Glutathione homeostasis disruption of erythrocytes, but not glutathione peroxidase activity change, is closely accompanied with neurological and radiological scoring of acute CNS inflammation

NeuroImmunoModulation

Volumn 21, Issue 1, 2013, Pages 13-20

  Ljubisavljevic, Srdjan ^a,b   Stojanovic, Ivana ^b   Cvetkovic, Tatjana ^b   Vojinovic, Slobodan ^a   Stojanov, Dragan ^a   Stojanovic, Dijana ^b   Bojanic, Vladmila ^b   Stokanovic, Dragana ^b   Pavlovic, Dusica ^b  

^a CLINICAL CENTER NI   (Serbia)

^b UNIVERSITY OF NI   (Serbia)

Author keywords

CNS inflammation; Erythrocytes; Glutathione; Glutathione peroxidase

Indexed keywords

GLUTATHIONE; GLUTATHIONE PEROXIDASE;

ACUTE DISEASE; ADULT; ARTICLE; CENTRAL NERVOUS SYSTEM INFLAMMATION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEMYELINATING DISEASE; DISEASE DURATION; DISEASE SEVERITY; ENZYME ACTIVITY; ERYTHROCYTE; FEMALE; HOMEOSTASIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROIMAGING; PRIORITY JOURNAL; ADOLESCENT; CELL DISRUPTION; CLINICAL FEATURE; CORRELATIONAL STUDY;

ADOLESCENT; ADULT; AGE FACTORS; CROSS-SECTIONAL STUDIES; DISABILITY EVALUATION; ENCEPHALITIS; ERYTHROCYTES; FEMALE; GADOLINIUM; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HOMEOSTASIS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; SEX FACTORS; YOUNG ADULT;

EID: 84885514217     PISSN: 10217401     EISSN: 14230216     Source Type: Journal    
DOI: 10.1159/000355040     Document Type: Article

References (33)

