1H NMR-based metabolic profiling of human rectal cancer tissue

Molecular Cancer

Volumn 12, Issue 1, 2013, Pages

  Wang, Huijuan ^a   Wang, Liang ^a   Zhang, Hailong ^a   Deng, Pengchi ^b   Chen, Jie ^a   Zhou, Bin ^a   Hu, Jing ^a   Zou, Jun ^a   Lu, Wenjie ^a   Xiang, Pu ^a   Wu, Tianming ^a   Shao, Xiaoni ^a   Li, Yuan ^a   Zhou, Zongguang ^a   Zhao, Ying Lan ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETIC ACID; ACETOACETIC ACID; ALANINE; BETAINE; BIOLOGICAL MARKER; CHOLINE; CREATINE; CREATINE PHOSPHATE; DIMETHYLAMINE; DIMETHYLGLYCINE; FORMIC ACID; GLUCOSE; GLUTAMINE; GLUTATHIONE; GLYCOLIC ACID; INOSITOL; ISOLEUCINE; LACTIC ACID; LEUCINE; LYSINE; METHYLAMINE; SARCOSINE; SERINE; SUCCINIC ACID; TAURINE; THREONINE; TYROSINE; URACIL; VALINE; TUMOR MARKER;

ADULT; AGED; AMINO ACID METABOLISM; ARTICLE; CANCER GROWTH; CANCER PATIENT; CANCER STAGING; CANCER TISSUE; CELL PROLIFERATION; CITRIC ACID CYCLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; ENERGY; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; METABOLITE; METABOLOMICS; MOLECULAR DIAGNOSIS; PROTON NUCLEAR MAGNETIC RESONANCE; PYRIMIDINE METABOLISM; RECTUM CANCER; TISSUE LEVEL; UPREGULATION; CASE CONTROL STUDY; METABOLISM; METABOLOME; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PRINCIPAL COMPONENT ANALYSIS; RECTUM; RECTUM TUMOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLIC NETWORKS AND PATHWAYS; METABOLOME; MIDDLE AGED; NEOPLASM STAGING; PRINCIPAL COMPONENT ANALYSIS; RECTAL NEOPLASMS; RECTUM; TUMOR MARKERS, BIOLOGICAL;

EID: 84885510469     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-121     Document Type: Article

References (41)

