QT variability in subjects with chronic heart failure secondary to ischemic cardiomyopathy. Am J Cardiol 90: 1113-1117, 2002.
43. Piccirillo G, Rossi P, Mitra M, Quaglione R, Dell'Armi A, Di Barba D, Maisto D, Lizio A, Barilla F, Magri D. Indexes of temporal myocardial repolarization dispersion and sudden cardiac death in heart failure: any difference? Ann Noninvasive Electrocardiol 18: 130-139, 2013.
44. Porta A, Tobaldini E, Gnecchi-Ruscone T, Montano N. RT variability unrelated to heart period and respiration progressively increases during graded head-up tilt. Am J Physiol Heart Circ Physiol 298: H1406-H1414, 2010.
45. Roden DM. Taking the "idio" out of "idiosyncratic": predicting torsades de pointes. Pacing Clin Electrophysiol 21: 1029-1034, 1998.
46. Roden DM, Yang T. Protecting the heart against arrhythmias: potassium current physiology and repolarization reserve. Circulation 112: 1376-1378, 2005.
47. Schwartz PJ, Wolf S. QT interval prolongation as predictor of sudden death in patients with myocardial infarction. Circulation 57: 1074-1077, 1978.
48. Starc V, Schlegel TT. Real-time multichannel system for beat-to-beat QT interval variability. J Electrocardiol 39: 358-367, 2006.
49. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93: 1043-1065, 1996.
50. Tereshchenko LG, Cygankiewicz I, McNitt S, Vazquez R, Bayes-Genis A, Han L, Sur S, Couderc JP, Berger RD, de Luna AB, Zareba W. Predictive value of beat-to-beat QT variability index across the continuum of left ventricular dysfunction: competing risks of noncardiac or cardiovascular death and sudden or nonsudden cardiac death. Circ Arrhythm Electrophysiol 5: 719-727, 2012.
51. Tereshchenko LG, Henrikson CA, Berger RD. Strong coherence between heart rate variability and intracardiac repolarization lability during biventricular pacing is associated with reverse electrical remodeling of the native conduction and improved outcome. J Electrocardiol 44: 713-717, 2011.
52. Vaseghi M, Lux RL, Mahajan A, Shivkumar K. Sympathetic stimulation increases dispersion of repolarization in humans with myocardial infarction. Am J Physiol Heart Circ Physiol 302: H1838-H1846, 2012.
53. Wiest DB, Haney JS. Clinical pharmacokinetics and therapeutic efficacy of esmolol. Clin Pharmacokinet 51: 347-356, 2012.
54. Wilkoff BL, Cook JR, Epstein AE, Greene HL, Hallstrom AP, Hsia H, Kutalek SP, Sharma A. Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial. JAMA 288: 3115-3123, 2002.
55. Yeragani V, Pohl R, Jampala V, Balon R, Kay J, Igel G. Effect of posture and isoproterenol on beat-to-beat heart rate and QT variability. Neuropsychobiology 41: 113-123, 2000.
56. Zaza A, Malfatto G, Schwartz PJ. Sympathetic modulation of the relation between ventricular repolarization and cycle length. Circ Res 68: 1191-1203, 1991.