1. Barnham KL, Masters CL, Bush AI: Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov 2004; 3: 205-214.
2. Floyd RA, Hensley K: Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases. Neurobiol Aging 2002; 23: 795-807. (Pubitemid 35217704)
3. Dalle-Donne I, Rossi R, Colombo R, Giustarini D, Milzani A: Biomarkers of oxidative damage in human disease. Clin Chem 2006; 52: 601-623.
4. Staron A, Makosa G, Koter-Michalak M: Oxidative stress in erythrocytes from patients with rheumatoid arthritis. Rheumatol Int 2012; 32: 331-334.
5. Deneke SM: Thiol-based antioxidants. Curr Top Cell Regul 2000; 36: 151-180.
6. Brack M, Brack O, Ménézo Y, Bonnefont Rousselot D, Dreyfus G, John Chapman M, Kontush A: Distinct profiles of systemic biomarkers of oxidative stress in chronic human pathologies: cardiovascular, psychiatric, neurodegenerative, rheumatic, infectious, neoplasmic and endocrinological diseases. Adv Biosci Biotechnol 2013; 4: 331-339.
7. Ljubisavljevic S, Stojanovic I, Vojinovic S, Stojanov D, Stojanovic S, Cvetkovic T, Savic D, Pavlovic D: The patients with clinically isolated syndrome and relapsing remitting multiples sclerosis show different levels of advanced protein oxidation products and reduced thiols content in sera and CSF. Neurochem Int 2013; 62: 988-997.
8. Ljubisavljevic S, Stojanovic I, Vojinovic S, Stojanov D, Stojanovic S, Kocic G, Savic D, Cvetkovic T, Pavlovic D: Cerebrospinal fluid and plasma oxidative stress biomarkers in different clinical phenotypes of neuroinflammatory acute attacks. Conceptual accession: from fundamental to clinic. Cell Mol Neurobiol 2013; 33: 767-777.
9. Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O?Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS: Diagnostic criteria for multiple sclerosis: 2010 revisions to the Mc- Donald criteria. Ann Neurol 2011; 69: 292-302.
10. Lublin FD, Reingold SC: Defining the clinical course of multiple sclerosis: results of an international survey - National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996; 46: 907-911.
11. Kurtzke JF: Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983; 33: 1444-1452. (Pubitemid 14237132)
12. Drabkin DL: The crystallographic and optical properties of the haemoglobin of man in comparison with those of other species. J Biol Chem 1946; 164: 703-723.
13. Ellman G: Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82: 70-77.
14. Paglia DE, Valentine WN: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. Lab Clin Med 1967; 70: 158-169.
15. Grinberg L, Fibach E, Amer J, Atlas D: N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress. Free Radic Biol Med 2005; 38: 1136-1145.
16. Calabrese V, Scapagnini G, Ravagna A, Bella R, Foresti R, Bates TE, Giuffrida Stella AM, Pennisi G: Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. J Neurosci Res 2002; 70: 580-587. (Pubitemid 35253528)
17. Kidd PM: Multiple sclerosis, an autoimmune inflammatory disease: prospects for its integrative management. Altern Med Rev 2001; 6: 540-566. (Pubitemid 34038811)
18. Ljubisavljevic S, Stojanovic I, Pavlovic R, Stojnev S, Stevanovic I, Sokolovic D, Pavlovic D: The reduced glutathione and S-nitrosothiol levels in acute phase of experimental demyelination - pathophysiological approach and possible clinical relevancy. Neuroscience 2012; 219: 175-182.
19. Tchantchou F, Graves M, Ortiz D, Rogers E, Shea TB: Dietary supplementation with apple juice concentrate alleviates the compensatory increase in glutathione synthase transcription and activity that accompanies dietary and genetically induced oxidative stress. J Nutr Health Aging 2004; 8: 492-496. (Pubitemid 39482181)
20. Besler HT, Comoglu S, Okcu Z: Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis. Nutr Neurosci 2002; 5: 215-220. (Pubitemid 34568217)
21. Rahman I, MacNee W: Regulation of redox glutathione levels and gene transcription in lung inflammation: Therapeutic approaches. Free Radic Biol Med 2000; 28: 1405-1420. (Pubitemid 30621483)
22. Rahman I: Inflammation and the regulation of glutathione level in lung epithelial cells. Antioxid Redox Signal 1999; 1: 425-447. (Pubitemid 129628308)
23. Pan Z, Perez-Polo R: Role of nerve growth factor in oxidant homeostasis: glutathione metabolism. J Neurochem 1993; 61: 1713-1721. (Pubitemid 23317194)
24. Calabrese V, Bella R, Testa D, Spadaro F, Scrofani A, Rizza V, Pennisi G: Increased cerebrospinal fluid and plasma levels of ultraweak chemiluminescence are associated with changes in the thiol pool and lipid-soluble fluorescence in multiple sclerosis: The pathogenic role of oxidative stress. Drugs Exp Clin Res 1998; 24: 125-131. (Pubitemid 28499567)
25. Hvaring C, Vujicic S, Aasly JO, Feinstein DL, White LR, Boullerne AI: IgM to S-nitrosylated protein is found intrathecally in relapsingremitting multiple sclerosis. J Neuroimmunol 2013; 256: 77-83.
26. van Meeteren ME, Teunissen CE, Dijkstra CD, van Tol EAF: Antioxidants and polyunsaturated fatty acids in multiple sclerosis. Eur J Clin Nutr 2005; 59: 1347-1361. (Pubitemid 43135149)
27. Tasset I, Agudie;era E, Sánchez-López F, Feijóo M, Giraldo AI, Cruz AH, Gascón F, Túnez I: Peripheral oxidative stress in relapsing-remitting multiple sclerosis. Clin Biochem 2012; 45: 440-444.
28. Lin SX, Lisi L, Dello Russo C, Polak PE, Sharp A, Weinberg G, Kalinin S, Feinstein DL: The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1. ASN Neuro 2011; 3:e00055.
29. Adamczyksowa M, Sowa P, Pierzchala K, Polaniak R, Labuzroszak B: Antioxidative enzyme activity and malondialdehyde concentration during mitoxantrone therapy in multiple sclerosis patients. J Physiol Pharmacol 2012; 63: 683-690.
30. Miller E, Mrowicka M, Zo?yński K, Kedziora J: Oxidative stress in multiple sclerosis. Pol Merkur Lekarski 2009; 162: 499-502.
31. Nath N, Morinaga O, Singh I: S-nitrosoglutathione, a physiologic nitric oxide carrier, attenuates experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol 2010; 2: 240-251.
32. Straif D, Werz DO, Kellner R, Bahr U, Steinhilber D: Glutathione peroxidase-1 but not -4 is involved in the regulation of cellular 5-lipoxygenase activity in monocytic cells. Biochem J 2000; 349: 455-461. (Pubitemid 30465780)
33. Forgione MA, Weiss N, Heydrick S, Cap A, Klings ES, Bierl C, Eberhardt RT, Farber HW, Loscalzo J: Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol 2002; 282:H1255-H1261. (Pubitemid 34654876)