1. Chan ECY, Koh PK, Mal M, Cheah PY, Eu KW, Backshall A, Cavill R, Nicholson JK, Keun HC. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). J Proteome Res 2008, 8:352-361.
2. Boras Z, Kondza G, Sisljagic V, Busic Z, Gmajnic R, Istvanic T. Prognostic factors of local recurrence and survival after curative rectal cancer surgery: a single institution experience. Coll Antropol 2012, 36:1355-1361.
3. Claudino WM, Quattrone A, Biganzoli L, Pestrin M, Bertini I, Di Leo A. Metabolomics: available results, current research projects in breast cancer, and future applications. J Clin Oncol 2007, 25:2840-2846. 10.1200/JCO.2006.09.7550, 17502626.
4. Yang J, Xu G, Hong Q, Liebich HM, Lutz K, Schmülling R-M, Wahl HG. Discrimination of type 2 diabetic patients from healthy controls by using metabonomics method based on their serum fatty acid profiles. J Chromatogr B 2004, 813:53-58.
5. Xue R, Lin Z, Deng C, Dong L, Liu T, Wang J, Shen X. A serum metabolomic investigation on hepatocellular carcinoma patients by chemical derivatization followed by gas chromatography/mass spectrometry. Rapid Commun Mass Spectrom 2008, 22:3061-3068. 10.1002/rcm.3708, 18767022.
6. Bogdanov M, Matson WR, Wang L, Matson T, Saunders-Pullman R, Bressman SS, Beal MF. Metabolomic profiling to develop blood biomarkers for Parkinson's disease. Brain 2008, 131:389-396. 10.1093/brain/awm304, 18222993.
7. Bertram HC, Hoppe C, Petersen BO, Duus J, Molgaard C, Michaelsen KF. An NMR-based metabonomic investigation on effects of milk and meat protein diets given to 8-year-old boys. Br J Nutr 2007, 97:758-763. 10.1017/S0007114507450322, 17349089.
8. Shi C, A-M CAO, H-Z SHENG, X-Z YAN, M-Y LIAO. NMR-spectroscopy-based metabonomic approach to the analysis of Bay41-4109, a novel anti-HBV compound, induced hepatotoxicity in rats. Toxicol Lett 2007, 173:161-167. 10.1016/j.toxlet.2007.07.010, 17826925.
9. Wei L, Liao P, Wu H, Li X, Pei F, Li W, Wu Y. Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum. Toxicol Appl Pharmacol 2008, 227:417-429. 10.1016/j.taap.2007.11.015, 18164359.
10. Kaddurah-Daouk R, Kristal BS, Weinshilboum RM. Metabolomics: a global biochemical approach to drug response and disease. Annu Rev Pharmacol Toxicol 2008, 48:653-683. 10.1146/annurev.pharmtox.48.113006.094715, 18184107.
11. Ward JL, Baker JM, Beale MH. Recent applications of NMR spectroscopy in plant metabolomics. FEBS J 2007, 274:1126-1131. 10.1111/j.1742-4658.2007.05675.x, 17298436.
12. Krishnan P, Kruger N, Ratcliffe R. Metabolite fingerprinting and profiling in plants using NMR. J Exp Bot 2005, 56:255-265.
13. Piotto M, Moussallieh F-M, Dillmann B, Imperiale A, Neuville A, Brigand C, Bellocq J-P, Elbayed K, Namer I. Metabolic characterization of primary human colorectal cancers using high resolution magic angle spinning 1 H magnetic resonance spectroscopy. Metabolomics 2009, 5:292-301.
14. Lai HS, Lee JC, Lee PH, Wang ST, Chen WJ. Plasma free amino acid profile in cancer patients. Semin Cancer Biol 2005, 15:267-276. 10.1016/j.semcancer.2005.04.003, 15894488.
15. Martinez-Zaguilan R, Seftor EA, Seftor RE, Chu Y-W, Gillies RJ, Hendrix MJ. Acidic pH enhances the invasive behavior of human melanoma cells. Clin Exp Metastasis 1996, 14:176-186. 10.1007/BF00121214, 8605731.
16. Gribbestad IS, Petersen SB, Fjøsne HE, Kvinnsland S, Krane J. 1H NMR spectroscopic characterization of perchloric acid extracts from breast carcinomas and non-involved breast tissue. NMR Biomed 1994, 7:181-194. 10.1002/nbm.1940070405, 7946996.
17. Muscaritoli M, Conversano L, Petti M, Cascino A, Mecarocci S, Annicchiarico M, Fanelli FR. Plasma amino acid concentrations in patients with acute myelogenous leukemia. Nutrition 1999, 15:195-199. 10.1016/S0899-9007(98)00179-8, 10198913.
18. Warburg O. On the origin of cancer cells. Science 1956, 123:309-314. 10.1126/science.123.3191.309, 13298683.
19. Schlappack O, Zimmermann A, Hill R. Glucose starvation and acidosis: effect on experimental metastatic potential, DNA content and MTX resistance of murine tumour cells. Br J Cancer 1991, 64:663-670. 10.1038/bjc.1991.378, 1977701, 1911214.
20. Onda T, Uzawa K, Endo Y, Bukawa H, Yokoe H, Shibahara T, Tanzawa H. Ubiquitous mitochondrial creatine kinase down regulated in oral squamous cell carcinoma. Br J Cancer 2006, 94:698-709. 2361206, 16479256.
21. Hirayama A, Kami K, Sugimoto M, Sugawara M, Toki N, Onozuka H, Kinoshita T, Saito N, Ochiai A, Tomita M. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res 2009, 69:4918-4925. 10.1158/0008-5472.CAN-08-4806, 19458066.
22. Maddocks OD, Berkers CR, Mason SM, Zheng L, Blyth K, Gottlieb E, Vousden KH. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 2012, 493:542-546. 10.1038/nature11743, 23242140.
23. Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet 2011, 43:869-874. 10.1038/ng.890, 3677549, 21804546.
24. Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo H-K, Jang HG, Jha AK. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 2011, 476:346-350. 10.1038/nature10350, 3353325, 21760589.
25. Lin J-K, Ho Y. Hepatotoxicity and hepatocarcinogenicity in rats fed squid with or without exogenous nitrite. Food Chem Toxicol 1992, 30:695-702. 10.1016/0278-6915(92)90165-H, 1328003.
26. Lehnhardt FG, Bock C, Röhn G, Ernestus RI, Hoehn M. Metabolic differences between primary and recurrent human brain tumors: a 1H NMR spectroscopic investigation. NMR Biomed 2005, 18:371-382. 10.1002/nbm.968, 15959923.
27. Davies N, Wilson M, Harris L, Natarajan K, Lateef S, Macpherson L, Sgouros S, Grundy R, Arvanitis T, Peet A. Identification and characterisation of childhood cerebellar tumours by in vivo proton MRS. NMR Biomed 2008, 21:908-918. 10.1002/nbm.1283, 18613254.
28. Ma Y, Liu W, Peng J, Huang L, Zhang P, Zhao X, Cheng Y, Qin H. A pilot study of gas chromatograph/mass spectrometry-based serum metabolic profiling of colorectal cancer after operation. Mol Biol Rep 2010, 37:1403-1411. 10.1007/s11033-009-9524-4, 19340605.
29. Asiago VM, Alvarado LZ, Shanaiah N, Gowda GN, Owusu-Sarfo K, Ballas RA, Raftery D. Early detection of recurrent breast cancer using metabolite profiling. Cancer Res 2010, 70:8309-8318. 10.1158/0008-5472.CAN-10-1319, 2995269, 20959483.
30. Owen O, Morgan A, Kemp H, Sullivan J, Herrera M, Cahill G. Brain metabolism during fasting. J Clin Invest 1967, 46:1589-1595. 10.1172/JCI105650, 292907, 6061736.
31. Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 2013, 339:211-214. 10.1126/science.1227166, 3735349, 23223453.
32. Yanagida O, Kanai Y, Chairoungdua A, Kim DK, Segawa H, Nii T, Cha SH, Matsuo H, Fukushima J, Fukasawa Y. Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta 2001, 1514:291-302. 10.1016/S0005-2736(01)00384-4, 11557028.
33. Vucenik I, Shamsuddin AM. Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. J Nutr 2003, 133:3778S-3784S.
34. Kassie F, Melkamu T, Endalew A, Upadhyaya P, Luo X, Hecht SS. Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination. Carcinogenesis 2010, 31:1634-1641. 10.1093/carcin/bgq139, 2930804, 20603442.
35. Hong Y, Ho KS, Eu KW, Cheah PY. A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis. Clin Cancer Res 2007, 13:1107-1114. 10.1158/1078-0432.CCR-06-1633, 17317818.
36. Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, Nicholson JK. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc 2007, 2:2692-2703. 10.1038/nprot.2007.376, 18007604.
37. Hu Z, Deng Y, Hu C, Deng P, Bu Q, Yan G, Zhou J, Shao X, Zhao J, Li Y. 1H NMR-based metabonomic analysis of brain in rats of morphine dependence and withdrawal intervention. Behav Brain Res 2012, 231:11-19. 10.1016/j.bbr.2012.02.026, 22391120.
38. Trygg J, Holmes E, Lundstedt T. Chemometrics in metabonomics. J Proteome Res 2007, 6:469-479. 10.1021/pr060594q, 17269704.
39. Martin FPJ, Wang Y, Sprenger N, Yap IK, Lundstedt T, Lek P, Rezzi S, Ramadan Z, Van Bladeren P, Fay LB. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Mol Syst Biol 2008, 4:157. 2238715, 18197175.
40. Feng J, Liu H, Bhakoo KK, Lu L, Chen Z. A metabonomic analysis of organ specific response to USPIO administration. Biomaterials 2011, 32:6558-6569. 10.1016/j.biomaterials.2011.05.035, 21641028.
41. Holmes E, Foxall PJ, Spraul M, Duncan Farrant R, Nicholson JK, Lindon JC. 750 MHz 1H NMR spectroscopy characterisation of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease. J Pharm Biomed Anal 1997, 15:1647-1659. 10.1016/S0731-7085(97)00066-6, 9260660.